Koichi Suzuki

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006
  2. pmc Paleopathological evidence and detection of Mycobacterium leprae DNA from archaeological skeletal remains of Nabe-kaburi (head-covered with iron pots) burials in Japan
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 9:e88356. 2014
  3. pmc Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages
    Yang Degang
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    PLoS Negl Trop Dis 6:e1936. 2012
  4. pmc Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage
    Kouji Kobiyama
    Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation Ibaraki, Osaka, Japan Laboratory of Vaccine Science, Immunology Frontier Research Center, World Premier International Research Center, Osaka University Suita, Osaka, Japan
    Front Genet 4:91. 2013
  5. doi Current status of leprosy: epidemiology, basic science and clinical perspectives
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases Department of Dermatology, National Center for Global Health and Medicine, Tokyo, Japan
    J Dermatol 39:121-9. 2012
  6. doi Chimpanzees used for medical research shed light on the pathoetiology of leprosy
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Future Microbiol 6:1151-7. 2011
  7. pmc Infection during infancy and long incubation period of leprosy suggested in a case of a chimpanzee used for medical research
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo 189 0002, Japan
    J Clin Microbiol 48:3432-4. 2010
  8. pmc Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 5:e12422. 2010
  9. ncbi [Leprosy situation in the world in 2009]
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 79:43-51. 2010
  10. pmc Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 393:286-90. 2010

Detail Information

Publications115 found, 100 shown here

  1. ncbi Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006
    ..These results suggest that SV2B is a functional molecule of podocyte, and SV2B may play a role in the expression and proper localization of CD2AP...
  2. pmc Paleopathological evidence and detection of Mycobacterium leprae DNA from archaeological skeletal remains of Nabe-kaburi (head-covered with iron pots) burials in Japan
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 9:e88356. 2014
    ..Demonstration of the presence of M. leprae DNA, combined with archeological and anthropological examinations, will aid in solving the mystery of why Nabe-kaburi burials were performed in medieval Japan. ..
  3. pmc Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages
    Yang Degang
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    PLoS Negl Trop Dis 6:e1936. 2012
    ..It also induces IFN production in M. leprae-infected cells. The resultant decrease in lipid accumulation, increase in lipolysis, and activation of innate immunity may be some of the key actions of clofazimine...
  4. pmc Role of Extrachromosomal Histone H2B on Recognition of DNA Viruses and Cell Damage
    Kouji Kobiyama
    Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation Ibaraki, Osaka, Japan Laboratory of Vaccine Science, Immunology Frontier Research Center, World Premier International Research Center, Osaka University Suita, Osaka, Japan
    Front Genet 4:91. 2013
    ..This mechanism may also play roles in autoimmunity, transplantation rejection, gene-mediated vaccines, and other therapeutic applications...
  5. doi Current status of leprosy: epidemiology, basic science and clinical perspectives
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases Department of Dermatology, National Center for Global Health and Medicine, Tokyo, Japan
    J Dermatol 39:121-9. 2012
    ..The introduction of multidrug therapy has significantly contributed to a decrease in the prevalence of the disease. However, leprosy control activities, including monitoring and prevention programs, must be maintained...
  6. doi Chimpanzees used for medical research shed light on the pathoetiology of leprosy
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Future Microbiol 6:1151-7. 2011
    ..Analysis of leprosy in chimpanzees can contribute not only to medical research but also to the understanding of the pathoetiology of leprosy...
  7. pmc Infection during infancy and long incubation period of leprosy suggested in a case of a chimpanzee used for medical research
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo 189 0002, Japan
    J Clin Microbiol 48:3432-4. 2010
    ..We report a rare case of leprosy in a chimpanzee in which a 30-year incubation period was strongly suggested by single nucleotide polymorphism (SNP) analysis...
  8. pmc Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 5:e12422. 2010
    ..However, it is very difficult to detect trace amounts of DNA remnants attached to the human skeleton, especially from those buried in a humid atmosphere with a relatively high environmental temperature such as in Asia...
