Research Topics
Genomes and Genes | Shigeki SekineSummaryAffiliation: National Cancer Center Country: Japan Publications
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Publications
Dome-type carcinoma of the colon; a rare variant of adenocarcinoma resembling a submucosal tumor: a case reportMasayoshi Yamada
Pathology Division, National Cancer Center Hospital, Tokyo, Japan
BMC Gastroenterol 12:21. 2012..Most of the previously reported cases were early lesions and no endoscopic observations have been described so far. We herein report a case of a DC invading the subserosal layer, including endoscopic findings...
Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinomaShigeki Sekine
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Cancer Sci 102:1742-7. 2011..As SLCO1B3 is involved in the uptake of a number of chemotherapeutic and diagnostic agents, SLCO1B3 expression and the status of CTNNB1 mutation might need to be considered in the drug delivery to HCC...- Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesisShigeki Sekine
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Gastroenterology 136:2304-2315.e1-4. 2009..We describe experiments to address the physiologic roles of these new regulators of gene expression in the liver that are as of yet largely undefined... - Dicer is required for proper liver zonationShigeki Sekine
Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
J Pathol 219:365-72. 2009..Dicer is essential for the suppression of periportal proteins by Wnt/beta-catenin/TCF signalling, albeit it likely acts in an indirect manner... - Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse modelShigeki Sekine
Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan 104 0045
Carcinogenesis 32:622-8. 2011..In addition, illegitimate deletion mutations should be recognized as potential adverse effects of the Cre-loxP system... - Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenumAkiko Matsubara
Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
J Pathol 229:579-87. 2013..In particular, the present study identified the frequent presence of activating GNAS mutations, which are often associated with KRAS mutations, as a characteristic genetic feature of PGAs of the stomach and duodenum... - Frequent activating GNAS mutations in villous adenoma of the colorectumMasayoshi Yamada
Pathology and Clinical Laboratory, National Cancer Centre Hospital, Tokyo, Japan
J Pathol 228:113-8. 2012..The current study showed that the presence of activating GNAS mutations, in association with KRAS or BRAF mutations, is a characteristic genetic feature of colorectal villous adenoma... - Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumoursAkiko Matsubara
Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
Histopathology 62:657-61. 2013..To determine the prevalence of MED12 mutations in smooth muscle tumours of different organs... - Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cellsHirokazu Ohata
Division of Cancer Differentiation, National Cancer Center Research Institute, Tokyo, Japan
Cancer Res 72:5101-10. 2012..We propose that the transition from CD44(-/low) to CD44(high) state helps to maintain a CD44(high) fraction and the tumorigenic diversity in colon cancer... - Overexpression of α-methylacyl-CoA racemase is associated with CTNNB1 mutations in hepatocellular carcinomasShigeki Sekine
Pathology Division, National Cancer Centre Research Institute, Tokyo, Japan
Histopathology 58:712-9. 2011..The aim of this study was to investigate the relationship between AMACR expression and the presence of CTNNB1 mutations in HCCs... - Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreasDaisuke Ban
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Am J Surg Pathol 34:1025-36. 2010..These findings suggest that a significant proportion of ACC shows IPG, which is potentially linked to less aggressive clinicopathologic characteristics... - Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cellsJun Okamura
Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
J Clin Pathol 63:266-9. 2010..This is the first report of a carcinosarcoma originating in IPMC. These findings imply that carcinosarcoma with a heterologous mesenchymal component is of ductal origin... - Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinomaTomohiro Yamaguchi
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
Histopathology 61:162-9. 2012..Mucinous adenocarcinoma (MUC) is a histological variant of colorectal adenocarcinoma. The aim of the present study was to characterize clinicopathological features and identify prognostic factors of MUCs... - Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging: radiological-pathological correlationHiroyasu Fujiwara
Diagnostic Radiology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
Jpn J Radiol 29:739-43. 2011..Ring-like enhancement during the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may be an important clue for the diagnosis of small FNH... - Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarrayJunichi Matsubara
Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
Cancer Epidemiol Biomarkers Prev 20:2195-203. 2011..The aim of this study was to identify a new plasma biomarker for use in early detection of colorectal cancer... - Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sitesShigeki Sekine
Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
Virchows Arch 454:513-7. 2009..The present study implies that esophageal melanomas have genetic alterations unique from those observed in other mucosal melanomas... 
CD10 expression in colorectal carcinoma correlates with liver metastasisYoshiya Fujimoto
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
Dis Colon Rectum 48:1883-9. 2005..CONCLUSIONS: CD10 expression in colorectal carcinoma is a good predictor of liver metastasis...- Beta-catenin mutations in sporadic fundic gland polypsShigeki Sekine
Pathology Division, National Cancer Center Research Institute and Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Virchows Arch 440:381-6. 2002..Therefore, a significant proportion of sporadic FGPs have genetic alterations involving beta-catenin stabilization, as did FAP-associated FGPs...