Akihiko Taguchi

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Circulating CD34-positive cells provide an index of cerebrovascular function
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circulation 109:2972-5. 2004
  2. pmc Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Clin Invest 114:330-8. 2004
  3. ncbi request reprint Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, Japan, 565 8565
    Eur J Neurosci 26:126-33. 2007
  4. ncbi request reprint Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex
    Daisuke Nakayama
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Eur J Neurosci 31:90-8. 2010
  5. doi request reprint Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 29:34-8. 2009
  6. doi request reprint Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vessels
    Tomoyuki Yoshihara
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 28:1086-9. 2008
  7. ncbi request reprint Pioglitazone treatment stimulates circulating CD34-positive cells in type 2 diabetes patients
    Hisashi Makino
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan
    Diabetes Res Clin Pract 81:327-30. 2008
  8. doi request reprint Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction
    Nami Nakagomi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Stem Cells 27:2185-95. 2009
  9. doi request reprint Cerebral blood flow during reperfusion predicts later brain damage in a mouse and a rat model of neonatal hypoxic-ischemic encephalopathy
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Exp Neurol 233:481-9. 2012
  10. pmc Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats
    Akihiko Taguchi
    Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 31:855-67. 2011

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Circulating CD34-positive cells provide an index of cerebrovascular function
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circulation 109:2972-5. 2004
    ..We hypothesized that diminished numbers of circulating immature cells might impair such physiological and reparative processes, potentially contributing to cerebrovascular dysfunction...
  2. pmc Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Clin Invest 114:330-8. 2004
    ..Our data suggest an essential role for CD34(+) cells in promoting directly or indirectly an environment conducive to neovascularization of ischemic brain so that neuronal regeneration can proceed...
  3. ncbi request reprint Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine model
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, Japan, 565 8565
    Eur J Neurosci 26:126-33. 2007
    ..Although clinical trials with G-CSF have been started for the treatment of myocardial and limb ischemia, our results indicate that caution should be exercised in applying these results to cerebral ischemia...
  4. ncbi request reprint Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex
    Daisuke Nakayama
    Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Eur J Neurosci 31:90-8. 2010
    ..Furthermore, observations underline the potential importance of supporting survival and differentiation of endogenous neural stem/progenitor cells in post-stroke human brain...
  5. doi request reprint Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 29:34-8. 2009
    ..These results support the hypothesis that levels of circulating CD34(+) cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation...
  6. doi request reprint Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vessels
    Tomoyuki Yoshihara
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 28:1086-9. 2008
    ..Our results suggest that the increased level of CD34(+) cells associated with ischemic stress is correlated with neovascularization at human ischemic brain...
  7. ncbi request reprint Pioglitazone treatment stimulates circulating CD34-positive cells in type 2 diabetes patients
    Hisashi Makino
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan
    Diabetes Res Clin Pract 81:327-30. 2008
    ..412, r=0.359, respectively). Our study demonstrated that pioglitazone treatment increased circulating CD34(+) cells, suggesting that this effect may at least partly contribute to the anti-atherosclerotic action of pioglitazone...
  8. doi request reprint Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarction
    Nami Nakagomi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Stem Cells 27:2185-95. 2009
    ..These data indicate that reconstitution of elements in the vascular niche enhances transplantation of adult neural progenitor cells...
  9. doi request reprint Cerebral blood flow during reperfusion predicts later brain damage in a mouse and a rat model of neonatal hypoxic-ischemic encephalopathy
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Exp Neurol 233:481-9. 2012
    ..These results suggest that the CBF level during reperfusion may be a useful predictive factor for later brain damage in immature mice. This may enable optimizing brain damage for detail analyses...
  10. pmc Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats
    Akihiko Taguchi
    Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 31:855-67. 2011
    ....
  11. doi request reprint Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cells
    Akie Kikuchi-Taura
    Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Cytotherapy 14:441-50. 2012
    ..However, harvesting cells from the human body can cause iatrogenic disorders and in vitro expansion of MSC carries a risk of tumorigenesis and/or expansion of unexpected cell populations...
  12. ncbi request reprint Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
    Yukiko Kasahara
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    Brain Res 1340:70-80. 2010
    ....
  13. ncbi request reprint Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Cereb Blood Flow Metab 28:445-9. 2008
    ....
  14. pmc Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells
    Kenichi Yamahara
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    PLoS ONE 9:e88319. 2014
    ..Our results highlight that human amnion- and chorion-derived MSCs, which showed differences in their soluble factor secretion and angiogenic/immuno-suppressive function, could be ideal cell sources for regenerative medicine. ..
  15. doi request reprint A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model
    Masahiro Tsuji
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Exp Neurol 247:218-25. 2013
    ..The contrasting variability between the two models may provide insights into the factors that contribute to inter-animal variability in brain injury...
  16. ncbi request reprint Imaging of distal internal carotid artery by ultrasonography with a 3.5-MHz convex probe
    Kenichi Todo
    Division of Strokology, Department of Cardiovascular Medicine and Clinical Research, Osaka Minami National Hospital, Kawachinagano City, Osaka, Japan
    Stroke 33:1792-4. 2002
    ..However, usually only the carotid bulb or proximal portion of the ICA can be evaluated. We attempted to evaluate the distal extracranial ICA with a 3.5-MHz convex probe...
  17. doi request reprint Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis
    Makiko Ohshima
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan
    J Mol Cell Cardiol 53:420-8. 2012
    ..These results suggest that intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity...
