Hidehiko Takahashi

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joy
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan 263 8555
    Cereb Cortex 18:898-903. 2008
  2. doi request reprint Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Neurosci 28:12032-8. 2008
  3. pmc Functional deficits in the extrastriate body area during observation of sports-related actions in schizophrenia
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Schizophr Bull 36:642-7. 2010
  4. doi request reprint Impact of changing the Japanese term for "schizophrenia" for reasons of stereotypical beliefs of schizophrenia in Japanese youth
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Schizophr Res 112:149-52. 2009
  5. doi request reprint Enhanced activation in the extrastriate body area by goal-directed actions
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Clin Neurosci 62:214-9. 2008
  6. doi request reprint Neural correlates of human virtue judgment
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Cereb Cortex 18:1886-91. 2008
  7. doi request reprint When your gain is my pain and your pain is my gain: neural correlates of envy and schadenfreude
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Science 323:937-9. 2009
  8. doi request reprint Contribution of dopamine D1 and D2 receptors to amygdala activity in human
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Neurosci 30:3043-7. 2010
  9. ncbi request reprint Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    Ryosuke Arakawa
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Psychopharmacology (Berl) 197:229-35. 2008
  10. doi request reprint Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010

Detail Information

Publications63

  1. ncbi request reprint Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joy
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan 263 8555
    Cereb Cortex 18:898-903. 2008
    ..At the same time, judgment of pride might require less self-reflection compared with those of negative self-conscious emotions such as guilt or embarrassment...
  2. doi request reprint Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Neurosci 28:12032-8. 2008
    ..Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory...
  3. pmc Functional deficits in the extrastriate body area during observation of sports-related actions in schizophrenia
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Schizophr Bull 36:642-7. 2010
    ..Dysfunction of the EBA might reflect a difficulty in representing dynamic aspects of human actions and possibly lead to impairments of simulation, learning, and execution of actions in schizophrenia...
  4. doi request reprint Impact of changing the Japanese term for "schizophrenia" for reasons of stereotypical beliefs of schizophrenia in Japanese youth
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Schizophr Res 112:149-52. 2009
    ..The old term was strongly associated with "criminal", and this association became significantly weaker with the new term. The strategy of renaming holds considerable promise for tempering negative bias toward this disorder in Japan...
  5. doi request reprint Enhanced activation in the extrastriate body area by goal-directed actions
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Clin Neurosci 62:214-9. 2008
    ..The aim of the present study was to investigate the role of EBA in processing goal-directed actions...
  6. doi request reprint Neural correlates of human virtue judgment
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Cereb Cortex 18:1886-91. 2008
    ..The central process of moral beauty evaluation might be related to that of aesthetic evaluation. Our finding might contribute to a better understanding of human morality...
  7. doi request reprint When your gain is my pain and your pain is my gain: neural correlates of envy and schadenfreude
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Science 323:937-9. 2009
    ..ACC activation in study one predicted ventral striatum activation in study two. Our findings document mechanisms of painful emotion, envy, and a rewarding reaction, schadenfreude...
  8. doi request reprint Contribution of dopamine D1 and D2 receptors to amygdala activity in human
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Neurosci 30:3043-7. 2010
    ..DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective...
  9. ncbi request reprint Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    Ryosuke Arakawa
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Psychopharmacology (Berl) 197:229-35. 2008
    ..Paliperidone ER is a novel antipsychotic drug in an extended-release (ER) formulation. As with all antipsychotics, careful dose setting is necessary to avoid side effects...
  10. doi request reprint Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010
    ..However, the magnitude of hyperprolactinemia differs among antipsychotics, and there is no reliable mechanism-related marker for the risk of hyperprolactinemia that would allow us to characterize antipsychotics...
  11. doi request reprint Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  12. pmc Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 7:e46488. 2012
    ..The therapeutic effects of aripiprazole in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  13. doi request reprint Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457
    Yoko Ikoma
    Molecular Imaging Center, National Institute of Radiological Sciences 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Neuroimage 42:1285-94. 2008
    ..These results demonstrated that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely with an optimal scan duration with [(11)C]raclopride and [(11)C]FLB 457...