  9. ncbi [Leprosy situation in the world in 2009]
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 79:43-51. 2010
    ..However, early case detection and prompt treatment with MDT remain the cornerstone of leprosy. In order to reduce the physical, mental and socioeconomic burded of leprosy, much remains to be done...
  10. pmc Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells
    Koichi Suzuki
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 393:286-90. 2010
    ..The results suggest that excess iodide affects thyroid vascular function in addition to iodide uptake. This study provides additional insights into the mechanism of action of excess iodide on thyroid function...
  11. doi Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, National Institute of Infectious Diseases, Leprosy Research Center, Higashimurayama, Tokyo 189 0002, Japan
    J Endocrinol 209:169-74. 2011
    ..These results indicate that Tg is an essential autocrine regulator of physiological thyroid follicular function that counteracts the effects of TSH...
  12. ncbi [Present leprosy situation in the world in 2007]
    Koichi Suzuki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 77:15-23. 2008
    ..However, Leprosy control programmes in many countries will need continued support from all partners to ensure that leprosy remains on the health agenda as long as necessary and that success does not lead to complacency...
  13. ncbi Expression of PDS/Pds, the Pendred syndrome gene, in endometrium
    Koichi Suzuki
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Endocrinol Metab 87:938. 2002
    ..Since there is no evidence of endometrial abnormalities in patients with Pendred syndrome, it suggests the existence of a compensatory mechanisms for pendrin's function in the uterus...
  14. pmc Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway
    K Suzuki
    Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Maryland, USA
    Clin Exp Immunol 127:234-42. 2002
    ..We suggest that this stimulatory effect is due to the double-stranded RNA formed during replication of single-stranded viral RNA, and involves both double-stranded, RNA-dependent protein kinase PKR and the secretion of IFNbeta...
  15. ncbi High-level expression of pseudogenes in Mycobacterium leprae
    Koichi Suzuki
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 259:208-14. 2006
    ..Although M. leprae has an exceptional number and proportion of pseudogenes among species, our results suggest that some of the M. leprae pseudogenes are not just 'decayed' genes, but may have a functional role...
  16. ncbi Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin
    Koichi Suzuki
    Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Endocrinol 189:247-55. 2006
    ..In addition, we found that PDS gene was induced by TSH/cAMP and iodide in the presence of Tg. Based on these results, we propose a model for the physiological turnover of follicular function that is dynamically regulated by Tg...
  17. ncbi [Global leprosy situation, beginning of 2008]
    Koichi Suzuki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:25-34. 2009
    ..However, maintaining political interest and mobilizing the necessary funds to implement activities in the field are challenges for many national programmes as the burden of disease declines further...
  18. ncbi [Comprehensive analysis of RNA expression of Mycobacterium leprae and clinical and biological significance]
    Koichi Suzuki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:61-5. 2009
    ..leprae is available as a criterion for therapeutic effect and disease type of leprosy, and a prognostic marker...
  19. ncbi Transcriptional regulation of the human TLR9 gene
    Fumihiko Takeshita
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Immunol 173:2552-61. 2004
    ..These findings will help to elucidate the mechanism of TLR9 gene regulation and to provide insight into the process by which TLR9 evolved in the mammalian immune system...
  20. doi Identification of microRNAs that mediate thyroid cell growth induced by TSH
    Takeshi Akama
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo, Japan
    Mol Endocrinol 26:493-501. 2012
    ..These results suggest that TSH activates cAMP/protein kinase A and PI3K cascades to decrease miR-16 and miR-195, which induce Mapk8, Ccne1, and Cdc6 to activate cell proliferation...
  21. doi Detection of RNA expression from pseudogenes and non-coding genomic regions of Mycobacterium leprae
    Kazuaki Nakamura
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Aoba cho, Higashimurayama, Tokyo, Japan
    Microb Pathog 47:183-7. 2009
    ..leprae and analysis of RNA expression patterns including pseudogene and non-coding genomic region in M. leprae may be useful in understanding the pathological states of infected patients...
