H Shimizu

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998
    H Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 52:12-5. 1999
  2. pmc Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 78:13512-21. 2004
  3. ncbi request reprint Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 86:1391-401. 2005
  4. ncbi request reprint [Laboratory diagnosis for enterovirus 71 infection]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 63:389-92. 2005
  5. pmc Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 6:e1001174. 2010
  6. pmc Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1
    Kohei Miyamura
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 92:287-91. 2011
  7. ncbi request reprint [Poliovirus vaccine]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Uirusu 62:57-65. 2012
  8. pmc The preparation of an infectious full-length cDNA clone of Saffold virus
    Toshiki Himeda
    Department of Microbiology, Kanazawa Medical University School of Medicine, Ishikawa, Japan
    Virol J 8:110. 2011
  9. pmc Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    BMC Infect Dis 9:208. 2009
  10. ncbi request reprint Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Pediatr Int 46:231-5. 2004

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998
    H Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 52:12-5. 1999
    ..However, all isolates from three fatal cases in Taiwan belonged to genotype B. The severity of the HFMD did not link directly to certain genotypes of EV71...
  2. pmc Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 78:13512-21. 2004
    ..Type 1 cVDPV was last detected in the Philippines in September 2001, and population immunity to polio was raised by extensive OPV campaigns in late 2001 and early 2002...
  3. ncbi request reprint Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 86:1391-401. 2005
    ..These results indicate that EV71 and PV1 share common genetic determinants of neurovirulence in monkeys, despite the distinct properties in their original pathogenesis...
  4. ncbi request reprint [Laboratory diagnosis for enterovirus 71 infection]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 63:389-92. 2005
  5. pmc Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    PLoS Pathog 6:e1001174. 2010
    ..Thus, the results presented in this study reveal that tyrosine sulfation, but not O-glycosylation, in the N-terminal region of PSGL-1 may facilitate virus entry and replication of EV71 in leukocytes...
  6. pmc Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1
    Kohei Miyamura
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 92:287-91. 2011
    ..The results suggest that an adaptive mutation, along with a PSGL-1-binding phenotype, may facilitate efficient PSGL-1-dependent replication of the EV71 strains in L-PSGL-1 cells...
  7. ncbi request reprint [Poliovirus vaccine]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Uirusu 62:57-65. 2012
    ..In this regard, further clinical studies on its efficacy, safety, and interchangeability of sIPV will be needed after the introduction of the sIPV products, which will be licensed in Japan for the first time in the world...
  8. pmc The preparation of an infectious full-length cDNA clone of Saffold virus
    Toshiki Himeda
    Department of Microbiology, Kanazawa Medical University School of Medicine, Ishikawa, Japan
    Virol J 8:110. 2011
    ..To obtain the infectious RNA using T7 promoter, a variant of T7 RNA polymerase, which fails to recognize the PTH signal, was useful. This study will provide a valuable technical insight into the reverse genetics of SAFV...
  9. pmc Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for a highly sensitive detection of enterovirus in the stool samples of acute flaccid paralysis cases
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    BMC Infect Dis 9:208. 2009
    ....
  10. ncbi request reprint Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Pediatr Int 46:231-5. 2004
    ..To monitor the realtime trend of EV71 transmission throughout the WPR, the authors conducted a molecular epidemiological analysis of EV71 infection...
  11. ncbi request reprint [The lost decade of global polio eradication and moving forward]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    Uirusu 60:49-58. 2010
    ....
  12. ncbi request reprint Surveillance of poliovirus-isolates in Japan, 2002
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 56:218-9. 2003
  13. ncbi request reprint [Roles and functions of WHO Enterovirus Collaborating Center]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    Uirusu 59:43-52. 2009
    ....
  14. ncbi request reprint Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  15. doi request reprint Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1214-24. 2011
    ..50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors...
  16. doi request reprint Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Causes Control 19:1095-102. 2008
    ..Here, we investigated the association between alcohol consumption and lung cancer incidence...
  17. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  18. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
    ..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...
  19. doi request reprint Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:294-91. 2009
    ..15–3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men...
  20. doi request reprint Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status--the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Tokyo, 104 0045, Japan
    Prev Med 52:227-33. 2011
    ..The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status...
  21. doi request reprint Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 124:1644-9. 2009
    ..Women with hepatitis virus infection may be advised to abstain from isoflavone consumption. Further studies are warranted to confirm these findings...
  22. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
    ....
  23. pmc Impact of lifestyle on overall cancer risk among Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Epidemiol 20:90-6. 2010
    ..Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population...
  24. doi request reprint Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma: A population-based cohort study (JPHC Study)
    Seiji Ishiguro
    National Cancer Center, Tokyo, Japan
    Cancer Lett 300:173-9. 2011
    ..The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence...
  25. doi request reprint Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study)
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Lett 275:240-6. 2009
    ..10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response...
  26. doi request reprint Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men: a nested case-control study
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Sci 101:2652-7. 2010
    ..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...
  27. doi request reprint High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Nutr 140:779-85. 2010
    ..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...
  28. doi request reprint Validity of self-reported cancer among a Japanese population: recent results from a population-based prospective study in Japan (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol 35:250-3. 2011
    ..Self-reported diagnoses of cancer do not provide sufficient accuracy for the detection and classification of incident cancers. Our findings may be extrapolated to other Japanese populations...
  29. ncbi request reprint Alcohol consumption-associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Int J Cancer 127:685-95. 2010
    ..15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification...
  30. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009
    ..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...
  31. doi request reprint Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study
    Munira Akhter
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:515-24. 2008
    ..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women...
  32. ncbi request reprint Taste preferences and body weight change in Japanese adults: the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 33:1191-7. 2009
    ..Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan...
  33. doi request reprint Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 18:1746-53. 2009
    ..Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk..
  34. doi request reprint Coffee consumption and risk of endometrial cancer: a prospective study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:2406-10. 2008
    ..Coffee consumption may be associated with a decreased risk of endometrial cancer...
  35. doi request reprint Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1718-29. 2011
    ..Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel...
  36. doi request reprint Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Sci Total Environ 402:176-83. 2008
    ..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...
  37. ncbi request reprint Evaluation of immunoelectron microscopic techniques in the study of basement membrane antigens
    T Masunaga
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Histochem Cell Biol 110:107-11. 1998
    ..These results confirm the advantages and limitations of these techniques of IEM and emphasize the importance of using different techniques of IEM in determining the precise ultrastructural distribution of basement membrane antigens...
  38. doi request reprint Consumption of sodium and salted foods in relation to cancer and cardiovascular disease: the Japan Public Health Center-based Prospective Study
    Ribeka Takachi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Clin Nutr 91:456-64. 2010
    ....
  39. ncbi request reprint [Laboratory diagnosis for non-polio enteroviruses]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 63:382-5. 2005
  40. ncbi request reprint Daily total physical activity level and premature death in men and women: results from a large-scale population-based cohort study in Japan (JPHC study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 18:522-30. 2008
    ..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...
  41. ncbi request reprint Compound heterozygosity for a point mutation and a deletion located at splice acceptor sites in the LAMB3 gene leads to generalized atrophic benign epidermolysis bullosa
    Y Takizawa
    Departments of Dermatology and Anatomy, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:312-6. 2000
    ....
  42. doi request reprint Fish intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study
    Akiko Nanri
    Department of Epidemiology and Prevention, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan
    Am J Clin Nutr 94:884-91. 2011
    ..However, data from populations with high fish consumption are scarce...
  43. pmc Education level and physical functional limitations among Japanese community residents-gender difference in prognosis from stroke
    Kaori Honjo
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    BMC Public Health 9:131. 2009
    ..We sought to examine the association between education level and physical functional limitations among Japanese men and women, and whether that association was modified by gender and history of stroke...
  44. ncbi request reprint Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 32:1861-7. 2008
    ..Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan...
  45. ncbi request reprint [Laboratory diagnosis for poliovirus]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 63:377-81. 2005
  46. doi request reprint Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 17:930-7. 2008
    ..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...
  47. ncbi request reprint Neurovirulence of Sabin 1-derived polioviruses isolated from an immunodeficient patient with prolonged viral excretion
    T Yoneyama
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Dev Biol (Basel) 105:93-8. 2001
    ..Thus, the Sabin 1 strain evolved towards full neuropathogenicity after long-term replication in humans by accumulating mutations. Therefore, OPV-vaccination of immunodeficient persons should be avoided...
  48. ncbi request reprint Genetic analysis of wild polioviruses towards the eradication of poliomyelitis from the Western Pacific Region
    A Hagiwara
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 52:146-9. 1999
    ..A nucleotide sequence analysis of these 1997 isolates indicated that they all belonged to the same strain that has been prevailing in the Indochina area, suggesting the complete interruption of wild poliovirus transmission in the region...
  49. ncbi request reprint Abnormalities of basal cell keratin in epidermolysis bullosa simplex do not affect the expression patterns of suprabasal keratins and cornified cell envelope proteins
    Y Sasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 290:591-7. 1998
    ..Thus, the abnormality in basal cell keratins in patients with EBS did not appear to alter the patterns of expression of the keratins and CCE precursor proteins...
  50. ncbi request reprint The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo
    S Nonaka
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:889-92. 2000
    ..This unique structure of the antigen is thought to contribute to dermo- epidermal adhesion by intertwining with other basement membrane components...
  51. ncbi request reprint Phylogenic analysis of echovirus type 30 isolated from a large epidemic of aseptic meningitis in Japan during 1997-1998
    H Yoshida
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 52:160-3. 1999
    ..All isolates identified during 1997-1998 belonged to only two genomic groups; these two groups are thought to be the causative viral agents involved in the recent epidemic...
  52. ncbi request reprint Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71
    Noriyo Nagata
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Virol 67:207-16. 2002
    ..The strains isolated during the 1970s and 1990s showed no particular differences with respect to neurotropism. Thus, it is clear that EV71 has a wider neurotropism than that of polioviruses...
  53. ncbi request reprint [Laboratory diagnosis for acute hemorrhagic conjunctivitis]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 63:386-8. 2005
  54. ncbi request reprint Evaluation of the clinical usefulness of measuring urinary excretion of 5-S-cysteinyldopa in melanoma: ten years' experience of 50 patients
    Y Sasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Acta Derm Venereol 77:379-81. 1997
    ..In conclusion, while data on the urinary excretion of 5-S-CD was not useful in the detection of early regional lymph node metastases, its increase indicated the presence of distant metastases and also provided prognostic information...
  55. ncbi request reprint Development of pemphigus vulgaris in a patient with pemphigus foliaceus: antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay
    K Ishii
    Department of Dermatology, Keio University School of Medicine, Saiseikai Central Hospital, Tokyo, Japan
    J Am Acad Dermatol 42:859-61. 2000
    ..Antidesmoglein (Dsg) 1 antibodies alone were detected in the PF stage, whereas both anti-Dsg3 and anti-Dsg1 antibodies were detected in the PV stage...
  56. ncbi request reprint [Universal use of inactivated poliovirus vaccine--the needs and challenges]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 66:1950-5. 2008
    ..Thus, further polio immunization strategies, including the introduction of Sabin IPV, instead of OPV, to Japan and to developing countries, should be carefully considered...
  57. doi request reprint Prediction of pre-eclampsia by an analysis of placenta-derived cellular mRNA in the blood of pregnant women at 15-20 weeks of gestation
    A Sekizawa
    Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan
    BJOG 117:557-64. 2010
    ..A panel of cellular mRNA markers was used to predict the occurrence of pre-eclampsia in pregnant women at 15-20 weeks of gestation...
  58. ncbi request reprint Immunomolecular mapping of adherens junction and desmosomal components in normal human epidermis
    A Ishiko
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 12:747-54. 2003
    ....
  59. ncbi request reprint Electron microscopic DOPA reaction test for oculocutaneous albinism
    Y Takizawa
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 292:301-5. 2000
    ....
  60. ncbi request reprint Selective perfusion of segmental arteries in patients undergoing thoracoabdominal aortic surgery
    T Ueda
    Department of Cardiovascular Surgery, School of Medicine, Keio University, Tokyo, Japan
    Ann Thorac Surg 70:38-43. 2000
    ..Nevertheless, even when important segmental arteries are reattached, ischemia causing spinal injury may occur during anastomosis...
  61. ncbi request reprint Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 87:3317-27. 2006
    ..These results indicate that PV replication in a small population of the motor neurons was critical for severe residual poliomyelitis-like paralysis in TgPVR21 mice...
  62. doi request reprint Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 90:1869-79. 2009
    ..These results suggest that cellular kinase inhibitors and enviroxime have a conserved target in viral protein 3A to suppress enterovirus replication...
  63. pmc Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Virol 82:1787-97. 2008
    ..These results suggest that a cooperative effect of the attenuation determinants of PV1(Sabin) is essential for attenuated neurovirulence of EV71...
  64. doi request reprint Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 89:2518-30. 2008
    ..These results suggest that GW5074 has strong and selective inhibitory effect against the replication of PV and EV71 by inhibiting conserved targets in the infection independently of the interferon response...
  65. pmc An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Virol 81:9386-95. 2007
    ..In the CNS, EV71(S1-3') was isolated only from the spinal cord. These results indicate that EV71(S1-3') acts as an effective antigen, although this attenuated strain was still neurotropic when inoculated via the intravenous route...
  66. pmc Rapid genome sequencing of RNA viruses
    Tetsuya Mizutani
    Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama City, Tokyo, Japan
    Emerg Infect Dis 13:322-4. 2007
    ..This method affords new opportunities to address the challenges of unknown or untypeable emerging viruses...
  67. doi request reprint A bifunctional anti-enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 91:2734-44. 2010
    ..These results suggest that AN-12-H5 is a bifunctional anti-enterovirus compound that belongs to a novel class of enviroxime-like compounds and targets both a replication step and an early stage of EV71 infection...
  68. pmc Development of a particle agglutination method with soluble virus receptor for identification of poliovirus
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Clin Microbiol 48:2698-702. 2010
    ..These results suggest that this PA method is useful for the simple and rapid identification of PV, although the sensitivity was not high enough to detect a minor population of PV (<1/10 of the major population) among mixed PVs...
  69. pmc Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Tokyo 208 0011, Japan
    J Virol 85:2364-72. 2011
    ....
  70. ncbi request reprint Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation
    Noriyo Nagata
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 85:2981-9. 2004
    ..Thus, intravenous inoculation with EV71 is an excellent model to study the neuropathology of EV71 and to evaluate candidate vaccines and potential antiviral agents...
  71. ncbi request reprint Characterization of in vitro and in vivo phenotypes of poliovirus type 1 mutants with reduced viral protein synthesis activity
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 85:1933-44. 2004
    ..These results suggest that reduced viral protein synthesis activity as measured in cultured cells (17-55 % of the wild-type activity) is not the main determinant of PV attenuation...
  72. pmc A Sabin 3-derived poliovirus recombinant contained a sequence homologous with indigenous human enterovirus species C in the viral polymerase coding region
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    J Virol 79:12650-7. 2005
    ..These results suggested that a part of the 3D(pol) coding region of PV3(Cambodia-02) was derived from a HEV-C strain genetically related to indigenous CAV13-CAV18 strains in 2002 in Cambodia...
  73. ncbi request reprint [Identification of P-selectin glycoprotein ligand-1 as one of the cellular receptors for enterovirus 71]
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    Uirusu 59:195-203. 2009
    ..Thus, further elucidation of the PSGL-1-dependent EV71 replication may provide valuable insights into the molecular basis of EV71 infection including HFMD and various neurological diseases...
  74. ncbi request reprint Pre-existing histological type and developmental mechanism of mucinous noncystic carcinoma of pancreas
    K Suda
    Juntendo University School of Medicine, Department of Pathology 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Pathol Oncol Res 6:125-9. 2000
    ..These two pre-existing types of MC involved mucin overproduction and mucinous degeneration. MUC immunoreactivity in MC revealed three patterns, which may be related to variable outcomes...
  75. ncbi request reprint Polymorphism in the tumor necrosis factor B gene is associated with Palmoplantar pustulosis
    K Hashigucci
    Department of Otolarynology, Kitsato Institute Hospital, Minato, Tokyo, Japan
    Tissue Antigens 54:288-90. 1999
    ..Furthermore, the DR9-TNFB2 haplotype was significantly more frequent in the PPP patients (P=0.0045). These results suggest that TNFB2 may confer susceptibility to PPP...
  76. ncbi request reprint A major improvement in the prognosis of individuals with IDDM in the past 30 years in Japan. The Diabetes Epidemiology Research International Study Group
    R Nishimura
    Department of Internal Medicine III, Jikei University School of Medicine, Tokyo, Japan
    Diabetes Care 19:758-60. 1996
    ..To evaluate the time trends of mortality among individuals with IDDM in Japan...
  77. ncbi request reprint Three cases of Darier's disease in a family showing marked heterogeneous clinical severity
    M Inada
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Dermatology 198:167-70. 1999
    ..Thus, spontaneous remission of skin lesions, rare in Darier's disease, and heterogeneous clinical severity between and within generations were noted in this family...
  78. pmc Non-polio enterovirus isolation among families in Ulaanbaatar and Tov province, Mongolia: prevalence, intrafamilial spread, and risk factors for infection
    M Kuramitsu
    Department of Health Policy and Planning, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Epidemiol Infect 133:1131-42. 2005
    ..Hand washing after defecation was protective against infection. Our study findings stress the importance of hand washing and cleaning hygienic facilities to prevent infection by enteric viruses in the home environment...
  79. ncbi request reprint Prenatal diagnosis as a test for genodermatoses: its past, present and future
    H Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 19:1-8. 1999
    ..Although there are many questions that remain unanswered, the outlook for further development of noninvasive PND in the future appears optimistic...
  80. ncbi request reprint New insights into the immunoultrastructural organization of cutaneous basement membrane zone molecules
    H Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Exp Dermatol 7:303-13. 1998
    ....
  81. doi request reprint Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
    Yorihiro Nishimura
    Department of Virology II, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    Nat Med 15:794-7. 2009
    ..The identification of PSGL-1 as a receptor for EV71 sheds new light on a role for PSGL-1-positive leukocytes in cell tropism and pathogenesis during the course of HFMD and other EV71-mediated diseases...
  82. ncbi request reprint Mutation report: complete paternal uniparental isodisomy of chromosome 1: a novel mechanism for Herlitz junctional epidermolysis bullosa
    Y Takizawa
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:307-11. 2000
    ..This is a novel mechanism resulting in Herlitz junctional epidermolysis bullosa and has implications for assessment of the risk in subsequent pregnancies...
  83. ncbi request reprint Present status of anticoagulation treatment in Japanese patients with atrial fibrillation: a report from the J-RHYTHM Registry
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    Circ J 75:1328-33. 2011
    ..Underuse and an inadequate range for the international normalized ratio (INR) for warfarin use are still problems in the management of the patients with atrial fibrillation (AF) in Japan...
  84. ncbi request reprint High density culture of immortalized liver endothelial cells in the radial-flow bioreactor in the development of an artificial liver
    T Matsuura
    Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Int J Artif Organs 21:229-34. 1998
    ..This suggests that immortalized liver endothelial cells and a radial-flow bioreactor can prove useful tools in the development an artificial liver...
  85. ncbi request reprint Dermatitis herpetiformis in Japan: an update
    M Shibahara
    Department of Dermatology, Tokyo Kousei Nenkin Hospital, Tokyo, Japan
    Dermatology 204:37-42. 2002
    ..We encountered a Japanese case of DH which showed granular IgA and C3 deposits in the papillary dermis and which was associated with gluten-sensitive enteropathy but no HLA-B8/DR3/DQ2...
  86. ncbi request reprint EAT/mcl-1 expression in the human embryonal carcinoma cells undergoing differentiation or apoptosis
    M Sano
    Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-582, Japan
    Exp Cell Res 266:114-25. 2001
    ..The findings suggest that rapid induction of EAT may prevent NCR-G3 cells from undergoing apoptosis, thereby supporting viability at the early stage of differentiation...
