T Suhara

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 49:1270-6. 2008
  2. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
  3. ncbi request reprint Lung as reservoir for antidepressants in pharmacokinetic drug interactions
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Lancet 351:332-5. 1998
  4. ncbi request reprint High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography
    Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Arch Gen Psychiatry 60:386-91. 2003
  5. ncbi request reprint Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone
    F Yasuno
    National Institute of Radiological Sciences, Chiba shi, Japan
    Psychopharmacology (Berl) 154:112-4. 2001
  6. ncbi request reprint Clozapine can induce high dopamine D(2) receptor occupancy in vivo
    Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Psychopharmacology (Berl) 160:107-12. 2002
  7. ncbi request reprint Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia
    Tetsuya Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Japan
    Arch Gen Psychiatry 59:25-30. 2002
  8. ncbi request reprint Muscarinic cholinergic receptors in human narcolepsy: a PET study
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Neurology 51:1297-302. 1998
  9. ncbi request reprint Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    Ryosuke Arakawa
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Psychopharmacology (Berl) 197:229-35. 2008
  10. ncbi request reprint Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 7:19-26. 2004

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 49:1270-6. 2008
    ..In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods...
  2. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
    ..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders...
  3. ncbi request reprint Lung as reservoir for antidepressants in pharmacokinetic drug interactions
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Lancet 351:332-5. 1998
    ..Substantial accumulation of selective serotonin-reuptake inhibitors (SSRIs) in the lungs has been reported. We have investigated the role of the lungs in pharmacokinetic drug interactions between tricyclic antidepressants and SSRIs...
  4. ncbi request reprint High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography
    Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Arch Gen Psychiatry 60:386-91. 2003
    ..However, there have only been a few studies about 5-HTT occupancy, and in particular, data concerning classical antidepressants are still limited...
  5. ncbi request reprint Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone
    F Yasuno
    National Institute of Radiological Sciences, Chiba shi, Japan
    Psychopharmacology (Berl) 154:112-4. 2001
    ..Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated...
  6. ncbi request reprint Clozapine can induce high dopamine D(2) receptor occupancy in vivo
    Tetsuya Suhara
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Psychopharmacology (Berl) 160:107-12. 2002
    ..Furthermore, even at maximum occupancy, 70% is not exceeded. Several mechanisms have been proposed as explanations for this low D(2) receptor occupancy, but clear evidence is limited...
  7. ncbi request reprint Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia
    Tetsuya Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Japan
    Arch Gen Psychiatry 59:25-30. 2002
    ..On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia...
  8. ncbi request reprint Muscarinic cholinergic receptors in human narcolepsy: a PET study
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Neurology 51:1297-302. 1998
    ..To investigate the function of the muscarinic cholinergic receptor (mAchR) in narcolepsy and the effects of pharmacotherapy on mAchRs...
  9. ncbi request reprint Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    Ryosuke Arakawa
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Psychopharmacology (Berl) 197:229-35. 2008
    ..Paliperidone ER is a novel antipsychotic drug in an extended-release (ER) formulation. As with all antipsychotics, careful dose setting is necessary to avoid side effects...
  10. ncbi request reprint Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 7:19-26. 2004
    ..3 h respectively. Using plasma pharmacokinetics and in-vivo ED50, the time-course of receptor occupancy could be calculated. Simulation of drug kinetics at receptors would provide useful information for the evaluation of antipsychotics...
  11. ncbi request reprint Age-related reduction of extrastriatal dopamine D2 receptor measured by PET
    M Inoue
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Life Sci 69:1079-84. 2001
    ..4% in parietal cortex, 12.4% in occipital cortex, 12.2% in hippocampus, and 4.8% in thalamus. These findings suggest that the amounts of D2 receptor declines in all brain regions as part of the normal aging process...
  12. ncbi request reprint Effect of endogenous dopamine on endogenous dopamine on extrastriated [11C]FLB 457 binding measured by PET
    T Okauchi
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba 263-8555, Japan
    Synapse 41:87-95. 2001
    ..These results suggest that [11C]FLB 457 is not sensitive to endogenous dopamine in the extrastriatal regions of rhesus monkeys, despite a sufficient dose of MAP to decrease the binding of [11C]raclopride in the striatum...
  13. pmc Brain muscarinic receptors in progressive supranuclear palsy and Parkinson's disease: a positron emission tomographic study
    M Asahina
    Division of Clinical Research and Radiation Health, National Institute of Radiological Science, Chiba, Japan
    J Neurol Neurosurg Psychiatry 65:155-63. 1998
    ....
  14. ncbi request reprint Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Nucl Med Mol Imaging 29:1289-97. 2002
    ..Both [(11)C](+)McN5652 and [(11)C]cyanoimipramine showed sufficient specific binding for performance of a quantitative analysis in the brain. [(11)C](+)McN5652 could be superior because of its higher distribution to the brain...
  15. ncbi request reprint A positron-emitter labeled glycine(B) site antagonist, [(11)C]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluR epsilon3 subunit in vivo, but not in vitro
    Terushi Haradahira
    Division of Medical Imaging, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 43:131-3. 2002
    ..Therefore, the present study clearly demonstrated that [(11)C]L-703,717 preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRepsilon3 subunit in vivo, but not in vitro...
  16. ncbi request reprint Muscarinic receptor occupancy by biperiden in living human brain
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Life Sci 64:PL99-104. 1999
    ..mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner...
  17. ncbi request reprint Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Neuroimage 34:1643-9. 2007
    ..Our findings suggest that dopamine D2 receptors in the hippocampus might affect the local hippocampal function, but also brain functions outside the hippocampus such as the prefrontal cortex...
  18. ncbi request reprint Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1 4 chome, Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:75-81. 2006
    ..At high plasma concentration, clozapine can induce high extrastriatal dopamine D2 receptor occupancy in the human brain, and this finding fitted well with the theoretical estimation...
  19. doi request reprint Positron emission tomography measurement of dopamine Dâ‚‚ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010
    ..However, the magnitude of hyperprolactinemia differs among antipsychotics, and there is no reliable mechanism-related marker for the risk of hyperprolactinemia that would allow us to characterize antipsychotics...
  20. pmc Measurement error analysis for the determination of dopamine D(2) receptor occupancy using the agonist radioligand [(11)C]MNPA
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 30:187-95. 2010
    ..Results showed that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely in region of interest analysis by SRTM with a longer than 60-min [(11)C]MNPA PET scan duration...
  21. pmc Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    Bin Ji
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 28:12255-67. 2008
    ....
  22. ncbi request reprint Relation among dopamine D(2) receptor binding, obesity and personality in normal human subjects
    F Yasuno
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, 263 8555, Chiba, Japan
    Neurosci Lett 300:59-61. 2001
    ..It can be assumed that variation of dopaminergic activity in the amygdala underlies the personality variants related to the concept of fundamental body type...
  23. ncbi request reprint Reproducibility of [11 C]FLB 457 binding in extrastriatal regions
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 22:1215-21. 2001
    ..These results support the suitability of using [11C]FLB 457 for the quantitative evaluation of extrastriatal D2 receptors and for protocols requiring repeated measurements in the same individual...
  24. ncbi request reprint Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Neuroimage 13:891-5. 2001
    ..No significant correlation was observed in any other region. Our result indicates that there is a significant association between dopamine D2 receptor binding and the human novelty seeking trait in the right insular cortex...
  25. ncbi request reprint Extrastriatal dopamine D(2) receptor occupancy in olanzapine-treated patients with schizophrenia
    Ryosuke Arakawa
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
    Eur Arch Psychiatry Clin Neurosci 260:345-50. 2010
    ..In conclusion, although the subjects and methods were different from previous striatal occupancy studies, these results suggest that limbic occupancy by olanzapine may not be so different from that in the striatum...
  26. ncbi request reprint GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit
    Yoshiyuki Asai
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Schizophr Res 99:333-40. 2008
    ..GABA(A)/BZ receptor including alpha5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia...
  27. ncbi request reprint Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Clin Neurosci 58:330-2. 2004
    ..It is suggested that the threshold level of cortical dopamine D(2) receptor occupancy for the suppression of CAR is demonstrated in the present study...
  28. ncbi request reprint Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457
    Yoko Ikoma
    Molecular Imaging Center, National Institute of Radiological Sciences 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Neuroimage 42:1285-94. 2008
    ..These results demonstrated that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely with an optimal scan duration with [(11)C]raclopride and [(11)C]FLB 457...
  29. ncbi request reprint Age-related decline of serotonin transporters in living human brain of healthy males
    Masahiro Yamamoto
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Life Sci 71:751-7. 2002
    ..There was a significant age-related decline in BP in the thalamus and midbrain. The decline in [11C](+)McN5652 binding was 9.6% per decade in the thalamus and 10.5% per decade in the midbrain...
  30. ncbi request reprint In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin
    J Maeda
    CREST, Japan Science and Technology Corporation (JST, Chiba, Japan
    Synapse 40:122-9. 2001
    ..These results indicated that the in vivo binding of [carbonyl-(11)C]WAY-100635 in the hippocampus and cerebral cortex mainly reflects postsynaptic 5-HT(1A) receptor binding, and that this binding is not sensitive to endogenous 5-HT...
  31. ncbi request reprint A prodrug of NMDA/glycine site antagonist, L-703,717, with improved BBB permeability: 4-acetoxy derivative and its positron-emitter labeled analog
    T Haradahira
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Chem Pharm Bull (Tokyo) 49:147-50. 2001
    ..These results indicate that 1 is a promising pharmacological tool as a prodrug of L-703,717 with improved BBB permeability...
  32. ncbi request reprint Functional brain mapping of monkey tool use
    S Obayashi
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neuroimage 14:853-61. 2001
    ..These tool use-specific areas may participate in maintaining and updating the body-image for the precise guidance of a hand-held rake onto a distant reward...
  33. ncbi request reprint Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia
    Jun Kosaka
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Life Sci 86:814-8. 2010
    ..However, the results of previous positron emission tomography (PET) studies of dopamine D1 receptor in schizophrenia were not consistent...
  34. ncbi request reprint Low dopamine d(2) receptor binding in subregions of the thalamus in schizophrenia
    Fumihiko Yasuno
    National Institute of Radioloogical Sciences, Chiba, Japan
    Am J Psychiatry 161:1016-22. 2004
    ..The aim of the present study was to examine dopamine D(2) receptor binding in subregions of the thalamus in patients with schizophrenia...
  35. ncbi request reprint Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    Jun Maeda
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Brain Res 1157:100-11. 2007
    ..The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue...
  36. ncbi request reprint Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    Michie Miyoshi
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Nucl Med 50:1095-101. 2009
    ..The aim of this study was to evaluate a quantification method of (11)C-AC-5216 binding in the human brain...
  37. ncbi request reprint Abnormal effective connectivity of dopamine D2 receptor binding in schizophrenia
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Psychiatry Res 138:197-207. 2005
    ..These results suggest that a systems-level change reflected in the connectivity of D2 receptor binding is present in schizophrenia...
  38. ncbi request reprint Neonatal phencyclidine treatment selectively attenuates mesolimbic dopamine function in adult rats as revealed by methamphetamine-induced behavior and c-fos mRNA expression in the brain
    J Semba
    Division of Health Sciences, University of the Air, Chiba, Japan
    Synapse 40:11-8. 2001
    ..These results suggest that neonatal blockade of NMDA receptor, which induces a number of effects in the developing nervous system, may cause long-lasting functional changes of the mesolimbic dopamine system...
  39. ncbi request reprint The role of extrastriatal dopamine D2 receptors in schizophrenia
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 59:919-28. 2006
    ..These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues regarding the pathogenesis and of possible treatments for schizophrenia...
  40. ncbi request reprint Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
    ..However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K(1)/k(2) between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model...
  41. ncbi request reprint Functional and structural synergy for resolution recovery and partial volume correction in brain PET
    Miho Shidahara
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Neuroimage 44:340-8. 2009
    ..When the method is combined with anatomical probabilistic atlases, the outcome is a functional volume corrected for partial volume effects...
  42. ncbi request reprint Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study
    Hidehiko Takahashi
    Brain Imaging Project, National Institute of Radiological Sciences, Japan
    Neuroimage 27:991-1001. 2005
    ..At the same time, our findings suggest that pharmacological fMRI could be a powerful tool for investigating the neurophysiological properties of drugs targeting neuropsychiatric disorders...
  43. ncbi request reprint [Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands]
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:17-21. 2006
    ..We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders...
  44. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  45. ncbi request reprint Effects of the reference tissue setting on the parametric image of 11C-WAY 100635
    Akihiro Takano
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 28:193-8. 2007
    ..In this study, regions of interest (ROIs) of the cerebellum for C-WAY 100635 were determined in five different approaches for six healthy male volunteers, and the effects on binding potential parametric images were compared...
  46. ncbi request reprint Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
    Fumihiko Yasuno
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 64:835-41. 2008
    ..The role of activated microglia in AD is an important topic in the pathophysiology of AD. The aim of this study was to quantify PBR in AD brain with a new high-sensitive PBR ligand, [(11)C]DAA1106...
  47. ncbi request reprint Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652
    Tetsuya Ichimiya
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 51:715-22. 2002
    ..The aim of this study was to examine whether 5-HTT binding was altered in patients with mood disorders using positron emission tomography (PET)...
  48. ncbi request reprint Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
    ..In this study, we validated the quantification methods of (11)C-verapamil transfer from plasma to the brain in humans...
  49. ncbi request reprint Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil
    Akihiro Takano
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1427-33. 2006
    ..In the present study, we investigated the P-gp functional differences at the BBB between the haplotypes (1236TT, 2677TT, 3435TT vs. 1236CC, 2677GG, 3435CC) of the MDR1 gene with different quantitative analyses of (11)C-verapamil...
  50. ncbi request reprint [Molecular imaging in the drug development of psychotropics using positron emission tomography]
    Harumasa Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba City, 263 8555 Chiba, Japan
    Brain Nerve 59:215-20. 2007
    ....
  51. ncbi request reprint Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography
    Yuji Nagai
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 61:809-19. 2007
    ....
  52. ncbi request reprint Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain
    Yota Fujimura
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:43-50. 2006
    ..To our knowledge, this is the first study to investigate the (18)F-FEDAA1106 binding to PBR in living human brain by PET. We also aimed to evaluate various analytic methods to quantify the density of PBR...
  53. doi request reprint Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain
    Tatsui Otsuka
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 50:703-10. 2009
    ..In the present study, the kinetics of (11)C-MNPA were examined for the first time, to our knowledge, in the human brain and analyzed using quantitative approaches with or without an arterial input function...
  54. ncbi request reprint In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems
    Eisuke Haneda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:205-15. 2007
    ....
  55. ncbi request reprint Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PET
    Shoko Nozaki
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Schizophr Res 108:78-84. 2009
    ..Patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia...
  56. doi request reprint Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 209:285-90. 2010
    ..There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with perospirone-like properties...
  57. ncbi request reprint Visualization of alpha5 subunit of GABAA/benzodiazepine receptor by 11C Ro15-4513 using positron emission tomography
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 47:200-8. 2003
    ....
  58. ncbi request reprint Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Am J Psychiatry 160:334-40. 2003
    ..To clarify this relationship, the authors determined the availability of 5-HT(1A) receptors in the human brain and the relationship between regional receptor binding and memory function...
  59. ncbi request reprint Template-based method for multiple volumes of interest of human brain PET images
    Fumihiko Yasuno
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 16:577-86. 2002
    ..The template-based method was found to be both accurate and robust and can be used as a reliable alternative for the manual determination of VOIs...
  60. ncbi request reprint Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 20:237-43. 2006
    ..In this study we compared mean regional radioactivity concentration in the late phase and binding potential (BP) between FBP and OSEM algorithms in neurotransmission PET studies for [11C]raclopride and [11C]DASB...
  61. ncbi request reprint Increase in thalamic binding of [(11)C]PE2I in patients with schizophrenia: a positron emission tomography study of dopamine transporter
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Psychiatr Res 43:1219-23. 2009
    ..75), positive (r=0.78) and negative PANSS scores (r=0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia...
  62. ncbi request reprint Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, 4 9 1 Aragawa, Inage, Chiba 305 8555, Japan
    Brain Res 1064:136-45. 2005
    ....
  63. ncbi request reprint Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 52:283-91. 2004
    ..11)C]DAA1106 binding was four times higher compared to the binding of [(11)C]PK11195 in the monkey occipital cortex. These results indicated that [(11)C]DAA1106 might be a good ligand for in vivo imaging of PBR...
  64. ncbi request reprint Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 27:10957-68. 2007
    ....
  65. doi request reprint Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study
    Ryohei Matsumoto
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:121-6. 2010
    ..The change in [(11)C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD...
  66. ncbi request reprint Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models
    Chie Seki
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Ann Nucl Med 24:249-60. 2010
    ..The aim of this study was to evaluate the applicability of quantification methods using reference tissue models for [(11)C]PE2I...
  67. ncbi request reprint 7Li 2D CSI of human brain on a clinical scanner
    F Girard
    Division of Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    MAGMA 13:1-7. 2001
    ..The distribution of 7Li appears uniform in the brains of the patients studied...
  68. doi request reprint Relationship between baseline cerebral blood flow and vascular responses to changes in PaCO2 measured by positron emission tomography in humans: implication of inter-individual variations of cerebral vascular tone
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Acta Physiol (Oxf) 193:325-30. 2008
    ..In the present study, the relationship between CBF and cerebral vascular tone to inter-individual variation at rest condition was investigated using positron emission tomography (PET)...
  69. ncbi request reprint Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University
    Ann Nucl Med 20:493-8. 2006
    ..Two IMPs (IMPA and IMPB) produced by different radiopharmaceutical companies are marketed in Japan. In the present study, whole-body distributions including brain and blood of the two IMPs were compared in the same human subjects...
  70. ncbi request reprint Regional heterogeneity and age-related change in sub-regions of internal capsule evaluated by diffusion tensor imaging
    Hiroshi Kawaguchi
    Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Japan
    Brain Res 1354:30-9. 2010
    ..Evaluation using eigenvalues (lambda(L) and lambda(T)), as well as FA and MD, may provide important information towards understanding age-related changes and may also be useful for clinical diagnosis of diseased IC...
  71. doi request reprint Neural correlates of human virtue judgment
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Cereb Cortex 18:1886-91. 2008
    ..The central process of moral beauty evaluation might be related to that of aesthetic evaluation. Our finding might contribute to a better understanding of human morality...
  72. ncbi request reprint [In vivo evaluation of expressed protein function by PET]
    Ryohei Matsumoto
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:137-41. 2005
    ..This approach can provide in vivo pharmacological evidences of antipsychotics and establish a rational therapeutic strategy. PET is a powerful tool not only in the field of brain research but also drug discovery and individual medicine...
  73. ncbi request reprint Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[11C]methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: a PET tracer for imaging sigma(1) receptors
    Ming Rong Zhang
    CREST, Japan Sciences and Technology Corporation, Kawaguchi, Japan
    Nucl Med Biol 29:469-76. 2002
    ..These results indicate that [11C]1 may have some specific binding to the sigma(1) receptors, which is consistent with the result of in vitro autoradiography...
  74. doi request reprint Monkey brain activity modulated by reward preferences: a positron emission tomography study
    Shigeru Obayashi
    Department of Molecular Neuroimaging, Molecular Imaging Center MIC, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neurosci Res 64:421-8. 2009
    ..The present results may include the brain regions subserving motivational changes by subjective reward significances...
  75. ncbi request reprint Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  76. doi request reprint In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Chiba 263 8555, Japan
    Biochim Biophys Acta 1802:373-88. 2010
    ....
  77. ncbi request reprint Syntheses and pharmacological evaluation of two potent antagonists for dopamine D4 receptors: [11C]YM-50001 and N-[2-[4-(4-Chlorophenyl)-piperizin-1-yl]ethyl]-3-[11C]methoxybenzamide
    Ming Rong Zhang
    CREST, Japan Sciences and Technology Corporation, 4 1 8 332 0012, Honmachi, Kawaguchi, Japan
    Nucl Med Biol 29:233-41. 2002
    ..However, the effort to determine the specific binding for D4 failed. These results indicate that both of the benzamide derivatives would not be suitable radioligands for D4 receptors with PET...
  78. ncbi request reprint Role of ventral striatal dopamine D1 receptor in cigarette craving
    Fumihiko Yasuno
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 61:1252-9. 2007
    ..The objective of this study was to determine correlations between craving-related brain activation and dopamine D1 receptor (D1R) binding in smokers...
  79. ncbi request reprint N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain
    Ming Rong Zhang
    Radiochemistry Section, Department of Molecular Probe, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Med Chem 50:848-55. 2007
    ..Ex vivo autoradiography of the rat brain gave visual evidence that [131I]3a was a potent and specific radioligand for PBR...
  80. ncbi request reprint Metabolite analysis of [11C]Ro15-4513 in mice, rats, monkeys and humans
    T Kida
    Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Nucl Med Biol 30:779-84. 2003
    ....
  81. ncbi request reprint Differential effects of acute and chronic treatment with typical and atypical neuroleptics on c-fos mRNA expression in rat forebrain regions using non-radioactive in situ hybridization
    J Semba
    University of the Air, Chiba, Japan
    Neurochem Int 34:269-77. 1999
    ..Since chronic neuroleptics do not induce tolerance to their antipsychotic activities, our study suggests that the shell region of N. accumbens is an important target site for antipsychotic effects of neuroleptics...
  82. ncbi request reprint Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    H Shimada
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 260 8555, Japan
    Neurology 73:273-8. 2009
    ..To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB)...
  83. ncbi request reprint Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains
    Shigeki Sasaki
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 27:531-7. 2004
    ..The present findings indicate that none of these (11)C-labelled analogues have potential for PET study of binding sites on the N-methyl-D-aspartate (NMDA) receptors...
  84. ncbi request reprint Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors
    Terushi Haradahira
    Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Nucl Med Biol 29:517-25. 2002
    ..Thus, the present studies point to the possibility that the polyamines and cations behave as endogenous inhibitors for (+/-)[11C]1 binding, leading to the loss of the specific binding in vivo...
  85. ncbi request reprint Decreased 5-HT1A receptor binding in amygdala of schizophrenia
    Fumihiko Yasuno
    Department of Psychiatry YO, Nippon Medical School, Tokyo, Japan
    Biol Psychiatry 55:439-44. 2004
    ....
  86. ncbi request reprint Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
    Masanori Ichise
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 23:1096-112. 2003
    ..MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies...
  87. ncbi request reprint [PET (positron emission tomography) research on schizophrenia]
    Akihiro Takano
    Nihon Yakurigaku Zasshi 128:177-83. 2006
  88. ncbi request reprint Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors
    Terushi Haradahira
    Department of Medical Imaging, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 50:130-6. 2003
    ....
  89. ncbi request reprint No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET
    Kunihiko Shioe
    Department of Neuropsychiatry, Faculty of Medicine, University of Yamanashi, Tamaho, Japan
    Synapse 48:184-8. 2003
    ..118, s/s: 0.825 +/- 0.209). In conclusion, this study does not support the assumption that the genotype-dependent differences of 5-HTTLPR directly contributes to the regulation of the 5-HTT binding site in the living human brain...
  90. ncbi request reprint [Pathophysiology of mood disorders and the therapy]
    Tetsuya Suhara
    Seishin Shinkeigaku Zasshi 104:464-71. 2002
  91. ncbi request reprint Quantitative analysis for estimating binding potential of the brain serotonin transporter with [11 C]McN5652
    Yoko Ikoma
    Department of Science and Engineering, Waseda University, Tokyo, Japan
    J Cereb Blood Flow Metab 22:490-501. 2002
    ....
  92. ncbi request reprint Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain
    Ming Rong Zhang
    Department of Medical Imaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Med Chem 47:2228-35. 2004
    ..No radioactive metabolite of [(18)F]5 was detected in the mouse brain. The biological data indicate that [(18)F]5 is a useful PET ligand for PBR and is currently used for imaging PBR in human brain...
  93. ncbi request reprint [Evaluation of drug therapy based on the results of imaging]
    Tetsuya Suhara
    Seishin Shinkeigaku Zasshi 106:916-20. 2004
  94. ncbi request reprint Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with (18)F-FEDAA1106
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Eur J Nucl Med Mol Imaging 35:416-23. 2008
    ..We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k (3)/k (4)) of the peripheral benzodiazepine receptor using (18)F-FEDAA1106 and nonlinear least-square fitting...
  95. ncbi request reprint [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain
    Ming Rong Zhang
    Department of Medical Imaging, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    J Med Chem 49:2735-42. 2006
    ..Metabolite analysis demonstrated that these [(11)C]ligands were metabolized by debenzylation to polar products mainly in the plasma...
  96. ncbi request reprint Quantitative magnetic resonance spectroscopy of schizophrenia: relationship between decreased N-acetylaspartate and frontal lobe dysfunction
    Yoko Tanaka
    Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University School of Medicine, and Asai Hospital, Tokyo, Japan
    Psychiatry Clin Neurosci 60:365-72. 2006
    ..544, P<0.05). Using quantitative MRS, decreased NAA concentration was confirmed in the left frontal lobe of schizophrenic patients and was demonstrated to be correlated with negative symptoms and cognitive dysfunction in schizophrenia...
  97. ncbi request reprint [Distribution and function of dopamine D1, D2 receptor]
    Tetsuya Suhara
    Department of Molecular Neuroimaging, Clinical Neuroimaging Section, National Institute of Radiological Sciences
    Rinsho Shinkeigaku 47:826-8. 2007
    ....
  98. ncbi request reprint Effects of repetitive transcranial magnetic stimulation on [11C]raclopride binding and cognitive function in patients with depression
    Yuko Kuroda
    Section of Psychiatry and Behavioral Science, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Affect Disord 95:35-42. 2006
    ..We attempted to determine the effects of chronic rTMS on central dopaminergic function in depression using positron emission tomography (PET) with [11C]raclopride...
  99. ncbi request reprint Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel
    Takeshi Fuchigami
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Nucl Med Biol 35:203-12. 2008
    ....
  100. ncbi request reprint In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, Inage Ku, Chiba, Japan
    Cell Transplant 14:655-63. 2005
    ..Repeated PET measurements of DA transporters are a useful tool in assessing the effectiveness of neural transplantations...
  101. ncbi request reprint [Usefulness of PET in clinical trials of psychotropic drugs]
    Tetsuya Suhara
    Seishin Shinkeigaku Zasshi 107:704-11. 2005