  22. ncbi [Current advances in leprosy research activities]
    Masahiko Makino
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 74:3-22. 2005
    ..Leprosy caused by M. leprae is still unclear on various aspects including transmission, immunology, nerve damage etc. Here we introduce the recent advances in the field of basic leprosy research...
  23. ncbi Whole-genome expression analysis of Mycobacterium leprae and its clinical application
    Takeshi Akama
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    Jpn J Infect Dis 63:387-92. 2010
    ....
  24. doi Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum
    Mariko Sue
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo 189 0002, Japan
    Biochem Biophys Res Commun 420:611-5. 2012
    ..The present results, together with the previous report, suggest that Tg utilizes multiple signaling cascades to induce thyroid cell growth independent of TSH/cAMP stimulation...
  25. ncbi Thyroglobulin suppresses thyroid-specific gene expression in cultures of normal but not neoplastic human thyroid follicular cells
    Yuko Ishido
    Laboratory of Molecular Diagnostics Y I, Y L, K S, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan Thyroid Disease Institute K Y, M K, Y S, E Y, T Y, Kanaji Thyroid Hospital, Tokyo 114 0015, Japan and Department of Medicine D F S, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814
    J Clin Endocrinol Metab 99:E694-702. 2014
    ..However, the actions of Tg as a regulatory molecule in human thyroid have not been studied...
  26. ncbi Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae
    Kazunari Tanigawa
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    FEMS Microbiol Lett 289:72-9. 2008
    ....
  27. pmc Demonstration of innate immune responses in the thyroid gland: potential to sense danger and a possible trigger for autoimmune reactions
    Akira Kawashima
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Thyroid 23:477-87. 2013
    ..The aim of this study was to conduct a more detailed analysis of innate immune responses of the thyroid upon stimulation with various "non-self" and "self" factors that might contribute to the initiation of autoimmune reactions...
  28. doi Iodide-induced chemokines and genes related to immunological function in cultured human thyroid follicles in the presence of thyrotropin
    Kazuko Yamazaki
    Thyroid Disease Institute, Kanaji Hospital, Tokyo, Japan
    Thyroid 20:67-76. 2010
    ..3-10 microU/mL) and maintain the Wolff-Chaikoff effect...
  29. pmc Propylthiouracil increases sodium/iodide symporter gene expression and iodide uptake in rat thyroid cells in the absence of TSH
    Mariko Sue
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Thyroid 22:844-52. 2012
    ..We hypothesized that PTU and MMI may have differential effects on thyroid-specific gene expression and function...
  30. doi Expression of a thyroglobulin (Tg) variant in mouse kidney glomerulus
    Huhehasi Wu
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan
    Biochem Biophys Res Commun 389:269-73. 2009
    ..Together these results suggest that a unique low molecular weight variant of Tg is expressed in the kidney, where it could serve both physiological and pathological roles, including that of an autoantigen...
  31. ncbi [Detection of RNA expression on whole genome analysis of Mycobacterium leprae by tiling array]
    Takeshi Akama
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:49-54. 2009
    ..Since some of the RNA expression levels were modulated by MDT, evaluation of RNA expression pattern might be a good indicator for the treatment of leprosy...
  32. ncbi Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages
    Kazunari Tanigawa
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Microb Pathog 52:285-91. 2012
    ..These results suggest that M. leprae suppresses lipid degradation through inhibition of HSL expression, and that the monitoring of HSL mRNA levels in slit-skin smear specimens may be a useful indicator of patient prognosis...
  33. pmc Regulation of dual oxidase expression and H2O2 production by thyroglobulin
    Aya Yoshihara
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Thyroid 22:1054-62. 2012
    ..Since follicular Tg regulates the expression of genes that are essential for thyroid hormone synthesis, we hypothesized that Tg might also regulate DUOX expression and H2O2 production...
  34. pmc Whole-genome tiling array analysis of Mycobacterium leprae RNA reveals high expression of pseudogenes and noncoding regions
    Takeshi Akama
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo 189 0002, Japan
    J Bacteriol 191:3321-7. 2009
    ..In addition, our study suggests that M. leprae will be a useful model organism for the study of the molecular mechanism underlying the creation of pseudogenes and the role of microRNAs derived from noncoding regions...
