Research Topics
Species | Hidehiko TakahashiSummaryAffiliation: National Institute of Radiological Sciences Country: Japan Publications
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Publications
Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joyHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan 263 8555
Cereb Cortex 18:898-903. 2008..At the same time, judgment of pride might require less self-reflection compared with those of negative self-conscious emotions such as guilt or embarrassment...
Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functionsHidehiko Takahashi
Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
J Neurosci 28:12032-8. 2008..Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory...- Impact of changing the Japanese term for "schizophrenia" for reasons of stereotypical beliefs of schizophrenia in Japanese youthHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
Schizophr Res 112:149-52. 2009..The strategy of renaming holds considerable promise for tempering negative bias toward this disorder in Japan... 
Functional deficits in the extrastriate body area during observation of sports-related actions in schizophreniaHidehiko Takahashi
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba 263 8555, Japan
Schizophr Bull 36:642-7. 2010..Dysfunction of the EBA might reflect a difficulty in representing dynamic aspects of human actions and possibly lead to impairments of simulation, learning, and execution of actions in schizophrenia...- Enhanced activation in the extrastriate body area by goal-directed actionsHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
Psychiatry Clin Neurosci 62:214-9. 2008..The aim of the present study was to investigate the role of EBA in processing goal-directed actions... - Neural correlates of human virtue judgmentHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
Cereb Cortex 18:1886-91. 2008..The central process of moral beauty evaluation might be related to that of aesthetic evaluation. Our finding might contribute to a better understanding of human morality... - When your gain is my pain and your pain is my gain: neural correlates of envy and schadenfreudeHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 9 1, 4 chome, Anagawa, Inage Ku, Chiba, 263 8555, Japan
Science 323:937-9. 2009..ACC activation in study one predicted ventral striatum activation in study two. Our findings document mechanisms of painful emotion, envy, and a rewarding reaction, schadenfreude... - Contribution of dopamine D1 and D2 receptors to amygdala activity in humanHidehiko Takahashi
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Neurosci 30:3043-7. 2010..DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective... - Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophreniaRyosuke Arakawa
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
Psychopharmacology (Berl) 197:229-35. 2008..Paliperidone ER is a novel antipsychotic drug in an extended-release (ER) formulation. As with all antipsychotics, careful dose setting is necessary to avoid side effects... - Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemiaRyosuke Arakawa
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
J Clin Psychiatry 71:1131-7. 2010..However, the magnitude of hyperprolactinemia differs among antipsychotics, and there is no reliable mechanism-related marker for the risk of hyperprolactinemia that would allow us to characterize antipsychotics... - Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?Hiroshi Ito
Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
J Neurosci 29:13730-4. 2009..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity... - Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPAHiroshi Ito
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
PLoS ONE 7:e46488. 2012..The therapeutic effects of aripiprazole in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity... - Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457Yoko Ikoma
Molecular Imaging Center, National Institute of Radiological Sciences 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
Neuroimage 42:1285-94. 2008..These results demonstrated that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely with an optimal scan duration with [(11)C]raclopride and [(11)C]FLB 457... - Extrastriatal dopamine D(2) receptor occupancy in olanzapine-treated patients with schizophreniaRyosuke Arakawa
Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
Eur Arch Psychiatry Clin Neurosci 260:345-50. 2010..In conclusion, although the subjects and methods were different from previous striatal occupancy studies, these results suggest that limbic occupancy by olanzapine may not be so different from that in the striatum... - Measurement error analysis for the determination of dopamine D(2) receptor occupancy using the agonist radioligand [(11)C]MNPAMiho Shidahara
Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Cereb Blood Flow Metab 30:187-95. 2010..Results showed that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely in region of interest analysis by SRTM with a longer than 60-min [(11)C]MNPA PET scan duration... - Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophreniaJun Kosaka
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
Life Sci 86:814-8. 2010..However, the results of previous positron emission tomography (PET) studies of dopamine D1 receptor in schizophrenia were not consistent... - Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PETShoko Nozaki
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Schizophr Res 108:78-84. 2009..Patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia... - A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studiesHiroshi Ito
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
Neuroimage 49:578-86. 2010..This method can be used to distinguish graphically whether the radioligand binding includes specific binding or not... - Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brainTatsui Otsuka
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Nucl Med 50:703-10. 2009..In the present study, the kinetics of (11)C-MNPA were examined for the first time, to our knowledge, in the human brain and analyzed using quantitative approaches with or without an arterial input function... - GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunitYoshiyuki Asai
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
Schizophr Res 99:333-40. 2008..GABA(A)/BZ receptor including alpha5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia... - Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue modelsChie Seki
Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
Ann Nucl Med 24:249-60. 2010..The aim of this study was to evaluate the applicability of quantification methods using reference tissue models for [(11)C]PE2I... - Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjectsRyosuke Arakawa
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
Psychopharmacology (Berl) 209:285-90. 2010..There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with perospirone-like properties... - Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphineFumitoshi Kodaka
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Int J Neuropsychopharmacol 14:83-9. 2011..01 ng/ml, respectively. Almost identical occupancies and ED50 values were observed between the two radioligands, indicating that risperidone bound to D2,high and D2,low at almost identical proportions in a dose-dependent manner... - Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomographyHiroshi Ito
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Neuroimage 39:555-65. 2008..This database could also be used to investigate regional abnormalities of dopaminergic neurotransmission in neuropsychiatric disorders... - Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET studyRyohei Matsumoto
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
Neuroimage 49:121-6. 2010..The change in [(11)C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD... - Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216Michie Miyoshi
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
J Nucl Med 50:1095-101. 2009..The aim of this study was to evaluate a quantification method of (11)C-AC-5216 binding in the human brain... - Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampusHidehiko Takahashi
Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
Neuroimage 34:1643-9. 2007..Our findings suggest that dopamine D2 receptors in the hippocampus might affect the local hippocampal function, but also brain functions outside the hippocampus such as the prefrontal cortex... - Increase in thalamic binding of [(11)C]PE2I in patients with schizophrenia: a positron emission tomography study of dopamine transporterRyosuke Arakawa
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
J Psychiatr Res 43:1219-23. 2009..75), positive (r=0.78) and negative PANSS scores (r=0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia... - Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2ITakeshi Sasaki
Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Nucl Med 53:1065-73. 2012..The aims of this study were to examine the quantification of DAT using (18)F-FE-PE2I and to assess the effect of radiometabolites of (18)F-FE-PE2I on the quantification in healthy humans... - Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[18F]FMeNER-D2Mizuho Sekine
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
Psychopharmacology (Berl) 210:331-6. 2010..Central norepinephrine transporter (NET) is one of the main targets of antidepressants. Although the measurement of NET occupancy has been attempted in humans, the outcomes have been inconclusive... - Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy menHarumasa Takano
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
Synapse 65:624-33. 2011..05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders... - Positron emission tomography inter-scanner differences in dopamine D₂ receptor binding measured with [¹¹C]FLB457Fumitoshi Kodaka
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
Ann Nucl Med 24:671-7. 2010..In the present study, the effect of inter-scanner difference of regional radioactivity on estimated binding potential (BP(ND)) of [¹¹C]FLB457 using the simplified reference tissue model (SRTM) was investigated... - Measurement of dopamine D2 receptors in living human brain using [11C]raclopride with ultra-high specific radioactivityYota Fujimura
Molecular Neuroimaging Group, Molecular Imaging Center, National Institutes of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
Nucl Med Biol 37:831-5. 2010..In the present study, we compared the [(11)C]raclopride bindings to dopamine D(2) receptors between radioligands with ultra-high specific radioactivity and ordinary high specific radioactivity in healthy human subjects... - No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography studyHiroshi Ito
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Int J Neuropsychopharmacol 12:667-75. 2009..Thus, limbic and cortical selectivity was not observed by one of the second-generation antipsychotics, risperidone... - Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot studyHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
Int J Neuropsychopharmacol 11:413-7. 2008..These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system... - Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2Ryosuke Arakawa
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Nucl Med 49:1270-6. 2008..In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods... - Men and women show distinct brain activations during imagery of sexual and emotional infidelityHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Japan
Neuroimage 32:1299-307. 2006..Our findings might contribute to a better understanding of the neural basis of the jealousy-related behaviors predominantly observed in males... - Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI studyHidehiko Takahashi
Brain Imaging Project, National Institute of Radiological Sciences, Japan
Neuroimage 27:991-1001. 2005..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders... - Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive-compulsive disorder: a voxel-based morphometric studyRyohei Matsumoto
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Psychiatry Clin Neurosci 64:541-7. 2010..The aim of the present study was to investigate the alterations in brain structure of patients with OCD using a voxel-based morphometry (VBM) method... - Neural circuits in the brain that are activated when mitigating criminal sentencesMakiko Yamada
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Nat Commun 3:759. 2012..These results could help the legal system understand how potential jurors actually decide, and contribute to growing knowledge about whether emotion and cognition are integrated sensibly in difficult judgments... - Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106Akihiro Takano
