Jun ichi Satoh

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Neuropathology 22:219-32. 2002
  2. ncbi request reprint Rapid identification of 14-3-3-binding proteins by protein microarray analysis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neurosci Methods 152:278-88. 2006
  3. ncbi request reprint The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neuropathol Exp Neurol 64:858-68. 2005
  4. ncbi request reprint Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neuropathol Exp Neurol 64:129-38. 2005
  5. ncbi request reprint Gene expression profile following stable expression of the cellular prion protein
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Cell Mol Neurobiol 24:793-814. 2004
  6. pmc The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 165:577-92. 2004
  7. ncbi request reprint Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neurol Sci 212:11-20. 2003
  8. pmc Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    BMC Neurol 6:18. 2006
  9. ncbi request reprint Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis
    Fumiko Koike
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Tokyo 187 8502, Kodaira, Japan
    J Neuroimmunol 139:109-18. 2003
  10. ncbi request reprint T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neuroimmunol 174:108-18. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Neuropathology 22:219-32. 2002
    ....
  2. ncbi request reprint Rapid identification of 14-3-3-binding proteins by protein microarray analysis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neurosci Methods 152:278-88. 2006
    ..These results suggest that protein microarray is a powerful tool for rapid and comprehensive profiling of 14-3-3-binding proteins...
  3. ncbi request reprint The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neuropathol Exp Neurol 64:858-68. 2005
    ....
  4. ncbi request reprint Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neuropathol Exp Neurol 64:129-38. 2005
    ....
  5. ncbi request reprint Gene expression profile following stable expression of the cellular prion protein
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Cell Mol Neurobiol 24:793-814. 2004
    ..This represents a possible mechanism underlying PrPC-mediated selective neurodegeneration...
  6. pmc The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 165:577-92. 2004
    ..These results suggest that the 14-3-3 protein plays an organizing role in the intermediate filament network in reactive astrocytes at the site of demyelinating lesions in MS...
  7. ncbi request reprint Detection of the 14-3-3 protein in the cerebrospinal fluid of Japanese multiple sclerosis patients presenting with severe myelitis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neurol Sci 212:11-20. 2003
    ....
  8. pmc Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    BMC Neurol 6:18. 2006
    ..The aim of this study is to identify a comprehensive list of early IFNbeta-responsive genes (IRGs) in peripheral blood mononuclear cells (PBMC) that may play a key role in induction of adverse effects...
  9. ncbi request reprint Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis
    Fumiko Koike
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Tokyo 187 8502, Kodaira, Japan
    J Neuroimmunol 139:109-18. 2003
    ..These genes included nine with IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some of the changes were unexpected but coincided with the beneficial effect of IFNbeta in MS...
  10. ncbi request reprint T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neuroimmunol 174:108-18. 2006
    ..These results suggest that T-cell gene expression profiling is valuable to identify distinct subgroups of MS associated with differential disease activity and therapeutic response to IFNbeta...
  11. doi request reprint Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University Department of Clinical Neuropathology, Tokyo, Japan
    Neuropathology 32:149-57. 2012
    ..These observations indicate that neuronal expression of pSyk was greatly enhanced in the cerebral cortex and the hippocampus of NHD brains, possibly via non-TREM2/DAP12 signaling pathways involved in Syk activation...
  12. doi request reprint Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Cell Mol Neurobiol 30:415-26. 2010
    ....
  13. ncbi request reprint Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses
    Jun ichi Satoh
    Department of Bioinformatics and Neuroinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Neurosci Res 56:61-72. 2006
    ..These observations suggest that 14-3-3sigma might serve as a marker of oxidative and DNA-damaging stresses inducing the mitotic checkpoint dysfunction in reactive astrocytes under pathological conditions...
  14. doi request reprint Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation
    Shinya Obayashi
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Cell Mol Neurobiol 29:423-38. 2009
    ....
  15. doi request reprint Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A
    Kenta Sumiyoshi
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo 204 8588, Japan
    Neuropathology 30:7-14. 2010
    ..Although CNP located chiefly in the cytoplasm of oligodendrocytes might not serve as a cell-surface NIG receptor, it could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo...
  16. ncbi request reprint Aberrant transcriptional regulatory network in T cells of multiple sclerosis
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, Tokyo, Japan
    Neurosci Lett 422:30-3. 2007
    ..This novel bioinformatic approach proposes the logical hypothesis that aberrant regulation of the complex transcriptional regulatory network contributes to development of pathogenic T cells in MS...
  17. ncbi request reprint Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Neuropathology 27:245-56. 2007
    ....
  18. doi request reprint Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathology 28:561-76. 2008
    ..These results suggest that profound activation of the macrophage-mediated proinflammatory immune mechanism plays a pivotal role in development of NMO brain lesions...
  19. pmc Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    PLoS ONE 8:e69130. 2013
    ..Our findings are expected to provide information needed to elucidate the molecular mechanism of decreased plasma UA levels in the clinical stage progression of PD. ..
