Y Shigeri

Summary

Affiliation: National Institute of Advanced Industrial Science and Technology
Country: Japan

Publications

  1. ncbi request reprint Desorption/ionization efficiency of peptides containing disulfide bonds in matrix-assisted laser desorption/ionization mass spectrometry
    Yasushi Shigeri
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Anal Sci 28:295-9. 2012
  2. ncbi request reprint [Pharmacology of inhibitory amino acid transporters (GABA transporters and glycine transporters)]
    Yasushi Shigeri
    Nihon Yakurigaku Zasshi 127:279-87. 2006
  3. ncbi request reprint [Pharmacology of excitatory amino acid transporters (EAATs and VGLUTs)]
    Yasushi Shigeri
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Nihon Yakurigaku Zasshi 122:253-64. 2003
  4. ncbi request reprint [Ca2+/calmodulin-dependent protein kinase signaling: regulatory mechanisms for switching on/off and their involvement in the pathogenesis of various diseases]
    Yasushi Shigeri
    Tanpakushitsu Kakusan Koso 53:1360-7. 2008
  5. ncbi request reprint Decomposition of intact chicken feathers by a thermophile in combination with an acidulocomposting garbage-treatment process
    Yasushi Shigeri
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Biosci Biotechnol Biochem 73:2519-21. 2009
  6. ncbi request reprint Synthesis and application of caged peptides and proteins
    Y Shigeri
    National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Pharmacol Ther 91:85-92. 2001
  7. ncbi request reprint Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)
    Y Shigeri
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    J Neurochem 79:297-302. 2001
  8. ncbi request reprint Molecular pharmacology of glutamate transporters, EAATs and VGLUTs
    Yasushi Shigeri
    National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Brain Res Brain Res Rev 45:250-65. 2004
  9. ncbi request reprint Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers
    K Shimamoto
    Suntory Institute for Bioorganic Research, Wakayamadai, Mishima, Osaka, Japan
    Bioorg Med Chem Lett 10:2407-10. 2000
  10. doi request reprint Two forms of secreted and thermostable luciferases from the marine copepod crustacean, Metridia pacifica
    Yasuhiro Takenaka
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, 16 1 Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Gene 425:28-35. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Desorption/ionization efficiency of peptides containing disulfide bonds in matrix-assisted laser desorption/ionization mass spectrometry
    Yasushi Shigeri
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Anal Sci 28:295-9. 2012
    ..These results imply that a rigid structure of peptides formed by disulfide bonds does not correlate with desorption/ionization efficiency in MALDI-MS...
  2. ncbi request reprint [Pharmacology of inhibitory amino acid transporters (GABA transporters and glycine transporters)]
    Yasushi Shigeri
    Nihon Yakurigaku Zasshi 127:279-87. 2006
  3. ncbi request reprint [Pharmacology of excitatory amino acid transporters (EAATs and VGLUTs)]
    Yasushi Shigeri
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Nihon Yakurigaku Zasshi 122:253-64. 2003
    ..In this review, the development of new compounds to regulate the function of VGLUTs and EAATs will be described...
  4. ncbi request reprint [Ca2+/calmodulin-dependent protein kinase signaling: regulatory mechanisms for switching on/off and their involvement in the pathogenesis of various diseases]
    Yasushi Shigeri
    Tanpakushitsu Kakusan Koso 53:1360-7. 2008
  5. ncbi request reprint Decomposition of intact chicken feathers by a thermophile in combination with an acidulocomposting garbage-treatment process
    Yasushi Shigeri
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Biosci Biotechnol Biochem 73:2519-21. 2009
    ....
  6. ncbi request reprint Synthesis and application of caged peptides and proteins
    Y Shigeri
    National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Pharmacol Ther 91:85-92. 2001
    ..In this review, we summarize recent advances made in the design, preparation, and application of caged peptides and proteins...
  7. ncbi request reprint Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)
    Y Shigeri
    National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    J Neurochem 79:297-302. 2001
    ..These results indicate that EAATs 4 and 5 show different sensitivities to THA analogs although they share properties of a glutamate-gated chloride channel...
  8. ncbi request reprint Molecular pharmacology of glutamate transporters, EAATs and VGLUTs
    Yasushi Shigeri
    National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Brain Res Brain Res Rev 45:250-65. 2004
    ..This review summarizes the development of these indispensable pharmacological tools, which have been critical to our understanding of normal and abnormal synaptic transmission...
  9. ncbi request reprint Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers
    K Shimamoto
    Suntory Institute for Bioorganic Research, Wakayamadai, Mishima, Osaka, Japan
    Bioorg Med Chem Lett 10:2407-10. 2000
    ..We also synthesized the substituent variants (methyl or naphthylmethyl derivatives) of L-TBOA. The results obtained here suggest that bulky substituents are crucial for non-transportable blockers...
  10. doi request reprint Two forms of secreted and thermostable luciferases from the marine copepod crustacean, Metridia pacifica
    Yasuhiro Takenaka
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, 16 1 Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Gene 425:28-35. 2008
    ..Continuous monitoring of secreted MpLuc1 driven by the c-fos promoter demonstrated the potential usefulness of MpLuc1 in nondisruptive reporter assays...