  35. ncbi [Present leprosy situation in the world in 2006]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 76:19-28. 2007
    ..The challenge will be to establish these facilities as part of an integrated system that provides referral services for other diseases in the area...
  36. doi Fragments of genomic DNA released by injured cells activate innate immunity and suppress endocrine function in the thyroid
    Akira Kawashima
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Endocrinology 152:1702-12. 2011
    ..These results suggest that sterile thyroid injury, in the absence of infection, may be sufficient to trigger autoimmune reaction and to induce thyroid dysfunction...
  37. ncbi [Present leprosy situation in the world in 2010]
    Shuichi Mori
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 80:37-46. 2011
    ..However, early case detection and prompt treatment with MDT remain the cornerstone of leprosy. In order to reduce the physical, mental and socioeconomic burden of leprosy, much remains to be done...
  38. ncbi [Report of the Ninth meeting of the WHO Technical Advisory Group of Leprosy Control]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 78:75-88. 2009
    ..In addition, several experts and members of the Technical Commission of the International Federation ofAnti-Leprosy Associations (ILEP) also attended the meeting...
  39. ncbi Suppression of iodide uptake and thyroid hormone synthesis with stimulation of the type I interferon system by double-stranded ribonucleic acid in cultured human thyroid follicles
    Kazuko Yamazaki
    Thyroid Disease Institute, Kanaji Hospital, Tokyo, and Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Japan
    Endocrinology 148:3226-35. 2007
    ..These in vitro findings suggest that when thyrocytes are infected with certain viruses, dsRNA formed intracellularly in thyrocytes may be a cause for thyroid dysfunction, leading to development of autoimmune thyroiditis...
  40. ncbi [Future strategies for global leprosy control, 2011-2015]
    Shuichi Mori
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 79:53-73. 2010
    ....
  41. doi Analysis of Mycobacterium leprae gene expression using DNA microarray
    Takeshi Akama
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Microb Pathog 49:181-5. 2010
    ..leprae genome. The present results will shed light on M. leprae gene function and further our understanding of the pathogenesis of leprosy...
  42. ncbi Co-expression of vascular endothelial growth factor and its receptor, neuropilin-1, in a B cell lymphoma cell line (OHK) with primary effusion lymphoma immunophenotype
    Hiroko Kuwabara
    Department of Pathology, Osaka Medical College, Osaka, Japan
    Pathol Int 53:649-51. 2003
  43. ncbi Regulation of dual oxidase (DUOX) expression and H2O2 production by thyroglobulin
    Aya Yoshihara
    NIID, LRC, Tokyo, Japan
    Thyroid . 2012
    ..The evidence supports a reported model in which accumulated Tg in thyroid follicles plays important roles in autoregulating the function of individual follicles, which produces the basis of follicular heterogeneity...
  44. ncbi [Molecular mechanisms for intracellular parasitisation and exclusion in macrophage infected with Mycobacterium leprae]
    Kazunari Tanigawa
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 77:57-61. 2008
    ..However, the functional relationship between TLR2 and CORO1A was not known. We show here that there is a functional counteraction between TLR2 and CORO1A...
  45. ncbi [Leprosy in a chimpanzee]
    Norihisa Ishii
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 80:29-36. 2011
    ..Single-nucleotide polymorphism (SNP) analysis verified the West African origin of the bacilli. This occurrence suggests the possibility of leprosy being endemic among wild chimpanzees in West Africa, potentially posing a zoonotic risk...
  46. ncbi [Report of the tenth meeting of the WHO Technical Advisory Group on Leprosy Control]
    Norihisa Ishii
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 79:37-42. 2010
    ....
  47. doi Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs
    Takeshi Akama
    Laboratory of Molecular Diagnostics T A, Y L, A K, K T, A Y, Y I, K N, K S, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama shi, Tokyo 189 0002, Japan Department of Medicine, Uniformed Services University of the Health Sciences D F S, Bethesda, Maryland 20814 4799 and Department of Pharmacology, National Research Institute for Child Health and Development K N, A T, Setagaya Ku, Tokyo 157 8538, Japan
    Mol Endocrinol 28:368-79. 2014
    ..The present data support an important role for miRNAs as effectors for the effect of Tg on cell proliferation and perhaps other functions of Tg in the thyroid cell...
