Hironori Sato

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint [RNA viruses and mutations]
    Hironori Sato
    Center for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan
    Uirusu 55:221-9. 2005
  2. pmc Structural basis for specific recognition of substrates by sapovirus protease
    Masaru Yokoyama
    Pathogen Genomics Center, National Institute of Infectious Diseases Tokyo, Japan
    Front Microbiol 3:312. 2012
  3. pmc Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity
    Satoshi Naganawa
    Department of Public Health, Yokohama City University School of Medicine, Kanagawa, Japan
    PLoS ONE 3:e3206. 2008
  4. pmc A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins
    Natsuko Inagaki
    International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Retrovirology 7:90. 2010
  5. pmc Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction
    Ken Kono
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Retrovirology 7:72. 2010
  6. ncbi request reprint [Survival strategies of human norovirus]
    Hironori Sato
    Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi, Murayama shi, Tokyo 208 0011, Japan
    Uirusu 60:21-32. 2010
  7. pmc Convergent evolution of reverse transcriptase (RT) genes of human immunodeficiency virus type 1 subtypes E and B following nucleoside analogue RT inhibitor therapies
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    J Virol 74:5357-62. 2000
  8. pmc Augmentation of human immunodeficiency virus type 1 subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase
    H Sato
    AIDS Research Center, National Institute of Infectious Diseases, Japan
    J Virol 75:5604-13. 2001
  9. ncbi request reprint Functional complementation of the envelope hypervariable V3 loop of human immunodeficiency virus type 1 subtype B by the subtype E V3 loop
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo, 162 8640, Japan
    Virology 257:491-501. 1999
  10. pmc Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo 162 8640, Japan
    J Virol 73:3551-9. 1999

Detail Information

Publications49

  1. ncbi request reprint [RNA viruses and mutations]
    Hironori Sato
    Center for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan
    Uirusu 55:221-9. 2005
    ..In addition, we will introduce recent advances in the computational science and its application on mutation studies and drug development...
  2. pmc Structural basis for specific recognition of substrates by sapovirus protease
    Masaru Yokoyama
    Pathogen Genomics Center, National Institute of Infectious Diseases Tokyo, Japan
    Front Microbiol 3:312. 2012
    ..These results suggest that the two clefts provide structural base points to realize the functional binding of various substrates...
  3. pmc Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity
    Satoshi Naganawa
    Department of Public Health, Yokohama City University School of Medicine, Kanagawa, Japan
    PLoS ONE 3:e3206. 2008
    ..The findings have molecular implications for the adaptive evolution and vaccine design of HIV-1...
  4. pmc A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins
    Natsuko Inagaki
    International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Retrovirology 7:90. 2010
    ..Here, by comparing two pathogenic SIV strains, SIVmac239 and SIVsmE543-3, we found critical amino acid residues for functional interaction between the N-terminal and the C-terminal domains in CA...
  5. pmc Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction
    Ken Kono
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Retrovirology 7:72. 2010
    ..In contrast, rhesus monkey (Rh) TRIM5α could restrict all HIV-2 strains tested but not simian immunodeficiency virus isolated from macaque (SIVmac), despite its genetic similarity to HIV-2...
  6. ncbi request reprint [Survival strategies of human norovirus]
    Hironori Sato
    Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi, Murayama shi, Tokyo 208 0011, Japan
    Uirusu 60:21-32. 2010
    ..Finally I will discuss survival strategies of human norovirus in nature by integrating the information...
  7. pmc Convergent evolution of reverse transcriptase (RT) genes of human immunodeficiency virus type 1 subtypes E and B following nucleoside analogue RT inhibitor therapies
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    J Virol 74:5357-62. 2000
    ..These data suggest that HIV-1 subtypes E and B evolve convergently at the phenotypic and amino acid levels when the nucleoside analogue RT inhibitors act as selective forces...
  8. pmc Augmentation of human immunodeficiency virus type 1 subtype E (CRF01_AE) multiple-drug resistance by insertion of a foreign 11-amino-acid fragment into the reverse transcriptase
    H Sato
    AIDS Research Center, National Institute of Infectious Diseases, Japan
    J Virol 75:5604-13. 2001
    ....
  9. ncbi request reprint Functional complementation of the envelope hypervariable V3 loop of human immunodeficiency virus type 1 subtype B by the subtype E V3 loop
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo, 162 8640, Japan
    Virology 257:491-501. 1999
    ..These findings are of immediate importance in understanding V3 structure-function relationship and for examining phenotypic evolution of HIV-1 subtype E...
  10. pmc Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family
    H Sato
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku, Tokyo 162 8640, Japan
    J Virol 73:3551-9. 1999
    ....
