Shigeki Sekine

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. doi request reprint Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer
    Masau Sekiguchi
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol 48:706-12. 2013
  2. doi request reprint Dicer is required for proper liver zonation
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
    J Pathol 219:365-72. 2009
  3. doi request reprint Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan 104 0045
    Carcinogenesis 32:622-8. 2011
  4. pmc Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 136:2304-2315.e1-4. 2009
  5. doi request reprint Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 102:1742-7. 2011
  6. doi request reprint Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 229:579-87. 2013
  7. ncbi request reprint Repeatedly recurrent colon cancer involving the appendiceal orifice after endoscopic piecemeal mucosal resection: a case report
    Masau Sekiguchi
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Korean J Gastroenterol 61:286-9. 2013
  8. doi request reprint Frequent activating GNAS mutations in villous adenoma of the colorectum
    Masayoshi Yamada
    Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 228:113-8. 2012
  9. doi request reprint Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours
    Akiko Matsubara
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Histopathology 62:657-61. 2013
  10. ncbi request reprint Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract
    Umio Yamaguchi
    Divisions of Orthopedic Oncology and Pathology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 14:46-51. 2006

Collaborators

Detail Information

Publications40

  1. doi request reprint Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer
    Masau Sekiguchi
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol 48:706-12. 2013
    ....
  2. doi request reprint Dicer is required for proper liver zonation
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
    J Pathol 219:365-72. 2009
    ..Dicer is essential for the suppression of periportal proteins by Wnt/beta-catenin/TCF signalling, albeit it likely acts in an indirect manner...
  3. doi request reprint Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan 104 0045
    Carcinogenesis 32:622-8. 2011
    ..In addition, illegitimate deletion mutations should be recognized as potential adverse effects of the Cre-loxP system...
  4. pmc Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 136:2304-2315.e1-4. 2009
    ..We describe experiments to address the physiologic roles of these new regulators of gene expression in the liver that are as of yet largely undefined...
  5. doi request reprint Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 102:1742-7. 2011
    ..As SLCO1B3 is involved in the uptake of a number of chemotherapeutic and diagnostic agents, SLCO1B3 expression and the status of CTNNB1 mutation might need to be considered in the drug delivery to HCC...
  6. doi request reprint Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 229:579-87. 2013
    ..In particular, the present study identified the frequent presence of activating GNAS mutations, which are often associated with KRAS mutations, as a characteristic genetic feature of PGAs of the stomach and duodenum...
  7. ncbi request reprint Repeatedly recurrent colon cancer involving the appendiceal orifice after endoscopic piecemeal mucosal resection: a case report
    Masau Sekiguchi
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Korean J Gastroenterol 61:286-9. 2013
    ..This case is important in considering indication for endoscopic resection in colorectal tumors involving the appendiceal orifice...
  8. doi request reprint Frequent activating GNAS mutations in villous adenoma of the colorectum
    Masayoshi Yamada
    Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 228:113-8. 2012
    ..The current study showed that the presence of activating GNAS mutations, in association with KRAS or BRAF mutations, is a characteristic genetic feature of colorectal villous adenoma...
  9. doi request reprint Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours
    Akiko Matsubara
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Histopathology 62:657-61. 2013
    ..To determine the prevalence of MED12 mutations in smooth muscle tumours of different organs...
  10. ncbi request reprint Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract
    Umio Yamaguchi
    Divisions of Orthopedic Oncology and Pathology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 14:46-51. 2006
    ....
  11. doi request reprint Long-term outcome of endoscopic resection of superficial adenocarcinoma of the esophagogastric junction
    Masayoshi Yamada
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 45:992-6. 2013
    ..The aim of the present study was to report the long-term follow-up and outcomes of endoscopic submucosal dissection (ESD), a representative endoscopic resection method, for the management of superficial AEGJ...
  12. ncbi request reprint High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Mod Pathol 17:1421-6. 2004
    ..These results imply that fundic gland polyps and high-grade dysplasia of the stomach have distinct preferences for APC genotypes in their development...
  13. doi request reprint Different histological status of gastritis in superficial adenocarcinoma of the esophagogastric junction
    Masayoshi Yamada
    5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 44:65-71. 2014
    ..We aim to investigate the histological status of gastritis in the background fundic gland mucosa of adenocarcinoma of the esophagogastric junction...
  14. ncbi request reprint Beta-catenin mutations in pulmonary blastomas: association with morule formation
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    J Pathol 200:214-21. 2003
    ..The presence of this common genetic alteration found in both WDFA and BPB implies a histogenetic linkage between these tumours...
  15. doi request reprint Favorable long-term outcomes of endoscopic submucosal dissection for locally recurrent early gastric cancer after endoscopic resection
    Masau Sekiguchi
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 45:708-13. 2013
    ..We aimed to evaluate the effectiveness, safety, and long-term clinical outcomes of ESD performed for locally recurrent EGC...
  16. doi request reprint Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma
    Tomohiro Yamaguchi
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Histopathology 61:162-9. 2012
    ..Mucinous adenocarcinoma (MUC) is a histological variant of colorectal adenocarcinoma. The aim of the present study was to characterize clinicopathological features and identify prognostic factors of MUCs...
  17. doi request reprint Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion
    Rie Ohtomo
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 62:356-9. 2012
    ..Our observations imply that SIN may be a precursor of anal canal NEC and that HPV18 may play an important role in the histogenesis of anal canal NEC, similar to its role in cervical NEC...
  18. doi request reprint Histologic and immunohistochemical analyses of α-fetoprotein--producing cancer of the stomach
    Tetsu Kinjo
    Pathology, Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 36:56-65. 2012
