Yasushi Satoh

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. ncbi Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Neurosci 27:10765-76. 2007
  2. doi Pulmonary blast injury in mice: a novel model for studying blast injury in the laboratory using laser-induced stress waves
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Lasers Surg Med 42:313-8. 2010
  3. ncbi ERK2 contributes to the control of social behaviors in mice
    Yasushi Satoh
    Department of Anesthesiology, National Defense Medical College, 359 8513 Tokorozawa, Japan
    J Neurosci 31:11953-67. 2011
  4. doi Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice
    Yasushi Satoh
    Department of Anesthesiology, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Neurosci 31:1149-55. 2011
  5. doi ERK2 dependent signaling contributes to wound healing after a partial-thickness burn
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Biochem Biophys Res Commun 381:118-22. 2009
  6. doi Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system
    Yukiko Otsubo
    Department of Anesthesiology, National Defense Medical College, Tokorozawa 359 8513, Japan
    Pain 153:2241-52. 2012
  7. doi Analysis of extracellular signal-regulated kinase 2 function in neural stem/progenitor cells via nervous system-specific gene disruption
    Osamu Imamura
    Department of Biochemistry, National Defense Medical College, Namiki, Tokorozawa, Japan
    Stem Cells 26:3247-56. 2008
  8. doi Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice
    Ryuji Yonamine
    Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 118:105-13. 2013
  9. ncbi Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
    Maiko Satomoto
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 110:628-37. 2009
  10. doi Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood
    Yumiko Takaenoki
    From the Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 120:403-15. 2014

Collaborators

Detail Information

Publications17

  1. ncbi Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Neurosci 27:10765-76. 2007
    ..The ERK1 expression level of the knockdown mice was comparable with the wild-type control. Together, our results indicate a noncompensable role of ERK2-dependent signal transduction in learning and memory...
  2. doi Pulmonary blast injury in mice: a novel model for studying blast injury in the laboratory using laser-induced stress waves
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Lasers Surg Med 42:313-8. 2010
    ..The aim of this study was to establish a small-animal model for blast injuries, using laser-induced stress waves (LISWs) with high controllability, high reproducibility, and easy experimental settings...
  3. ncbi ERK2 contributes to the control of social behaviors in mice
    Yasushi Satoh
    Department of Anesthesiology, National Defense Medical College, 359 8513 Tokorozawa, Japan
    J Neurosci 31:11953-67. 2011
    ..Our findings suggest that ERK2 has complex and multiple roles in the CNS, with important implications for human psychiatric disorders characterized by deficits in social behaviors...
  4. doi Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice
    Yasushi Satoh
    Department of Anesthesiology, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Neurosci 31:1149-55. 2011
    ..These results suggest that total ERK1/2 activity governs cellular behaviors to ensure proper brain development...
  5. doi ERK2 dependent signaling contributes to wound healing after a partial-thickness burn
    Yasushi Satoh
    Department of Biochemistry, National Defense Medical College, 3 2 Namiki, Tokorozawa 359 8513, Japan
    Biochem Biophys Res Commun 381:118-22. 2009
    ..An in vitro proliferation assay revealed that keratinocytes from Erk2(+/-) mice grew significantly slower than those prepared from wild-type. These results highlight the importance of ERK2 in the process of burn healing...
  6. doi Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system
    Yukiko Otsubo
    Department of Anesthesiology, National Defense Medical College, Tokorozawa 359 8513, Japan
    Pain 153:2241-52. 2012
    ..Together, these results indicate that ERK2 plays a predominant and/or specific role in pain plasticity, while the contribution of ERK1 is limited...
  7. doi Analysis of extracellular signal-regulated kinase 2 function in neural stem/progenitor cells via nervous system-specific gene disruption
    Osamu Imamura
    Department of Biochemistry, National Defense Medical College, Namiki, Tokorozawa, Japan
    Stem Cells 26:3247-56. 2008
    ....
  8. doi Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice
    Ryuji Yonamine
    Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 118:105-13. 2013
    ..In an investigation of potential therapies that could protect against this type of damage, we studied the effects of molecular hydrogen on anesthetic-induced neurotoxicity in the developing mouse brain...
  9. ncbi Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
    Maiko Satomoto
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 110:628-37. 2009
    ..The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities...
  10. doi Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood
    Yumiko Takaenoki
    From the Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 120:403-15. 2014
    ..These abnormalities include not only reduced learning abilities but also impaired social behaviors, suggesting pervasive deficits in brain functioning. But the underlying features of these deficits are still largely unknown...
  11. doi Induction of cell migration of neural progenitor cells in vitro by alpha-1 adrenergic receptor and dopamine D1 receptor stimulation
    Takeshi Hiramoto
    Departments of Pharmacology, National Defense Medical College, Tokorozawa, Japan
    Neuroreport 19:793-7. 2008
    ..Our results suggest that alpha-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively...
  12. ncbi Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus
    Takeshi Hiramoto
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Japan
    Neuroreport 18:659-64. 2007
    ..Thus, we suggest that the stimulation of dopamine D2 receptors increases the proliferation of neural progenitor cells both in vivo and in vitro...
  13. pmc Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction
    Takehiko Kujiraoka
    Division of Cardiovascular Medicine, Department of Internal Medicine, National Defense Medical College, Sayama, Japan
    J Am Heart Assoc 2:e000361. 2013
    ..The liver plays a central role in metabolism, and hepatosteatosis is associated with vascular diseases. The aim of study was to elucidate the role of hepatic ERK2 in hepatosteatosis, metabolic remodeling, and endothelial dysfunction...
  14. doi Neonatal desflurane exposure induces more robust neuroapoptosis than do isoflurane and sevoflurane and impairs working memory
    Mitsuyoshi Kodama
    Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 115:979-91. 2011
    ..In animal models, neonatal exposure to volatile anesthetics induces neuroapoptosis, leading to memory deficits in adulthood. However, effects of neonatal exposure to desflurane are largely unknown...
  15. ncbi Molecular hydrogen attenuates neuropathic pain in mice
    Masanori Kawaguchi
    Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    PLoS ONE 9:e100352. 2014
    ..In conclusion, oral administration of hydrogen water may be useful for alleviating neuropathic pain in a clinical setting. ..
  16. doi Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture
    Yoshiaki Ueda
    Department of Ophthalmology, National Defense Medical College, Saitama, Japan
    Invest Ophthalmol Vis Sci 50:1978-87. 2009
    ..Reconstruction of acinarlike structures in three-dimensional culture conditions from this epithelial cell population was attempted...
  17. ncbi A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives
    Shogo Endo
    Unit for Molecular Neurobiology of Learning and Memory, Initial Research Project, Okinawa Institute of Science and Technology, Uruma, Japan
    Biochem Biophys Res Commun 341:261-5. 2006
    ..These results suggest that the Gln residue of subdomain V is important in determining the susceptibility of ERK1/2 to 1NA-PP1 without significant changes in their enzymatic characteristics...