Research Topics
Genomes and Genes | Hidehiro TakahashiSummaryAffiliation: National Institute of Infectious Diseases Country: Japan Publications
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Publications
Analysis of human lymphotropic T-cell virus type II-like particle production by recombinant baculovirus-infected insect cellsR H Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo, 162, Japan
Virology 256:371-80. 1999..These results suggest the intracellular expression of Gag with Pro of HTLV-II is essential for the production of mature virus particles, whereas that of Pol is not...
Effects of the number of amino acid residues in the signal segment upstream or downstream of the NS2B-3 cleavage site on production and secretion of prM/M-E virus-like particles of West Nile virusHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Microbes Infect 11:1019-28. 2009....- Monoclonal antibody and siRNAs for topoisomerase I suppress telomerase activityHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama, Tokyo, Japan
Hybridoma (Larchmt) 28:63-5. 2009..In addition, siRNAs of topoisomerase I has attenuated telomerase activity in culture cells. These results suggest that topoisomerase I is involved in telomerase activity, as well as HIV-1 reverse transcription... - Dicer and positive charge of proteins decrease the stability of RNA containing the AU-rich element of GM-CSFHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
Biochem Biophys Res Commun 340:807-14. 2006..These findings suggest that degradation of mRNAs containing an ARE might be regulated by positive charge of polypeptides and Dicer... - Topoisomerase I dissociates human immunodeficiency virus type 1 reverse transcriptase from genomic RNAsHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Biochem Biophys Res Commun 313:1073-8. 2004..We propose that human topoisomerase I may regulate the binding of RT to RNAs and play a pivotal role in HIV-1 replication... - Binding and dissociation of human topoisomerase I with hairpin-loop RNAs: implications for the regulation of HIV-1 replicationHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Biochem Biophys Res Commun 297:593-9. 2002..A mechanism is proposed in which human topoisomerase I is carried into virions and regulates the repair of genomic RNA by its ligation activity... 
Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob diseaseH Takahashi
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Clin Diagn Lab Immunol 6:983-5. 1999..Furthermore, dot immunoblot analysis showed that MAbs were more specific for native antigen than polyclonal antibodies were...- Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAsHidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Biochem Biophys Res Commun 293:1084-91. 2002..Single-stranded oligoribonucleotides were cleaved between C and A or U and A, leaving 2',3'-cyclic phosphate and 5'-hydroxyl termini. These findings might explain the rapid degradation of genomic RNAs in HIV-1 particles... - Monoclonal antibodies against topoisomerase I suppressed DNA relaxation and HIV-1 cDNA synthesisH Takahashi
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Hybridoma 19:331-4. 2000..Thus, the results suggest that topoisomerase I plays an important role in RNA-directed DNA polymerization... - Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1Hidehiro Takahashi
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Biochem Biophys Res Commun 294:509-17. 2002..These findings suggest that cellular topoisomerase I and ATP play a pivotal role in the synthesis of cDNA of HIV-1... - Intranasal administration of adjuvant-combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infectionYasuko Asahi-Ozaki
Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan
Microbes Infect 8:2706-14. 2006..These results indicate that poly (I:C) and CMP are highly effective as mucosal adjuvants for use with the nasal H5N1 vaccine... - Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infectionYuko Shoya
Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
Proc Natl Acad Sci U S A 100:8442-7. 2003..Thus, human topoisomerase I plays an important role in HIV-1 replication and infectivity, and differences in the species specificity of HIV-1 infection can at least in part be attributed to differences in topoisomerase I activities... - Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom myceliaTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
J Med Virol 82:128-37. 2010..The use of extracts of mycelia derived from edible mushrooms is proposed as a new safe and effective mucosal adjuvant for use for nasal vaccination against influenza virus infection... - Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccineTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
J Infect Dis 196:1313-20. 2007..We evaluated the ability of currently licensed seasonal influenza vaccine to confer cross-protection against highly pathogenic H5N1 influenza virus in mice... - Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infectionTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan
J Virol 79:2910-9. 2005..We propose that poly(I:C) is a new effective intranasal adjuvant for influenza virus vaccine... - Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvantHideki Hasegawa
Department of Pathology, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
J Med Virol 75:130-6. 2005..It is suggested that CMP provide a safe and effective adjuvant for nasal vaccination with inactivated influenza vaccine... - Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challengeTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
Microbes Infect 9:1333-40. 2007.... - Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvantTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
J Med Virol 78:954-63. 2006..The use of SMP is suggested as a new safe and effective mucosal adjuvant for nasal vaccination against influenza virus infection... - Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virusTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
J Med Virol 82:1754-61. 2010.... - Nucleolin and the packaging signal, psi, promote the budding of human immunodeficiency virus type-1 (HIV-1)Tomonori Ueno
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Microbiol Immunol 48:111-8. 2004..Our results suggest that an empty particle which contains neither nucleolin nor the genomic RNA is eliminated during the budding process, and this mechanism is beneficial for escape from the host immune response against HIV-1... - Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virusTakeshi Ichinohe
Department of Pathology, National Institute of Infectious Diseases, Gakuen, Musashimurayama shi, Tokyo, Japan
J Med Virol 79:811-9. 2007.... - Tristetraprolin inhibits HIV-1 production by binding to genomic RNAMasae Maeda
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
