Kaoru Sato

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. pmc Discovery of a Tamoxifen-related compound that suppresses glial l-glutamate transport activity without interaction with estrogen receptors
    Kaoru Sato
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    ACS Chem Neurosci 3:105-13. 2012
  2. ncbi request reprint A 72 kDa heat shock protein is protective against the selective vulnerability of CA1 neurons and is essential for the tolerance exhibited by CA3 neurons in the hippocampus
    K Sato
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Neuroscience 109:745-56. 2002
  3. ncbi request reprint Effects of tamoxifen on L-glutamate transporters of astrocytes
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    J Pharmacol Sci 107:226-30. 2008
  4. ncbi request reprint beta-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Brain Res 1150:108-20. 2007
  5. ncbi request reprint Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    J Neurochem 86:1498-505. 2003
  6. ncbi request reprint Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Neuroendocrinology 76:223-34. 2002
  7. pmc L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammation
    Junpei Takaki
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    J Neuroinflammation 9:275. 2012
  8. ncbi request reprint Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner
    Kanako Takahashi
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences
    Biol Pharm Bull 36:1996-2004. 2013
  9. doi request reprint Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
    Yukari Shigemoto-Mogami
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Tokyo 158 8501, Japan, and Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Neurosci 34:2231-43. 2014
  10. ncbi request reprint Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid
    Atsuko Oguchi-Katayama
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 38:391-402. 2013

Collaborators

Detail Information

Publications13

  1. pmc Discovery of a Tamoxifen-related compound that suppresses glial l-glutamate transport activity without interaction with estrogen receptors
    Kaoru Sato
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    ACS Chem Neurosci 3:105-13. 2012
    ..Compound 3 may represent a new platform for developing novel l-glutamate transporter inhibitors with higher brain transfer rates and reduced adverse effects...
  2. ncbi request reprint A 72 kDa heat shock protein is protective against the selective vulnerability of CA1 neurons and is essential for the tolerance exhibited by CA3 neurons in the hippocampus
    K Sato
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    Neuroscience 109:745-56. 2002
    ....
  3. ncbi request reprint Effects of tamoxifen on L-glutamate transporters of astrocytes
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    J Pharmacol Sci 107:226-30. 2008
    ....
  4. ncbi request reprint beta-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Brain Res 1150:108-20. 2007
    ..These results suggest that E2 induces synaptogenesis between mossy fibers and CA3 neurons by enhancing BDNF release from DG granule cells in a nER-independent and PKA-dependent manner...
  5. ncbi request reprint Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    J Neurochem 86:1498-505. 2003
    ..The colocalization of ERalpha with GLAST on plasma membranes was immunohistochemically detected in these cells. From these results, we concluded that estrogens down-regulate l-glu uptake activity of astrocytes via membrane ERalpha...
  6. ncbi request reprint Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture
    Kaoru Sato
    Division of Pharmacology, National Institute of Health Sciences, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Neuroendocrinology 76:223-34. 2002
    ..These results suggest that exposure to E(2) and xenoestrogens during the developmental stage results in a marked influence on synaptogenesis and neuronal vulnerability through mechanisms other than ERs...
  7. pmc L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammation
    Junpei Takaki
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    J Neuroinflammation 9:275. 2012
    ..Microglia become activated with inflammation; however, the correlation between activated microglia and the impairment of L-Glu transporters is unknown...
  8. ncbi request reprint Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner
    Kanako Takahashi
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences
    Biol Pharm Bull 36:1996-2004. 2013
    ..NFA activated additional currents of EAAT1 in a substrate-dependent manner. ..
  9. doi request reprint Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
    Yukari Shigemoto-Mogami
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Tokyo 158 8501, Japan, and Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Neurosci 34:2231-43. 2014
    ..These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines. ..
  10. ncbi request reprint Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid
    Atsuko Oguchi-Katayama
    Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 38:391-402. 2013
    ..It was considered that gene expression changes per se in the amygdala might be an important cause for impaired social behavior and enhanced anxiety, rather than expression changes of particular genes...
  11. ncbi request reprint Modulation of voltage-gated Ca2+ current by 4-hydroxynonenal in dentate granule cells
    Tatsuhiro Akaishi
    Department of Pharmacology, College of Pharmacy, Nihon University, Funabashi 274 8555, Japan
    Biol Pharm Bull 27:174-9. 2004
    ..These results suggest that 4HN modulates L-type Ca2+ channels in the dentate granule cells, and thereby plays a role in the physiological and pathophysiological responses of these cells to oxidative stress...
  12. ncbi request reprint 4-Hydroxynonenal modulates the long-term potentiation induced by L-type Ca2+ channel activation in the rat dentate gyrus in vitro
    Tatsuhiro Akaishi
    Department of Pharmacology, College of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi shi, Chiba 274 8555, Japan
    Neurosci Lett 370:155-9. 2004
    ..4HN thereby plays an important role in both physiological and pathophysiological events in the hippocampus...
  13. ncbi request reprint Hydrogen peroxide modulates whole cell Ca2+ currents through L-type channels in cultured rat dentate granule cells
    Tatsuhiro Akaishi
    Department of Pharmacology, College of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi shi, Chiba 274 8555, Japan
    Neurosci Lett 356:25-8. 2004
    ..These results suggest that oxidative stress induced by hydrogen peroxide selectively regulates the activity of L-type Ca(2+) channels...