  11. pmc Divergent evolution of norovirus GII/4 by genome recombination from May 2006 to February 2009 in Japan
    Kazushi Motomura
    Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    J Virol 84:8085-97. 2010
    ....
  12. ncbi request reprint Mutations at the monomer-monomer interface away from the active site of influenza B virus neuraminidase reduces susceptibility to neuraminidase inhibitor drugs
    Seiichiro Fujisaki
    Laboratory of Influenza Virus Surveillance, Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, 208 0011, Japan
    J Infect Chemother 19:891-5. 2013
    ..In addition to amino acid substitutions around the active site of NA, these observations suggest that alterations in the monomer-monomer interface region of NA may contribute to reduced sensitivity to NA inhibitors. ..
  13. pmc Identification of monomorphic and divergent haplotypes in the 2006-2007 norovirus GII/4 epidemic population by genomewide tracing of evolutionary history
    Kazushi Motomura
    Center for Pathogen Genomics, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama shi, Tokyo 208 0011, Japan
    J Virol 82:11247-62. 2008
    ....
  14. doi request reprint Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins
    Tomoichiro Oka
    Department of Virology II, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama, Tokyo 208 0011, Japan
    Virology 394:119-29. 2009
    ....
  15. doi request reprint A single E105K mutation far from the active site of influenza B virus neuraminidase contributes to reduced susceptibility to multiple neuraminidase-inhibitor drugs
    Seiichiro Fujisaki
    Laboratory of Influenza Virus Surveillance, Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Biochem Biophys Res Commun 429:51-6. 2012
    ..These results have implications for understanding the mechanism of resistance against NA-inhibitor drugs...
  16. ncbi request reprint [A mechanism of norovirus pandemic based on comprehensive genome analysis]
    Kazushi Motomura
    Pathogen Genomics Center, National Institute of Infectious Diseases
    Kansenshogaku Zasshi 86:563-8. 2012
    ..These data and computer-assisted structural study of NoV capsid protein are compatible with a model of antigenic drift with tuning of the structure-functions of multiple proteins for the survival strategy of GII.4 2006b variant...
  17. pmc Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop
    Masaru Yokoyama
    Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama shi, Tokyo, Japan
    PLoS ONE 7:e37530. 2012
    ..The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular mechanisms underlying the modulation remain poorly understood...
  18. ncbi request reprint HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors
    Masanobu Kinomoto
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Infect Dis 41:243-51. 2005
    ..In this study, we investigated whether Ghanaian HIV-1 isolates, as representatives of West African isolates, are susceptible to PIs...
  19. ncbi request reprint [Structure and molecular mechanisms of infection and replication of HIV]
    Hironori Sato
    Laboratory of Viral Genomics, Center for Pathogen Genomics, National Institute of Infectious Diseases
    Nihon Rinsho 67:37-42. 2009
    ..We also summarize the latest methods for the structural study, mainly focusing on computational simulation technology (in silico analysis). Finally, we summarize briefly standard methods to study replication of viruses...
  20. doi request reprint Impact of human leukocyte antigen-B*51-restricted cytotoxic T-lymphocyte pressure on mutation patterns of nonnucleoside reverse transcriptase inhibitor resistance
    Hiroyuki Gatanaga
    AIDS Clinical Center, International Medical Center of Japan, Tokyo, Japan
    AIDS 24:F15-22. 2010
    ..The objective of this study is to determine the impact of human leukocyte antigen (HLA)-B*51-restricted cytotoxic T-lymphocyte (CTL) pressure on the development of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance...
  21. pmc Highly conserved configuration of catalytic amino acid residues among calicivirus-encoded proteases
    Tomoichiro Oka
    Department of Virology II, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 81:6798-806. 2007
    ..These results strongly suggest that the H, E, C, and H residues are involved in the formation of a conserved catalytic surface of the SaV and FCV 3C-like proteases...
  22. doi request reprint Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis
    Satoko Matsunaga
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Proteomics 75:4863-73. 2012
    ..This system may provide an attractive means for analyzing the function of retrovirus proteases and provide a technology platform for drug screening...
  23. doi request reprint Identification of folding preferences of cleavage junctions of HIV-1 precursor proteins for regulation of cleavability
    Hirotaka Ode
    Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Mol Model 17:391-9. 2011
    ..These data suggest that the dihedral angles at the specific positions around the cleavage junctions before and after binding to PR are both critical for regulating the cleavability of precursor proteins by HIV-1 PR...