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Int J Neuropsychopharmacol 13:943-50. 2010..Although the correlations need to be interpreted very cautiously, involvement of glial reaction process in the pathophysiology of positive symptoms or progressive change of schizophrenia might be suggested... - Relation between presynaptic and postsynaptic dopaminergic functions measured by positron emission tomography: implication of dopaminergic toneHiroshi Ito
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
J Neurosci 31:7886-90. 2011.... - No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [¹¹C]verapamilRyosuke Arakawa
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
Ann Nucl Med 24:83-7. 2010..To investigate the effects of the clinical dose of clarithromycin, a substrate of P-glycoprotein (P-gp), on P-gp function using positron emission tomography (PET) with [11C]verapamil... - Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPAHiroshi Ito
Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
Ann Nucl Med 21:355-60. 2007..In the present study, we developed a simple method for calculating an indicator of the dopamine synthesis rate with L-[beta-11C]DOPA on a voxel-by-voxel basis for parametric mapping... - Quantitative analysis of NK1 receptor in the human brain using PET with 18F-FE-SPA-RQMasaki Okumura
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
J Nucl Med 49:1749-55. 2008..In this study, we used 18F-FE-SPA-RQ with PET to visualize and quantify NK1 receptor in the human brain... - Effect of cooperation level of group on punishment for non-cooperators: a functional magnetic resonance imaging studyFumitoshi Kodaka
Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
PLoS ONE 7:e41338. 2012..This indicates that the cooperation level of the group, as well as aversive emotion for inequity, is the important factor of punishing behavior... - Relationship between neuroticism personality trait and serotonin transporter bindingAkihiro Takano
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Biol Psychiatry 62:588-92. 2007..In this study, we investigated the relation between in vivo regional 5-HTT binding in the brain and personality inventory measures in normal male volunteers... - The antipsychotic sultopride is overdosed--a PET study of drug-induced receptor occupancy in comparison with sulpirideAkihiro Takano
Brain Imaging Project, National Institute of Radiological Sciences, 9-1, Anagawa 4-Chome, Inage-ku, Chiba, Japan
Int J Neuropsychopharmacol 9:539-45. 2006..Evidence for the optimal doses of conventional antipsychotics based on dopamine D2 receptor occupancy would be helpful for rational antipsychotic therapy... - Superiority illusion arises from resting-state brain networks modulated by dopamineMakiko Yamada
Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
Proc Natl Acad Sci U S A 110:4363-7. 2013..Our findings help elucidate how this key aspect of the human mind is biologically determined, and identify potential molecular and neural targets for treatment for depressive realism... - The role of extrastriatal dopamine D2 receptors in schizophreniaHidehiko Takahashi
Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
Biol Psychiatry 59:919-28. 2006..These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues regarding the pathogenesis and of possible treatments for schizophrenia... - Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomographyRyohei Matsumoto
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Synapse 61:795-800. 2007..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain... - [Molecular imaging of psychiatric disorders]Hidehiko Takahashi
Department of Molecular Neuroimaging, Clinical Neuroimaging Section, National Institute of Radiological Sciences
Nihon Rinsho 65:336-41. 2007..This approach can provide in vivo pharmacological evidences of antipsychotics and establish the rational therapeutic strategy. PET is a powerful tool not only in the field of brain research but also drug discovery... - [Molecular imaging in the drug development of psychotropics using positron emission tomography]Harumasa Takano
Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba City, 263 8555 Chiba, Japan
Brain Nerve 59:215-20. 2007.... - Regional cerebral blood flow changes associated with interoceptive awareness in the recovery process of anorexia nervosaRyohei Matsumoto
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Prog Neuropsychopharmacol Biol Psychiatry 30:1265-70. 2006..An abnormality in regional cerebral blood flow (rCBF) in anorexia nervosa (AN) patients has been reported. There are very few studies that have investigated the rCBF changes in the recovery process of AN... - It's not my fault: postdictive modulation of intentional binding by monetary gains and lossesKeisuke Takahata
Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
PLoS ONE 7:e53421. 2012..Our study not only provides evidence for postdictive modification of agency, but also proposes a possible mechanism of human causality bias... - Functional significance of central D1 receptors in cognition: beyond working memoryHidehiko Takahashi
Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Cereb Blood Flow Metab 32:1248-58. 2012.... - Effects of chewing on cognitive processing speedYoshiyuki Hirano
Research Program for Carbon Ion Therapy and Diagnostic Imaging Research, Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Brain Cogn 81:376-81. 2013..These results suggested that chewing induced an increase in the arousal level and alertness in addition to an effect on motor control and, as a consequence, these effects could lead to improvements in cognitive performance... - Brain activation associated with evaluative processes of guilt and embarrassment: an fMRI studyHidehiko Takahashi
Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
Neuroimage 23:967-74. 2004..At the same time, our functional fMRI data are in favor of the notion that evaluative process of embarrassment might be a more complex process than that of guilt... - Language processing and human voice perception in schizophrenia: a functional magnetic resonance imaging studyMichihiko Koeda
Department of Bioinformatics, Medical Research Institute, Tokyo, Japan
Biol Psychiatry 59:948-57. 2006.... - Pharmacological modulations in human cognitive processes: an fMRI studyNoriaki Yahata
Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
J Nippon Med Sch 72:2-3. 2005 - An fMRI study of differential neural response to affective pictures in schizophreniaHidehiko Takahashi
Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
Neuroimage 22:1247-54. 2004..In particular, decreased activation in the right amygdala and MPFC appears to be an important finding related to dysfunctional emotional behavior in schizophrenia...