  87. ncbi request reprint Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector
    H Shimizu
    Department of Biochemistry and Molecular Biology, Center for Advanced Medical Technology, Nippon Medical School, Tokyo, Japan
    Urology 57:579-84. 2001
    ..Intravesical instillation of adenoviral vectors does not result in systemic infection. These results encourage the consideration of gene therapy in the treatment of human bladder cancer...
  88. ncbi request reprint Cortical oscillations in human medial temporal lobe during wakefulness and all-night sleep
    S Uchida
    Department of Psychophysiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, 156 8585, Tokyo, Japan
    Brain Res 891:7-19. 2001
    ..Functional significances of the gamma activity should be further investigated...
  89. ncbi request reprint Mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes (MELAS) with prominent degeneration of the intestinal wall and cactus-like cerebellar pathology
    O Mori
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    Acta Neuropathol 100:712-7. 2000
    ..The intestinal dysmotility due to MELAS and cerebellar changes were presumed to be associated with a disturbance of copper metabolism...
  90. ncbi request reprint Antigenic characterization of a formalin-inactivated poliovirus vaccine derived from live-attenuated Sabin strains
    Yoshio Tano
    Department of Virology II, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama shi, Tokyo 208 0011, Japan Japan Poliomyelitis Research Institute, Kumegawa cho 5 34 4, Higashimurayama shi, Tokyo 189 0003, Japan
    Vaccine 25:7041-6. 2007
    ..Our results suggest that the differences in epitope structure after formalin inactivation may account, at least in part, for the observed differences in immunogenicity between Sabin and wild-type inactivated poliovaccines...
  91. ncbi request reprint Rapid serological diagnosis of enterovirus 71 infection by IgM ELISA
    Yoshio Tano
    Department of Virology II, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 55:133-5. 2002
  92. doi request reprint Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Carcinogenesis 29:1042-8. 2008
    ..Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer...
  93. ncbi request reprint A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens
    Y Takizawa
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 114:193-5. 2000
    ..Our data indicate aspartic acid substitution in codon 192 in the 1A helix initiation site is deleterious to keratin filament network integrity and leads to ichthyosis bullosa of Siemens phenotype...
  94. ncbi request reprint Molecular basis of recessive dystrophic epidermolysis bullosa: genotype/phenotype correlation in a case of moderate clinical severity
    H Shimizu
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 106:119-24. 1996
    ..Information about these mutations advances our understanding of genotype-phenotype correlations in dystrophic epidermolysis bullosa, and further delineates the mechanisms involved in dermal-epidermal dysadhesion...
  95. ncbi request reprint Identification of the canarypox virus thymidine kinase gene and insertion of foreign genes
    H Amano
    Virology II, VIrology I, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama, Tokyo, 208, Japan
    Virology 256:280-90. 1999
    ..The recombinant viruses obtained were unstable, although the foreign genes were expressed efficiently in the mammalian cells infected with the viruses...
  96. ncbi request reprint Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study
    Yasuyuki Suzuki
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Ophthalmology 113:1613-7. 2006
    ..To identify the risk factors associated with primary open-angle glaucoma (POAG) in the Tajimi Study...
  97. ncbi request reprint [Hand, foot and mouth disease]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 65:339-42. 2007
  98. pmc Circulating vaccine-derived polioviruses: current state of knowledge
    Olen M Kew
    WHO Global Specialized Reference Laboratory, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Bull World Health Organ 82:16-23. 2004
    ..Particular attention must be given to areas where the risks for wild poliovirus circulation have been highest, and where the highest rates of polio vaccine coverage must be maintained to suppress cVDPV emergence...
  99. ncbi request reprint Persistence of oral polio vaccine virus after its removal from the immunisation schedule in New Zealand
    Q Sue Huang
    Institute of Environmental Science and Research, PO Box 50348, Porirua, New Zealand
    Lancet 366:394-6. 2005
    ..Sequence homology with Sabin vaccine parent strains indicated that polioviruses detected more than 4 months after the switch were of recent origin, consistent with importation from OPV-using countries...
  100. pmc Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient
    Chen Fu Yang
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:12623-34. 2005
    ..The appearance of a chronic VDPV excretor in a tropical, developing country has important implications for the strategy to stop OPV immunization after eradication of wild polioviruses...