Mamoru Satoh

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and Toll-like receptor 4 signal
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Japan
    Immunobiology 217:533-9. 2012
  2. ncbi A cellular microRNA, let-7i, is a novel biomarker for clinical outcome in patients with dilated cardiomyopathy
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine, and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan
    J Card Fail 17:923-9. 2011
  3. ncbi The expression of TNF-alpha converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction
    M Satoh
    Department of Internal Medicine II and Memorial Heart Centre, Iwate Medical University School of Medicine, Iwate, Japan
    Eur J Clin Invest 38:97-105. 2008
  4. ncbi Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 6:869-75. 2004
  5. ncbi Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease
    Mamoru Satoh
    Department of Internal Medicine II and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Atherosclerosis 198:347-53. 2008
  6. ncbi Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine Uchimaru 19 1, Morioka, Iwate, Japan
    Int J Cardiol 109:226-34. 2006
  7. ncbi C-reactive protein co-expresses with tumor necrosis factor-alpha in the myocardium in human dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 7:748-54. 2005
  8. ncbi Myocardial osteopontin expression is associated with collagen fibrillogenesis in human dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 7:755-62. 2005
  9. ncbi Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Am Heart J 154:581-8. 2007
  10. ncbi Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Lab Invest 84:173-81. 2004

Collaborators

Detail Information

Publications42

  1. ncbi Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and Toll-like receptor 4 signal
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Japan
    Immunobiology 217:533-9. 2012
    ..This study suggests that atorvastatin down-regulates TLR4 signal via let-7i expression in CAD patients, possibly contributing to the beneficial effects of atorvastatin on let-7i-mediated TLR4 signal in this disorder...
  2. ncbi A cellular microRNA, let-7i, is a novel biomarker for clinical outcome in patients with dilated cardiomyopathy
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine, and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan
    J Card Fail 17:923-9. 2011
    ..The aim of this study was to determine whether let-7i, miR-21, miR-126, and miR-155 are expressed with TLR4 in human DCM, and whether let-7i levels are related to clinical outcomes...
  3. ncbi The expression of TNF-alpha converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction
    M Satoh
    Department of Internal Medicine II and Memorial Heart Centre, Iwate Medical University School of Medicine, Iwate, Japan
    Eur J Clin Invest 38:97-105. 2008
    ..This study analysed TACE-mediated TNF-alpha shedding at the site of ruptured plaques in AMI patients and compared them with a systemic mechanism...
  4. ncbi Increased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 6:869-75. 2004
    ....
  5. ncbi Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease
    Mamoru Satoh
    Department of Internal Medicine II and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Atherosclerosis 198:347-53. 2008
    ..These results suggest that EPC telomere shortening via increased oxidative DNA damage may play an important role in the pathogenesis of CAD. In addition, MS may be related to increased oxidative DNA damage and EPC telomere shortening...
  6. ncbi Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine Uchimaru 19 1, Morioka, Iwate, Japan
    Int J Cardiol 109:226-34. 2006
    ..Activation of TLR4 through a myocytic inflammatory reaction is associated with HF after AMI. These observations suggest that TLR4 signaling in monocytes may play a role in the development of HF after AMI...
  7. ncbi C-reactive protein co-expresses with tumor necrosis factor-alpha in the myocardium in human dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 7:748-54. 2005
    ..Cardiac expression of tumor necrosis factor-alpha (TNF-alpha) plays an important role in the pathogenesis of dilated cardiomyopathy (DCM)...
  8. ncbi Myocardial osteopontin expression is associated with collagen fibrillogenesis in human dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 7:755-62. 2005
    ..Osteopontin (OPN), an extracellular matrix (ECM) protein, plays an important role in myocardial remodeling by promoting collagen synthesis and accumulation in experimental animal models...
  9. ncbi Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Am Heart J 154:581-8. 2007
    ..The purpose of this study was to determine whether TLR8 was expressed with EV replication in patients with enterovirus-associated DCM...
  10. ncbi Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Lab Invest 84:173-81. 2004
    ..EV RNA and TLR4 mRNA levels may correlate with LV dysfunction in DCM. The expression of TLR4 against EV replication may be involved in the pathogenesis of DCM...
  11. ncbi Role of Toll like receptor signaling pathway in ischemic coronary artery disease
    Mamoru Satoh
    Department of Internal Medicine II and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Japan
    Front Biosci 13:6708-15. 2008
    ..A better understanding of TLR signal may provide a novel therapeutic agent for the treatment of CAD. This review summarizes the relationship between the pathogenesis of ischemic coronary artery disease and the human TLR system...
  12. ncbi Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan
    J Card Fail 16:404-10. 2010
    ....
  13. ncbi Immune modulation: role of the inflammatory cytokine cascade in the failing human heart
    Mamoru Satoh
    Department of Internal Medicine II and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Curr Heart Fail Rep 5:69-74. 2008
    ..Thus, in view of the emerging importance of TNF-alpha in the pathogenesis of HF, we review the effects of TNF-alpha on the physiology of the heart and the development of clinical strategies to target the inflammatory cytokine cascade...
  14. ncbi Effect of intensive lipid-lowering therapy on telomere erosion in endothelial progenitor cells obtained from patients with coronary artery disease
    Mamoru Satoh
    Division of Cardiology and Memorial Heart Center, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 116:827-35. 2009
    ..In conclusion, the present study has demonstrated that intensive LLT may prevent EPC telomere erosion in patients with CAD, possibly contributing to the beneficial effects of intensive LLT in this disorder...
  15. ncbi Expression of Toll-like receptor 4 is associated with enteroviral replication in human myocarditis
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 104:577-84. 2003
    ..The present study has shown that increased expression of TLR4 is associated with EV replication and that these RNA levels are related to cardiac dysfunction in human myocarditis...
  16. ncbi Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Eur J Heart Fail 8:810-5. 2006
    ..Recent studies have shown that heat shock protein (HSP) 70 may serve as a "damage signal" to the immune system and could be the endogenous ligand for Toll-like receptor (TLR) 4 mediating synthesis of inflammatory cytokines...
  17. ncbi Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 102:381-6. 2002
    ..In addition, CYP11B2 expression and cardiac fibrosis are found to be decreased in CHF patients on drug therapy comprising spironolactone combined with ACEIs...
  18. ncbi Prospective, randomized, single-blind comparison of effects of 6 months of treatment with telmisartan versus enalapril on high-molecular-weight adiponectin concentrations in patients with coronary artery disease
    Mamoru Satoh
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Morioka, Iwate, Japan
    Clin Ther 31:2113-25. 2009
    ..High-molecular-weight (HMW) adiponectin has important antiatherosclerotic properties...
  19. ncbi Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels
    Yuji Takahashi
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 119:395-405. 2010
    ..The present study demonstrates that combined treatment with an ARB and a statin decreases miR-146a/b and the TLR4 signal in CAD patients, possibly contributing to the anti-atherogenic effects of ARBs and statins in this disorder...
  20. ncbi MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
    Tsuyoshi Tabuchi
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan
    Clin Sci (Lond) 123:161-71. 2012
    ....
  21. ncbi A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    J Card Fail 13:114-9. 2007
    ..The purpose of this study was to determine whether FROUNT is expressed with CCR2 and its ligand (CCL2) in failing human heart...
  22. ncbi Increased mRNA expression of tumour necrosis factor-alpha and its converting enzyme in circulating leucocytes of patients with acute myocardial infarction
    Tomonari Akatsu
    Second Department of Internal Medicine, Iwate Medical University, 19 1 Uchimaru, Morioka, Iwate 020 8505, Japan
    Clin Sci (Lond) 105:39-44. 2003
    ..60, P <0.01). The TACE-TNF-alpha system in circulating leucocytes is stimulated and may have a negative impact on clinical outcome in AMI...
  23. ncbi Activated tumour necrosis factor-alpha shedding process is associated with in-hospital complication in patients with acute myocardial infarction
    Yudai Shimoda
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Iwate, Japan
    Clin Sci (Lond) 108:339-47. 2005
    ..These results demonstrate that TACE-mediated TNF-alpha maturation in PBMCs may play an important role in poor outcomes from AMI, suggesting that TACE may be a potential target for the inhibition of cellular TNF-alpha production in AMI...
  24. ncbi Prospective, randomized, single-blind comparison of effects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease
    Yuji Takahashi
    Department of Internal Medicine, Division of Cardiology and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka, Iwate 020 8505, Japan
    Heart Vessels 27:337-43. 2012
    ..This study suggests that LLT with atorvastatin decreases leptin levels and angiogenic factors in patients with CAD, possibly contributing to the beneficial effects of LLT with atorvastatin in CAD...
  25. ncbi Expression and localization of tumour necrosis factor-alpha and its converting enzyme in human abdominal aortic aneurysm
    Hidetoshi Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Clin Sci (Lond) 106:301-6. 2004
    ..In conclusion, the concomitant activation and localization of TNF-alpha and TACE in the media and adventitia of the transition zone in human AAA underlines the importance of this system in the pathogenesis of this disorder...
  26. ncbi Local expression of Toll-like receptor 4 at the site of ruptured plaques in patients with acute myocardial infarction
    Yuh Ishikawa
    Department of Internal Medicine II and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru 19 1, Morioka 020 8505, Iwate, Japan
    Clin Sci (Lond) 115:133-40. 2008
    ..In conclusion, expression of both systemic and local plaque TLR4 may be one of the mechanisms responsible for the pathogenesis of AMI...
  27. ncbi Reversible restrictive cardiomyopathy due to light-chain deposition disease
    Motoyuki Nakamura
    Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Mayo Clin Proc 77:193-6. 2002
    ..We emphasize that restrictive cardiomyopathy due to light-chain deposition may be reversible and have a relatively better prognosis after remission of plasma cell dyscrasias...
  28. ncbi Short consensus probes with 3'-minor groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas
    Michihiro Uchiyama
    Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19-1, 020-8505 Morioka, Japan
    Lab Invest 84:932-6. 2004
    ..6%) than with the non-MGB probes (23/59, 39.0%) designed by Donovan et al. MGB technology is useful for the design of consensus fluorogenically labeled probes of the IgH gene for detecting MRD...
  29. ncbi Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis
    M Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
    J Am Coll Cardiol 36:1288-94. 2000
    ..We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis...
  30. ncbi Establishment of gingival epithelial cell lines from transgenic mice harboring temperature sensitive simian virus 40 large T-antigen gene
    S Hatakeyama
    Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    J Oral Pathol Med 30:296-304. 2001
    ..The GE cell lines thus could serve as an excellent experimental system for further studies on the physiology of gingival epithelium and corresponding diseases, such as periodontal disease, epithelial hyperplasia, and gingival tumors...
  31. ncbi Tumor necrosis factor-alpha-converting enzyme and tumor necrosis factor-alpha in human dilated cardiomyopathy
    M Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Circulation 99:3260-5. 1999
    ..The aim of this study was to determine whether TACE is expressed with TNF-alpha in myocardium and whether levels of TACE and TNF-alpha are related to clinical severity of DCM...
  32. ncbi Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease
    Y Minami
    Iwate Medical University School of Medicine, Iwate, Japan
    Eur J Clin Invest 39:359-67. 2009
    ..We therefore investigated whether LLT with statins might affect miR-221/222 expression in EPCs obtained from patients with coronary artery disease (CAD)...
  33. ncbi Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse
    Naoko Kumagai
    Laboratory of Immunobiology, Department of Life Science, Niigata University Graduate School of Science and Technology, 950 2181, Niigata City, Niigata, Japan
    Brain Res 1185:75-85. 2007
    ..Neuroinflammation is a possible mechanism of age-associated neurodegeneration in SAMP10 mice...
  34. ncbi Functional characterization of 3 thioredoxin homology domains of ERp72
    Mamoru Satoh
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
    Cell Stress Chaperones 10:278-84. 2005
    ..This assignment of functions to individual domains is similar to that observed in other PDI domains, which is consistent with the high sequence homology between ERp and PDI domains...
  35. ncbi Age-related loss of synapses in the frontal cortex of SAMP10 mouse: a model of cerebral degeneration
    Atsuyoshi Shimada
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan
    Synapse 48:198-204. 2003
    ....
  36. ncbi Involvement of platelet-activating factor and LIS1 in neuronal migration
    Suzumi M Tokuoka
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, CREST of JST, Tokyo 113 0033, Japan
    Eur J Neurosci 18:563-70. 2003
    ....
  37. ncbi Age-related progressive neuronal DNA damage associated with cerebral degeneration in a mouse model of accelerated senescence
    Atsuyoshi Shimada
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Japan
    J Gerontol A Biol Sci Med Sci 57:B415-21. 2002
    ..SAMP10 is a useful mouse model of brain aging that mimics the progressive neuronal DNA damage associated with human neurodegenerative disorders...
  38. ncbi Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations
    Yoichi Chiba
    Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
    J Gerontol A Biol Sci Med Sci 60:1087-98. 2005
    ..These results suggest that cells from SAMP11 mice are useful models for spontaneous higher oxidative stress in vitro due to dysfunctional mitochondria...
  39. ncbi Detection of biomarkers for alcoholism by two-dimensional differential gel electrophoresis
    Di Wu
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Chiba, Japan
    Alcohol Clin Exp Res 31:S67-71. 2007
    ..Therefore, for novel markers need to be searched...
  40. ncbi Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin
    Kinnosuke Yahiro
    Departments of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Mol Microbiol 62:480-90. 2006
    ..These results suggested that SubAB recognizes alpha2beta1 integrin as a functional receptor; this first interaction may be an important key step leading to the SubAB-induced morphological changes in Vero cells...
  41. ncbi Differential cooperative enzymatic activities of protein disulfide isomerase family in protein folding
    Mamoru Satoh
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan
    Cell Stress Chaperones 10:211-20. 2005
    ..These data suggest that differential enzymatic activities of ERp proteins and PDI represent a complementary contribution of these enzymes to protein folding in the ER...
  42. ncbi Aberrant promoter hypermethylation in serum DNA from patients with silicosis
    Shigeki Umemura
    Department of Hematology, Oncology and Respiratory Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan
    Carcinogenesis 29:1845-9. 2008
    ..These results suggest that testing for aberrant promoter methylation of tumor suppressor genes using serum DNA may facilitate early detection of lung cancer in patients with silicosis...