W Shimizu

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. pmc Genotype-phenotype aspects of type 2 long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 54:2052-62. 2009
  2. ncbi request reprint Clinical impact of genetic studies in lethal inherited cardiac arrhythmias
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 72:1926-36. 2008
  3. ncbi request reprint Catecholamines in children with congenital long QT syndrome and Brugada syndrome
    W Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Electrocardiol 34:173-5. 2001
  4. doi request reprint How the knowledge of genetic "makeup" and cellular data can affect the analysis of repolarization in surface electrocardiogram
    Wataru Shimizu
    Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    J Electrocardiol 43:583-7. 2010
  5. ncbi request reprint Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation
    W Shimizu
    Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    J Cardiovasc Electrophysiol 12:1418-21. 2001
  6. ncbi request reprint Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome: multicenter study in Japan
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 44:117-25. 2004
  7. ncbi request reprint Mechanisms of disease: current understanding and future challenges in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Nat Clin Pract Cardiovasc Med 2:408-14. 2005
  8. ncbi request reprint Genotype-specific clinical manifestation in long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Expert Rev Cardiovasc Ther 1:401-9. 2003
  9. ncbi request reprint Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 39:1984-91. 2002
  10. pmc Images in cardiology: Visualisation of activation and repolarisation in congenital long QT syndrome
    W Shimizu
    Heart 88:190. 2002

Detail Information

Publications104 found, 100 shown here

  1. pmc Genotype-phenotype aspects of type 2 long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 54:2052-62. 2009
    ..The purpose of this study was to investigate the effect of location, coding type, and topology of KCNH2(hERG) mutations on clinical phenotype in type 2 long QT syndrome (LQTS)...
  2. ncbi request reprint Clinical impact of genetic studies in lethal inherited cardiac arrhythmias
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 72:1926-36. 2008
    ..Individuals with Haplotype B show significantly longer duration of both PQ and QRS than those without Haplotype B, indicating that Haplotype B likely contributes to the higher incidence of BrS in Asian populations...
  3. ncbi request reprint Catecholamines in children with congenital long QT syndrome and Brugada syndrome
    W Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Electrocardiol 34:173-5. 2001
    ..In our preliminary result of patients with Brugada syndrome including a child, isoproterenol infusion was effective to decrease the ST-segment elevation in leads V1-V2 and to suppress the electrical storm of ventricular fibrillation...
  4. doi request reprint How the knowledge of genetic "makeup" and cellular data can affect the analysis of repolarization in surface electrocardiogram
    Wataru Shimizu
    Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    J Electrocardiol 43:583-7. 2010
    ....
  5. ncbi request reprint Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation
    W Shimizu
    Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    J Cardiovasc Electrophysiol 12:1418-21. 2001
    ..Our data support the hypothesis that heterogenous response of repolarization across the ventricular wall in the RVOT is responsible for accentuation of ST segment elevation in the right precordial leads...
  6. ncbi request reprint Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome: multicenter study in Japan
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 44:117-25. 2004
    ..We sought to compare the arrhythmic risk and sensitivity to sympathetic stimulation of mutations located in transmembrane regions and C-terminal regions of the KCNQ1 channel in the LQT1 form of congenital long QT syndrome (LQTS)...
  7. ncbi request reprint Mechanisms of disease: current understanding and future challenges in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Nat Clin Pract Cardiovasc Med 2:408-14. 2005
    ..In this review, we discuss future challenges relating to risk stratification, genetic heterogeneity, sex and ethnic differences in Brugada syndrome...
  8. ncbi request reprint Genotype-specific clinical manifestation in long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Expert Rev Cardiovasc Ther 1:401-9. 2003
    ....
  9. ncbi request reprint Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 39:1984-91. 2002
    ..This study compared the effects of beta-blockade on transmural and spatial dispersion of repolarization (TDR and SDR, respectively) between the LQT1 and LQT2 forms of congenital long QT syndrome (LQTS)...
  10. pmc Images in cardiology: Visualisation of activation and repolarisation in congenital long QT syndrome
    W Shimizu
    Heart 88:190. 2002
  11. ncbi request reprint Effects of sympathetic stimulation on various repolarization indices in the congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Ann Noninvasive Electrocardiol 7:332-42. 2002
    ....
  12. ncbi request reprint Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Am Coll Cardiol 41:633-42. 2003
    ..This study was designed to test the hypothesis that epinephrine infusion may be a provocative test able to unmask nonpenetrant KCNQ1 mutation carriers...
  13. ncbi request reprint Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Heart Rhythm 1:276-83. 2004
    ..The aim of this study was to test the hypothesis that epinephrine test may have diagnostic value for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome (LQTS)...
  14. doi request reprint Phenotypic manifestations of mutations in genes encoding subunits of cardiac potassium channels
    Wataru Shimizu
    Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circ Res 109:97-109. 2011
    ....
  15. ncbi request reprint Mechanism and new findings in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 71:A32-9. 2007
    ..In this review article, new findings relating to several unresolved problems such as gender difference (male predominance) and ethnic difference (higher incidence in Asian population) are also presented...
  16. ncbi request reprint Sex hormone and gender difference--role of testosterone on male predominance in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 18:415-21. 2007
    ..Brugada syndrome has been reported to be thinner than asymptomatic normal controls. We tested the hypothesis that higher testosterone level associated with lower visceral fat may relate to Brugada phenotype and male predominance...
  17. pmc Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Curr Pharm Des 11:1561-72. 2005
    ..Oral denopamine, atropine or cilostazol all increase ICa-L, and for this reason may be effective in reducing episodes of VF...
  18. ncbi request reprint The long QT syndrome: therapeutic implications of a genetic diagnosis
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Cardiovasc Res 67:347-56. 2005
    ....
  19. doi request reprint Arrhythmias originating from the right ventricular outflow tract: how to distinguish "malignant" from "benign"?
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Heart Rhythm 6:1507-11. 2009
    ....
  20. ncbi request reprint Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome
    W Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 11:1320-9. 2000
    ..The aim of this study was to examine the effects of Na+ channel blockers on ST segment elevation, QRS, corrected QT (QTc) interval, and ventricular arrhythmias in patients with Brugada syndrome...
  21. ncbi request reprint Acquired forms of the Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Electrocardiol 38:22-5. 2005
    ..In this review, several drugs in addition to sodium-channel blockers and conditions that induce transient ST-segment elevation such as that in the Brugada syndrome, developing acquired forms of the Brugada syndrome, are discussed...
  22. ncbi request reprint Body surface distribution and response to drugs of ST segment elevation in Brugada syndrome: clinical implication of eighty-seven-lead body surface potential mapping and its application to twelve-lead electrocardiograms
    W Shimizu
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 11:396-404. 2000
    ..Body surface distribution and magnitude of ST segment elevation and their reflection in 12-lead ECGs have not been clarified in Brugada syndrome...
  23. ncbi request reprint Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome
    Y Tanabe
    Department of Internal Medicine, Okayama University Medical School, Suita, Japan
    J Am Coll Cardiol 37:911-9. 2001
    ....
  24. ncbi request reprint Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    Circulation 104:1430-5. 2001
    ..We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF)...
  25. ncbi request reprint Localization of optimal ablation site of idiopathic ventricular tachycardia from right and left ventricular outflow tract by body surface ECG
    S Kamakura
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 98:1525-33. 1998
    ..However, reliable noninvasive methods to localize the optimum ablation site for VT have not been reported. METHODS and..
  26. ncbi request reprint Influence of epinephrine, propranolol, and atrial pacing on spatial distribution of recovery time measured by body surface mapping in congenital long QT syndrome
    W Shimizu
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    J Cardiovasc Electrophysiol 8:1102-14. 1997
    ....
  27. ncbi request reprint Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome
    T Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Eur Heart J 23:975-83. 2002
    ..This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome...
  28. ncbi request reprint The role of Purkinje and pre-Purkinje potentials in the reentrant circuit of verapamil-sensitive idiopathic LV tachycardia
    T Aiba
    Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565 Japan
    Pacing Clin Electrophysiol 24:333-44. 2001
    ..The reentrant circuit of ILVT could be constructed based on the pre-PP, PP, and slow conduction between the PP and pre-PP. Catheter ablation of ILVT was successful at the pre-PP recording site...
  29. ncbi request reprint Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome
    M Takagi
    Division of Cardiology and Radiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Eur Heart J 22:1032-41. 2001
    ..These morphological abnormalities may be related to arrhythmogenic substrates in patients with the Brugada syndrome...
  30. ncbi request reprint Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome
    W Shimizu
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 97:1581-8. 1998
    ....