  20. pmc BmDJ-1 is a key regulator of oxidative modification in the development of the silkworm, Bombyx mori
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    PLoS ONE 6:e17683. 2011
    ..These results suggest that BmDJ-1 might control oxidative stress in the cell due to NO and serves as a development modulation factor in B. mori...
  21. pmc Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Japan
    Dis Markers 25:27-35. 2008
    ....
  22. doi request reprint Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
    Takashi Yoshino
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Cell Mol Neurobiol 31:1009-20. 2011
    ..These observations suggest that FTY720-non-P-induced apoptosis of HMO6 human microglia is independent of S1P receptor binding, and positively regulated by the SREBP2-dependent proapoptotic signaling pathway...
  23. doi request reprint Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Cell Mol Neurobiol 32:337-43. 2012
    ..These results suggest that a molecular defect of DAP12 in human monocytes deregulates the gene network pivotal for maintenance of myeloid cell function in NHD...
  24. pmc Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains
    Tamako Misawa
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Acta Neuropathol 116:247-60. 2008
    ..These observations suggest the possible association of astrocytic AQP1 with Abeta deposition in AD brains...
  25. doi request reprint Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Neurosci Res 61:271-80. 2008
    ..These observations suggest that a molecular adaptor 14-3-3 and a molecular chaperone Hsp60 cooperate to achieve a wide range of cellular functions in B. mori...
  26. pmc Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan
    Dis Markers 27:239-52. 2009
    ....
  27. ncbi request reprint A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Alzheimers Res Ther 5:30. 2013
  28. ncbi request reprint [Recent progress in bioinformatics for microarray analysis]
    Jun ichi Satoh
    Department of Bioinformatics, Faculty of Pharmaceutical Sciences, Meiji Pharmaceutical University, Kiyose City, Tokyo, Japan
    Yakugaku Zasshi 128:1537-45. 2008
    ..Thus, the molecular network analysis is highly valuable to extract biological implications from a huge amount of microarray data...
  29. ncbi request reprint MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Japan
    J Pharmacol Sci 114:269-75. 2010
    ..This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains...
  30. doi request reprint TDP-43 dimerizes in human cells in culture
    Yuki Shiina
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio Kiyose, Tokyo, 204 8588, Japan
    Cell Mol Neurobiol 30:641-52. 2010
    ..These results suggest that the 86-kDa band represents dimerized TDP-43 expressed constitutively in normal cells under physiological conditions...
  31. ncbi request reprint [Molecular biomarkers for prediction of multiple sclerosis relapse]
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University
    Nihon Rinsho 66:1103-11. 2008
    ..Thus, DNA microarray technology is highly valuable to identify molecular mechanism-based biomarkers for classification of MS subgroups and prediction of MS relapse...
  32. pmc Dystrophic neurites express C9orf72 in Alzheimer's disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Alzheimers Res Ther 4:33. 2012
    ..At present, a pathological role of C9orf72 in the process of neurodegeneration remains unknown...
  33. doi request reprint Molecular network of microRNA targets in Alzheimer's disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Exp Neurol 235:436-46. 2012
    ....
  34. doi request reprint Immunohistochemical characterization of microglia in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University Department of Clinical Neuropathology, Tokyo, Japan
    Neuropathology 31:363-75. 2011
    ....
  35. ncbi request reprint Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurobiol Dis 18:537-50. 2005
    ..These results suggest that MS lymphocytes show a complex pattern of gene regulation that represents a counterbalance between promoting and preventing apoptosis and DNA damage of lymphocytes...
  36. ncbi request reprint [Molecular network analysis of multiple sclerosis brain lesion proteome]
    Jun ichi Satoh
    Department of Bioinformatics, Meiji Pharmaceutical University, Tokyo, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 33:182-8. 2010
    ..These observations indicate that the selective blockade of the interaction between ECM and integrins would be a rational approach for designing inhibitors of chronic inflammatory demyelination in MS brain lesions...
  37. doi request reprint Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Mult Scler 19:1035-45. 2013
    ..Vitamin D deficiency due to insufficient sunlight exposure confers an increased risk for multiple sclerosis (MS)...
  38. pmc A Comprehensive Profile of ChIP-Seq-Based STAT1 Target Genes Suggests the Complexity of STAT1-Mediated Gene Regulatory Mechanisms
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical, University, Noshio, Kiyose, Tokyo, Japan
    Gene Regul Syst Bio 7:41-56. 2013
    ..These results indicate that the binding of STAT1 to GAS is not sufficient to fully activate target genes, suggesting the high complexity of STAT1-mediated gene regulatory mechanisms...
  39. pmc Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Cancer Cell Int 12:14. 2012
    ..abstract:..
  40. pmc Comprehensive analysis of human microRNA target networks
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    BioData Min 4:17. 2011
    ..abstract:..