  24. pmc Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity: implications for the molecular mechanism of viral escape from a fusion inhibitor
    Masanobu Kinomoto
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 79:5996-6004. 2005
    ..The correlation between these previous findings and our findings was suggested by structural analysis. Our finding, therefore, has implications for a molecular basis of the viral escape from this drug...
  25. doi request reprint Within-host co-evolution of Gag P453L and protease D30N/N88D demonstrates virological advantage in a highly protease inhibitor-exposed HIV-1 case
    Junko Shibata
    School of Biomedical Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Antiviral Res 90:33-41. 2011
    ..Furthermore, database analysis indicated that the P453L(Gag)/D30N(PR)/N88D(PR) association was not specific only to our clinical case, but was common among AIDS patients...
  26. doi request reprint Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection
    Yoshinao Kubo
    Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 375:130-40. 2008
    ....
  27. ncbi request reprint Isolation and characterization of replication-competent molecular DNA clones of HIV type 1 CRF01_AE with different coreceptor usages
    Shigeru Kusagawa
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    AIDS Res Hum Retroviruses 18:115-22. 2002
    ..These replication-competent CRF01_AE molecular clones with different coreceptor usages would be useful tools for the study of CRF01_AE, one of the most prevalent strains in Asia...
  28. pmc Isolation and molecular characterization of a nelfinavir (NFV)-resistant human immunodeficiency virus type 1 that exhibits NFV-dependent enhancement of replication
    Saori Matsuoka-Aizawa
    AIDS Clinical Center, International Medical Center of Japan, Tokyo, Japan
    J Virol 77:318-27. 2003
    ..Our data suggest a novel adaptation mechanism of HIV-1 to NFV, in which coevolution of Gag and PR genes generates a variant that replicates more efficiently in the cellular environment in the presence of NFV than without the drug...
  29. pmc Allosteric regulation of HIV-1 reverse transcriptase by ATP for nucleotide selection
    Masaru Yokoyama
    Pathogen Genomics Center, National Institute of Infectious Diseases, Musashi Murayama shi, Tokyo, Japan
    PLoS ONE 5:e8867. 2010
    ..How HIV-1 RT regulates nucleotide selectivity is a central issue for genetics and the nucleoside analog RT inhibitor (NRTI) resistance of HIV-1...
  30. pmc A group of V3 sequences from human immunodeficiency virus type 1 subtype E non-syncytium-inducing, CCR5-using variants are resistant to positive selection pressure
    T Shiino
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    J Virol 74:1069-78. 2000
    ..These data suggest that V3 sequences of the subtype E NSI/R5 variants are more resistant to positive selection pressure than those of the SI/X4 variants...
  31. doi request reprint The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
    Ayumi Kudoh
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Retrovirology 11:9. 2014
    ..In our present study, we identified this kinase using a proteomic approach and further delineate its role in HIV-1 replication...
  32. pmc APOBEC3G oligomerization is associated with the inhibition of both Alu and LINE-1 retrotransposition
    Takayoshi Koyama
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    PLoS ONE 8:e84228. 2013
    ..Importantly, the anti-L1 activity of hA3G was also associated with hA3G oligomerization. These results suggest that the inhibitory activities of hA3G against Alu and L1 retrotransposition might involve a common mechanism. ..
  33. pmc Evaluation of influenza virus A/H3N2 and B vaccines on the basis of cross-reactivity of postvaccination human serum antibodies against influenza viruses A/H3N2 and B isolated in MDCK cells and embryonated hen eggs
    Noriko Kishida
    Laboratory of Influenza Virus Surveillance, Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Vaccine Immunol 19:897-908. 2012
    ..The results of these human serological studies suggest that the influenza A/H3N2 vaccine for the 2010-2011 season and B vaccine for the 2009-2010 and 2010-2011 seasons may possess insufficient efficacy and low efficacy, respectively...
  34. ncbi request reprint Infection of macaques with an R5-tropic SHIV bearing a chimeric envelope carrying subtype E V3 loop among subtype B framework
    M Kaizu
    Vaccine Research and Development Group, AIDS Research Center, NIID, Tokyo, Japan
    Arch Virol 148:973-88. 2003
    ..Future study of infecting macaques with SHIV-TH09V3 and SHIV(MD14) will focus on differences of the outcome caused by the different V3 sequences in connection with coreceptor usage...
  35. pmc A proposal for a new HIV-1 DLS structural model
    Jun ichi Sakuragi
    Department of Viral Infections, RIMD, Osaka Univ 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nucleic Acids Res 40:5012-22. 2012
    ....
  36. ncbi request reprint Higher levels of IL-18 circulate during primary infection of monkeys with a pathogenic SHIV than with a nonpathogenic SHIV
    Masahiko Kaizu
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo 162 8640, Japan
    Virology 313:8-12. 2003
    ..Thus, the elevation of circulating IL-18 level during primary viral infection can be a good indicator of an active pathogenic viral infection. However, the role of increased IL-18 remains to be elucidated and needs further investigation...