  48. ncbi [Mycobacterium shinshuense and Mycobacterium leprae infections: usefulness of genetical examinations]
    Kazue Nakanaga
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 76:245-50. 2007
    ..marinum and M. ulcerans, and also M. tuberculosis) are relatively related species and distantly related to rapidly growing species among 30 species of pathogenic mycobacteria which have been isolated in Japan...
  49. ncbi Latent IgA deposition from donor kidney is the major risk factor for recurrent IgA nephropathy in renal transplantation
    Takahito Moriyama
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Clin Transplant 19:41-8. 2005
    ..Previous studies have recognized risk factors for recurrent IgA nephropathy (r-IgAN) in renal transplantation. However the clinical significance of latent IgA deposition from the donor kidney remains to be determined...
  50. ncbi Pancreatic Stellate Cells and CX3CR1: Occurrence in Normal Pancreas and Acute and Chronic Pancreatitis and Effect of Their Activation by a CX3CR1 Agonist
    Masahiko Uchida
    From the Department of Medicine and Bioregulatory Science, Kyushu University, Fukuoka, Japan Department of Cell Biology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD and Department of Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Pancreas 43:708-19. 2014
    ..Therefore, we investigated CX3CL1 receptor (CX3CR1) occurrence in normal pancreas and pancreatitis (acute/chronic) tissues and the effects of CX3CL1 on activated PSCs...
  51. ncbi [Present leprosy situation in the world in 2012]
    Shuichi Mori
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 82:59-69. 2013
    ..It is important that all endemic countries continue to provide innovative solutions to address barriers to timely case detection and treatment completion, to ensure that the current declining trend is sustained...
  52. ncbi [Present leprosy situation in the world in 2011]
    Shuichi Mori
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 81:145-54. 2012
    ....
  53. ncbi [Leprosy services following elimination in WPRO and SEARO regions]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo Japan
    Nihon Hansenbyo Gakkai Zasshi 75:239-48. 2006
    ..The main strategy involves timely detection of new cases, multidrug treatment, and the key element of integration of leprosy services into general health services...
  54. ncbi High levels of hyaluronan production by a malignant lymphoma cell line with primary effusion lymphoma immunophenotype OHK
    Hiroko Kuwabara
    Department of Pathology, Osaka Medical College, Osaka, Japan
    Br J Haematol 120:1055-7. 2003
    ..These results show that HA is produced and secreted by the malignant lymphoma cell line OHK...
  55. doi Innate immune activation and thyroid autoimmunity
    Akira Kawashima
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    J Clin Endocrinol Metab 96:3661-71. 2011
    ..However, the underlying mechanisms by which specific antibodies against thyroid proteins are produced are largely unknown...
  56. pmc "Mycobacterium ulcerans subsp. shinshuense" isolated from a skin ulcer lesion: identification based on 16S rRNA gene sequencing
    Kazue Nakanaga
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama shi, Tokyo, Japan
    J Clin Microbiol 45:3840-3. 2007
    ..Definitive identification involved IS2404 detection, 16S rRNA gene sequencing, and analysis of the 16S rRNA gene 3'-terminal region and the virulence plasmid pMUM001...
  57. pmc Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice
    Hiroaki J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 4:e7857. 2009
    ..They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown...
  58. doi Leprosy as a model of immunity
    Yang Degang
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama, Tokyo 189 0002, Japan
    Future Microbiol 9:43-54. 2014
    ..Thus, leprosy is an exciting model for investigating the role of the human immune system in host defense and susceptibility to infection. ..
  59. ncbi Buruli ulcer and mycolactone-producing mycobacteria
    Kazue Nakanaga
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189 0002, Japan nakanaga nih go jp
    Jpn J Infect Dis 66:83-8. 2013
    ..The discovery of such a linkage of plasmid and its pathogenesis has not been reported in other human disease-causing mycobacteria...