    ....
  19. doi request reprint Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis
    Michihiro Ishida
    Gastric Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 37:949-59. 2013
    ..03). Although gastric NECs exhibit significant morphologic diversity, their histologic subclassification is unlikely to be of immediate clinical relevance...
  20. pmc Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukuji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 163:1707-12. 2003
    ..Although ameloblastoma closely resembles COC histologically, the two have genetically distinctive features...
  21. doi request reprint Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
    Virchows Arch 454:513-7. 2009
    ..The present study implies that esophageal melanomas have genetic alterations unique from those observed in other mucosal melanomas...
  22. ncbi request reprint Two distinct pathways of tumorigenesis of adenocarcinomas of the esophagogastric junction, related or unrelated to intestinal metaplasia
    Souya Nunobe
    Clinical Laboratory Division, National Cancer Center Central Hospital, Tokyo, Japan
    Pathol Int 57:315-21. 2007
    ..It is suggested that AEGJ may develop via two distinct pathways in Japanese patients: IM-related and IM-unrelated...
  23. doi request reprint Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas
    Daisuke Ban
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 34:1025-36. 2010
    ..These findings suggest that a significant proportion of ACC shows IPG, which is potentially linked to less aggressive clinicopathologic characteristics...
  24. pmc Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukuji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 161:1997-2001. 2002
    ..Thus, at least a subset of adamantinomatous craniopharyngioma is considered to be biphasic...
  25. ncbi request reprint CD10 expression in colorectal carcinoma correlates with liver metastasis
    Yoshiya Fujimoto
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Dis Colon Rectum 48:1883-9. 2005
    ..If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis...
  26. pmc Dome-type carcinoma of the colon; a rare variant of adenocarcinoma resembling a submucosal tumor: a case report
    Masayoshi Yamada
    Pathology Division, National Cancer Center Hospital, Tokyo, Japan
    BMC Gastroenterol 12:21. 2012
    ..Most of the previously reported cases were early lesions and no endoscopic observations have been described so far. We herein report a case of a DC invading the subserosal layer, including endoscopic findings...
  27. pmc Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 164:2269-78. 2004
    ..Collectively, our results suggest that cytoplasmic p120ctn may contribute to the invasive phenotype of E-cadherin-deficient breast cancer cells...
  28. doi request reprint Hepatocyte nuclear factor 4A expression discriminates gastric involvement by metastatic breast carcinomas from primary gastric adenocarcinomas
    Taiga Koyama
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, 104 0045 Tokyo, Japan
    Hum Pathol 42:1777-84. 2011
    ..In particular, the present study identified hepatocyte nuclear factor 4A as an excellent marker for differentiating the 2 lesions...
  29. ncbi request reprint Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 21:5906-11. 2002
    ..Although beta-catenin stabilization affects some biological characteristics including adhesive properties, it may not have growth-promoting effects at least in some colorectal carcinomas...
  30. doi request reprint Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells
    Hirokazu Ohata
    Division of Cancer Differentiation, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 72:5101-10. 2012
    ..We propose that the transition from CD44(-/low) to CD44(high) state helps to maintain a CD44(high) fraction and the tumorigenic diversity in colon cancer...
  31. doi request reprint Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma
    Ryoji Kushima
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 63:318-25. 2013
    ..Based on these observations, we suggest that both GAFGs and PGAs are closely related lesions characterized by a mucous neck cell/chief cell lineage phenotype...
  32. doi request reprint NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma
    Akihiko Yoshida
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 36:993-9. 2012
    ..All the other non-Ewing tumors tested were negative for this marker. NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors...
  33. doi request reprint Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells
    Jun Okamura
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Pathol 63:266-9. 2010
    ..This is the first report of a carcinosarcoma originating in IPMC. These findings imply that carcinosarcoma with a heterologous mesenchymal component is of ductal origin...
  34. doi request reprint Overexpression of α-methylacyl-CoA racemase is associated with CTNNB1 mutations in hepatocellular carcinomas
    Shigeki Sekine
    Pathology Division, National Cancer Centre Research Institute, Tokyo, Japan
    Histopathology 58:712-9. 2011
    ..The aim of this study was to investigate the relationship between AMACR expression and the presence of CTNNB1 mutations in HCCs...
  35. doi request reprint Pulmonary neuroendocrine tumors with nuclear inclusion
    Saori Kobayashi
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Pathol Res Pract 209:574-7. 2013
    ..The mechanisms of nuclear inclusion differed, with one due to herniation of the cytoplasm into the nucleus (pseudoinclusion) and the other due to accumulation of biotin resulting from a CTNNB1 gene mutation. ..
  36. doi request reprint Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray
    Junichi Matsubara
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2195-203. 2011
    ..The aim of this study was to identify a new plasma biomarker for use in early detection of colorectal cancer...
  37. ncbi request reprint Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis
    Umio Yamaguchi
    Divisions of Orthopaedic Oncology, Pathology and Clinical Laboratory, National Cancer Centre Hospital and Research Institute, Tokyo, Japan
    Virchows Arch 445:142-50. 2004
    ....
  38. doi request reprint Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging: radiological-pathological correlation
    Hiroyasu Fujiwara
    Diagnostic Radiology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Radiol 29:739-43. 2011
    ..Ring-like enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may be an important clue for the diagnosis of small FNH...
  39. doi request reprint Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan
    Gastroenterology 145:1300-11. 2013
    ..Reduced p27Kip1 increases degradation of the transcription factor CDX2; levels of CDX2 have been reported to decrease during progression of BE to EAC...
  40. ncbi request reprint Beta-catenin mutations in sporadic fundic gland polyps
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute and Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Virchows Arch 440:381-6. 2002
    ..Therefore, a significant proportion of sporadic FGPs have genetic alterations involving beta-catenin stabilization, as did FAP-associated FGPs...