N Shinomiya

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. ncbi request reprint Telomerase activation and MAPK pathways in regenerating hepatocytes
    T Inui
    Department of Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Hum Cell 14:275-82. 2001
  2. ncbi request reprint Different mechanisms between premitotic apoptosis and postmitotic apoptosis in X-irradiated U937 cells
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Namiki 3 2, Saitama 359 8513, Tokorozawa, Japan
    Int J Radiat Oncol Biol Phys 47:767-77. 2000
  3. ncbi request reprint New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
    J Cell Mol Med 5:240-53. 2001
  4. ncbi request reprint Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction
    Y Habu
    Department of Immunology and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Clin Exp Med 7:30-8. 2007
  5. ncbi request reprint Urokinase type plasminogen activator and its receptor regulate the invasive potential of gastric cancer cell lines
    Y Okusa
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Int J Oncol 17:1001-5. 2000
  6. pmc Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal Escherichia coli infection
    M Kinoshita
    Division of Basic Traumatology, National Defense Medical College, Namiki, Tokorozawa, Japan
    Clin Exp Immunol 143:41-9. 2006
  7. pmc Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an in vitro study
    N Kuranaga
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    BMC Cancer 1:10. 2001
  8. ncbi request reprint Induction of CD16+ CD56bright NK cells with antitumour cytotoxicity not only from CD16- CD56bright NK Cells but also from CD16- CD56dim NK cells
    E Takahashi
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Scand J Immunol 65:126-38. 2007
  9. ncbi request reprint Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines
    K Uefuji
    Department of Surgery I and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Anticancer Res 20:4279-84. 2000
  10. pmc Analysis of the susceptibility of CD57 T cells to CD3-mediated apoptosis
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Tokorozawa, Japan
    Clin Exp Immunol 139:268-78. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Telomerase activation and MAPK pathways in regenerating hepatocytes
    T Inui
    Department of Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Hum Cell 14:275-82. 2001
    ..The activation of the growth-related signaling pathways seems to play essential roles in the upregulation of the telomerase activity...
  2. ncbi request reprint Different mechanisms between premitotic apoptosis and postmitotic apoptosis in X-irradiated U937 cells
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Namiki 3 2, Saitama 359 8513, Tokorozawa, Japan
    Int J Radiat Oncol Biol Phys 47:767-77. 2000
    ..We show here that the human monoblastoid cell line U937 can be induced to undergo these two different types of apoptosis...
  3. ncbi request reprint New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
    J Cell Mol Med 5:240-53. 2001
    ..Characterization of these two types of apoptotic cell death regarding the cell cycle regulation and intracellular signaling will greatly help to understand the mechanisms of radiation-induced apoptosis...
  4. ncbi request reprint Mice deficient in Vbeta8+NKT cells are resistant to experimental hepatitis but are partially susceptible to generalised Shwartzman reaction
    Y Habu
    Department of Immunology and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Clin Exp Med 7:30-8. 2007
    ..These results confirm the critical role that Vbeta8(+)NKT cells play in both liver and multi-organ injury...
  5. ncbi request reprint Urokinase type plasminogen activator and its receptor regulate the invasive potential of gastric cancer cell lines
    Y Okusa
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Int J Oncol 17:1001-5. 2000
    ..These results suggest that uPA promotes the invasive capacity of the uPAR-positive cancer cells, and that stromal cells may play an important role in cancer cell invasion by supplying uPA and/or promoting uPA production...
  6. pmc Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal Escherichia coli infection
    M Kinoshita
    Division of Basic Traumatology, National Defense Medical College, Namiki, Tokorozawa, Japan
    Clin Exp Immunol 143:41-9. 2006
    ..Our findings suggest that multiple injections of IL-18 up-regulate both the cellular and humoral innate immunities, thereby enhancing host defence against bacterial infections...
  7. pmc Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an in vitro study
    N Kuranaga
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    BMC Cancer 1:10. 2001
    ..Therefore, we investigated the relationships, among the telomerase activity, telomere length and the expression of multidrug resistance genes in colorectal cancer cell lines cultivated with anti-cancer drugs...
  8. ncbi request reprint Induction of CD16+ CD56bright NK cells with antitumour cytotoxicity not only from CD16- CD56bright NK Cells but also from CD16- CD56dim NK cells
    E Takahashi
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Scand J Immunol 65:126-38. 2007
    ..The proliferation of CD16(+) CD56(bright) NK cells was also induced when PBMC were stimulated with penicillin-treated Streptococcus pyogenes, thus suggesting their role in tumour immunity and bacterial infections...
  9. ncbi request reprint Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines
    K Uefuji
    Department of Surgery I and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Anticancer Res 20:4279-84. 2000
    ..These effects of JTE-522 were more dramatic in MKN45 than in MKN28. Since JTE-522 strongly suppresses cell growth by inducing apoptosis in gastric cancer cell lines, it may therefore serve as a chemopreventive agent...
  10. pmc Analysis of the susceptibility of CD57 T cells to CD3-mediated apoptosis
    N Shinomiya
    Department of Microbiology, National Defense Medical College, Tokorozawa, Japan
    Clin Exp Immunol 139:268-78. 2005
    ....
  11. ncbi request reprint Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas
    F Kumaki
    Department of Pathology, National Defense Medical College, Tokorozawa, Japan
    Hum Pathol 32:188-95. 2001
    ..Determinations of telomerase activity by in situ hybridization, immunohistochemistry, and TRAP assay are useful for evaluating the diagnosis and prognosis of lung carcinomas...
  12. pmc A defective Th1 response of the spleen in the initial phase may explain why splenectomy helps prevent a Listeria infection
    N Kuranaga
    Department of Microbiology, National Defense Medical College, Tokorozawa, Japan
    Clin Exp Immunol 140:11-21. 2005
    ..p. injection just after the Listeria challenge. Our findings suggest that Listeria exploit the defective Th1 environment of the spleen in the initial phase and afterwards overcome the host defense mechanism of the liver...
  13. ncbi request reprint Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
    M Fukasawa
    Department of Microbiology, Department of Parasitology, National Defense Medical College, Namiki 3 2, Tokorozawa, Sitama, 359 8513, Japan
    Biochem Biophys Res Commun 267:703-8. 2000
    ..We propose that the transcription of HP2K is strictly controlled by tissue-specific factors even though its genomic DNA contains several transcriptional elements...