  60. ncbi [Current practice of genetic diagnosis for Mycobacterium leprae]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 75:261-4. 2006
    ..These examinations include histopathology, serum antibody titers (anti-PGL-I antibody), PCR test and bioactivity of anti-bacterial agents...
  61. ncbi Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis
    Kosaku Nitta
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Am J Kidney Dis 44:680-8. 2004
    ..The purpose of the present study is to assess the effects of etidronate, a synthetic analogue of pyrophosphate, on progression of CAC score...
  62. ncbi [Physiological and pathological significance of Na/I symporter gene and PDS gene on the thyroid function]
    Koichi Suzuki
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases
    Nihon Rinsho 63:20-3. 2005
  63. ncbi [Research update on pathogenesis of autoimmune thyroid diseases]
    Koichi Suzuki
    Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases
    Nihon Rinsho 70:1880-4. 2012
    ..One of the recent topics is the effect of self genomic DNA fragments on immune activation. Here we review by focusing on the possible role of innate immune activation in the development of AITD...
  64. ncbi [Summary of questionnaires on slit skin smear test in clinics, hospitals, and university hospitals]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 76:227-32. 2007
    ..Supply of the glass slide with a marker, the spread of staining methods, technical improvement of an inspection are demanded in future...
  65. ncbi [Diagnosis of Hansen's disease]
    Rie Roselyne Yotsu
    Department of Dermatology, National Center for Global Health and Medicine, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 80:59-70. 2011
    ..This article includes the translation and some of the most informative photos. For more information, please refer to the homepage where you will find all photos in the atlas...
  66. ncbi [History for animal model of Hansen's disease and characteristics of leprosy in hypertensive nude rat]
    Yasuko Yogi
    Leprosy Research Center, National Institute of Infectious Diseases, 1 6 7 502 Hirose, Sayama, Saitama 350 1319, Japan
    Nihon Hansenbyo Gakkai Zasshi 77:197-204. 2008
    ..Also this hypertensive nude rat strain produce high level of IL-10. Therefore, congenic hypertensive nude rat may be useful for an animal model to leprosy...
  67. ncbi The 90K protein increases major histocompatibility complex class I expression and is regulated by hormones, gamma-interferon, and double-strand polynucleotides
    Antonino Grassadonia
    Cell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 145:4728-36. 2004
    ..The present data along with results from previous studies suggest that 90K plays an important role in the maintenance of an appropriate level of immune response...
  68. ncbi Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome
    Pnina Rotman-Pikielny
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mol Genet 11:2625-33. 2002
    ..These findings suggest that ER retention and defective plasma membrane targeting of pendrin mutants play a key role in the pathogenesis of Pendred syndrome...
  69. ncbi [Future strategies for global leprosy control]
    Koichi Suzuki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 75:23-39. 2006
    ..It is expected that the number of newly detected cases are expected to decline in the future by early detection, accurate diagnosis, early treatment, preventing disabilities and by further continuing the leprosy control activities...
  70. ncbi [Situation of global leprosy]
    Norihisa Ishii
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Higashimurayama, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 75:41-9. 2006
    ....
  71. doi Buruli ulcer and current situation in Japan: a new emerging cutaneous Mycobacterium infection
    Rie R Yotsu
    Department of Dermatology, National Center for Global Health and Medicine Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Dermatol 39:587-93. 2012
    ..Here, to establish a base for future progress in better understanding of this infectious disease, we reviewed the characteristics of the disease together with an update of reported cases in Japan...
  72. pmc Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
    Koichi Ojima
    Calpain Project, The Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo, Japan
    J Clin Invest 120:2672-83. 2010
    ..Furthermore, our data provide direct evidence that loss of p94 protease activity can result in LGMD2A and molecular insight into how this could occur...
  73. ncbi TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells
    Donald F Sellitti
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Endocr J 54:449-58. 2007
    ..These results suggest that Tg and other proteins could initiate glomerular injury by reproducing the actions of TGF-beta1 in the mesangial cell...