Microbes Infect 8:2647-56. 2006..These results suggest that tristetraprolin is a regulator of HIV-1 replication and enhances splicing by direct binding to AU-rich sequence of HIV-1 RNAs... - Covalent bonded Gag multimers in human immunodeficiency virus type-1 particlesYoshinori Kitagawa
Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
Microbiol Immunol 53:609-20. 2009..These results suggest that, under non-reducing conditions, covalent bonded Gag multimers are formed within the viral particles and play a role in protection of the viral genome... - Immunogenicity and efficacy of two types of West Nile virus-like particles different in size and maturation as a second-generation vaccine candidateNaohiro Ohtaki
Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
Vaccine 28:6588-96. 2010..These results indicate that F-VLPs more closely resemble the virions and take a better immunogenic form than S-VLPs as WNV vaccine candidates... - Distinct immunohistochemical localization in Kuru plaques using novel anti-prion protein antibodiesTomoko Hosokawa
Nippon Institute for Biological Science, University of Tokyo, Tokyo, Japan
Microbiol Immunol 52:25-9. 2008..The fact that different anti-PrP mAbs possess distinct staining properties suggests that the PrP(c) to PrP(Sc) conversion might involve a multiple-step process... - Purification and concentration of non-infectious West Nile virus-like particles and infectious virions using a pseudo-affinity Cellufine Sulfate columnNaohiro Ohtaki
Department of Pathology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
J Virol Methods 174:131-5. 2011..These results indicate that, in addition to conventional methods, Cellufine Sulfate column chromatography is an effective preparation technique for WNV particulate antigens that does not impair the antigen virological characteristics... - Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type IHideki Hasegawa
Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, Japan
Nat Med 12:466-72. 2006..Our model accurately reproduces human disease and will provide a tool for analysis of the molecular events in transformation and for the development of new therapeutics... - Processing of the HTLV-II envelope precursor glycoprotein gp63 by furin is essential for cell fusion activityHideki Hasegawa
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
AIDS Res Hum Retroviruses 18:1253-60. 2002..Our findings suggest that furin plays a pivotal role in cleavage of the HTLV-II envelope gp63, which in turn is a prerequisite for the fusogenic properties of the virus... - Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutininIzumi Watanabe
Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan
Vaccine 21:4532-8. 2003..Thus, C3d fused to the influenza HA antigen is an effective and safe tool for mucosal vaccination... - ImmunoAT method: An initial assessment for the detection of abnormal isoforms of prion protein in formalin-fixed and paraffin-embedded tissuesYuko Sato
Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
J Virol Methods 165:261-7. 2010..PrP(sc) detection was consistent using all three methods. The clearest signals were obtained using the indirect immunoAT method, suggesting significant potential for this method... - BCL-6-positive human herpesvirus 8-associated solid lymphoma arising from liver and spleen as multiple nodular lesionsHideki Hasegawa
Department of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
Leuk Lymphoma 45:2169-72. 2004..Chemotherapy was effective and reduced the size of the lymphoma dramatically. This is the first case report of a germinal center B cell-originating lymphoma with HHV-8 infection... - Specific reactions between purified HIV-1 particles and CD4+ cell membrane fragments in a cell-free system of virus fusion or entryTakayuki Harada
Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan
Microbes Infect 6:421-8. 2004..These results suggest that this cell-free reaction system provides a useful tool to study biochemical fusion/entry mechanisms of HIV-1 and its inhibitors... - Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brainReisuke H Takahashi
Department of Anatomic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
Neuropathology 31:208-14. 2011.... - Persistent infection of influenza virus in irradiated mice and its prevention by intranasal vaccinationHideki Hasegawa
Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, 162 8640, Tokyo, Japan
Vaccine 20:1050-7. 2002..These results demonstrate that the exacerbation of influenza is induced by the irradiation during early days of infection (0-2 days) and that the exacerbation is prevented by the intranasal vaccination at least 3 days before irradiation... - In situ hybridization AT-tailing with catalyzed signal amplification for sensitive and specific in situ detection of human immunodeficiency virus-1 mRNA in formalin-fixed and paraffin-embedded tissuesNoriko Nakajima
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
Am J Pathol 162:381-9. 2003.... - A monoclonal antibody (1D12) defines novel distribution patterns of prion protein (PrP) as granules in nucleusTomoko Hosokawa
Nippon Institute for Biological Science, Ome 198 0024, Tokyo, Japan
Biochem Biophys Res Commun 366:657-63. 2008..No reactivity in the nucleus was observed to HpL3-4, or HpL3-4mPrP cells expressing mouse PrP. This is the first paper that has reported the detection of the PrP(C) at both cell surface and nuclei of prion-uninfected cell line... - Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy brainYuki Okada
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
Acta Neuropathol (Berl) 104:130-6. 2002..Thus, JCV agnoprotein was mostly expressed in the infected oligodendrocytes and mainly localized in the cytoplasmic processes apart from virus particles in the demyelinated lesions... - Temporal alterations in concentrations of sera cytokines/chemokines in sepsis due to group B streptococcus infection in a neonateKaoru Okazaki
Divisions of Neonatology, Tokyo Metropolitan Hachioji Children s Hospital, Tokyo 193 0931, Japan
Jpn J Infect Dis 61:382-5. 2008..At birth, the concentrations of different cytokines/chemokines increased and that of granulocyte colony-stimulating factor remained high. Thus, these cytokines/chemokines might be associated with the pathophysiology of GBS infection... - [Lessons from prion disease, mad cow disease, and iatrogenic Creutzfeldt-Jakob disease]Hidehiro Takahashi
Nippon Naika Gakkai Zasshi 92:2439-45. 2003 - Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particlesYuki Okada
Laboratory of Molecular and Cellular Pathology, Graduate School of Hokkaido University, N15, W7, Kita-ku, Sapporo 060-8638, Japan
EMBO Rep 6:452-7. 2005..These results indicate that dissociation of HP1alpha from LBR and consequent perturbation of the nuclear envelope induced by polyomavirus Agno promote the translocation of virions out of the nucleus...