K Suzuki

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi The role of computed tomographic scanning in diagnosing mediastinal node involvement in non-small cell lung cancer
    K Takamochi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 119:1135-40. 2000
  2. ncbi Risk factors of treatment-related death in chemotherapy and thoracic radiotherapy for lung cancer
    Y Ohe
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, 6 5 1 Kashiwanoha, Kashiwa City, 277 8577, Chiba, Japan
    Eur J Cancer 37:54-63. 2001
  3. ncbi Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Osaka, Japan
    Ind Health 39:24-8. 2001
  4. pmc Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung
    K Takamochi
    Divsion of Investigative Treatment, National Cancer Center Research Institute East, Chiba, Japan
    Am J Pathol 159:1941-8. 2001
  5. ncbi Diagnostic significance of digital rectal examination and transrectal ultrasonography in men with prostate-specific antigen levels of 4 NG/ML or less
    T Yamamoto
    Department of Urology, Gunma University School of Medicine, Maebashi, Japan
    Urology 58:994-8. 2001
  6. ncbi Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Chest 115:563-8. 1999
  7. ncbi Prognostic factors in clinical stage I non-small cell lung cancer
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 67:927-32. 1999
  8. ncbi Synchronous double primary lung carcinomas associated with multiple atypical adenomatous hyperplasia
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Lung Cancer 19:131-9. 1998
  9. ncbi Clinicopathological characteristics of surgically resected lung cancer associated with idiopathic pulmonary fibrosis
    H Kawasaki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Surg Oncol 76:53-7. 2001
  10. ncbi Clinical predictors of N2 disease in non-small cell lung cancer
    K Takamochi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Chest 117:1577-82. 2000

Detail Information

Publications90

  1. ncbi The role of computed tomographic scanning in diagnosing mediastinal node involvement in non-small cell lung cancer
    K Takamochi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 119:1135-40. 2000
    ..We attempted to identify significant factors responsible for false-positive and false-negative scans...
  2. ncbi Risk factors of treatment-related death in chemotherapy and thoracic radiotherapy for lung cancer
    Y Ohe
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, 6 5 1 Kashiwanoha, Kashiwa City, 277 8577, Chiba, Japan
    Eur J Cancer 37:54-63. 2001
    ..20-90.2, P=0.033) were also associated with treatment-related death from thoracic radiotherapy. The administration of mitomycin C in addition to cisplatin-based regimens for patients with lung cancer should be carefully considered...
  3. ncbi Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Osaka, Japan
    Ind Health 39:24-8. 2001
    ..9 g/day of ethanol, and 2.09 (95% CI: 1.35-3.26) for those who drank 69.0 or more g/day of ethanol (P for trend < 0.001). These results suggest that alcohol consumption is closely associated with development of aortic stiffness...
  4. pmc Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung
    K Takamochi
    Divsion of Investigative Treatment, National Cancer Center Research Institute East, Chiba, Japan
    Am J Pathol 159:1941-8. 2001
    ..Especially, the frequencies of LOH on 9q and at the TSC1 gene-associated region were high. The TSC1 gene or another neighboring tumor suppressor gene on 9q might be involved in an early stage of the pathogenesis of lung adenocarcinoma...
  5. ncbi Diagnostic significance of digital rectal examination and transrectal ultrasonography in men with prostate-specific antigen levels of 4 NG/ML or less
    T Yamamoto
    Department of Urology, Gunma University School of Medicine, Maebashi, Japan
    Urology 58:994-8. 2001
    ..0 to 4.0 ng/mL would improve the sensitivity of prostate cancer detection. The diagnostic algorithm proposed in the present study is useful as a screening method for prostate cancer in subjects with PSA levels of 4.0 ng/mL or less...
  6. ncbi Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Chest 115:563-8. 1999
    ..To determine the indications for preoperative localization of a small indeterminate pulmonary nodule...
  7. ncbi Prognostic factors in clinical stage I non-small cell lung cancer
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 67:927-32. 1999
    ..Management of patients with early-stage lung cancer but a poor prognosis is controversial...