  74. pmc Mycobacterium leprae infection in monocyte-derived dendritic cells and its influence on antigen-presenting function
    Ken Hashimoto
    Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Tokyo, Japan
    Infect Immun 70:5167-76. 2002
    ..M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection...
  75. ncbi Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9
    Fumihiko Takeshita
    Center for Biologics Evaluation and Research Food and Drug Administration, Bldg 29A, Rm 3D10, Bethesda, MD 20892, USA
    Semin Immunol 16:17-22. 2004
    ....
  76. ncbi [Pendred syndrome]
    Koichi Suzuki
    Department of Bioregulation, Leprosy Research Center, National Institute of Infectious Diseases
    Nihon Rinsho . 2006
  77. ncbi Structure, activation, and biology of calpain
    Koichi Suzuki
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Diabetes 53:S12-8. 2004
    ....
  78. ncbi Incidence of latent mesangial IgA deposition in renal allograft donors in Japan
    Koichi Suzuki
    Department of Medicine, Kidney Center, Tokyo, Japan
    Kidney Int 63:2286-94. 2003
    ..The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy...
  79. ncbi An evaluation of 1-84 PTH measurement in relation to bone alkaline phosphatase and bone Gla protein in hemodialysis patients
    Naoko Miwa
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Nephron Clin Pract 94:c29-32. 2003
    ..The aim of the present study was to assess the clinical usefulness of whole PTH assay on the evaluation of bone turnover in HD patients...
  80. ncbi [Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages]
    Yasuko Yogi
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aobacho, Higasimurayama shi, Tokyo 189 0002, Japan
    Nihon Hansenbyo Gakkai Zasshi 71:39-45. 2002
    ..We also examined the cytokine production. The resident peritoneal macrophages of SHR/NCrj-rnu rats produced IL-1 alpha, IL-6, IL-10 and TNF alpha, whereas those of F344/NJcl-rnu rats produced only TNF alpha...
  81. ncbi Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation
    Kei Takeshita
    Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Respir Cell Mol Biol 29:124-32. 2003
    ....
  82. ncbi [Low-dose cyclosporin therapy combined with prednisolone for relapsing minimal change nephrotic syndrome in adults]
    Minako Koike
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 44:447-52. 2002
    ..7 +/- 24.3%-->88.6 +/- 14.5%, p = 0.01). Thus, the low dose cyclosporin(CsA) therapy combined with prednisolone was an effective treatment for adult MCNS patients who relapsed frequently under conventional prednisolone therapy...
  83. ncbi Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes
    Koichi Suzuki
    Genetics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 307:814-9. 2003
    ..This study supports the development of IFN-alpha gene therapy for HCV-associated liver diseases...
  84. ncbi Leprosy situation in Vietnam--reduced burden of stigma
    Pham Dang Bang
    Dermatology Department, Hanoi Medical University, Vietnam
    Nihon Hansenbyo Gakkai Zasshi 77:29-36. 2008
  85. ncbi Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts
    Takaki Hiwasa
    Department of Biochemistry, Graduate School of Medicine, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 290:510-7. 2002
    ..These results are concordant with the notion that calpain suppresses malignant transformation by predominant degradation of PKCepsilon...
  86. pmc The Atg5 Atg12 conjugate associates with innate antiviral immune responses
    Nao Jounai
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 104:14050-5. 2007
    ..Thus, in contrast to its role in promoting the bactericidal process, a component of the autophagic machinery appears to block innate antiviral immune responses, thereby contributing to RNA virus replication in host cells...
  87. ncbi Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells
    Akio Yoshida
    First Department of Internal Medicine, Tottori University Faculty of Medicine, Nishimachi 36 1, Yonago, Tottori 683 8504, Japan
    J Clin Endocrinol Metab 87:3356-61. 2002
    ....
