Morio Saito

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats
    Morio Saito
    National Institute of Health and Nutrition, Tokyo, Japan
    Ann Nutr Metab 46:176-81. 2002
  2. ncbi request reprint Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats
    Morio Saito
    Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
    Br J Nutr 89:19-28. 2003
  3. ncbi request reprint Role of FOSHU (food for specified health uses) for healthier life
    Morio Saito
    Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Yakugaku Zasshi 127:407-16. 2007
  4. ncbi request reprint Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids
    M Saito
    Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Biofactors 13:15-24. 2000
  5. ncbi request reprint High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis
    M Saito
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Food Chem Toxicol 43:411-9. 2005
  6. ncbi request reprint Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats
    Seiji Sekine
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 22:385-94. 2006
  7. ncbi request reprint Primary aminophospholipids in the external layer of liposomes protect their component polyunsaturated fatty acids from 2,2'-azobis(2-amidinopropane)- dihydrochloride-mediated lipid peroxidation
    Kazuhiro Kubo
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Agric Food Chem 53:750-8. 2005
  8. ncbi request reprint Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats
    Junichi Nagata
    Food Function and Labeling Program, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:133-7. 2007
  9. ncbi request reprint Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppressed by higher intake of ascorbic acid in genetically scorbutic Osteogenic Disorder Shionogi/Shi-od/od rats
    Seiji Sekine
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Br J Nutr 90:385-94. 2003
  10. ncbi request reprint Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats
    Jun ichi Nagata
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biofactors 22:157-60. 2004