  8. ncbi Synchronous double primary lung carcinomas associated with multiple atypical adenomatous hyperplasia
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Lung Cancer 19:131-9. 1998
    ..This case might be an example of the adenoma-carcinoma sequence of lung cancer. A careful follow-up study is mandatory for this patient with special regard to the further development of lung carcinoma in the future...
  9. ncbi Clinicopathological characteristics of surgically resected lung cancer associated with idiopathic pulmonary fibrosis
    H Kawasaki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Surg Oncol 76:53-7. 2001
    ..We compared clinicopathological factors of lung cancer in patients with and without IPF...
  10. ncbi Clinical predictors of N2 disease in non-small cell lung cancer
    K Takamochi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Chest 117:1577-82. 2000
    ..To identify clinical or radiologic predictors of mediastinal lymph node involvement in patients with non-small cell lung cancer, and to define the indications of preoperative mediastinoscopy...
  11. ncbi Primary unknown cancer in pulmonary hilar lymph node with spontaneous transient regression: report of a case
    H Kawasaki
    Division of Thoracic Oncology, National Cancer Center Hospital East Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 28:405-9. 1998
    ..We concluded that the coagulation necrosis might have been the primary site of the tumor, which had spontaneously regressed and then appeared in the metastatic interlobar node...
  12. ncbi Pathologic N0 status in pulmonary adenocarcinoma is predictable by combining serum carcinoembryonic antigen level and computed tomographic findings
    K Takamochi
    Division of Thoracic Oncology and the Epidemiology and Biostatistics Division, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 122:325-30. 2001
    ..To avoid unnecessary lymphadenectomy, we attempted to identify clinical or radiologic predictors of pathologic N0 disease in patients with peripheral adenocarcinoma...
  13. ncbi Muscarinic cholinergic receptors in human narcolepsy: a PET study
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Neurology 51:1297-302. 1998
    ..To investigate the function of the muscarinic cholinergic receptor (mAchR) in narcolepsy and the effects of pharmacotherapy on mAchRs...
  14. pmc Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Br J Cancer 77:1003-8. 1998
    ..Our results show that a significantly higher rate of MSI is associated with familial clustering of malignancy. MSI could be one of the underlying mechanisms for familial clustering of malignancy in female NSCLC patients...
  15. ncbi Young lung cancer patients in Japan: different characteristics between the sexes
    I Sekine
    Division of Thoracic Oncology, National Cancer Center Hospital, East, Kashiwa, Japan
    Ann Thorac Surg 67:1451-5. 1999
    ..The percentage of smokers among younger patients ranges from 40% to 50% in Asia to 90% in Western countries. The prognosis for young patients with this disease is controversial...
  16. ncbi Prognostic significance of the size of central fibrosis in peripheral adenocarcinoma of the lung
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Ann Thorac Surg 69:893-7. 2000
    ..The prognostic significance of the characteristics of central fibrosis in peripheral adenocarcinoma of the lung has been reported. However, the prognostic significance of the size of central fibrosis has never been evaluated...
  17. pmc Monoclonality of atypical adenomatous hyperplasia of the lung
    S Niho
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Am J Pathol 154:249-54. 1999
    ..Two lesions of bronchiolar metaplasia, which was considered reactive, were polyclonal. Our results demonstrated the monoclonal nature of AAH, and this finding suggests that AAH is a precursor of BAC or a preneoplastic condition...
  18. ncbi Lung as reservoir for antidepressants in pharmacokinetic drug interactions
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Lancet 351:332-5. 1998
    ..Substantial accumulation of selective serotonin-reuptake inhibitors (SSRIs) in the lungs has been reported. We have investigated the role of the lungs in pharmacokinetic drug interactions between tricyclic antidepressants and SSRIs...
  19. ncbi Postoperative mediastinal chyloma
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 68:1857-8. 1999
    ..Although posttraumatic mediastinal chyloma is not rare, postoperative mediastinal chyloma has not been reported in the literature. However, it should be noted as a differential diagnosis for a postoperative mediastinal mass...