  14. doi request reprint Extrastriatal dopamine D(2) receptor occupancy in olanzapine-treated patients with schizophrenia
    Ryosuke Arakawa
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
    Eur Arch Psychiatry Clin Neurosci 260:345-50. 2010
    ..In conclusion, although the subjects and methods were different from previous striatal occupancy studies, these results suggest that limbic occupancy by olanzapine may not be so different from that in the striatum...
  15. pmc Measurement error analysis for the determination of dopamine D(2) receptor occupancy using the agonist radioligand [(11)C]MNPA
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 30:187-95. 2010
    ..Results showed that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely in region of interest analysis by SRTM with a longer than 60-min [(11)C]MNPA PET scan duration...
  16. doi request reprint Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia
    Jun Kosaka
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Life Sci 86:814-8. 2010
    ..However, the results of previous positron emission tomography (PET) studies of dopamine D1 receptor in schizophrenia were not consistent...
  17. doi request reprint Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain
    Tatsui Otsuka
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 50:703-10. 2009
    ..In the present study, the kinetics of (11)C-MNPA were examined for the first time, to our knowledge, in the human brain and analyzed using quantitative approaches with or without an arterial input function...
  18. doi request reprint Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PET
    Shoko Nozaki
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Schizophr Res 108:78-84. 2009
    ..Patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia...
  19. doi request reprint A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:578-86. 2010
    ..This method can be used to distinguish graphically whether the radioligand binding includes specific binding or not...
  20. doi request reprint Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [(11)C]DASB and (S,S)-[(18)F]FMeNER-D(2)
    Tsuyoshi Nogami
    Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 16:937-43. 2013
    ..9 mg for NET. Both 5-HTT and NET occupancies were observed in a dose-dependent manner. Both 5-HTT and NET occupancies were about 40% by milnacipran at 100 mg, the dose most commonly administered to MDD patients...
  21. doi request reprint Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphine
    Fumitoshi Kodaka
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 14:83-9. 2011
    ..01 ng/ml, respectively. Almost identical occupancies and ED50 values were observed between the two radioligands, indicating that risperidone bound to D2,high and D2,low at almost identical proportions in a dose-dependent manner...
  22. doi request reprint Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models
    Chie Seki
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Ann Nucl Med 24:249-60. 2010
    ..The aim of this study was to evaluate the applicability of quantification methods using reference tissue models for [(11)C]PE2I...
  23. doi request reprint Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 209:285-90. 2010
    ..There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with perospirone-like properties...
  24. ncbi request reprint GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit
    Yoshiyuki Asai
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Schizophr Res 99:333-40. 2008
    ..GABA(A)/BZ receptor including alpha5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia...
  25. ncbi request reprint Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neuroimage 39:555-65. 2008
    ..This database could also be used to investigate regional abnormalities of dopaminergic neurotransmission in neuropsychiatric disorders...
  26. doi request reprint Increase in thalamic binding of [(11)C]PE2I in patients with schizophrenia: a positron emission tomography study of dopamine transporter
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Psychiatr Res 43:1219-23. 2009
    ..75), positive (r=0.78) and negative PANSS scores (r=0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia...
  27. doi request reprint Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study
    Ryohei Matsumoto
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:121-6. 2010
    ..The change in [(11)C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD...
  28. ncbi request reprint Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Neuroimage 34:1643-9. 2007
    ..Our findings suggest that dopamine D2 receptors in the hippocampus might affect the local hippocampal function, but also brain functions outside the hippocampus such as the prefrontal cortex...
  29. doi request reprint Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    Michie Miyoshi
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Nucl Med 50:1095-101. 2009
    ..The aim of this study was to evaluate a quantification method of (11)C-AC-5216 binding in the human brain...
  30. doi request reprint Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I
    Takeshi Sasaki
    Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 53:1065-73. 2012
    ..The aims of this study were to examine the quantification of DAT using (18)F-FE-PE2I and to assess the effect of radiometabolites of (18)F-FE-PE2I on the quantification in healthy humans...
