M Shibutani

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi request reprint Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 208:35-48. 2005
  2. ncbi request reprint Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Dev Neurobiol 67:253-69. 2007
  3. ncbi request reprint Methacarn fixation: a novel tool for analysis of gene expressions in paraffin-embedded tissue specimens
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Tokyo, Japan
    Lab Invest 80:199-208. 2000
  4. ncbi request reprint Assessment of renal toxicity by analysis of regeneration of tubular epithelium in rats given low-dose cadmium chloride or cadmium-polluted rice for 22 months
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Arch Toxicol 74:571-7. 2000
  5. ncbi request reprint Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Carcinogenesis 23:1047-55. 2002
  6. ncbi request reprint Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    J Toxicol Sci 26:337-58. 2001
  7. ncbi request reprint Subchronic toxicity study of gallic acid by oral administration in F344 rats
    N Niho
    Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Food Chem Toxicol 39:1063-70. 2001
  8. ncbi request reprint Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years
    K Toyoda
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Food Chem Toxicol 38:187-93. 2000
  9. ncbi request reprint Correlation between nucleolar organizer regions and cell proliferation in pancreatic acinar cell proliferative lesions in rats
    T Imazawa
    Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan
    Pancreas 9:219-24. 1994
  10. ncbi request reprint Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas
    S Hara
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 151:10-8. 2014

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 208:35-48. 2005
    ....
  2. ncbi request reprint Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Dev Neurobiol 67:253-69. 2007
    ..Moreover, many selected genes common to EB and FA showed down-regulation in females with both drugs, suggesting a common mechanism for endocrine center disruption in females, at least at early stages of post-natal development...
  3. ncbi request reprint Methacarn fixation: a novel tool for analysis of gene expressions in paraffin-embedded tissue specimens
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Tokyo, Japan
    Lab Invest 80:199-208. 2000
    ..Thus, in addition to its advantages for immunohistochemistry, methacarn-fixed paraffin-embedded tissue has benefits for analysis of both RNAs and proteins in the cells of histologically defined areas...
  4. ncbi request reprint Assessment of renal toxicity by analysis of regeneration of tubular epithelium in rats given low-dose cadmium chloride or cadmium-polluted rice for 22 months
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Arch Toxicol 74:571-7. 2000
    ....
  5. ncbi request reprint Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Carcinogenesis 23:1047-55. 2002
    ..These genes might be candidates for biomarkers in screening of non-genotoxic hepatocarcinogens by analysis in two-stage carcinogenesis models...
  6. ncbi request reprint Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    J Toxicol Sci 26:337-58. 2001
    ..Possible protective mechanisms may be operating...
  7. ncbi request reprint Subchronic toxicity study of gallic acid by oral administration in F344 rats
    N Niho
    Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Food Chem Toxicol 39:1063-70. 2001
    ..Based on the present toxicology data, 0.2% was determined to be a no-observed-adverse-effect level (NOAEL) in rats. This level was translated into 119 and 128 mg/kg/day, respectively for male and female rats...
  8. ncbi request reprint Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years
    K Toyoda
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Food Chem Toxicol 38:187-93. 2000
    ..There was no significant induction of any other neoplastic or non-neoplastic lesions. These results indicate a lack of carcinogenicity of 5-FU under the present experimental conditions using rats...
  9. ncbi request reprint Correlation between nucleolar organizer regions and cell proliferation in pancreatic acinar cell proliferative lesions in rats
    T Imazawa
    Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan
    Pancreas 9:219-24. 1994
    ..The present results suggest that mean numbers of AgNORs may reflect cellular kinetics in rat pancreatic acinar cell lesions...
  10. ncbi request reprint Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas
    S Hara
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 151:10-8. 2014
    ..This study was the first to show positive immunoreactivity for Sall4 in canine seminomas and dysgerminomas and expression of PGP9.5 in canine dysgerminomas. ..
  11. doi request reprint Tumour endothelial marker-1 is expressed in canine Haemangiopericytomas
    Y Fujii
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 149:172-81. 2013
    ..NG-2 expression may be a phenotype of smooth muscle cells rather than pericytes in dogs. ..
  12. ncbi request reprint A 13-week subchronic toxicity study of madder color in F344 rats
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:241-52. 2008
    ..6% in diet, that is attributable to be the lowest-observed adverse effect level (305.8-309.2mg/kg body weight/day)...
  13. doi request reprint Immunohistochemical characterization of neuroendocrine differentiation of canine anal sac glandular tumours
    K Suzuki
    Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 149:199-207. 2013
    ..These results suggest that some ASGCs have neuroendocrine differentiation regardless of histological pattern, but clinical outcome is more related to the histological pattern than to neuroendocrine differentiation. ..
  14. doi request reprint Gingival rhabdomyosarcoma accompanied by an immature myogenic population immunoreactive for α-smooth muscle actin in a dog
    M Kimura
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 149:48-52. 2013
    ..Based on the morphological and immunohistochemical features, the gingival mass was diagnosed as alveolar rhabdomyosarcoma accompanied by α-SMA-positive immature myogenic cells...
  15. ncbi request reprint Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitrosourethane
    A Maekawa
    Division of Pathology, National Institute of Hygienic Sciences, Tokyo
    Jpn J Cancer Res 80:632-6. 1989
    ..365 x 10(-2), 0.110 x 10(-1) and 0.779 x 10(-1) ppm, respectively. The VSDs estimated in the present study are discussed in comparison with those of other carcinogens...
  16. ncbi request reprint Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique
    Natsumi Kato
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 200:179-92. 2004
    ..0 ppm, up-regulation of genes dose-dependently in females provides a sensitive tool to detect estrogenic effects in the rat liver in the framework of the 28-day toxicity study...
  17. ncbi request reprint Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Histochem Cytochem 52:903-13. 2004
    ..These results indicate high performance with methacarn, close to that of unfixed tissues, regarding quantitative expression analysis of mRNAs in microdissected PET-specimens...
  18. ncbi request reprint Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 45:1160-4. 2007
    ..The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis...
  19. doi request reprint Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice
    Masaomi Kawai
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Toxicol Pathol 36:950-7. 2008
    ....
  20. ncbi request reprint Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens
    Chikako Uneyama
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    J Histochem Cytochem 50:1237-45. 2002
    ..The results thus demonstrate the superior performance of methacarn to that reported with formalin in genomic DNA analysis using microdissected PET specimens...
  21. ncbi request reprint Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats
    N Niho
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Food Chem Toxicol 40:715-22. 2002
    ..Based on the observed steepness in dose- and time-responses, any implied cancer risk of OPP-Na at the low doses of interest to man must be considered to be very small...
  22. ncbi request reprint Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats
    M Hirose
    Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Cancer Lett 143:173-8. 1999
    ..It is suggested that depression of metabolic activation rather than antioxidant activity is responsible for the observed effect. However, other mechanisms, including the effects on phase II enzymes cannot be ruled out...
  23. ncbi request reprint Spontaneous histiocytic sarcoma with possible origin from the bone marrow and lymph node in Donryu and F-344 rats
    H Ogasawara
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Toxicol Pathol 21:63-70. 1993
    ....
  24. ncbi request reprint Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats
    Masayoshi Takabatake
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology Technology, Fuchu, Tokyo, Japan
    J Toxicol Sci 33:127-40. 2008
    ..These results indicate that the concerted effects of AA on cell proliferation and apoptosis/cell cycle arrest probably through its antioxidant activity are involved in this enhancement...
  25. doi request reprint Molecular expression analysis of beta-naphthoflavone-induced hepatocellular tumors in rats
    Yasuaki Dewa
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Toxicol Pathol 37:446-55. 2009
    ..These results suggest that enhanced cell proliferation and protection against oxidative stress play an important role in BNF-induced hepatocarcinogenesis in rats...
  26. doi request reprint Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Cancer Sci 100:2261-7. 2009
    ..Rubiadin may also target the liver and large intestine, suggesting a major role in madder color-induced carcinogenicity...
  27. ncbi request reprint A repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Arch Toxicol 81:77-88. 2007
    ..The no-observed-adverse-effect level of NP was estimated to be 10 mg/kg per day...
  28. ncbi request reprint Subchronic toxicity study of water pepper extract in F344 rats
    Keiko Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 44:1236-44. 2006
    ..Based on the present toxicity data, 1000 ppm was determined to be the no-observed-adverse-effect level, translating into 57.4 and 62.9 mg/kg/day for male and female rats, respectively...
  29. ncbi request reprint Subchronic toxicity study of dietary N-acetylglucosamine in F344 rats
    Kyoung Youl Lee
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 42:687-95. 2004
    ..Based on the present toxicity data, > or =5% was determined to be a no-observed-adverse-effect level, translated into 2476 and 2834 mg/kg/day for male and female rats, respectively...
  30. ncbi request reprint Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 18:687-700. 2004
    ..GEN alone also affected estrous cyclicity and the reproductive system in females. However, no combination effects of GEN with EE were evident, suggesting no synergism between the two...
  31. ncbi request reprint Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 192:149-70. 2003
    ..The SDN-POA volume remained unchanged with all three chemicals. The results demonstrated that perinatal dietary exposure to EDCs for a limited period causes endocrine disruption in offspring only at high doses...
  32. ncbi request reprint Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats
    N Masutomi
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Toxicol Pathol 29:617-22. 2001
    ....
  33. doi request reprint Nivalenol and the targeting of the female reproductive system as well as haematopoietic and immune systems in rats after 90-day exposure through the diet
    Y Sugita-Konishi
    Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:1118-27. 2008
    ..Based on a significant decrease in white blood cells in female rats relative to controls, the lowest observable effect level was calculated as 0.4 mg kg(-1) body weight day(-1)...
  34. doi request reprint One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:3303-10. 2008
    ..0% in both sexes. These results indicate that MC has chronic toxicity targeting kidney, liver and blood cells. Moreover, the results strongly suggest that MC may have the carcinogenic potential in the kidney and the liver...
  35. ncbi request reprint Methacarn: a fixation tool for multipurpose genetic analysis from paraffin-embedded tissues
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Methods Enzymol 356:114-25. 2002
  36. doi request reprint Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 47:184-91. 2009
    ..These data provide clear evidence that MC exerts unequivocal carcinogenicity against renal tubule cells and hepatocytes in rats...
  37. ncbi request reprint Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Food Chem Toxicol 47:752-9. 2009
    ..These results indicate that Rub may be a potent carcinogenic metabolite of MC, targeting proximal tubule cells in the outer medulla, although oxidative stress increased by Alz or LuP might also be involved in renal carcinogenesis by MC...
  38. ncbi request reprint A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:125-35. 2008
    ..Based on the hematological data, the no-observed-adverse-effect level of NIV was determined to be less than 6.25 ppm (0.4 mg/kg body weight/day for both males and females)...
  39. doi request reprint Lack of chronic toxicity or carcinogenicity of dietary N-acetylglucosamine in F344 rats
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 47:462-71. 2009
    ....
  40. ncbi request reprint Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats
    Masao Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 39:271-8. 2002
    ..The present results indicate that a number of compounds may be candidate chemopreventive agents against PhIP-induced mammary carcinogenesis, acting through different mechanisms and depending on the stage of carcinogenesis...
  41. ncbi request reprint Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation
    Kyoung Youl Lee
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 203:221-38. 2004
    ..Thus, developmental exposure to DBP affected female sexual development involving pituitary function, while in males testicular toxicity was mostly reversible but mammary gland toxicity was persistent at a dose level as low as 20 ppm...
  42. ncbi request reprint Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Appl Pharmacol 208:127-36. 2005
    ..The results thus suggest that agents causing developmental and/or reproductive abnormalities in later life may affect hypothalamic PR expression during the exposure period in early life...
  43. ncbi request reprint Methacarn fixation for genomic DNA analysis in microdissected cells
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Methods Mol Biol 293:11-25. 2005
    ..These features demonstrate the suitability of methacarn-fixed wax-embedded tissue for practical genomic DNA analysis in terms of tissue handling, extraction efficiency, and satisfactory PCR results...
  44. doi request reprint Pancreatic carcinosarcoma in a cat
    R Yamamoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 147:223-6. 2012
    ..The pancreatic lesion is proposed to be a primary carcinosarcoma with metastasis of only the mesenchymal component to distant sites. This the first report of pancreatic carcinosarcoma in a cat...
  45. ncbi request reprint Evaluation of in vivo liver genotoxic potential of Wy-14,643 and piperonyl butoxide in rats subjected to two-week repeated oral administration
    Terumasa Suzuki
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo, 183 8509, Japan
    Arch Toxicol 84:493-500. 2010
    ..The results of the present study suggest that WY, but not PBO, causes some DNA damage in livers of rats, but such DNA damage was repaired by the increased activity of some DNA repair genes and may not lead to a DNA mutation...
  46. ncbi request reprint Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
    Makoto Ueda
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Nutr Cancer 47:141-7. 2003
    ..The present study indicates that genistein does not exert clear inhibitory effects on mammary carcinogenesis in the promotion/progression stage in female rats under ovarian hormone-free conditions...
  47. doi request reprint A non-joint tissue biphasic synovial sarcoma in a dog
    N Takimoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 150:204-7. 2014
    ..The tumour was diagnosed as a biphasic type of synovial sarcoma. Synovial sarcoma in man may develop in tissues unrelated to joints and this is the first report of a non-joint synovial sarcoma in a dog. ..
  48. ncbi request reprint Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide
    T Imazawa
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Toxicol Pathol 29:320-7. 2001
    ..Thus our results indicate that repeated intravenous administration of 4HAQO to rats is useful for the induction of islet cell tumors at high incidence...
  49. doi request reprint Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
    Eriko Taniai
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Cancer Sci 100:813-20. 2009
    ....
