Research Topics
| Akihiko TaguchiSummaryAffiliation: National Cardiovascular Center Country: Japan Publications
| Collaborators
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Detail Information
Publications
Circulating CD34-positive cells provide an index of cerebrovascular functionAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
Circulation 109:2972-5. 2004..We hypothesized that diminished numbers of circulating immature cells might impair such physiological and reparative processes, potentially contributing to cerebrovascular dysfunction...
Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse modelAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
J Clin Invest 114:330-8. 2004..Our data suggest an essential role for CD34(+) cells in promoting directly or indirectly an environment conducive to neovascularization of ischemic brain so that neuronal regeneration can proceed...- Granulocyte colony-stimulating factor has a negative effect on stroke outcome in a murine modelAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, Japan, 565 8565
Eur J Neurosci 26:126-33. 2007..Although clinical trials with G-CSF have been started for the treatment of myocardial and limb ischemia, our results indicate that caution should be exercised in applying these results to cerebral ischemia... - Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortexDaisuke Nakayama
Department of Cerebrovascular Disease, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
Eur J Neurosci 31:90-8. 2010..Furthermore, observations underline the potential importance of supporting survival and differentiation of endogenous neural stem/progenitor cells in post-stroke human brain... 
Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarctionAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
J Cereb Blood Flow Metab 29:34-8. 2009..These results support the hypothesis that levels of circulating CD34(+) cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation...- Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vesselsTomoyuki Yoshihara
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
J Cereb Blood Flow Metab 28:1086-9. 2008..Our results suggest that the increased level of CD34(+) cells associated with ischemic stress is correlated with neovascularization at human ischemic brain... - Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem/progenitor cells after cerebral infarctionNami Nakagomi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
Stem Cells 27:2185-95. 2009..These data indicate that reconstitution of elements in the vascular niche enhances transplantation of adult neural progenitor cells... - Pioglitazone treatment stimulates circulating CD34-positive cells in type 2 diabetes patientsHisashi Makino
Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan
Diabetes Res Clin Pract 81:327-30. 2008..412, r=0.359, respectively). Our study demonstrated that pioglitazone treatment increased circulating CD34(+) cells, suggesting that this effect may at least partly contribute to the anti-atherosclerotic action of pioglitazone... - Cerebral blood flow during reperfusion predicts later brain damage in a mouse and a rat model of neonatal hypoxic-ischemic encephalopathyMakiko Ohshima
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
Exp Neurol 233:481-9. 2012..These results suggest that the CBF level during reperfusion may be a useful predictive factor for later brain damage in immature mice. This may enable optimizing brain damage for detail analyses... - Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged ratsAkihiko Taguchi
Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
J Cereb Blood Flow Metab 31:855-67. 2011.... - Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cellsAkie Kikuchi-Taura
Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
Cytotherapy 14:441-50. 2012..However, harvesting cells from the human body can cause iatrogenic disorders and in vitro expansion of MSC carries a risk of tumorigenesis and/or expansion of unexpected cell populations... - Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairmentAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
J Cereb Blood Flow Metab 28:445-9. 2008.... - Telmisartan suppresses cerebral injury in a murine model of transient focal ischemiaYukiko Kasahara
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
Brain Res 1340:70-80. 2010.... - Imaging of distal internal carotid artery by ultrasonography with a 3.5-MHz convex probeKenichi Todo
Division of Strokology, Department of Cardiovascular Medicine and Clinical Research, Osaka-Minami National Hospital, Kawachinagano City, Osaka, Japan
Stroke 33:1792-4. 2002..5-MHz probe. CONCLUSIONS: This form of carotid imaging is feasible and may be potentially useful in the evaluation of carotid disease... - Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditisMakiko Ohshima
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Osaka, Japan
J Mol Cell Cardiol 53:420-8. 2012..These results suggest that intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity... - Mouse ES cells maintained in different pluripotency-promoting conditions differ in their neural differentiation propensityHaruka Hirose
Department of Regenerative Medicine, National Cerebral and Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, Japan, 565 8565