  31. doi request reprint Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[18F]FMeNER-D2
    Mizuho Sekine
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 210:331-6. 2010
    ..Central norepinephrine transporter (NET) is one of the main targets of antidepressants. Although the measurement of NET occupancy has been attempted in humans, the outcomes have been inconclusive...
  32. doi request reprint Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men
    Harumasa Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Synapse 65:624-33. 2011
    ..05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders...
  33. doi request reprint Positron emission tomography inter-scanner differences in dopamine D₂ receptor binding measured with [¹¹C]FLB457
    Fumitoshi Kodaka
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Ann Nucl Med 24:671-7. 2010
    ..In the present study, the effect of inter-scanner difference of regional radioactivity on estimated binding potential (BP(ND)) of [¹¹C]FLB457 using the simplified reference tissue model (SRTM) was investigated...
  34. doi request reprint Measurement of dopamine D2 receptors in living human brain using [11C]raclopride with ultra-high specific radioactivity
    Yota Fujimura
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institutes of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
    Nucl Med Biol 37:831-5. 2010
    ..In the present study, we compared the [(11)C]raclopride bindings to dopamine D(2) receptors between radioligands with ultra-high specific radioactivity and ordinary high specific radioactivity in healthy human subjects...
  35. doi request reprint No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 12:667-75. 2009
    ..Thus, limbic and cortical selectivity was not observed by one of the second-generation antipsychotics, risperidone...
  36. pmc Superiority illusion arises from resting-state brain networks modulated by dopamine
    Makiko Yamada
    Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Proc Natl Acad Sci U S A 110:4363-7. 2013
    ..Our findings help elucidate how this key aspect of the human mind is biologically determined, and identify potential molecular and neural targets for treatment for depressive realism...
  37. ncbi request reprint Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Int J Neuropsychopharmacol 11:413-7. 2008
    ..These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system...
  38. doi request reprint Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 49:1270-6. 2008
    ..In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods...
  39. ncbi request reprint Men and women show distinct brain activations during imagery of sexual and emotional infidelity
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Japan
    Neuroimage 32:1299-307. 2006
    ..Our findings might contribute to a better understanding of the neural basis of the jealousy-related behaviors predominantly observed in males...
  40. doi request reprint Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive-compulsive disorder: a voxel-based morphometric study
    Ryohei Matsumoto
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Clin Neurosci 64:541-7. 2010
    ..The aim of the present study was to investigate the alterations in brain structure of patients with OCD using a voxel-based morphometry (VBM) method...
  41. ncbi request reprint Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  42. doi request reprint Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[18F]FMeNER-D2
    Harumasa Takano
    Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 17:553-60. 2014
    ....
  43. pmc Neural circuits in the brain that are activated when mitigating criminal sentences
    Makiko Yamada
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Nat Commun 3:759. 2012
    ..These results could help the legal system understand how potential jurors actually decide, and contribute to growing knowledge about whether emotion and cognition are integrated sensibly in difficult judgments...
  44. doi request reprint Relation between presynaptic and postsynaptic dopaminergic functions measured by positron emission tomography: implication of dopaminergic tone
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 31:7886-90. 2011
    ....
  45. doi request reprint Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106
    Akihiro Takano
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 13:943-50. 2010
    ..Although the correlations need to be interpreted very cautiously, involvement of glial reaction process in the pathophysiology of positive symptoms or progressive change of schizophrenia might be suggested...
  46. ncbi request reprint Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:355-60. 2007
    ..In the present study, we developed a simple method for calculating an indicator of the dopamine synthesis rate with L-[beta-11C]DOPA on a voxel-by-voxel basis for parametric mapping...
  47. doi request reprint No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [¹¹C]verapamil
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 24:83-7. 2010
    ..To investigate the effects of the clinical dose of clarithromycin, a substrate of P-glycoprotein (P-gp), on P-gp function using positron emission tomography (PET) with [11C]verapamil...
  48. doi request reprint Quantitative analysis of NK1 receptor in the human brain using PET with 18F-FE-SPA-RQ
    Masaki Okumura
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 49:1749-55. 2008
    ..In this study, we used 18F-FE-SPA-RQ with PET to visualize and quantify NK1 receptor in the human brain...
  49. doi request reprint Effects of chewing on cognitive processing speed
    Yoshiyuki Hirano
    Research Program for Carbon Ion Therapy and Diagnostic Imaging Research, Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Brain Cogn 81:376-81. 2013
    ..These results suggested that chewing induced an increase in the arousal level and alertness in addition to an effect on motor control and, as a consequence, these effects could lead to improvements in cognitive performance...
  50. pmc Effect of cooperation level of group on punishment for non-cooperators: a functional magnetic resonance imaging study
    Fumitoshi Kodaka
    Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    PLoS ONE 7:e41338. 2012
    ..This indicates that the cooperation level of the group, as well as aversive emotion for inequity, is the important factor of punishing behavior...
  51. ncbi request reprint The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpiride
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba, Japan
    Int J Neuropsychopharmacol 9:539-45. 2006
    ..Evidence for the optimal doses of conventional antipsychotics based on dopamine D2 receptor occupancy would be helpful for rational antipsychotic therapy...
  52. ncbi request reprint Relationship between neuroticism personality trait and serotonin transporter binding
    Akihiro Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Biol Psychiatry 62:588-92. 2007
    ..In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers...
  53. ncbi request reprint The role of extrastriatal dopamine D2 receptors in schizophrenia
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 59:919-28. 2006
    ..These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues regarding the pathogenesis and of possible treatments for schizophrenia...
  54. ncbi request reprint [Molecular imaging of psychiatric disorders]
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Clinical Neuroimaging Section, National Institute of Radiological Sciences
    Nihon Rinsho 65:336-41. 2007
    ..This approach can provide in vivo pharmacological evidences of antipsychotics and establish the rational therapeutic strategy. PET is a powerful tool not only in the field of brain research but also drug discovery...
  55. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  56. ncbi request reprint [Molecular imaging in the drug development of psychotropics using positron emission tomography]
    Harumasa Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba City, 263 8555 Chiba, Japan
    Brain Nerve 59:215-20. 2007
    ....
  57. ncbi request reprint Regional cerebral blood flow changes associated with interoceptive awareness in the recovery process of anorexia nervosa
    Ryohei Matsumoto
    Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1265-70. 2006
    ..An abnormality in regional cerebral blood flow (rCBF) in anorexia nervosa (AN) patients has been reported. There are very few studies that have investigated the rCBF changes in the recovery process of AN...
  58. pmc It's not my fault: postdictive modulation of intentional binding by monetary gains and losses
    Keisuke Takahata
    Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 7:e53421. 2012
    ..Our study not only provides evidence for postdictive modification of agency, but also proposes a possible mechanism of human causality bias...
  59. pmc Functional significance of central D1 receptors in cognition: beyond working memory
    Hidehiko Takahashi
    Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cereb Blood Flow Metab 32:1248-58. 2012
    ....
  60. ncbi request reprint Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI study
    Hidehiko Takahashi
    Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Neuroimage 23:967-74. 2004
    ..At the same time, our functional fMRI data are in favor of the notion that evaluative process of embarrassment might be a more complex process than that of guilt...
  61. ncbi request reprint Language processing and human voice perception in schizophrenia: a functional magnetic resonance imaging study
    Michihiko Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo, Japan
    Biol Psychiatry 59:948-57. 2006
    ..We aimed to clarify the cerebral function of language processing in schizophrenia patients by considering cerebral activation of human voice perception...
  62. ncbi request reprint Pharmacological modulations in human cognitive processes: an fMRI study
    Noriaki Yahata
    Department of Neuropsychiatry, Nippon Medical School, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 72:2-3. 2005
  63. ncbi request reprint An fMRI study of differential neural response to affective pictures in schizophrenia
    Hidehiko Takahashi
    Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Neuroimage 22:1247-54. 2004
    ..In particular, decreased activation in the right amygdala and MPFC appears to be an important finding related to dysfunctional emotional behavior in schizophrenia...