Genomes and Genes
Affiliation: National Institute of Genetics
- Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesisY Shirayoshi
Mammalian Development Laboratory, National Institute of Genetics, Mishima, Japan
Genes Cells 2:213-24. 1997..However, the exact nature and the in vivo expression pattern of the int-3 proto-oncogene are unknown. The function of gene products in embryogenesis is also not clear...
- Recombination in the class III region of the mouse major histocompatibility complexM Yoshino
Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
Immunogenetics 40:280-6. 1994..The result demonstrated that an unequal distribution of recombination is a general feature of the mouse MHC, suggesting the presence of a recombinational hotspot within the Int3:Tnx interval...
- Functional conservation of mouse Notch receptor family membersH Kato
Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Sakyo ku, Japan
FEBS Lett 395:221-4. 1996..These results indicate that all mouse Notch family members have biochemical functions similar to mNotch1, which transduces proliferative signal by direct interaction with the DNA binding protein RBP-Jkappa...
- A human gene responsible for Zellweger syndrome that affects peroxisome assemblyN Shimozawa
Department of Pediatrics, Gifu University School of Medicine, Japan
Science 255:1132-4. 1992..The homozygous patient apparently inherited the mutation from her parents, each of whom was heterozygous for that mutation...
- Cyclic AMP-mediated augmentation of thrombomodulin gene expression: cell type-dependent usage of control regionsY Shirayoshi
Division of Cell Biology, Meiji Institute of Health Science, Meiji Milk Products Co Ltd, Odawara, Japan
Exp Cell Res 208:75-83. 1993..We propose that there are at least two separate genomic DNA regions that regulate cyclic AMP-dependent TM gene expression and that their functions are cell type dependent...
- Cloning of inv, a gene that controls left/right asymmetry and kidney developmentT Mochizuki
Department of Medicine, Kidney Center, Tokyo Women s Medical University, School of Medicine, Japan
Nature 395:177-81. 1998..Transgenic introduction of a minigene encoding the candidate protein restores normal left/right asymmetry and kidney development in the inv mutant, confirming the identity of the candidate gene...
- The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryoS I Yoshikawa
Department of Molecular Biology, Biomolecular Engineering Research Institute, 6 2 3 Furuedai, Suita, Osaka, Japan
Mech Dev 91:439-44. 2000..Interestingly, in the lens placodes and in early Rathke's pouch, ActR-I protein is transiently localized at the apical surface of the epithelial cells, indicating the presence of an apical-basal asymmetry in these cells...
- Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosomeY Kazuki
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori, Japan
Gene Ther 15:617-24. 2008..Therefore, the combination of using mGS cells with HACs provides a new tool for gene and cell therapies. The next step is to demonstrate functional restoration using animal models for future gene therapy...