  88. ncbi Insect diapause-specific peptide from the leaf beetle has consensus with a putative iridovirus peptide
    Hiromasa Tanaka
    Laboratory of Applied Entomology, Department of Agro bioscience, Faculty of Agriculture, Iwate University, Morioka, Japan
    Peptides 24:1327-33. 2003
    ..These results indicate that the diapause-specific peptide may be utilized as a probe to analyze and compare functional and evolutional aspects of the life cycles of insects and iridoviruses...
  89. doi Clinical analysis of multibacillary leprosy patients after 1-year fixed World Health Organization recommended multidrug therapy at Yangon General Hospital, Myanmar
    Kyaw Kyaw
    Central Special Skin Clinic, Yangon General Hospital, Yangon, Myanmar
    J Dermatol 35:264-9. 2008
    ..The present study indicates that it is important to follow up patients for several years after completion of MDT in order to detect possible lepra reactions and relapses...
  90. ncbi Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
    Shoji Hata
    Department of Enzymatic Regulation for Cell Functions, The Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo 113 8613, Japan
    J Biol Chem 281:11214-24. 2006
    ..These results strongly suggest novel functions for nCL-2 that involve the membrane trafficking of mucus cells via interactions with coat protein...
  91. ncbi TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF
    Fumihiko Takeshita
    Department of Molecular Biodefense Research, Yokohama City University School of Medicine, Yokohama, Japan
    Eur J Immunol 35:2477-85. 2005
    ..These results suggest that TRAF4 participates in the molecular mechanism underlying silencing of TLR-mediated signaling through the interaction with molecules harboring phagosome/endosome membrane...
  92. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  93. ncbi Mechanism of iodide/chloride exchange by pendrin
    Akio Yoshida
    Division of Regenerative Medicine and Therapeutics, Tottori University Faculty of Medicine, 36 1 Nishimachi, Yonago, Tottori 683 8504, Japan
    Endocrinology 145:4301-8. 2004
    ....
  94. doi Fluorescence-labeled methylation-sensitive amplified fragment length polymorphism (FL-MS-AFLP) analysis for quantitative determination of DNA methylation and demethylation status
    Shinji Kageyama
    1st Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431 3192, Japan
    Jpn J Clin Oncol 38:317-22. 2008
    ....
  95. ncbi Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers
    Maryla Krajewska
    The Burnham Institute, Department of Family Preventive Medicine, University of California San Diego, La Jolla, California, USA
    Clin Cancer Res 11:5451-61. 2005
    ..We tested the hypothesis that differences in expression of apoptosis-regulating proteins account for differences in clinical outcome among patients with early-stage colorectal cancer...
  96. ncbi Altered expression of junctional adhesion molecule 4 in injured podocytes
    Yutaka Harita
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Am J Physiol Renal Physiol 290:F335-44. 2006
    ..JAM4 may have a different role at the apical membrane besides the role as a junctional molecule and is likely associated with the unique structure of this epithelium...
  97. ncbi Expression of retinoic acid-inducible gene-I in lupus nephritis
    Koichi Suzuki
    Nephrol Dial Transplant 22:2407-9. 2007
  98. ncbi Identification and transcriptional organization of aerobactin transport and biosynthesis cluster genes of Vibrio hollisae
    Koichi Suzuki
    Department of Molecular Biopharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Res Microbiol 157:730-40. 2006
    ..The arrangement of the aerobactin gene clusters thus far found in Vibrio and enterobacterial species was compared and discussed from an evolutionary point of view...
  99. pmc Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
    Roberto Rocchi
    Department of Pathology and Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:6019-24. 2007
    ..The study demonstrates a link between Toll-like and Fc receptor signaling and thyroid gland function, uncovering a role of mast cells in murine NTI...
  100. ncbi Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer
    Kazuteru Hatanaka
    Genetics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Gene Med 6:1139-48. 2004
    ..This study suggested that the combination of IFN-alpha and antisense K-ras RNA is a promising gene therapy strategy against pancreatic cancer...
  101. ncbi Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody
    Yigang Wan
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 99:e121-9. 2005
    ..1.1 glomerulonephritis (Thy1.1GN) model and then to clarify the action mechanism of GTW at molecular level by examining its effects on various injurious factors in this model...