  37. ncbi request reprint Isolates of Cryptococcus neoformans serotype A and D developed on canavanine-glycine-bromthymol blue medium
    Y Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Mycoses 41:35-40. 1998
    ..1 mmol l-1 of canavanine and 133 mmol l-1 of glycine. Three isolates of Cr. neoformans developed on CGB medium were also confirmed to be serotype A or D by the molecular analysis...
  38. ncbi request reprint ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)
    T Yamochi
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    Eur J Biochem 268:6076-82. 2001
    ..We therefore conclude that p70ik3-1 is a substrate for cdk3-mediated phosphorylation...
  39. ncbi request reprint Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts
    M Kajita
    Department of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo, Japan
    FEBS Lett 457:353-6. 1999
    ..and failed to express protein, and the other is the major transcript that has an extended open reading frame and expressed 67 and 71 kDa translation products. Thus, functional mt4-mmp has been identified for the first time...
  40. ncbi request reprint Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-I
    K Yamana
    Teijin Institute for Biomedical Research, Teijin Limited, 4 3 2 Asahigaoka, Hino, Tokyo, 191 8512, Japan
    Biochem Biophys Res Commun 280:1101-6. 2001
    ..These data suggest that ChM1L is a novel membrane molecule which is similar to ChM-I that plays a regulatory role in eye, skeletal muscle, and development of embryo...
  41. pmc Notch3 gene polymorphism and ischaemic cerebrovascular disease
    D Ito
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 72:382-4. 2002
    ..65, p=0.311). In conclusion, the results indicate that T6746C polymorphism in the intracellular domain of the Notch3 gene is not associated with an increased risk for CVD...
  42. ncbi request reprint RANTES expression in psoriatic skin, and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol)
    M Fukuoka
    Teijin Institute for Bio Medical Research, Tokyo, Japan
    Br J Dermatol 138:63-70. 1998
    ..This result indicates that active vitamin D3 is effective in the regulation of chemokine production by epidermal keratinocytes, which may partly account for its action as an antipsoriatic drug...
  43. ncbi request reprint Access to antiretroviral therapy among HIV/AIDS patients in Khon Kaen Province, Thailand
    T Kitajima
    Faculty of General Policy Studies, Kyorin University, Tokyo, Japan
    AIDS Care 17:359-66. 2005
    ..The current government announced that they would include ARV in the benefits package of UC. It would be important to monitor how this policy will improve the access to ARV among HIV/AIDS patients...
  44. ncbi request reprint Myasthenia gravis accompanied by alopecia areata: clinical and immunogenetic aspects
    S Suzuki
    Department of Neurology, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Eur J Neurol 12:566-70. 2005
    ..In conclusion, a subset of MG patients who have severe neuromuscular symptoms and thymoma develop AA several years after thymectomy...
  45. pmc A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas
    Haihan Song
    Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 81:7280-5. 2007
    ..Mutagenesis studies indicated that the single amino acid at the 120th position indeed affected the sensitivity of the virus to CM TRIM5alpha...
  46. ncbi request reprint Identification of the suppressive factors for human immunodeficiency virus type-1 replication using the siRNA mini-library directed against host cellular genes
    Masanori Kameoka
    Section of Viral Infections, Thailand Japan Research Collaboration Center on Emerging and Re emerging Infections, Nonthaburi 11000, Thailand
    Biochem Biophys Res Commun 359:729-34. 2007
    ..We also discuss the possible mechanisms by which those cellular proteins regulate viral replication...
  47. pmc Human immunodeficiency virus mutagenesis during antiviral therapy: impact of drug-resistant reverse transcriptase and nucleoside and nonnucleoside reverse transcriptase inhibitors on human immunodeficiency virus type 1 mutation frequencies
    Renxiang Chen
    Institute for Molecular Virology, University of Minnesota, 18 242 Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, USA
    J Virol 79:12045-57. 2005
    ..The results further suggest that high-level drug-resistant RT can significantly influence virus mutation frequencies. A structural model that explains the mutation frequency data is discussed...
  48. ncbi request reprint Cooperative contribution of gag substitutions to nelfinavir-dependent enhancement of precursor cleavage and replication of human immunodeficiency virus type-1
    Saori Matsuoka-Aizawa
    AIDS Clinical Center, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Antiviral Res 70:51-9. 2006
    ..Efficient replication enhancement with NFV can be observed only in the presence of the substitutions in entire Gag and protease of CL-4...