In Vitro Cell Dev Biol Anim 48:143-8. 2012..We partly attribute this difference in the initial value of ES cells to the naïve-to-primed status of pluripotency, which in turn may affect early events of the differentiation in vitro... - Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke modelYukiko Kasahara
Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Osaka, Japan
Stroke 43:499-506. 2012..Prior use of antiplatelet agents improves stroke outcome in patients undergoing thrombolytic therapy as shown by reduced arterial reocclusion, although the risk of cerebral hemorrhage can be increased... - Cell-based therapy to promote angiogenesis in the brain following ischemic damageMasahiro Uemura
Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
Curr Vasc Pharmacol 10:285-8. 2012.... - Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and 123I-iodoamphetamineTsutomu Zeniya
Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
Nucl Med Biol 38:1157-64. 2011.... - Nitric oxide release in human aortic endothelial cells mediated by delivery of amphiphilic polysiloxane nanoparticles to caveolaeTakehiro Nishikawa
National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
Biomacromolecules 10:2074-85. 2009..These findings support our idea that delivery of the polymeric nanoparticles to endothelial cells can lead to the induction of nitric oxide release... - Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature ratsMasahiro Tsuji
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
Exp Neurol 233:214-20. 2012..This is in line with the notion that GABA is excitatory for immature neurons, while it is inhibitory for mature neurons... - Relationship between detectability of ischemic lesions by diffusion-weighted imaging and embolic sources in transient ischemic attacksHisakazu Uno
Department of Cerebrovascular Medicine, National Cardiovascular Center, Suita, Japan
Eur Neurol 59:38-43. 2008..The aim of this study is to clarify the relationship between lesion detectability by diffusion-weighted magnetic resonance imaging (DWI) and the etiology of transient ischemic attacks (TIAs)... - Circulating CD34-positive cell number is associated with brain natriuretic peptide level in type 2 diabetic patientsSadanori Okada
Department of Atherosclerosis, National Cardiovascular Center, Suita, Japan
Diabetes Care 31:157-8. 2008 - Case reports of unexpected suicides in patients within six months after strokeMasahiro Katayama
Department of Neurology, Senri Chuou Hospital, Shinsenri higashi machi 1 4 3, Toyonaka City, Osaka, 560 0082, Japan
Kobe J Med Sci 56:E184-94. 2011..Physicians should carefully observe patients with infarction extending from the temporal cortex to the parietal cortex, depression and moderate disability, in order to prevent suicidal behavior... 
Cadherin activity is required for activity-induced spine remodelingKo Okamura
Department of Pharmacology, Osaka University Medical School, Suita, Japan
J Cell Biol 167:961-72. 2004..Together, our data suggest that cadherin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone...- Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the ratNaoya Matsumoto
Department of Trauma and Acute Critical Care Center, Osaka University Hospital, 2 15 Yamadaoka, Suita, Osaka 565 0871, Japan
Neurosci Lett 469:283-8. 2010..The transplantation of CPECs via CSF is a potential new strategy for protecting against ischemic brain injury... - Cell-based therapy for patients with vascular dementiaAkihiko Taguchi
Department of Cerebrovascular Disease, National Cerebral and Cardiovascular Center, Osaka, Japan
Psychogeriatrics 11:113-5. 2011..In the present review, current findings about the correlation between circulating immature cells and microcirculation are reviewed, and the possibility of novel cell-based therapy in patients with vascular dementia is discussed... - Vascular factors in diabetes and Alzheimer's diseaseAkihiko Taguchi
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
J Alzheimers Dis 16:859-64. 2009.... - Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritisHidetoshi Tsuda
Dept of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Am J Physiol Renal Physiol 299:F1004-13. 2010..Our results indicate that allogenic FM-MSC transplantation is a potent therapeutic strategy for the treatment of acute glomerulonephritis... - Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarctionTsutomu Sasaki
Department of Internal Medicine and Therapeutics, Osaka University, Graduate School of Medicine, Osaka, Japan
Stroke 33:1493-6. 2002..Larger prospective studies are necessary to establish whether higher tHcy levels serve as a harbinger for insidious carotid and cerebrovascular diseases... - A new protocol for quantifying CD34(+) cells in peripheral blood of patients with cardiovascular diseaseAkie Kikuchi-Taura
Department of Clinical Laboratory, National Hospital Organization, Osaka Minami Medical Center, Osaka 586-8521, Japan
Tex Heart Inst J 33:427-9. 2006..The new method is useful to precisely measure low numbers of CD34(+) cells in samples, and it has potential as a screening tool to evaluate cardiovascular risk in large patient populations... - Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injuryTomoyuki Yoshihara
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Neurotrauma 24:1026-36. 2007..Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans...