Takashi Sugimura

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi Nutrition and dietary carcinogens
    T Sugimura
    National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 21:387-95. 2000
  2. ncbi Congratulatory dedication to Professor Osamu Hayaishi: from Bethesda to Ueno Park (Japan Academy)
    Takashi Sugimura
    President Emeritus, National Cancer Center, Chairman of Section II, The Japan Academy, Tokyo, Japan
    IUBMB Life 58:251-2. 2006
  3. ncbi Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
    Takashi Sugimura
    National Cancer Center, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:290-9. 2004
  4. ncbi Genetic and epigenetic alterations in carcinogenesis
    T Sugimura
    Carcinogenesis Division, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mutat Res 462:235-46. 2000
  5. ncbi Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age
    Atsushi Shibata
    Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Mutat Res 664:20-7. 2009
  6. ncbi Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas
    Tohru Niwa
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
    Cancer Sci 96:409-13. 2005
  7. ncbi Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays
    Masanobu Abe
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan
    Carcinogenesis 24:861-7. 2003
  8. ncbi Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma
    Yoshito Takeuchi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:1692-6. 2007
  9. ncbi Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor
    Mami Takahashi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 29:1608-13. 2008
  10. ncbi Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers
    Atsushi Kaneda
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 64:6410-5. 2004

Detail Information

Publications100

  1. ncbi Nutrition and dietary carcinogens
    T Sugimura
    National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 21:387-95. 2000
    ..Studies of nutrition and dietary condition will eventually lead us to cancer prevention, namely delay of onset of cancer to the late phase of human life, which is called 'natural-end cancer' (Tenju-gann)...
  2. ncbi Congratulatory dedication to Professor Osamu Hayaishi: from Bethesda to Ueno Park (Japan Academy)
    Takashi Sugimura
    President Emeritus, National Cancer Center, Chairman of Section II, The Japan Academy, Tokyo, Japan
    IUBMB Life 58:251-2. 2006
  3. ncbi Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
    Takashi Sugimura
    National Cancer Center, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:290-9. 2004
    ..Advice to the general public about how to reduce the carcinogenic load imposed by HCAs would be an important contribution to cancer prevention...
  4. ncbi Genetic and epigenetic alterations in carcinogenesis
    T Sugimura
    Carcinogenesis Division, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mutat Res 462:235-46. 2000
    ..Based on the growing understanding of the roles of DNA methylation, several new methodologies were developed to make a genome-wide search for changes in DNA methylation. Now, a wave of new findings is in sight...
  5. ncbi Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age
    Atsushi Shibata
    Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Mutat Res 664:20-7. 2009
    ..05) but not in Parp-1(+/+) brains, suggesting that Parp-1 deficiency causes an increase of point mutations in the brain by aging...
  6. ncbi Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas
    Tohru Niwa
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
    Cancer Sci 96:409-13. 2005
    ..The search for other genes involved in these carcinomas needs to be continued...
  7. ncbi Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays
    Masanobu Abe
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan
    Carcinogenesis 24:861-7. 2003
    ....
  8. ncbi Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma
    Yoshito Takeuchi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:1692-6. 2007
    ....
  9. ncbi Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor
    Mami Takahashi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 29:1608-13. 2008
    ..Moreover, treatment with 200 p.p.m. ONO-1714 reduced the number of BOP-induced cholangiocellular tumors. These results suggest that iNOS plays roles in promoting pancreatic carcinogenesis in both early and late stages in hamsters...
  10. ncbi Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers
    Atsushi Kaneda
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 64:6410-5. 2004
    ..These data showed that LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers...
  11. ncbi Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045
    Cancer Sci 94:960-4. 2003
    ..A suppressive effect of pioglitazone on colon polyp formation was also found. The PPAR gamma agonist, pioglitazone, may thus be a promising candidate chemopreventive agent for colon cancer...
  12. ncbi Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 97:248-51. 2006
    ..Chafuroside-associated toxicity was not observed at 2.5-10 p.p.m. in Min mice and 10-20 p.p.m. in AOM-treated rats. These results suggest that chafuroside might be a good chemopreventive agent for colon cancer...
  13. ncbi Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 29:824-9. 2008
    ..These results indicate that Pai-1 induction associated with hypertriglyceridemia may contribute to intestinal polyp formation with Apc deficiency, and PAI-1 could thus be a novel target for colorectal chemopreventive agents...
  14. ncbi Decreased expression of the seven ARP2/3 complex genes in human gastric cancers
    Atsushi Kaneda
    National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Cancer Lett 212:203-10. 2004
    ..The consistent decrease of the Arp2/3 complex genes and its important role in actin organization suggested that the decrease could be involved in cancer phenotypes, such as dysplastic morphology...
  15. ncbi Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Masako Ochiai
    Division of Biochemistry and Cancer Prevention, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 163:1607-14. 2003
    ..The results of our present study indicate that dysplastic ACF, which accounted for approximately one-fourth of the total ACF, are preneoplastic lesions of colon cancers induced by PhIP in rats...
  16. ncbi Induction of glandular stomach cancers in Helicobacter pylori-infected Mongolian gerbils by 1-nitrosoindole-3-acetonitrile
    Satoshi Matsubara
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 130:259-66. 2012
    ..pylori alone. Thus, endogenous carcinogens formed from nitrosation of indole compounds could be critical risk factors for human gastric cancer development under the influence of H. pylori infection...
  17. ncbi Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples
    Rena Nishigaki
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Epidemiol Biomarkers Prev 16:151-6. 2007
    ..These results suggest that APNH should be considered as a novel endogenous mutagen/carcinogen; thus, it is very important to determine the biological significance of this carcinogen for human cancer development...
  18. ncbi Improvement of hyperlipidemia by indomethacin in Min mice
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 121:1665-9. 2007
    ..Furthermore, TNFalpha was downregulated. These results indicate that indomethacin might suppress intestinal tumor formation together with a hyperlipidemic state by regulating LPL and other lipid metabolic factors...
  19. ncbi Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 96:260-4. 2005
    ..p.m. ONO-8711. These results confirm that EP(1) is involved in colon carcinogenesis and that EP(1)-selective antagonists might be promising candidates for colon cancer chemopreventive agents...
  20. ncbi Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae
    Masafumi Yamamoto
    Division of Cancer Development System, Carcinogenesis Research Group, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Genetica 139:1251-8. 2011
    ..Thus, we confirmed that the pierisin-1 gene is located in the genome of P. rapae...
  21. ncbi Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet
    Mika Hori
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Pancreas 40:1234-40. 2011
    ..Obesity is associated with increased pancreatic cancer risk, although the mechanisms have yet to be detailed. This study aimed to elucidate promotion of pancreatic cancer by obesity and hyperlipidemia...
  22. ncbi Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers
    Kazuaki Miyamoto
    National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 22:274-80. 2003
    ..From the high incidence, silencing of the 3-OST-2 gene is expected to have high diagnostic, and potentially therapeutic, values...
  23. ncbi Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 97:1011-4. 2006
    ..No side effects were observed in any of the groups. These results confirm that COX-1, as well as COX-2, contributes to colon carcinogenesis and that mofezolac may be a good chemopreventive agent for human colon cancer...
  24. ncbi Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Kyoko Fujiwara
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1495-505. 2004
    ..Our results suggest that Paneth cell differentiation in colon epithelial cells could be an early morphological change in cryptic cells during colon carcinogenesis...
  25. ncbi Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers
    Mitsunori Ushigome
    Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 26:635-40. 2005
    ....
  26. ncbi Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
    Hideki Ogino
    ADP ribosylation in Oncology Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    BMC Genomics 8:41. 2007
    ..However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet...
  27. ncbi Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 125:2505-10. 2009
    ..It is speculated that lipid accumulation in the intestinal polyps may play an important role in intestinal polyp formation in Apc-deficient mice...
  28. ncbi Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus
    Hirokazu Fukuda
    Biochemistry Division, National Cancer Center Research Institute, 1 1, Tsukiji 5, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:25585-92. 2009
    ..This slippage probably leads to the single dG base deletion in colon tumors...
  29. ncbi High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice
    Naoya Teraoka
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 129:528-35. 2011
    ..These results indicate that the KK-A(y) mouse, featuring intact leptin and leptin receptor Ob-Rbl, could be a useful animal model to investigate obesity-associated cancer...
  30. ncbi Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis
    Mami Takahashi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Tokyo 104 0045, Japan
    Nitric Oxide 14:130-6. 2006
    ..01). These results suggest that iNOS plays roles in both early and late stages of colon carcinogenesis...