  31. ncbi request reprint Clinical usefulness of a multielectrode basket catheter for idiopathic ventricular tachycardia originating from right ventricular outflow tract
    T Aiba
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Suita, Japan
    J Cardiovasc Electrophysiol 12:511-7. 2001
    ..The aim of our study was to evaluate the usefulness of a multielectrode basket catheter for ablation of idiopathic VT originating from the RVOT...
  32. ncbi request reprint Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome
    Atsushi Kobori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cardiovasc Electrophysiol 15:190-9. 2004
    ..Beta-blockers are widely used to prevent the lethal cardiac events associated with the long QT syndrome (LQTS), especially in KCNQ1-related LQTS (LQT1) patients. Some LQT1 patients, however, are refractory to this therapy...
  33. ncbi request reprint Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 104:2034-8. 2001
    ..We sought to investigate the pathophysiology of ghrelin in the cachexia associated with chronic heart failure (CHF)...
  34. ncbi request reprint Acute effects of different atrial pacing sites in patients with atrial fibrillation: comparison of single site and biatrial pacing
    M Ogawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Pacing Clin Electrophysiol 24:1470-8. 2001
    ..The CS-d paced drive was more effective for suppressing AF induction than biatrial or RAA paced drive by alleviating conduction delay. CS-d and biatrial pacing significantly reduced ARTD compared with RAA pacing...
  35. ncbi request reprint Diagnostic value of plasma levels of brain natriuretic peptide in arrhythmogenic right ventricular dysplasia
    K Matsuo
    Divisions of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 98:2433-40. 1998
    ..We hypothesized that BNP is increasingly secreted from the residual myocytes within the atrophic tissue in patients with ARVD...
  36. ncbi request reprint Unique electrophysiologic characteristics of atrioventricular nodal reentrant tachycardia with different ventriculoatrial block patterns: effects of slow pathway ablation and insights into the location of the reentrant circuit
    Kiyoshi Otomo
    Division of Cardiology, National Cardiovascular Center, Suita, Japan
    Heart Rhythm 3:544-54. 2006
    ..The electrophysiologic mechanisms of different ventriculoatrial (VA) block patterns during atrioventricular nodal reentrant tachycardia (AVNRT) are poorly understood...
  37. doi request reprint A spontaneous Type 1 electrocardiogram pattern in lead V2 is an independent predictor of ventricular fibrillation in Brugada syndrome
    Yukiko Nakano
    Department of Cardiovascular Medicine, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Europace 12:410-6. 2010
    ..We investigated the relationships between episodes of ventricular fibrillation (VF) and various clinical, electrocardiographic, electrophysiologic, and genetic parameters both retrospectively and prospectively...
  38. ncbi request reprint Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study
    Takeshi Aiba
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan
    J Am Coll Cardiol 47:2074-85. 2006
    ..We examined how repolarization and depolarization abnormalities contribute to the development of extrasystoles and subsequent ventricular fibrillation (VF) in a model of the Brugada syndrome...
  39. ncbi request reprint ST-segment elevation and ventricular fibrillation without coronary spasm by intracoronary injection of acetylcholine and/or ergonovine maleate in patients with Brugada syndrome
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565 Japan
    J Am Coll Cardiol 40:1841-7. 2002
    ..The study examined whether patients with Brugada syndrome are sensitive to vagal stimulation or ischemia...
  40. ncbi request reprint Participation of a concealed atriohisian tract in the reentrant circuit of the slow-fast type of atrioventricular nodal reentrant tachycardia
    Kiyoshi Otomo
    Division of Cardiology, National Cardiovascular Center, Suita, Japan
    Heart Rhythm 4:703-10. 2007
    ..The retrograde fast pathway in typical atrioventricular nodal reentrant tachycardia (AVNRT) exhibits marked variation in its electrophysiologic properties...
  41. ncbi request reprint Electrophysiologic characteristics and implications of induced ventricular fibrillation in symptomatic patients with Brugada syndrome
    Munetake Kanda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Am Coll Cardiol 39:1799-805. 2002
    ....
  42. ncbi request reprint Predictors of electrical storm in patients with idiopathic dilated cardiomyopathy--how to stratify the risk of electrical storm
    Masateru Takigawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 74:1822-9. 2010
    ..The purpose of this study was to clarify the predictors of ES for risk stratification in DCM patients with an ICD...
  43. ncbi request reprint Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5A-positive probands and the SCN5A-negative probands
    Miki Yokokawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Cardiol 100:649-55. 2007
    ..In conclusion, conduction slowing was more marked and more progressively accentuated in Brugada probands with SCN5A mutation than in those without SCN5A mutation...
  44. ncbi request reprint The Brugada syndrome--an update
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Intern Med 44:1224-31. 2005
    ..In this review, the recent understanding and knowledge of Brugada syndrome will be updated...
  45. ncbi request reprint Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome
    Kotoe Takenaka
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 107:838-44. 2003
    ....
  46. ncbi request reprint Extremely late pacemaker-infective endocarditis due to Stenotrophomonas maltophilia
    Masateru Takigawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Cardiology 110:226-9. 2008
    ..She was discharged from our center after a 6-week course of antibiotics and implantation of a new pacemaker...
  47. doi request reprint Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long QT syndrome
    Tomoko Sakaguchi
    Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan
    J Cardiovasc Electrophysiol 19:794-9. 2008
    ....
  48. doi request reprint Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3
    Shiro Kamakura
    Division of Cardiology, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Circ Arrhythm Electrophysiol 2:495-503. 2009
    ..The purpose of this study was to clarify the long-term prognosis of probands with non-type 1 ECG and those with coved (type 1) Brugada-pattern ECG...
  49. ncbi request reprint The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome
    Takashi Kurita
    Division of Cardiology, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Am Coll Cardiol 40:330-4. 2002
    ..We sought to demonstrate the electrophysiologic (EP) mechanism of the ST-T change in Brugada syndrome...
  50. ncbi request reprint Idiopathic ventricular fibrillation associated with J wave and early repolarization: a really benign electrocardiographic sign?
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Future Cardiol 5:227-9. 2009
    ..1; 95% CI: 1.2-3.5; p = 0.008). This study raises a question on the general concept that J wave and early repolarization are benign electrocardiographic patterns...
  51. ncbi request reprint QRS prolongation is associated with high defibrillation thresholds during cardioverter-defibrillator implantations in patients with hypertrophic cardiomyopathy
    Takayuki Nagai
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 73:1028-32. 2009
    ..The purpose of this study was to assess the predictors of a high DFT in patients with HCM...
  52. ncbi request reprint Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats
    Noritoshi Nagaya
    Dept of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 285:H2125-31. 2003
    ..10% 6-wk survival, log-rank test, P < 0.01). In conclusion, repeated inhalation of AM inhibited MCT-induced pulmonary hypertension without systemic hypotension and thereby improved survival in MCT rats...
  53. doi request reprint Mitral isthmus pathology of re-entrant ventricular tachycardia in a patient with idiopathic dilated cardiomyopathy
    Taka aki Matsuyama
    Department of Pathology, National Cardiovascular Center, 5 7 1 Fujishirodai Suita City, Osaka 565 8565, Japan
    Europace 11:827-30. 2009
    ..Therefore, this bundle appeared to comprise the slow conduction area of the re-entrant VT in this case...
  54. ncbi request reprint Noninvasive characterization of intra-atrial reentrant tachyarrhythmias after surgical repair of congenital heart diseases
    Takeshi Aiba
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 73:451-60. 2009
    ..Intra-atrial reentrant tachyarrhythmia (IART) after surgical repair for congenital heart diseases (CHD) has not been noninvasively characterized...
  55. doi request reprint The positional relationship between the coronary sinus musculature and the atrioventricular septal junction
    Taka aki Matsuyama
    Department of Pathology, National Cardiovascular Center, 5 7 1 Fujishirodai Suita City, 565 8565 Osaka, Japan
    Europace 12:719-25. 2010
    ..We tried to explore the histological muscular diversity within the AV septal junction...
  56. pmc The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Invest 118:2219-29. 2008
    ....
  57. ncbi request reprint Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
    ..We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF)...
  58. ncbi request reprint Response of beat-by-beat QT variability to sympathetic stimulation in the LQT1 form of congenital long QT syndrome
    Kazuhiro Satomi
    Division of Cardiology, Department of Internal MedicineNational Cardiovascular Center, Suita, Japan
    Heart Rhythm 2:149-54. 2005
    ..We analyzed beat-by-beat QT variability using a newly developed program and applied cross-correlation methods in LQT1 patients before and after epinephrine infusion...
  59. ncbi request reprint Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 86:5854-9. 2001
    ..In summary, iv infusion of ghrelin, a potent GH-releasing peptide, had beneficial hemodynamic effects in patients with CHF in the absence of renal effects...
  60. ncbi request reprint Implications of 2:1 atrioventricular block during typical atrioventricular nodal reentrant tachycardia
    Kiyoshi Otomo
    Division of Cardiology, National Cardiovascular Center, Suita, Japan
    J Interv Card Electrophysiol 19:109-19. 2007
    ..The effects of 2:1 AV block (AVB) on AV nodal reentrant tachycardia (AVNRT) remain to be elucidated. This study was performed to localize the site of 2:1 AVB and elucidate the effects of 2:1 AVB on typical AVNRT...
  61. ncbi request reprint Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation
    Takeshi Ohgo
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Heart Rhythm 4:695-700. 2007
    ..Some patients with Brugada syndrome experience an electrical storm of ventricular fibrillation (VF)...
  62. ncbi request reprint Prevention of life-threatening ventricular tachyarrhythmia by a novel and pure class-III agent, nifekalant hydrochloride
    Junko Ohashi
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    J Cardiovasc Pharmacol 48:274-9. 2006
    ....
  63. ncbi request reprint Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil
    Takeshi Aiba
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Am Coll Cardiol 45:300-7. 2005
    ..We examined the cellular and ionic mechanism for QT prolongation and subsequent Torsade de Pointes (TdP) and the effect of verapamil under conditions mimicking KCNQ1 (I(Ks) gene) defect linked to acquired long QT syndrome (LQTS)...
  64. doi request reprint Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome
    Seiko Ohno
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hum Mutat 30:557-63. 2009
    ..This is the first report of KCNE3 mutations associated with LQTS. Screening for variants in the KCNE3 gene is of clinical importance for LQTS patients...
  65. ncbi request reprint Catheter ablation of stable and unstable ventricular tachycardias in patients with arrhythmogenic right ventricular dysplasia
    Kazuhiro Satomi
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    J Cardiovasc Electrophysiol 17:469-76. 2006
    ..A reentrant circuit within an area of abnormal myocardium is suspected as the origin of ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular dysplasia (ARVD)...
  66. ncbi request reprint Transmural heterogeneity of the action potential configuration in the feline left ventricle
    Takeshi Aiba
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan
    Circ J 67:449-54. 2003
    ....
  67. ncbi request reprint Two adults requiring implantable defibrillators because of ventricular tachycardia and left ventricular dysfunction caused by presumed Kawasaki disease
    Syusuke Yagi
    Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 69:870-4. 2005
    ..Physicians must be aware that VT can occur in older patients with LV dysfunction many years after KD...
  68. ncbi request reprint Excessive increase in QT interval and dispersion of repolarization predict recurrent ventricular tachyarrhythmia after amiodarone
    Takeshi Aiba
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Pacing Clin Electrophysiol 27:901-9. 2004
    ..4, 95%, CI 2.7 to 40.5, P = 0.0008). Excessive QT prolongation associated with increased spatial and transmural dispersions of repolarization predict the recurrence of VT/VF after amiodarone treatment...
  69. ncbi request reprint [Arrhythmogenic right ventricular dysplasia]
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
    Nippon Rinsho . 2007
  70. ncbi request reprint Ventricular tachycardia associated with bidirectional reentrant circuit around the tricuspid annulus in arrhythmogenic right ventricular dysplasia
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Pacing Clin Electrophysiol 26:2050-1. 2003
    ..Multiple radiofrequency linear ablation could abolish both VTs, and this patient has been clinically free from symptoms of VTs at 1-year follow-up...
  71. ncbi request reprint Spatial distribution of repolarization and depolarization abnormalities evaluated by body surface potential mapping in patients with Brugada syndrome
    Miki Yokokawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Pacing Clin Electrophysiol 29:1112-21. 2006
    ..We examined spatial distribution of both repolarization and depolarization abnormalities in patients with Brugada syndrome by using 87-leads body surface potential mapping (BSPM)...
  72. ncbi request reprint Electrophysiologic study-guided amiodarone for sustained ventricular tachyarrhythmias associated with structural heart diseases
    Takeshi Aiba
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 72:88-93. 2008
    ....
  73. ncbi request reprint Pronounced HR variability after exercise in inferior ischemia: evidence that the cardioinhibitory vagal reflex is invoked by exercise-induced inferior ischemia
    Nobuhiro Tahara
    Department of Medicine, National Cardiovascular Center, Japan
    Am J Physiol Heart Circ Physiol 288:H1179-85. 2005
    ..These new findings must be taken into account in interpreting vagal activity in patients with coronary artery disease...
  74. ncbi request reprint Prominent J wave and ST segment elevation: serial electrocardiographic changes in accidental hypothermia
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    J Cardiovasc Electrophysiol 14:223. 2003
  75. ncbi request reprint Ventricular tachycardia with figure eight pattern originating from the right ventricle in a patient with cardiac sarcoidosis
    Takashi Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Pacing Clin Electrophysiol 27:561-2. 2004
    ..Multiple radiofrequency linear ablation could abolish the VT, and this patient has been clinically free from symptoms of VT during a 6-month follow-up...
  76. ncbi request reprint Site-specific influence of transversal conduction across crista terminalis on recognition of isthmus block
    Kiyoshi Otomo
    Division of Cardiology, National Cardiovascular Center, Suita, Japan
    Pacing Clin Electrophysiol 29:589-99. 2006
    ..Site-specific influence of trans-cristal conduction gap on recognition of clockwise IB has been poorly understood...
  77. ncbi request reprint "Left-variant" atypical atrioventricular nodal reentrant tachycardia: electrophysiological characteristics and effect of slow pathway ablation within coronary sinus
    Kiyoshi Otomo
    Department of Cardiovascular Medicine, Cardiovascular Center, Tsuchiura Kyodo Hospital, 11 7 Manabe shin machi, Tsuchiura, Ibaraki Prefecture, 300 0053, Japan
    J Cardiovasc Electrophysiol 17:1177-83. 2006
    ..This study was performed to characterize successful slow pathway (SP) ablation site and to elucidate the role of LPNE in genesis of atypical AVNRT with eccentric activation patterns within the coronary sinus (CS)...
  78. ncbi request reprint Genotype-phenotype correlations of KCNJ2 mutations in Japanese patients with Andersen-Tawil syndrome
    Yoshisumi Haruna
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Hum Mutat 28:208. 2007
    ..In our study, all of the clinically diagnosed ATS patients had KCNJ2 mutations and showed a high penetrance with regard to the typical cardiac phenotypes: predominant U wave and ventricular arrhythmias, typically bidirectional VT...
  79. doi request reprint Radiofrequency catheter ablation of parasystole originating from the inferior vena cava
    Miki Yokokawa
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Pacing Clin Electrophysiol 33:e62-4. 2010
    ..After RF isolation of the IVC, the patient has remained arrhythmia-free over a 5-year follow-up...
  80. ncbi request reprint Cellular mechanisms underlying the long QT syndrome
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, USA National Cardiovascular Center, Osaka, Japan
    Curr Opin Cardiol 17:43-51. 2002
    ..The available data suggest that that the principal problem with the long QT syndrome is not long QT intervals but rather the dispersion of repolarization that often accompanies prolongation of the QT interval...
  81. doi request reprint Augmented ST-segment elevation during recovery from exercise predicts cardiac events in patients with Brugada syndrome
    Hisaki Makimoto
    Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 56:1576-84. 2010
    ..The goal of this study was to evaluate the prevalence and the clinical significance of ST-segment elevation during recovery from exercise testing...
  82. ncbi request reprint Directions of atrial excitation wavefront influenced antegrade conduction of manifest accessory atrioventricular pathway: a case report
    Takeshi Aiba
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Interv Card Electrophysiol 8:129-33. 2003
    ....
  83. ncbi request reprint Intraoperative and conformal external-beam radiation therapy in patients with locally advanced pancreatic carcinoma; results from a feasibility phase II study
    J Furuse
    Department of Internal Medicine, National Cancer Center Hospital East, Chiba, Japan
    Hepatogastroenterology 47:1142-6. 2000
    ..The purpose of this study is to clarify the efficacy and safety of a more intensive radiotherapy for those patients...
  84. ncbi request reprint Gender difference and drug challenge in Brugada syndrome
    Wataru Shimizu
    J Cardiovasc Electrophysiol 15:70-1. 2004
  85. pmc Does Tpeak-Tend provide an index of transmural dispersion of repolarization?
    Charles Antzelevitch
    Heart Rhythm 4:1114-6; author reply 1116-9. 2007
  86. ncbi request reprint Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome
    Matteo Vatta
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:337-45. 2002
    ..Based upon these observations we suggest that SUNDS and Brugada syndrome are phenotypically, genetically and functionally the same disorder...
  87. ncbi request reprint Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes
    Ping Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 105:1943-8. 2002
    ..We have previously identified functionally important DNA variants in genes encoding K+ channel ancillary subunits in 11% of an aLQTS cohort...
  88. ncbi request reprint Detection of spatial repolarization abnormalities in patients with LQT1 and LQT2 forms of congenital long-QT syndrome
    Akihiko Kandori
    Central Research Laboratory, Hitachi Ltd, 1 280 Higashi Koigakubo, Kokubunji, Tokyo 185 8601, Japan
    Physiol Meas 23:603-14. 2002
    ..The estimation of the origin in LQTS patients can provide important information such as the risk factor of sudden death...
  89. ncbi request reprint Brugada syndrome: report of the second consensus conference
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Heart Rhythm 2:429-40. 2005
    ....
  90. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  91. ncbi request reprint Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications
    Hanno L Tan
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 114:2096-103. 2006
    ..This disparity may point to different arrhythmia mechanisms and may affect therapy strategies. We studied whether the proportion of pause-dependent TdP onset varies among LQTS genotypes...
  92. ncbi request reprint [Ion channel disorders and arrhythmia--special reference to long QT syndrome and Brugada syndrome]
    Wataru Shimizu
    Nihon Naika Gakkai Zasshi 95:2321-9. 2006
  93. ncbi request reprint Magnetocardiography study on ventricular depolarization-current pattern in patients with brugada syndrome and complete right-bundle branch blocks
    Akihiko Kandori
    Advanced Research Laboratory, Hitachi, Ltd, Kokubunji, Tokyo 185 8601, Japan
    Pacing Clin Electrophysiol 29:1359-67. 2006
    ..To understand this small difference in abnormal current during ventricular depolarization, we compared abnormal currents of patients with cases of complete right-bundle-branch block (CRBBB)...
  94. ncbi request reprint Does an overlap syndrome really exist between Brugada syndrome and progressive cardiac conduction defect (Lenegre syndrome)?
    Wataru Shimizu
    J Cardiovasc Electrophysiol 17:276-8. 2006
  95. ncbi request reprint Visualization of three-dimensional cardiac electrical excitation using standard heart model and anterior and posterior magnetocardiogram
    Kuniomi Ogata
    Hitachi Ltd, Central Research Laboratory, Kokubunji, Tokyo, Japan
    Int J Cardiovasc Imaging 22:581-93. 2006
    ..Therefore, the PCAMs give us a clear view of the anterior and posterior myocardial excitation for the respective electrophysiological phases...
  96. pmc Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  97. ncbi request reprint Electrical space-time abnormalities of ventricular depolarization in patients with Brugada syndrome and patients with complete right-bundle branch blocks studied by magnetocardiography
    Akihiko Kandori
    Central Research Laboratory, Hitachi, Ltd, Kokubunji, Tokyo, Japan
    Pacing Clin Electrophysiol 29:15-20. 2006
    ....
  98. ncbi request reprint Assessment of ability of activation mapping by duodecapolar catheter to diagnose complete isthmus block utilizing electroanatomical mapping system
    Kiyoshi Otomo
    Division of Cardiology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita City, Osaka Prefecture, 565 8565, Japan
    J Interv Card Electrophysiol 14:183-92. 2005
    ..The purpose of this study was to assess the ability of DPC to diagnose isthmus block utilizing electroanatomical mapping system (CARTO)...
  99. ncbi request reprint Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 113:338-44. 2006
    ..In this study, we tested the hypothesis that an SCN5A promoter polymorphism common in Asians modulates variability in cardiac conduction...
  100. ncbi request reprint [Tachycardia- and bradycardia-dependent paroxysmal atrioventricular block]
    Hideo Okamura
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
    Nippon Rinsho . 2007
  101. ncbi request reprint The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification
    Lia Crotti
    Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Circulation 116:2366-75. 2007
    ..We tested whether the arrhythmic risk was caused directly by A341V or by its presence in the specific ethnic setting of the SA families...