  11. ncbi request reprint Effective detection of peptides containing cysteine sulfonic acid using matrix-assisted laser desorption/ionization and laser desorption/ionization on porous silicon mass spectrometry
    Tomoya Kinumi
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    J Mass Spectrom 41:103-12. 2006
    ....
  12. ncbi request reprint A potent nonpeptide neuropeptide Y Y1 receptor antagonist, a benzodiazepine derivative
    Y Shigeri
    Shionogi Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Life Sci 63:PL 151-60. 1998
    ..We conclude that Compound 1 is a useful molecule not only for studying the physiological role of neuropeptide Y but also for exploring more specific Y1 receptor antagonists...
  13. ncbi request reprint [Excitatory amino acid transporters: development of regulatory molecules for their functional analysis]
    Yasushi Shigeri
    National Institute of Advanced Industrial Science and Technology, AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Seikagaku 75:288-92. 2003
  14. doi request reprint High-energy electron transfer dissociation (HE-ETD) using alkali metal targets for sequence analysis of post-translational peptides
    Shigeo Hayakawa
    Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan
    J Am Soc Mass Spectrom 21:1482-9. 2010
    ....
  15. ncbi request reprint Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II
    Coleen M Atkins
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 24:5193-201. 2004
    ..These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity...
  16. ncbi request reprint Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters
    Keiko Shimamoto
    Suntory Institute for Bioorganic Research, 1 1 1, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Mol Pharmacol 65:1008-15. 2004
    ..Taken together, these findings indicate that novel TBOA analogs, especially TFB-TBOA, should serve as useful tools for elucidating the physiological roles of the glutamate transporters...
  17. ncbi request reprint Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters
    Keiko Shimamoto
    Suntory Institute for Bioorganic Research, 1 1 1, Wakayamadai, Mishima gun, Osaka 618 8503, USA
    Mol Pharmacol 71:294-302. 2007
    ..The rank order of inhibition by these compounds was consistent with glutamate uptake assay results reported previously. Thus, the [3H]ETB-TBOA binding assay will be useful to screen novel EAAT ligands for all EAAT subtypes...
  18. ncbi request reprint Integrins are involved in synaptogenesis, cell spreading, and adhesion in the postnatal brain
    Irina Nikonenko
    Department of Pharmacology, Centre Medical Universitaire, 1211 4, Geneva, Switzerland
    Brain Res Dev Brain Res 140:185-94. 2003
    ..The results demonstrate that integrins markedly affect postnatal CNS development, in both ultrastructural construction and organizational processes...
  19. ncbi request reprint Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology
    Atsuhiko Ishida
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, 078 8510, Japan
    Pharmacol Ther 100:291-305. 2003
    ....
  20. ncbi request reprint Inhibitors of the Ca(2+)/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)
    Noriyuki Sueyoshi
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kagawa 761 0795, Japan
    Biochem Biophys Res Commun 363:715-21. 2007
    ....
  21. ncbi request reprint Recent advances in technologies for analyzing protein kinases
    Atsuhiko Ishida
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Pharmacol Sci 103:5-11. 2007
    ..In this review, we briefly summarize the technologies to detect or characterize protein kinases with special emphasis on recently developed and/or commercially available techniques...
  22. ncbi request reprint Knockdown of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafish
    Takaki Nimura
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa 761 0795, Japan
    Arch Biochem Biophys 457:205-16. 2007
    ..A number of apoptotic cells were observed in brain and spinal cord of the abnormal embryos. These results suggest that zCaMKP-N plays a crucial role in the early development of zebrafish...
  23. ncbi request reprint Mutational analysis of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP)
    Yukiyo Tada
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Ikenobe 2393, Miki cho, Kagawa 761 0795, Japan
    Arch Biochem Biophys 452:174-85. 2006
    ..The results suggested that the N- and C-terminal sequences of CaMKP are essential for the regulation and stability of CaMKP...
  24. pmc Lactococcin Q, a novel two-peptide bacteriocin produced by Lactococcus lactis QU 4
    Takeshi Zendo
    Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Appl Environ Microbiol 72:3383-9. 2006
    ..The MIC of Qalpha plus Gbeta was 32 times higher than that of Qalpha plus Qbeta, suggesting that the difference in beta peptides was important for the intensity of antibacterial activity...
  25. ncbi request reprint Generation and application of a monoclonal antibody that detects a wide variety of protein tyrosine kinases
    Yasunori Sugiyama
    Department of Life Sciences, Faculty of Agriculture, Kagawa University, Japan
    Anal Biochem 347:112-20. 2005
    ..These results suggest that the YK34 antibody will be a powerful tool for analysis of a variety of cellular PTKs...
  26. ncbi request reprint Generation of a polyclonal antibody that simultaneously detects multiple Ser/Thr protein kinases
    Isamu Kameshita
    Faculty of Agriculture, Department of Life Sciences, Kagawa University, Miki cho, Kagawa 761 0795, Japan
    J Biochem Biophys Methods 60:13-22. 2004
    ..The present anti-peptide antibody with a broad spectrum of cross-reactivity to multiple protein kinases may be a powerful tool for comprehensive analysis focused on protein kinases...