  31. ncbi Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins
    Mami Mihara
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji 5-chome, Tokyo 104, Japan
    Am J Pathol 169:1643-51. 2006
    ....
  32. ncbi Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers
    Takeshi Nakajima
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 15:2317-21. 2006
    ..Quantitative analysis of methylation levels is a promising risk marker for gastric cancers...
  33. ncbi Enzymatic properties of pierisin-1 and its N-terminal domain, a guanine-specific ADP-ribosyltransferase from the cabbage butterfly
    Masahiko Watanabe
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045
    J Biochem 135:471-7. 2004
    ..Long-term reactions indicated that a single molecule of pierisin-1 has the capacity to generate more than 10(6) ADP-ribosylated DNA adducts, which could cause the death of a mammalian cell...
  34. ncbi Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis
    Yutaka Shoji
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 26:2116-22. 2005
    ..Furthermore, benign keratoacanthomas only developed in EP(3)-knockout mice (6/19 versus 0/24, P < 0.01). The results suggest that PGE(2) receptor EP(3) signaling might contribute to development of SCCs in the skin...
  35. ncbi Silencing of the thrombomodulin gene in human malignant melanoma
    Junichi Furuta
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Melanoma Res 15:15-20. 2005
    ..These findings suggest that most human melanomas lack TM expression, and that methylation of the promoter CpG island is one of the mechanisms responsible...
  36. ncbi Reduced expression of GNA11 and silencing of MCT1 in human breast cancers
    Kiyoshi Asada
    Division of Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Oncology 64:380-8. 2003
    ..MCT1 is involved in cellular transportation of butyrate, which induces cellular differentiation. Downregulation of these two genes was suggested to be involved in human breast cancers...
  37. ncbi Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis
    Masako Nakanishi
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    Cancer Sci 98:1157-63. 2007
    ..The present results provide strong evidence that prolonged chronic inflammatory responses induced by DSS are directly responsible for the observed enhancement of PhIP-induced large bowel carcinogenicity...
  38. ncbi Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers
    Satoshi Yamashita
    Carcinogenesis Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Mutat Res 549:185-93. 2004
    ..Persistent expression changes are considered to be important for prediction of past carcinogen exposure, and could provide a molecular environment favorable for malignant transformation...
  39. ncbi Establishment of a detection system for demethylating agents using an endogenous promoter CpG island
    Eriko Okochi-Takada
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan
    Mutat Res 568:187-94. 2004
    ..We believe that this is the first assay system that detects agents that disturb the methylated status of a CGI that regulates an endogenous promoter...
  40. ncbi Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:2000-8, 2008.e1-2. 2011
    ..Visceral fat accumulation and decreased levels of plasma adiponectin (APN) have been associated with development of human colorectal adenoma. We investigated the function of APN in intestinal carcinogenesis...
  41. ncbi Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays
    Satoshi Yamashita
    Carcinogenesis Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Mamm Genome 14:845-52. 2003
    ..All three genes are known to be involved in retinoic acid-mediated signaling and could be involved in the control of differential induction of cell proliferation...
  42. ncbi Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT)
    Tsukasa Kitahashi
    Central Animal Laboratory, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:1761-6. 2010
    ..Thus, micro-CT could be useful to evaluate the carcinogenic processes and preventive methods of pancreatic cancer in hamsters and to assess the novel contrast agents for detection of small pancreatic cancer in humans...
  43. ncbi Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development
    Toshihiko Kawamori
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 26:353-7. 2005
    ..These results provide strong evidence that the EP(1) receptor is of major importance for colon cancer development and it could be a new target for a mechanism-based chemoprevention strategy against colon cancer development...
  44. ncbi Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi
    Masafumi Yamamoto
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Comp Biochem Physiol B Biochem Mol Biol 154:326-33. 2009
    ..These findings could provide useful information for understanding the importance of apoptosis-inducing ability and molecular evolution of Pierisin-like proteins in family Pieridae...
  45. ncbi Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates
    Yukari Totsuka
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Chem Res Toxicol 18:1553-62. 2005
    ....
  46. ncbi Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas
    Eriko Okochi
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 34:211-8. 2002
    ..As underlying mechanisms, alterations in posttranscriptional regulation or stability of Brca1 protein were suggested...
  47. ncbi Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor
    Naoya Teraoka
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Prev Res (Phila) 4:445-53. 2011
    ..These results indicated that pitavastatin has potential benefit for the suppression of intestinal polyp development...
  48. ncbi Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae
    Yasuko Matsumoto
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 105:2516-20. 2008
    ..These findings offer insight to understanding the nature of DNA ADP-ribosylating activity in the butterfly...
  49. ncbi High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
    Takao Maekita
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    Clin Cancer Res 12:989-95. 2006
    ..02). CONCLUSIONS: It was indicated that H. pylori infection potently induces methylation of CGIs to various degrees. Methylation levels of specific CGIs seemed to reflect gastric cancer risk in H. pylori-negative individuals...
  50. ncbi Identification of 20 genes aberrantly methylated in human breast cancers
    Kazuaki Miyamoto
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
    Int J Cancer 116:407-14. 2005
    ..This may serve as markers for early-stage breast cancers and suggests that aberrant methylation targets transcriptionally inactive genes in vivo...
  51. ncbi Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts
    Akemi Gunji
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 241:87-92. 2006
    ..This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO...
  52. ncbi SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis
    Naoto Tsuchiya
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Res 67:9568-76. 2007
    ..Up-regulation of SND1 may thus occur at a very early stage in colon carcinogenesis and contribute to the posttranscriptional regulation of key players in colon cancer development, including APC and beta-catenin...
  53. ncbi Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil
    Nobuo Takasuka
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 275:150-7. 2009
    ..The results indicate that DAG-rich oil has promoting potential for skin carcinogenesis, and thus, further investigations of its tumor-promoting potential in other organs are warranted...
  54. ncbi Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus
    Katsuhisa Sakano
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:2193-8. 2007
    ..Our results indicate that diabetic/hyperlipidemic state can enhance BOP-induced carcinogenesis of the thyroid gland and to a lesser extent the colon in OLETF rats...
  55. ncbi Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors
    Tsukasa Kitahashi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:241-5. 2008
    ....
  56. ncbi Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged
    Satoshi Yamashita
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo, Japan
    Cancer Res 65:2610-6. 2005
    ..These results showed that prostate cancer susceptibility of ACI rats involves at least four loci, and suggested Mme and Cdkn1a as candidates for Pcr1 and Pcs2...
  57. ncbi Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1
    Hirokazu Fukuda
    Biochemistry Division, National Cancer Center Research Institute, 1 1, Tsukiji 5, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 99:12685-90. 2002
    ..This ability of UP1 suggests that unfolding of quadruplex DNA is required for DNA synthesis processes...
  58. ncbi Cloning of the 5' upstream region of the rat p16 gene and its role in silencing
    Masanobu Abe
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1100-6. 2002
    ....
  59. ncbi Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
    Atsushi Hagihara
    Carcinogenesis Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Oncogene 23:8705-10. 2004
    ..MSP of 24 primary pancreatic cancers showed that all these genes, except for THBD, were methylated in at least one cancer. Some of those were suggested to be potentially involved in pancreatic cancer development and progression...
  60. ncbi LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo
    Naoto Tsuchiya
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji Chuo ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 317:736-43. 2004
    ..Taking all these results together, it is suggested that LRP130, a novel type of RNA-binding protein, associates with mRNA/mRNP complexes at the outside of NE and ER, and plays a role in control of mRNA metabolisms...
  61. ncbi Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
    Tadashige Nozaki
    Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 94:497-500. 2003
    ..Therefore, the results indicate that susceptibility to AOM-induced tumorigenesis in the colon and also in the liver is enhanced in Parp-1(-/-) mice, and Parp-1 could have a substantial role in colon and liver tumorigenesis...
  62. ncbi Fidelity of the methylation pattern and its variation in the genome
    Toshikazu Ushijima
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Genome Res 13:868-74. 2003
    ..The differential MPERs even among unmethylated CGIs indicated that a promoter-specific protection mechanism(s) from de novo methylation was present...
  63. ncbi Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent
    Atsushi Shibata
    Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 24:1328-37. 2005
    ..These results indicate that Parp-1 is implicated in suppressing deletion mutations in vivo, especially those accompanying small insertions or rearrangements...
  64. ncbi Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography
    Yusaku Hori
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:1774-7. 2008
    ..Other tumors, histopathologically adenomas, grew slowly or moderately. The results provide evidence that micro-CT is a useful non-invasive imaging approach for evaluating the characteristics and growth of lung tumors in mice...
  65. ncbi Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 36:166-71. 2006
    ..The triglyceride (TG) levels were approximately 10-fold higher than the levels observed in wild-type mice...
  66. ncbi Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis
    Michihiro Mutoh
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 62:28-32. 2002
    ....
  67. ncbi Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis
    Tomohiro Kitamura
    Cancer Prevention Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:1463-6. 2002
    ..The data indicate that both COX-1 and COX-2 can contribute to intestinal tumorigenesis...
  68. ncbi Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility
    Satoshi Yamashita
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:923-8. 2002
    ....
  69. ncbi Etiology-specific gene expression profiles in rat mammary carcinomas
    Takashi Kuramoto
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
    Cancer Res 62:3592-7. 2002
    ..Our results indicated that gene expression profiles in cancers reflect their etiology and suggested a possibility that etiology of cancers could be retrospectively estimated from their expression profiles...
  70. ncbi Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice
    Tomohiro Kitamura
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 94:618-21. 2003
    ..Our results indicate that EP(1) and EP(4) may have separate intrinsic roles and, to some extent, contribute to polyp formation independently. Thus, combination treatment has potential for the chemoprevention of colon carcinogenesis...
  71. ncbi Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly
    Yuko Matsushima-Hibiya
    Cancer Prevention Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 278:9972-8. 2003
    ..Thus, our results suggest that pierisin-1 binds to Gb3 and Gb4 receptors at the C-terminal region, in a manner similar to ricin, and then exhibits cytotoxicity after incorporation into the cell...
  72. ncbi Food and cancer
    Takashi Sugimura
    National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicology 181:17-21. 2002
    ..HCAs can produce other toxicological effects including salivary gland atrophy and myocardial degeneration. Improved food, better life styles and developments in the functional food industry are all crucila to cancer prevention...
  73. ncbi Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems
    Yukari Totsuka
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Part Fibre Toxicol 6:23. 2009
    ..abstract:..
  74. ncbi Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000
    Katsuhiro Fukuta
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:1055-62. 2008
    ..PEG injection therapy could therefore be adopted as an alternative chemotherapeutic strategy for localized prostate cancers, including those that become refractory to androgen-deprivation therapy...
  75. ncbi Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly
    Takashi Kanazawa
    Cancer Prevention Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Biochem Biophys Res Commun 296:20-5. 2002
    ..In contrast, this caspase activation was not observed in bcl-2-transfected HeLa cells. Our results thus indicate that pierisin-1-induced apoptosis is mediated primarily via a mitochondrial pathway involving Bcl-2 and caspases...
  76. ncbi A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP
    Hitoshi Nakagama
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mutat Res 506:137-44. 2002
    ..Other unknown genetic or epigenetic alterations, which are essential for the development of early lesions of colon carcinogenesis, could also be clarified using this system...
  77. ncbi Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands
    Naoko Niho
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 63:6090-5. 2003
    ..Hyperlipidemia in these mice may thus be associated with their intestinal lesion development...
  78. ncbi Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 102:2970-4. 2005
    ....
  79. ncbi Decreased fidelity in replicating CpG methylation patterns in cancer cells
    Toshikazu Ushijima
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 65:11-7. 2005
    ..These data showed that some cancer cells have decreased fidelity in replicating methylation patterns in some CGIs, and that the decrease could lead to methylation of the entire CGIs...
  80. ncbi Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription
    Takeji Takamura-Enya
    Cancer Prevention Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Chem Res Toxicol 15:419-25. 2002
    ....
  81. ncbi Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats
    Minako Nagao
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Environ Mol Mutagen 39:158-64. 2002
    ..These mutational characteristics were also observed in the original tumors. Single-nucleotide instability (SNI) might be implicated in the mammary cancer induced by PhIP...
  82. ncbi Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells
    Mami Takahashi
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 22:7667-76. 2003
    ....
  83. ncbi Poly(ADP-ribose) and carcinogenesis
    Mitsuko Masutani
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 38:339-48. 2003
    ..Highlights during the last four decades of studies by laboratories focusing on poly(ADP-ribose)/PARP, including our own, are condensed and summarized in this review...
  84. ncbi Modification of the 32P-postlabeling method to detect a single adduct species as a single spot
    Masako Ochiai
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Methods Mol Biol 291:13-9. 2005
    ..The advantage of these methods is that the number of adduct species formed can be estimated by TLC...
  85. ncbi Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?
    Eriko Okochi
    Carcinogenesis Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuoku, Tokyo, Japan
    Mutat Res 506:101-11. 2002
    ..These human breast cancer cell lines were proficient in G/T mismatch binding, and were reported to lack MSI. SNI was suggested to play a wide involvement in human and rat mammary carcinogenesis...
  86. ncbi Causal relationship between the loss of RUNX3 expression and gastric cancer
    Qing Lin Li
    Department of Biochemistry, College of Medicine, Institute of Medical Research, Chungbuk National University, 361 763, Cheongju, South Korea
    Cell 109:113-24. 2002
    ....
  87. ncbi Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells
    Hideaki Inamori
    Biochemistry Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 93:382-8. 2002
    ..Although the biological relevance of MN mutations still remains to be clarified, a subset of colorectal and gastric cancers could feature a new type of genomic instability, distinct from MSI...
  88. ncbi [The principles of cancer treatment--changes in chemotherapy]
    Takashi Sugimura
    Gan To Kagaku Ryoho 29:1263-78. 2002
  89. ncbi Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly
    Masanobu Kawanishi
    Environmental Genetics Laboratory, Frontier Science Innovation Center, Osaka Prefecture University, 1 2 Gakuen cho, Sakai, Osaka 599 8570, Japan
    Chem Res Toxicol 20:694-700. 2007
    ..More mutations were induced in the plasmid propagated in NER-deficient cells than that in wild-type human cells. These results indicate the involvement of the NER system in the repair of N2-ADPR-dG in both E. coli and human cells...
  90. ncbi Serendipitous discoveries from sudden inspirations and the joy of being a scientist
    Takashi Sugimura
    Biochem Biophys Res Commun 296:1037-8. 2002
  91. ncbi Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice
    Kumiko Ogawa
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Cancer Lett 236:32-8. 2006
    ....
  92. ncbi Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1
    Bunsyo Shiotani
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Mol Cancer Res 4:125-33. 2006
    ..From these findings, it is suggested that mono-ADP-ribosylation of DNA causes a specific type of fork blockage that induces checkpoint activation and signaling...
  93. ncbi Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae
    Takeji Takamura-Enya
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Biochem Biophys Res Commun 323:579-82. 2004
    ....
  94. ncbi Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats
    Toshihiko Kawamori
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Carcinogenesis 25:1967-72. 2004
    ..beta-Catenin protein accumulations in the nucleus and cytoplasm were also revealed in both liver and colon tumors. Thus, APNH induced liver and colon cancers with K-ras, beta-catenin and Apc gene mutations in F344 rats...
  95. ncbi Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation
    Atsushi Kaneda
    Carcinogenesis Division and Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan
    Cancer Sci 95:58-64. 2004
    ....
  96. ncbi Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice
    Herve Huang
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon 08, France
    Cancer Lett 198:29-35. 2003
    ....
  97. ncbi Enhancement of colon carcinogenesis by prostaglandin E2 administration
    Toshihiko Kawamori
    Cancer Prevention Division, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Carcinogenesis 24:985-90. 2003
    ..Our results provide evidence that PGE(2) enhances colon carcinogenesis through induction of cell proliferation and reduction of apoptosis...
  98. ncbi Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae
    Masahiko Watanabe
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Comp Biochem Physiol A Mol Integr Physiol 139:125-31. 2004
    ..Thus, the results indicate that mRNA of pierisin-1 was highly expressed in late stages of larvae, and that the protein accumulated in fat bodies where it persists during pupation...
  99. ncbi Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat
    Kyoko Fujiwara
    Biochemistry Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan
    Cancer Sci 94:672-8. 2003
    ..The combined effects of the repertoire of these differentially expressed genes in normal colon epithelial tissues may account for the distinct susceptibilities of F344 and ACI strains to colon carcinogenesis...
  100. ncbi Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats
    Masako Ochiai
    Biochemistry Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Cancer Lett 220:67-74. 2005
    ....