  18. doi request reprint Mouse ES cells maintained in different pluripotency-promoting conditions differ in their neural differentiation propensity
    Haruka Hirose
    Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, Japan, 565 8565
    In Vitro Cell Dev Biol Anim 48:143-8. 2012
    ..We partly attribute this difference in the initial value of ES cells to the naïve-to-primed status of pluripotency, which in turn may affect early events of the differentiation in vitro...
  19. doi request reprint Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model
    Yukiko Kasahara
    Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 43:499-506. 2012
    ..Prior use of antiplatelet agents improves stroke outcome in patients undergoing thrombolytic therapy as shown by reduced arterial reocclusion, although the risk of cerebral hemorrhage can be increased...
  20. ncbi request reprint Cell-based therapy to promote angiogenesis in the brain following ischemic damage
    Masahiro Uemura
    Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Curr Vasc Pharmacol 10:285-8. 2012
    ....
  21. ncbi request reprint Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protects against ischemia/reperfusion-induced acute kidney injury
    Hidetoshi Tsuda
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Osaka, Japan
    Cell Transplant 23:889-99. 2014
    ..We concluded that allogenic FM-MSC transplantation is a potent therapeutic strategy for the treatment of AKI. ..
  22. doi request reprint Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and 123I-iodoamphetamine
    Tsutomu Zeniya
    Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nucl Med Biol 38:1157-64. 2011
    ....
  23. doi request reprint Nitric oxide release in human aortic endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolae
    Takehiro Nishikawa
    National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Biomacromolecules 10:2074-85. 2009
    ..These findings support our idea that delivery of the polymeric nanoparticles to endothelial cells can lead to the induction of nitric oxide release...
  24. doi request reprint Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats
    Masahiro Tsuji
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Exp Neurol 233:214-20. 2012
    ..This is in line with the notion that GABA is excitatory for immature neurons, while it is inhibitory for mature neurons...
  25. ncbi request reprint Circulating CD34-positive cell number is associated with brain natriuretic peptide level in type 2 diabetic patients
    Sadanori Okada
    Department of Atherosclerosis, National Cardiovascular Center, Suita, Japan
    Diabetes Care 31:157-8. 2008
  26. ncbi request reprint Relationship between detectability of ischemic lesions by diffusion-weighted imaging and embolic sources in transient ischemic attacks
    Hisakazu Uno
    Department of Cerebrovascular Medicine, National Cardiovascular Center, Suita, Japan
    Eur Neurol 59:38-43. 2008
    ..The aim of this study is to clarify the relationship between lesion detectability by diffusion-weighted magnetic resonance imaging (DWI) and the etiology of transient ischemic attacks (TIAs)...
  27. ncbi request reprint Case reports of unexpected suicides in patients within six months after stroke
    Masahiro Katayama
    Department of Neurology, Senri Chuou Hospital, Shinsenri higashi machi 1 4 3, Toyonaka City, Osaka, 560 0082, Japan
    Kobe J Med Sci 56:E184-94. 2011
    ..Physicians should carefully observe patients with infarction extending from the temporal cortex to the parietal cortex, depression and moderate disability, in order to prevent suicidal behavior...
  28. pmc Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study
    Masafumi Ihara
    Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center Hospital, Osaka, Japan Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan
    PLoS ONE 9:e89516. 2014
    ..We investigated whether the phosphodiesterase III inhibitor cilostazol, which is often used in the prevention of stroke and peripheral artery disease, may delay cognitive decline in the elderly receiving donepezil...
  29. doi request reprint Cell-based therapy for patients with vascular dementia
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Osaka, Japan
    Psychogeriatrics 11:113-5. 2011
    ..In the present review, current findings about the correlation between circulating immature cells and microcirculation are reviewed, and the possibility of novel cell-based therapy in patients with vascular dementia is discussed...
  30. doi request reprint Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the rat
    Naoya Matsumoto
    Department of Trauma and Acute Critical Care Center, Osaka University Hospital, 2 15 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 469:283-8. 2010
    ..The transplantation of CPECs via CSF is a potential new strategy for protecting against ischemic brain injury...
  31. pmc Cadherin activity is required for activity-induced spine remodeling
    Ko Okamura
    Department of Pharmacology, Osaka University Medical School, Suita, Japan
    J Cell Biol 167:961-72. 2004
    ..Together, our data suggest that cadherin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone...
  32. doi request reprint Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis
    Hidetoshi Tsuda
    Dept of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Renal Physiol 299:F1004-13. 2010
    ..Our results indicate that allogenic FM-MSC transplantation is a potent therapeutic strategy for the treatment of acute glomerulonephritis...
  33. doi request reprint Vascular factors in diabetes and Alzheimer's disease
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Alzheimers Dis 16:859-64. 2009
    ....
  34. ncbi request reprint Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction
    Tsutomu Sasaki
    Department of Internal Medicine and Therapeutics, Osaka University, Graduate School of Medicine, Osaka, Japan
    Stroke 33:1493-6. 2002
    ..Additionally, because lacunar infarction is the most prevalent type of ischemic stroke in Japan, we also investigated its associations with tHcy levels...
  35. pmc A new protocol for quantifying CD34(+) cells in peripheral blood of patients with cardiovascular disease
    Akie Kikuchi-Taura
    Department of Clinical Laboratory, National Hospital Organization, Osaka Minami Medical Center, Osaka 586 8521, Japan
    Tex Heart Inst J 33:427-9. 2006
    ..The new method is useful to precisely measure low numbers of CD34(+) cells in samples, and it has potential as a screening tool to evaluate cardiovascular risk in large patient populations...
  36. ncbi request reprint Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury
    Tomoyuki Yoshihara
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurotrauma 24:1026-36. 2007
    ..Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans...