Shuji Shimizu

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Medetomidine, an α(2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control
    Shuji Shimizu
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan
    Circ J 76:152-9. 2012
  2. doi request reprint In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 152:115-8. 2010
  3. doi request reprint Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation: a theoretical analysis
    Shuji Shimizu
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    J Physiol Sci 61:457-65. 2011
  4. doi request reprint Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, Japan
    J Physiol Sci 60:205-12. 2010
  5. doi request reprint Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits
    Shuji Shimizu
    National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 162:60-5. 2011
  6. ncbi request reprint Apico-brachiocephalic artery bypass for aortic stenosis with porcelain aorta
    Shuji Shimizu
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Thorac Surg 89:621-3. 2010
  7. doi request reprint In vivo direct monitoring of vagal acetylcholine release to the sinoatrial node
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 148:44-9. 2009
  8. ncbi request reprint Accentuated antagonism in vagal heart rate control mediated through muscarinic potassium channels
    Masaki Mizuno
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    J Physiol Sci 58:381-8. 2008
  9. doi request reprint Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Japan
    Life Sci 85:597-601. 2009
  10. doi request reprint Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls
    Toru Kawada
    Dept of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 296:H1666-74. 2009

Detail Information

Publications43

  1. ncbi request reprint Medetomidine, an α(2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control
    Shuji Shimizu
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan
    Circ J 76:152-9. 2012
    ..Using a cardiac microdialysis technique, we investigated the effects of medetomidine, an α(2)-adrenergic agonist, on norepinephrine (NE) and acetylcholine (ACh) release from cardiac nerve endings...
  2. doi request reprint In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 152:115-8. 2010
    ..These results suggest that atrial dialysate NE level reflects the relative change of NE concentration in the synaptic cleft. Microdialysis is a powerful tool to assess in vivo interstitial NE levels at the sinoatrial node...
  3. doi request reprint Norwood procedure with non-valved right ventricle to pulmonary artery shunt improves ventricular energetics despite the presence of diastolic regurgitation: a theoretical analysis
    Shuji Shimizu
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, 565 8565, Japan
    J Physiol Sci 61:457-65. 2011
    ....
  4. doi request reprint Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka, Japan
    J Physiol Sci 60:205-12. 2010
    ..These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV...
  5. doi request reprint Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits
    Shuji Shimizu
    National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 162:60-5. 2011
    ..The elevated dialysate ACh concentration declined rapidly after transection of cervical vagal nerves. These results indicate that centrally administered ghrelin activates cardiac vagal nerve...
  6. ncbi request reprint Apico-brachiocephalic artery bypass for aortic stenosis with porcelain aorta
    Shuji Shimizu
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Thorac Surg 89:621-3. 2010
    ..We performed apico-brachiocephalic artery bypass under circulatory arrest with deep hypothermia. This procedure may become a useful surgical option for patients with a severe porcelain aorta...
  7. doi request reprint In vivo direct monitoring of vagal acetylcholine release to the sinoatrial node
    Shuji Shimizu
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 148:44-9. 2009
    ..In conclusion, ACh concentration in dialysate from the right atrium, sampled by microdialysis, is a good marker of ACh release from postganglionic vagal nerves to the sinoatrial node...
  8. ncbi request reprint Accentuated antagonism in vagal heart rate control mediated through muscarinic potassium channels
    Masaki Mizuno
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    J Physiol Sci 58:381-8. 2008
    ..The rapidity of the HR response obtained by the K(ACh) channel pathway was robust during the accentuated antagonism...
  9. doi request reprint Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Japan
    Life Sci 85:597-601. 2009
    ..To examine endogenous acetylcholine (ACh) release in the rabbit left ventricle during acute ischemia, ischemic preconditioning and electrical vagal stimulation...
  10. doi request reprint Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls
    Toru Kawada
    Dept of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 296:H1666-74. 2009
    ....
  11. doi request reprint Vagal stimulation suppresses ischemia-induced myocardial interstitial myoglobin release
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan
    Life Sci 83:490-5. 2008
    ..To evaluate vagal stimulation-mediated myocardial protection against ischemia and reperfusion in in vivo ischemic myocardium...
  12. doi request reprint Large conductance Ca2+-activated K+ channels inhibit vagal acetylcholine release at the rabbit sinoatrial node
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 156:149-51. 2010
    ..11 mg/body) did not increase the stimulation-induced ACh release further (10.8+/-4.4 nM). These results indicate that the BK channels play an inhibitory role in the vagal ACh release to the sinoatrial node...
  13. ncbi request reprint Baroreflex increases correlation and coherence of muscle sympathetic nerve activity (SNA) with renal and cardiac SNAs
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute, Osaka, 565 8565 Japan
    J Physiol Sci 56:325-33. 2006
    ..The arterial baroreflex is capable of potently homogenizing neural discharges of these SNAs by modulating SNA at the nonpeak frequencies of SNA autospectra...
  14. doi request reprint Contrasting effects of moderate vagal stimulation on heart rate and carotid sinus baroreflex-mediated sympathetic arterial pressure regulation in rats
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    Life Sci 89:498-503. 2011
    ..To examine whether moderate efferent vagal nerve stimulation (VNS) attenuates the carotid sinus baroreflex-mediated arterial pressure (AP) regulation via its antagonism to the sympathetic system...
  15. ncbi request reprint Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs
    Masaru Sugimachi
    National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan
    Conf Proc IEEE Eng Med Biol Soc 2009:2030-2. 2009
    ..These variables remained stable for 60 minutes (RMS 4+/-3 mmHg, 5+/-2 ml.min(-1).kg(-1), 0.8+/-0.6 mmHg, respectively)...
  16. ncbi request reprint Macroscopic two-pump two-vasculature cardiovascular model to support treatment of acute heart failure
    Masaru Sugimachi
    National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan
    Conf Proc IEEE Eng Med Biol Soc 2009:2365-8. 2009
    ..The equations for both the cardiac output curve and venous return surface would facilitate precise diagnosis (especially evaluation of blood volume) and choice of appropriate treatments, including application to autopilot systems...
  17. ncbi request reprint High levels of circulating angiotensin II shift the open-loop baroreflex control of splanchnic sympathetic nerve activity, heart rate and arterial pressure in anesthetized rats
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    J Physiol Sci 59:447-55. 2009
    ..1.28 +/- 0.19 beats min(-1) mmHg(-1)). It is concluded that high levels of circulating ANG II did not attenuate the response range of open-loop carotid sinus baroreflex control for AP, SNA or HR in anesthetized and vagotomized rats...
  18. ncbi request reprint Regional difference in ischaemia-induced myocardial interstitial noradrenaline and acetylcholine releases
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Auton Neurosci 137:44-50. 2007
    ....
  19. doi request reprint Consideration on parameter determination of a new model describing dynamic vagal heart rate control in rats
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565 8565, Japan
    Conf Proc IEEE Eng Med Biol Soc 2012:3809-12. 2012
    ..2 Hz. Determination of proper model parameters was crucial for the development of a new model to describe the dynamic heart rate response to vagal stimulation in rats...
  20. doi request reprint Consideration on step duration to assess open-loop static characteristics of the carotid sinus baroreflex in rats
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 565 8565 Osaka, Japan
    Conf Proc IEEE Eng Med Biol Soc 2011:689-92. 2011
    ....
  21. ncbi request reprint Slow head-up tilt causes lower activation of muscle sympathetic nerve activity: loading speed dependence of orthostatic sympathetic activation in humans
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Am J Physiol Heart Circ Physiol 297:H53-8. 2009
    ..These results indicate that slower HUT results in lower activation of MSNA, suggesting that HUT-induced sympathetic activation depends partially on the speed of inclination during HUT in humans...
  22. ncbi request reprint Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control
    Toru Kawada
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Japan
    Circ J 73:851-9. 2009
    ..Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases...
  23. ncbi request reprint Comprehensive physiological cardiovascular model enables automatic correction of hemodynamics in patients with acute life-threatening heart failure
    Kazunori Uemura
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Conf Proc IEEE Eng Med Biol Soc 1:198-201. 2006
    ..2 +/- 6.6, 6.8 +/- 4.6, and 11.7 +/- 9.8 minutes), stably, and simultaneously...
  24. ncbi request reprint Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change
    Masaru Sugimachi
    National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan
    Conf Proc IEEE Eng Med Biol Soc 2010:5205-8. 2010
    ..The estimated curve and surface predicted new hemodynamics after volume change precisely...
  25. ncbi request reprint Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    J Physiol Sci 60:283-98. 2010
    ....
  26. doi request reprint In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice
    Dong Yun Zhan
    Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Auton Neurosci 176:91-4. 2013
    ..Microdialysis permits monitoring of ACh release from post-ganglionic cardiac vagal nerves that are most likely to be innervating the left ventricle in mice...
  27. doi request reprint Dynamic characteristics of baroreflex neural and peripheral arcs are preserved in spontaneously hypertensive rats
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R155-65. 2011
    ..In conclusion, the dynamic characteristics of AP regulation by the carotid sinus baroreflex were well preserved in SHR despite significantly higher mean AP...
  28. ncbi request reprint Muscarinic potassium channels augment dynamic and static heart rate responses to vagal stimulation
    Masaki Mizuno
    Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 293:H1564-70. 2007
    ..We conclude that K(ACh) channels contribute to a rapid HR change and to a larger decrease in the steady-state HR in response to more potent tonic vagal stimulation...
  29. ncbi request reprint Upright tilt resets dynamic transfer function of baroreflex neural arc to minify the pressure disturbance in total baroreflex control
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute, Osaka, Japan
    J Physiol Sci 58:189-98. 2008
    ..In conclusion, upright tilt resets the dynamic transfer function of the baroreflex neural arc to minify the pressure disturbance in total baroreflex control...
  30. doi request reprint Successful one-stage surgical removal of intravenous leiomyomatosis with cardiac extension in an elderly patient
    Masahiro Okada
    Department of Cardiovascular Surgery, National Hospital Organization Okayama Medical Center, Tamasu, Kita ku, Okayama, Japan
    Gen Thorac Cardiovasc Surg 60:153-6. 2012
    ..She underwent a one-stage surgical removal with cardiopulmonary bypass and circulatory arrest. We therefore recommend a one-stage operation, if possible, even in elderly patients...
  31. pmc Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: predictability analysis
    Atsunori Kamiya
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita City, Osaka 565 8565, Japan
    J Physiol 589:1769-90. 2011
    ....
  32. ncbi request reprint Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure
    Kazunori Uemura
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Appl Physiol (1985) 100:1278-86. 2006
    ..4)] and Pla [0.8 mmHg (SD 0.6)]. In conclusion, by directly controlling the mechanical determinants of circulation, our system has enabled simultaneous control of AP, CO, and Pla with good accuracy and stability...
  33. doi request reprint Both skeletonized and pedicled internal thoracic arteries supply adequate graft flow after coronary artery bypass grafting even during intense sympathoexcitation
    Dai Une
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Physiol Sci 60:407-13. 2010
    ..Based on these results, we conclude that metabolic demand can override the potential difference in sympathetic vasoconstriction in both pedicled and skeletonized ITA grafts...
  34. doi request reprint Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla
    Tsuyoshi Akiyama
    Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neurochem Int 56:263-9. 2010
    ..BK channels on Epi-storing cells may play an inhibitory role in nerve stimulation-induced Epi release. SK channels on NE- and Epi-storing cells play a minor role in nerve stimulation-induced catecholamine release...
  35. ncbi request reprint Sustained reduction in blood pressure from electrical activation of the baroreflex is mediated via the central pathway of unmyelinated baroreceptors
    Michael J Turner
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan Electronic address
    Life Sci 106:40-9. 2014
    ..This study aims to identify the contribution of myelinated (A-fiber) and unmyelinated (C-fiber) baroreceptor central pathways to the baroreflex control of sympathetic nerve activity and arterial pressure...
  36. ncbi request reprint Chronic vagal nerve stimulation improves baroreflex neural arc function in heart failure rats
    Toru Kawada
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan and
    J Appl Physiol (1985) 116:1308-14. 2014
    ..In conclusion, the 6-wk VS treatment significantly improved the baroreflex control of SNA, but the effect was limited for the baroreflex total-loop function due to the lack of significant improvement in the AP response to percent SNA. ..
  37. ncbi request reprint Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure
    Atsunori Kamiya
    Dept of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 289:H2641-8. 2005
    ..In conclusion, dynamic-linear and static-nonlinear baroreflex control of muscle SNA is similar to that of renal and cardiac SNAs under physiological pressure change...
  38. ncbi request reprint Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits
    Atsunori Kamiya
    Dept of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute, Suita 565 8565, Japan
    Am J Physiol Heart Circ Physiol 298:H1966-75. 2010
    ..In conclusion, upright posture caused a resetting of arterial baroreflex control of SNA similarly in renal and cardiac SNAs in anesthetized rabbits...
  39. doi request reprint Cerebral thromboembolism in a patient awaiting surgery for left ventricular diverticulum
    Koji Nakanishi
    Department of Cardiovascular Surgery, Saiseikai Imabari Hospital, 7 1 6 Kita mura, Imabari, Ehime 799 1592, Japan
    Interact Cardiovasc Thorac Surg 12:319-20. 2011
    ..Following admission for correction, she complained of headache, and magnetic resonance imaging revealed multiple cerebral infarctions. We recommend surgical treatment for asymptomatic LV diverticula to prevent systemic thromboembolism...
  40. ncbi request reprint [Endovascular repair for ruptured thoracic aortic aneurysm and traumatic aortic injury]
    Mikizo Nakai
    Department of Cardiovascular Surgery, Okayama Medical Center, Okayama, Japan
    Kyobu Geka 64:69-73. 2011
    ..However, a careful follow-up is necessary because TEVAR has several unique late complications...
  41. pmc Efficacy of contrast-enhanced ultrasonography in detecting graft rupture sites after abdominal aortic aneurysm repair
    Koji Nakanishi
    Department of Cardiovascular Surgery, Japanese Red Cross Okayama Hospital, Okayama, Japan
    Interact Cardiovasc Thorac Surg 18:250-2. 2014
    ..5 cm distal to the proximal anastomosis, and endovascular stent grafting was successfully performed. Contrast-enhanced ultrasonography might be useful in detecting the graft rupture. ..
  42. ncbi request reprint Bilateral iliopsoas hematomas under sedation: a complication of postoperative therapy after coronary artery bypass grafting
    Dai Une
    Department of Cardiovascular Surgery, Saiseikai Imabari Hospital, Imabari, Ehime 799 1592, Japan
    Acta Med Okayama 64:71-3. 2010
    ..In anticoagulant and antiplatelet therapies under sedation, when the cause of anemia and shock is not clear, we should suspect peritoneal hematoma and examine the peritoneal space...
  43. ncbi request reprint Protein-losing enteropathy seven years after total right ventricular exclusion procedure for arrhythmogenic right ventricular dysplasia
    Koki Nakamura
    Department of Cardiovascular Surgery, Okayama University Medical School, Japan
    Ann Thorac Cardiovasc Surg 12:207-9. 2006
    ..Therefore, fenestration of TCPC, mitral annuloplasty and ligation of arteriovenous fistula were performed. After the operation, symptoms and levels of total protein and albumin were immediately improved and normalized...