  50. ncbi request reprint Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 158 8501, Tokyo, Japan
    Arch Toxicol 78:97-105. 2004
    ..The results indicated that maternal dietary exposure to NP or BPA at concentrations up to 3000 ppm from GD 15 through PND 10 do not exert any apparent adverse effects on the endocrine/reproductive systems of offspring...
  51. doi request reprint Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 28:297-307. 2009
    ....
  52. doi request reprint Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats
    Jihei Nishimura
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo, 183 8509, Japan
    Arch Toxicol 84:143-53. 2010
    ..These results suggest that coadministration of EMIQ or MLT suppresses the hepatocellular tumor-promoting activity of OX in rats through the decrease in ROS production by the activation of CYPs...
  53. ncbi request reprint Methacarn fixation--effects of tissue processing and storage conditions on detection of mRNAs and proteins in paraffin-embedded tissues
    Kyoung Youl Lee
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Anal Biochem 351:36-43. 2006
    ....
  54. doi request reprint Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Science, Setagaya Ku, Tokyo, Japan
    Cancer Sci 100:617-25. 2009
    ..Decrease of thyroglobulin in Ca may reflect dedifferentiation with progression...
  55. ncbi request reprint Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats
    Hironobu Yasuno
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Toxicol Sci 33:197-207. 2008
    ....
  56. ncbi request reprint Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 219:147-53. 2005
    ..The results suggest a limited initiation activity of PEITC with induction of irreversible lesions by 24 weeks of exposure...
  57. doi request reprint Low-grade myofibroblastic sarcoma of the maxillary region in a dog
    T Tsuchiya
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Comp Pathol 147:42-5. 2012
    ..These results suggested that the neoplastic cells were derived from myofibroblasts and that the tumour was a low-grade myofibroblastic sarcoma...
  58. ncbi request reprint Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501 Tokyo, Japan
    Arch Toxicol 78:232-40. 2004
    ..The difference in the pituitary effect between MXC and EE is discussed...
  59. ncbi request reprint Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Food Chem Toxicol 45:1507-15. 2007
    ....
  60. ncbi request reprint Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Tokyo, Japan
    J Toxicol Sci 33:11-24. 2008
    ..Therefore, poor lactational ACR-exposure due to maternal toxicity might account for the lack of ACR-induced offspring toxicity other than retarded body growth...
  61. ncbi request reprint Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 18:23-33. 2004
    ..The results thus demonstrated differential effects of perinatal EE depending on the basal diet used, with enhancement of typical estrogenic responses in females by potential soybean-derived factor(s)...
  62. doi request reprint Modification of dietary copper levels on the early stage of tumor-promotion with propylthiouracil in a rat two-stage thyroid carcinogenesis model
    Tomomi Shima
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Chem Biol Interact 180:262-70. 2009
    ..6 ppm. These results suggest an involvement of Cp and MT-1/2 on the thyroid tumor promotion that can be suppressed by dietary Cu level through inhibition of cell proliferation associated with altered redox balance...
  63. ncbi request reprint Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate
    Kyoung Youl Lee
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Arch Toxicol 79:531-41. 2005
    ..These antioxidative agents may therefore reduce/prevent ACR-induced toxicity, at least in the testes...
  64. ncbi request reprint A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat
    Hitoshi Fujimoto
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Pathol 34:164-7. 2006
    ..Collectively, these features meet the criteria for a GIST, with limited potential for differentiation to smooth muscle and neural cells...
  65. ncbi request reprint Immunotoxicity of nivalenol after subchronic dietary exposure to rats
    Atsutaka Kubosaki
    Division of Microbiology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:253-8. 2008
    ..4 mg/kg judging from the increase of NK activity, although nutritional suppression might have influenced the immunological changes appeared from 1.5mg/kg...
  66. ncbi request reprint Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats
    Ryosuke Nakamura
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Int Immunopharmacol 7:1630-8. 2007
    ..Most of the above-described changes had recovered to normal levels at PNW11. These results suggest that ATDs might have temporal immunomodulatory effects on the developing immune system...
  67. doi request reprint Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Carcinogenesis 29:2218-26. 2008
    ..Selective expression of Tfrc in proliferative lesions suggests an involvement of changes in iron homeostasis during the process of tumor promotion/progression driven by FB or PB...
  68. ncbi request reprint A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse
    Masayoshi Takabatake
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Vet Med Sci 70:483-5. 2008
    ..Based on the morphological and immunohistochemical findings, this tumor was diagnosed as a MESTK...
  69. doi request reprint Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model
    Shigeo Masuda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Cancer Sci 100:2444-50. 2009
    ....