  20. ncbi Synthesis and evaluation of 11C-labeled nonpeptide antagonists for cholecystokinin receptors: [11C]L-365,260 and [11C]L-365,346
    T Haradahira
    National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Biol 25:203-8. 1998
    ..Owing to the very low brain permeability, however, [11C]L-365,260 may have no potential as a PET tracer for probing brain CCK-B receptors...
  21. ncbi Predictors of lymph node and intrapulmonary metastasis in clinical stage IA non-small cell lung carcinoma
    K Suzuki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 72:352-6. 2001
    ..The feasibility of limited surgical resection for clinical stage IA non-small cell lung cancer still remains controversial...
  22. ncbi A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding
    T Haradahira
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Biol 27:357-60. 2000
    ....
  23. pmc Brain muscarinic receptors in progressive supranuclear palsy and Parkinson's disease: a positron emission tomographic study
    M Asahina
    Division of Clinical Research and Radiation Health, National Institute of Radiological Science, Chiba, Japan
    J Neurol Neurosurg Psychiatry 65:155-63. 1998
    ....
  24. ncbi Specific renal delivery of sugar-modified low-molecular-weight peptides
    K Suzuki
    Drug Delivery System Institute, Ltd, Noda shi, Chiba, Japan
    J Pharmacol Exp Ther 288:888-97. 1999
    ..Thus, the renal uptake may not be dependent on derivatives having a cationic nature. We conclude that there is a novel transport mechanism in the kidneys that can be used for the specific renal delivery of glycosylated peptides...
  25. pmc Feasibility trial for adjuvant chemotherapy with docetaxel plus cisplatin followed by single agent long-term administration of S-1 chemotherapy in patients with completely resected non-small cell lung cancer: Thoracic Oncology Research Group Study 0809
    S Niho
    National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Br J Cancer 109:545-51. 2013
    ..We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer...
  26. ncbi Muscarinic receptor occupancy by biperiden in living human brain
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Life Sci 64:PL99-104. 1999
    ..mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner...
  27. ncbi Human lysozyme secretion increased by alpha-factor pro-sequence in Pichia pastoris
    C Oka
    Chiba Prefectural Industrial Research Institute, Chiba, Japan
    Biosci Biotechnol Biochem 63:1977-83. 1999
    ..The secreted protein by MF-alpha Prepro construct was identical with the authentic human lysozyme, judging from N-terminal amino acid sequencing and molecular mass spectrometric and crystallographic analysis...
  28. ncbi Renal drug targeting using a vector "alkylglycoside"
    K Suzuki
    Drug Delivery System Institute, Ltd, Noda shi, Chiba, Japan
    J Pharmacol Exp Ther 288:57-64. 1999
    ..In addition, these renally targeted derivatives inhibited the binding of [3H]Glc-S-C7-Me to the kidney membrane fraction. Our findings allow us to conclude that the alkylglycoside is a suitable candidate vector for renal targeting...
  29. ncbi A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog
    T Haradahira
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Chem Pharm Bull (Tokyo) 49:147-50. 2001
    ..These results indicate that 1 is a promising pharmacological tool as a prodrug of L-703,717 with improved BBB permeability...
  30. ncbi Synthesis of a F-18 labeled analog of antitumor prostaglandin delta 7-PGA1 methyl ester using p-[18F]fluorobenzylamine
    T Haradahira
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Appl Radiat Isot 49:1551-6. 1998
    ..The total synthesis time was 70 min from the start of the radiosynthesis of p-[18F]FBnA...
  31. ncbi Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Suita Shi, Osaka, Japan
    Eur J Epidemiol 18:523-30. 2003
    ..2 kg/m2, although the absolute risk was greater in more obese men. These results indicate that SUA level is closely associated with an increased risk for hypertension and IFG or Type II diabetes...
  32. doi Effects of serum calcium, phosphorous, and intact parathyroid hormone levels on survival in chronic hemodialysis patients in Japan
    Shigeru Nakai
    Fujita Health University School of Medicine, Dengakugakubo 1 98, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Ther Apher Dial 12:49-54. 2008
    ..Results showed that disturbances in bone mineral metabolism, such as those involving serum calcium, phosphorous, and iPTH, have a significant impact on survival in Japanese dialysis patients...
  33. pmc Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population
    H Nakazato
    Department of Urology, Gunma University School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma, 3718511, Japan
    Br J Cancer 89:691-6. 2003
    ..40, P=0.11) and high-grade disease (Gleason score >or=7) (OR=3.07, P=0.14). These findings suggested that the polymorphic changes within the RNASEL gene may be associated with familial prostate cancer risk in a Japanese population...
  34. ncbi Heat shock induces centrosomal dysfunction, and causes non-apoptotic mitotic catastrophe in human tumour cells
    K Nakahata
    Laboratory of Radiation and Life Science, School of Pharmaceutical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Int J Hyperthermia 18:332-43. 2002
    ..Instead, cell lethality was associated with mitotic catastrophe...
  35. ncbi Distant failure after treatment of postoperative locoregional recurrence of non-small cell lung cancer
    K Hotta
    Division of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Thorac Cardiovasc Surg 51:283-7. 2003
    ..The aim of this study was to evaluate clinicopathologic characteristics, type of locoregional recurrence, pattern of subsequent failure, and survival after the recurrence...
  36. ncbi Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Causes Control 19:33-41. 2008
    ..Particular focus was placed on a history of cholelithiasis, body mass index (BMI), and their effect modification, and whether risk differs by cancer subsite, namely by gallbladder cancer and extrahepatic bile duct cancer...
  37. ncbi Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita Shi, Osaka, Japan
    J Intern Med 254:287-95. 2003
    ..To investigate the association between serum gamma-glutamyltransferase (GGT) and risk for development of diabetes...
  38. pmc Earlier surveillance colonoscopy programme improves survival in patients with ulcerative colitis associated colorectal cancer: results of a 23-year surveillance programme in the Japanese population
    K Hata
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Cancer 89:1232-6. 2003
    ..Our surveillance programme is useful for detecting UC-associated CRC, and survival may be improved by surveillance colonoscopy...
  39. pmc Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women
    M Kojima
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Br J Cancer 90:1397-401. 2004
    ..There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer...
  40. ncbi The occurrence of Japanese cedar pollinosis with rheumatoid arthritis
    K Koizumi
    Clin Exp Rheumatol 25:505-6. 2007
  41. pmc How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer
    H Kunitoh
    Department of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 96:1498-503. 2007
    ..Numerous clinical questions remain, and enrolment of patients into well-designed clinical trials should be encouraged...
  42. ncbi Daily life activity and risk of developing impaired fasting glucose or type 2 diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
    Diabetologia 47:1768-75. 2004
    ..The aim of this study was to investigate the association between daily life activity and risk of developing diabetes...
  43. ncbi White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetologia 45:42-8. 2002
    ..To investigate the association between white blood-cell (WBC) count and the development of diabetes, independent of cigarette smoking...
  44. doi Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Carcinogenesis 29:1042-8. 2008
    ..Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer...
  45. ncbi Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study
    Taiki Yamaji
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:1935-40. 2008
    ..Finally, cruciferous vegetables deserve further investigation as foods possibly effective in the prevention of esophageal SCC...
  46. doi Coffee consumption and risk of endometrial cancer: a prospective study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:2406-10. 2008
    ..Coffee consumption may be associated with a decreased risk of endometrial cancer...
  47. ncbi Hematocrit and risk for hypertension in middle-aged Japanese male office workers
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Japan
    Ind Health 39:17-20. 2001
    ..97-3.97) for 46.4 to 48.1% hematocrit level, and 2.06 (95% CI: 1.02-4.15) for 48.2% or more hematocrit level. These results suggest that hematocrit is closely associated with development of hypertension in middle-aged Japanese men...
  48. ncbi Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I
    Mitsumasa Umesawa
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Stroke 39:2449-56. 2008
    ....
  49. ncbi Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  50. ncbi Predictors for development of hyperuricemia: an 8-year longitudinal study in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Japan
    Metabolism 50:621-6. 2001
    ..6%. In conclusion, obesity, alcohol intake, and multimetabolic disorders were determined to be independent predictors for the development of hyperuricemia. In addition, the white blood cell level may be a contributory factor...
  51. ncbi Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  52. ncbi Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Sci Total Environ 402:176-83. 2008
    ..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...
  53. ncbi Daily total physical activity level and premature death in men and women: results from a large-scale population-based cohort study in Japan (JPHC study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 18:522-30. 2008
    ..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...
  54. ncbi Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I
    Junko Ishihara
    Department of Public Health Medicine, University of Tsukuba, Ibaraki, Japan
    J Am Coll Nutr 27:127-36. 2008
    ..To investigate the association of dietary folate, vitamin B(6) (VB(6)) and vitamin B(12) (VB(12)) with the risk of coronary heart disease among middle-aged persons...
  55. ncbi T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non-small cell lung cancer
    E Carbone
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 122:907-12. 2001
    ..Consequently, T2b might be upgraded to at least T3...
  56. ncbi Validity and reliability of single-item questions about physical activity
    N Iwai
    Department of Public Health, Faculty of Medicine, Tottori University, Yonago, Japan
    J Epidemiol 11:211-8. 2001
    ....
  57. doi Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 17:930-7. 2008
    ..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...
  58. ncbi Impact of valvular thickness on stroke recurrence in medically treated patients with stroke
    K Okajima
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cerebrovasc Dis 24:375-80. 2007
    ..It remains controversial whether left-sided valvular thickening (VaT) is a risk factor for ischemic stroke. Little is known about the relationship between VaT and the recurrent adverse event rate in medically treated patients with stroke...
  59. pmc A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer
    S Tsutsui
    Department of Breast Surgery, Matsuyama Red Cross Hospital, Japan
    Br J Cancer 94:1874-8. 2006
    ..The prognostic implications of the c-kit expression seem to be due to fact that a loss of the c-kit expression is associated with an advanced stage of breast cancer...
  60. pmc Adolescent smoking behaviour and cigarette brand preference in Japan
    Y Osaki
    Division of Environmental and Preventive Medicine, Faculty of Medicine, Tottori University, Tottori, Japan
    Tob Control 15:172-80. 2006
    ..As part of efforts to develop a smoking control strategy for Japanese adolescents, the results of two nationwide surveys on adolescent smoking behaviour were compared...
  61. ncbi [Anti-flu measures in Japan]
    K Suzuki
    Rev Pneumol Clin 62:213-4. 2006
  62. ncbi Age and comorbidity as risk factors for vocal cord paralysis associated with tracheal intubation
    M Kikura
    Department of Anaesthesiology and Intensive Care, Hamamatsu Medical Center, Hamamatsu, Japan
    Br J Anaesth 98:524-30. 2007
    ..Vocal cord paralysis after tracheal intubation may be attributed to ageing and comorbidity. However, the relationship between patient characteristics and the risk of vocal cord paralysis is unknown...
  63. ncbi [Postoperative penicillin-resistant streptococcus pneumonia in lung cancer patient]
    Hironori Ishibashi
    Department of Thoracic Surgery, Shizuoka General Hospital, Shizuoka, Japan
    Kyobu Geka 61:199-203. 2008
    ..Although the patient recovered from penicillin resistant Streptococcus pneumonia, he was suffered from Klebsiella sepsis and expired on the POD 26...
  64. ncbi Glucose intolerance during hormonal therapy for prostate cancer
    K Suzuki
    Department of Urology, Jichi Medical University, Tochigi, Japan
    Prostate Cancer Prostatic Dis 10:384-7. 2007
    ..HT for PCa patients, especially with concurrent DM or obesity, induces elevation of the blood glucose level and deterioration of glucosuria. Therefore, glucose intolerance should be considered during HT for PCa...
  65. ncbi Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Causes Control 19:67-74. 2008
    ..We investigated the association between plasma folate and the risk of colorectal cancer in a nested case-control study...
  66. ncbi Carbon beam therapy in recurrent ovarian cancer
    A Nawa
    Ann Oncol 19:192-4. 2008
  67. ncbi Lower haemoglobin level and subsequent decline in kidney function in type 2 diabetic adults without clinical albuminuria
    T Babazono
    Division of Nephrology and Hypertension, Diabetes Centre, Tokyo Women s Medical University School of Medicine, 8 1 Kawadacho, Shinjukuku, Tokyo, 162 8666, Japan
    Diabetologia 49:1387-93. 2006
    ....
  68. pmc Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis
    C Maesawa
    Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19 1, 020 8505 Morioka, Japan
    J Clin Pathol 59:328-30. 2006
    ..We investigated maspin expression in non-tumorous gallbladder epithelium in patients with cholelithiasis...
  69. ncbi [Five cases of lung cancer with emphysematous bullae]
    S Hatakeyama
    Department of Respiratory Medicine, Yaizu Municipal Hospital, Yaizu, Japan
    Nihon Kokyuki Gakkai Zasshi 39:415-8. 2001
    ..About 18 months later, the patient was found to have poorly differentiated adenocarcinoma of the left lung, which was treated surgically. We should always be careful of lung cancer associated with emphysematous bullae and pneumothorax...
  70. ncbi Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients
    N Nishiguchi
    Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Biol Psychiatry 50:123-8. 2001
    ....
  71. ncbi Primary synovial sarcoma of the lung: a case report confirmed by molecular detection of SYT-SSX fusion gene transcripts
    H Terasaki
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 31:212-6. 2001
    ..This tumor should be considered in the differential diagnosis of round to short spindle cell tumors arising in the lung...
  72. ncbi Intrapulmonary metastasis of non-small cell lung cancer: a prognostic assessment
    T Okumura
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 122:24-8. 2001
    ..In terms of postoperative prognosis, the revised TNM classification for intrapulmonary metastasis seems to be appropriate...
  73. ncbi [A case of advanced gastric cancer treated with neoadjuvant chemotherapy of low-dose CPT-11 + CDDP]
    H Tadatomo
    Dept. of Surgery, Tokyo Metropolitan Toshima Hospital
    Gan To Kagaku Ryoho 28:821-4. 2001
    ..However, it was considered that this method of "low-dose CPT-11 + CDDP" was very effective as the neoadjuvant chemotherapy in a patient with advanced gastric cancer...
  74. ncbi [Suppressive effects of the antiandrogen flutamide on adrenal androgens in advanced prostate cancer patients]
    H Nakazato
    Department of Urology, Gunma University School of Medicine
    Nippon Hinyokika Gakkai Zasshi 92:6-12. 2001
    ..CONCLUSION: From our observations, we found that flutamide reduced adrenal androgen levels in prostate cancer patients treated with LH-RH agonist. ACTH suppression might be related to this phenomenon...
  75. ncbi A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency
    K Suzuki
    Gene Therapy Center, University of Alabama at Birmingham, 35294-3300, USA
    Clin Cancer Res 7:120-6. 2001
    ..We conclude that the combination of genomic modification to achieve tumor-selective replication and capsid modification to enhance infectivity yields more potent oncolytic adenoviruses for use in cancer treatment...
  76. pmc Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to t
    R Yamada
    Laboratory of Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research, Tokyo, Japan
    Am J Hum Genet 68:674-85. 2001
    ..The utility of combining the genotype data in this way to identify possible contributions of various genes to this disease is discussed...
  77. ncbi Pathological changes of renal tubular dysplasia in Japanese black cattle
    Y Sasaki
    Laboratory of Internal Medicine, Faculty of Agriculture, Gifu University, Japan
    Vet Rec 150:628-32. 2002
    ..It was concluded that renal tubular dysplasia was the primary lesion of the disease, and that interstitial fibrosis and reductions in the numbers of nephrons were secondary lesions...
  78. ncbi Fiber shaft extension in combination with HI loop ligands augments infectivity for CAR-negative tumor targets but does not enhance hepatotropism in vivo
    T Seki
    Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, 35294 3300, USA
    Gene Ther 9:1101-8. 2002
    ..We suggest that Ad vectors with artificial fiber shaft extension in combination with HI loop ligands may be useful for gene therapy applications...
  79. pmc Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population
    J Matsuzawa
    Division of Bio systemic Gastroenterology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan
    Gut 52:75-8. 2003
    ..We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located on chromosome 19p13 and IBD in a Japanese population...
  80. ncbi Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population
    K Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neural Transm 113:1279-85. 2006
    ..The distribution of neither beta3 adrenergic receptor gene nor CCK-AR polymorphism differed between EDs and control subjects. Therefore, the CC type of GHSR gene polymorphism (171T/C) is a risk factor for BN, but not for AN...
  81. ncbi [Surgical resection for T4 lung cancer invading thoracic aorta]
    K Suzuki
    Department of First Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Kyobu Geka 58:963-8. 2005
    ..Pulmonary resection with the involved aorta can be done safely using cardiopulmonary bypass, with encouraging long-term survivals in patients without N2 or N3 nodal metastasis...
  82. ncbi [Non-small cell lung cancer simultaneously metastatic to the brain treated by lobectomy and stereotactic irradiation]
    S Ohi
    Department of Tuhoracic Surgery, Iwata City Hospital, Iwata, Japan
    Kyobu Geka 58:865-7. 2005
    ..He has been doing well now without recurrence for 5 years after the operation. We think that STI and radical lobectomy are good alternatives for patients with NSCLC metastatic to the brain...
  83. ncbi Serum procalcitonin levels are elevated in esophageal cancer patients with postoperative infectious complications
    S Ito
    Department of Surgery 1, Critical Care Medicine and Anesthesiology, School of Medicine, Iwate Medical University, Morioka, Japan
    Eur Surg Res 37:22-8. 2005
    ..The normal systemic inflammatory response to surgical stimuli often makes early diagnosis of postoperative infections difficult...
  84. ncbi Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss
    Y Saijo
    Department of Public Health and Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mol Hum Reprod 10:729-33. 2004
    ..71-1.88, CYP1B1: Leu/Leu (reference); Leu/Val and Val/Val, OR = 1.18; 95% CI = 0.68-2.02]. The present study suggests that the Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not major genetic regulators in RPL...
  85. ncbi Clinical and immunohistochemical characteristics of benign giant cell tumour of bone with pulmonary metastases: case series
    S Osaka
    Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Orthop Surg (Hong Kong) 12:55-62. 2004
    ..In this study, we present clinical and immunohistochemical findings associated with giant cell tumour of bone with pulmonary metastases...
  86. ncbi Haematocrit and risk of development of Type 2 diabetes mellitus in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabet Med 21:476-82. 2004
    ..Men in whom Type 2 diabetes mellitus (FPG > or = 7.0 mmol/l or receiving hypoglycaemic medication) was found during repeated surveys were classified as having Type 2 diabetes...
  87. ncbi A prospective study of body size and colon cancer mortality in Japan: The JACC Study
    K Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Int J Obes Relat Metab Disord 28:551-8. 2004
    ..To determine whether body size measurements are risk factors for colon cancer death among the Japanese...
  88. ncbi Intratumoral expression of a fusogenic membrane glycoprotein enhances the efficacy of replicating adenovirus therapy
    A Ahmed
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55902, USA
    Gene Ther 10:1663-71. 2003
    ....
  89. ncbi An evaluation of the Banff 97 classification after kidney transplantation
    T Tanaka
    Department of Urology, Gunma University School of Medicine, Gunma, Osaka, Japan
    Transplant Proc 35:860-1. 2003
  90. ncbi Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q
    K Miura
    Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Japan
    Cancer Res 56:1629-34. 1996
    ....