Akihiko Saitoh

Summary

Affiliation: National Center for Child Health and Development
Country: Japan

Publications

  1. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
  2. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
  3. doi request reprint A universal preemptive therapy for cytomegalovirus infections in children after live-donor liver transplantation
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan
    Transplantation 92:930-5. 2011
  4. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
  5. ncbi request reprint Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
  6. ncbi request reprint An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
  7. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
  8. ncbi request reprint Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004
  9. doi request reprint Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
  10. doi request reprint Is a 6-week course of ganciclovir therapy effective for chorioretinitis in infants with congenital cytomegalovirus infection?
    Kensuke Shoji
    Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr 157:331-3. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  2. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  3. doi request reprint A universal preemptive therapy for cytomegalovirus infections in children after live-donor liver transplantation
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan
    Transplantation 92:930-5. 2011
    ..The current set of guidelines recommends prophylaxis over a preemptive therapy for pediatric LT; however, the data regarding the optimal approach after LT in children are limited...
  4. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
    ..This may be of particular importance in resource-limited countries where didanosine is widely used for the treatment of HIV-infected children...
  5. ncbi request reprint Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
    ..The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage...
  6. ncbi request reprint An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
    ..This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children...
  7. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
    ....
  8. ncbi request reprint Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004
    ..These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults...
  9. doi request reprint Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
    ..The objective of this study was to investigate the actual prevalence and clinical outcomes of a treatment interruption in children and adolescents with perinatally acquired HIV-1 infection...
  10. doi request reprint Is a 6-week course of ganciclovir therapy effective for chorioretinitis in infants with congenital cytomegalovirus infection?
    Kensuke Shoji
    Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    J Pediatr 157:331-3. 2010
    ..We report an infant with congenital CMV infection, who required a 6-month course of antiviral therapy to control his chorioretinitis. Long-term treatment may be necessary for managing congenital CMV-associated chorioretinitis...
  11. ncbi request reprint Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
    ..Thus, despite prolonged maintenance of undetectable levels of plasma HIV-1 RNA, HIV-1 DNA remains detectable in PBMC of children and may be a useful marker of further virus suppression...
  12. ncbi request reprint Myelomeningocele in an infant with intrauterine exposure to efavirenz
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Perinatol 25:555-6. 2005
    ..Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available...
  13. ncbi request reprint Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear
    Stephen A Spector
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, USA
    AIDS 20:1777-8. 2006
  14. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
    ..These findings may be of particular importance in developing countries, where ddI is widely used for first-line treatment of HIV-infected children...
  15. doi request reprint The value of radiographic findings for the progression of pandemic 2009 influenza A/H1N1 virus infection
    Takanori Funaki
    Department of Medical Subspecialties, Division of Infectious Diseases, National Center for Child Health and Development, Tokyo, Japan
    BMC Infect Dis 13:516. 2013
    ..We investigated factors associated with rapid disease progression among children admitted to hospital for A/H1N1 infection, particularly findings on initial chest radiographs...
  16. doi request reprint Treatment of pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in children
    Tomohiro Katsuta
    Department of Pediatrics, Division of Infectious Diseases, St Marianna University School of Medicine, Kanagawa, Japan
    Pediatr Infect Dis J 32:417-9. 2013
    ..Children with pyelonephritis caused by extended-spectrum β-lactamase-producing Enterobacteriaceae can be successfully treated with noncarbapenem antimicrobials...
  17. doi request reprint Safety and persistence of immunological response 6 months after intramuscular vaccination with an AS03-adjuvanted H1N1 2009 influenza vaccine: an open-label, randomized trial in Japanese children aged 6 months to 17 years
    Akihiko Saitoh
    Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Vaccin Immunother 8:749-58. 2012
    ..75 µg HA AS03-adjuvanted H1N1 2009 pandemic influenza vaccine in children aged 6 mo-17 y induced strong immune responses against the vaccine homologous strain that persisted for at least six months after the first vaccine dose...
  18. doi request reprint Complete atrioventricular block as a complication of varicella in children
    Tomohiro Katsuta
    Division of Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Infect Dis J 30:445-6. 2011
    ..Universal vaccination is warranted to prevent such a potentially fatal complication in Japan where varicella is still endemic...
  19. doi request reprint Dermatologic manifestations of human parechovirus type 3 infection in neonates and infants
    Kensuke Shoji
    Department of Medical Subspecialties, Division of Infectious Diseases, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Infect Dis J 32:233-6. 2013
    ..Although maculopapular rash is a reported clinical manifestation of HPeV3 infection, the frequency and detailed characteristics of rash in neonates and young infants with HPeV3 infection are unknown...
  20. doi request reprint Current issues with the immunization program in Japan: can we fill the "vaccine gap"?
    Akihiko Saitoh
    Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Vaccine 30:4752-6. 2012
    ....
  21. ncbi request reprint [Haemophilus influenzae type b vaccine]
    Tomohiro Katsuta
    Department of Medical Specialties, National Center for Child Health and Development
    Nihon Rinsho 69:1589-93. 2011
    ..It is important to make an effort to fill the "vaccine gap" between Japan and other developed countries and increase a vaccine coverage rate including Hib vaccine to decrease vaccine preventable diseases in Japanese children...
  22. ncbi request reprint Fulminant bacterial meningitis complicating sphenoid sinusitis
    Akihiko Saitoh
    Division of Pediatric Infectious Diseases, University of California, San Diego, La Jolla 92093, USA
    Pediatr Emerg Care 19:415-7. 2003
  23. doi request reprint Immunogenicity of influenza vaccine in children with pediatric rheumatic diseases receiving immunosuppressive agents
    Chikara Ogimi
    Division of Infectious Diseases, Immunology, and Allergy, Saitama Children s Medical Center, Saitama, Japan
    Pediatr Infect Dis J 30:208-11. 2011
    ..Children with rheumatic diseases receiving immunosuppressive therapy are a high-risk group for influenza virus infection; however, few data are available regarding the efficacy and safety of influenza vaccine for those individuals...