Detail Information

Publications33

  1. ncbi request reprint An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured rats
    Morio Saito
    National Institute of Health and Nutrition, Tokyo, Japan
    Ann Nutr Metab 46:176-81. 2002
    ....
  2. ncbi request reprint Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats
    Morio Saito
    Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
    Br J Nutr 89:19-28. 2003
    ....
  3. ncbi request reprint Role of FOSHU (food for specified health uses) for healthier life
    Morio Saito
    Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Yakugaku Zasshi 127:407-16. 2007
    ..as well as understanding mechanisms of the effectiveness of FOSHU, which ranges over pharmacology, medicine, and food and nutrition...
  4. ncbi request reprint Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids
    M Saito
    Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Biofactors 13:15-24. 2000
    ..Owing to these suppressive mechanisms, physiological efficacy of n-3 fatty acids may be exerted effectively...
  5. ncbi request reprint High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis
    M Saito
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Food Chem Toxicol 43:411-9. 2005
    ..Accordingly, 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL)...
  6. ncbi request reprint Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats
    Seiji Sekine
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 22:385-94. 2006
    ..We examined the effects of ascorbic acid (AsA) and glutathione (GSH; experiment 1) and of GSH in acetaminophen-fed rats (experiment 2) on dietary docosahexaenoic acid (DHA)-induced tissue lipid peroxidation...
  7. ncbi request reprint Primary aminophospholipids in the external layer of liposomes protect their component polyunsaturated fatty acids from 2,2'-azobis(2-amidinopropane)- dihydrochloride-mediated lipid peroxidation
    Kazuhiro Kubo
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Agric Food Chem 53:750-8. 2005
    ....
  8. ncbi request reprint Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats
    Junichi Nagata
    Food Function and Labeling Program, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:133-7. 2007
    ....
  9. ncbi request reprint Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppressed by higher intake of ascorbic acid in genetically scorbutic Osteogenic Disorder Shionogi/Shi-od/od rats
    Seiji Sekine
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Br J Nutr 90:385-94. 2003
    ..The present results suggest that higher than normal concentrations of tissue AsA are not necessarily associated with the suppressive mechanisms against dietary DHA-induced tissue lipid peroxide formation...
  10. ncbi request reprint Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats
    Jun ichi Nagata
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biofactors 22:157-60. 2004
    ..Therefore, further study will be needed to ascertain the most desirable structural configuration...
  11. ncbi request reprint Transbilayer distribution of aminophospholipids and the oxidative stability of their component polyunsaturated fatty acids
    Kazuhiro Kubo
    Division of Food Science, Department of Food Science Research for Health, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biofactors 21:235-9. 2004
    ..Additionally, aminophospholipids in the external layer of smaller-sized liposomes were able to protect their component PUFAs from 2,2'-azobis(2-amidinopropane)dihydrochloride-mediated lipid peroxidation...
  12. ncbi request reprint Effect of dietary DHA on DHA levels in retinal rod outer segments in young versus mature rats
    Chieko Nishizawa
    Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Int J Vitam Nutr Res 73:259-65. 2003
    ..Our findings indicate that mature rats maintain a constant level of DHA in the ROS membranes even after being directly supplemented with high doses of DHA...
  13. ncbi request reprint Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress
    Shun Sunada
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Free Radic Res 40:837-46. 2006
    ..These results suggest that dietary DHA does not necessarily promote lipid peroxidation in the retina even under high oxidative stress...
  14. ncbi request reprint Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats
    Jin Ye Wang
    Division of Food Science, Independently Administered Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Free Radic Res 37:419-24. 2003
    ..In conclusion, high DHA feeding induced a marked increase of phospholipid hydroperoxides in ROS membranes of ODS rats. Supplementation of ascorbic acid did not reverse this increase...
  15. ncbi request reprint Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats
    Tomomi Sugiyama
    Division of Applied Food Research, National Institute of Health and Nutrition, Shinjuku ku, Japan
    Life Sci 78:2188-93. 2006
    ..Dietary intake of curcumin may protect against CCl(4)-induced hepatic CYP inactivation via its antioxidant properties, without inducing hepatic CYPs...
  16. ncbi request reprint Effects of simultaneous intakes of indigestible dextrin and diacylglycerol on lipid profiles in rats fed cholesterol diets
    Jun ichi Nagata
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 22:395-400. 2006
    ....
  17. ncbi request reprint Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cells
    Tatsuya Sugawara
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr 133:2777-82. 2003
    ..Isomers of 4,8-sphingadienine degraded from dietary plant cerebrosides appear to be poorly absorbed from the digestive tract...
  18. ncbi request reprint Effects of water-soluble hemicellulose from soybean hull on serum antibody levels and activation of macrophages in rats
    J Nagata
    Division of Food Science, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Agric Food Chem 49:4965-70. 2001
    ..4 (mg/mL) compared with those of a saline group. These findings demonstrate that WSHC enhances humoral immunity and activation of macrophages, thereby leading to the augmentation of immune responses in rats...
  19. pmc Effect of Docosahexaenoic Acid Ingestion on Temporal Change in Urinary Excretion of Mercapturic Acid in ODS Rats
    Seiji Sekine
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Clin Biochem Nutr 41:184-90. 2007
    ..Accordingly, we presume from these results that after dietary DHA-induced lipid peroxidation, a proportion of the lipid peroxidation-derived aldehydic degradation products is excreted into urine as mercapturic acids...
  20. ncbi request reprint Effects of highly purified structured lipids containing medium-chain fatty acids and linoleic acid on lipid profiles in rats
    Jun ichi Nagata
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 67:1937-43. 2003
    ..These results indicate that the feeding of highly purified L-M-L types could effectively improve serum and liver lipid profiles and that M-L-M types may be a preferable substrate for the pancreas and contribute to energy supply in rats...
  21. ncbi request reprint Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation
    Kazuhiro Kubo
    Division of Food Science, Department of Food Science Research for Health, Independent Administrative Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Arch Biochem Biophys 410:141-8. 2003
    ..Additionally, PE-DHA in the external layer of liposomes prepared using a filter with smaller pore sizes could protect DHA itself from 2,2(')-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation...
  22. ncbi request reprint Dietary supplementation of N-3 fatty acids and hydroperoxide levels in rat retinas
    J Y Wang
    Division of Food Science, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Free Radic Res 35:367-75. 2001
    ..But UV irradiation on separated ROS membranes accelerated the formation of phospholipid hydroperoxides in high DHA feeding rats, and PEOOH was produced more efficiently than PCOOH in vitro...
  23. ncbi request reprint Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells
    Tatsuya Sugawara
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 102 8471, Japan
    Biosci Biotechnol Biochem 68:2541-6. 2004
    ..Thus P-glycoprotein probably contributes to the selective absorption of sphingosine from dietary sphingolipids in the digestive tract...
  24. ncbi request reprint [Current situation and future perspective in FOSHU (foods for specified health uses)]
    Morio Saito
    Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Shinjiku ku, Tokyo, Japan
    Shokuhin Eiseigaku Zasshi 46:J289-91. 2005
  25. ncbi request reprint CDNA cloning of feline leptin and its mRNA expression in adipose tissue
    N Sasaki
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 63:1115-20. 2001
    ..brain and skeletal muscle. These data show that feline leptin is highly homologous to leptins of other species, and expressed in adipose tissues in cats...
  26. ncbi request reprint Influence of different types and levels of dietary lipids on liver microsomal mixed function oxidase system in rats
    M Saito
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    Ann Nutr Metab 34:288-96. 1990
    ..5% linolenic acid seemed unlikely to stimulate enough the mixed function oxidase system. On the other hand, no definite effects of large doses of dietary lipids, 25% in the diets, on the mixed function oxidase system were observed...
  27. ncbi request reprint Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Osteoporos Int 17:1514-23. 2006
    ..Seventy male WBN/Kob rats were obtained at the ages of 1 to 18 months...
  28. ncbi request reprint A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis
    A Shiraishi
    Product Research Laboratory, Chugai Pharmaceutical Co, Ltd, Tokyo, Japan
    Calcif Tissue Int 71:69-79. 2002
    ..These results have important implications in understanding the characteristic actions of vitamin K and active vitamin D on bone metabolism...
  29. ncbi request reprint Toluene inhalation induced epididymal sperm dysfunction in rats
    A Ono
    Division of Toxicology, National Institute of Health Sciences, Tokyo, Japan
    Toxicology 139:193-205. 1999
    ..These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation...
  30. ncbi request reprint Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats
    M Saito
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    Ann Nutr Metab 38:212-20. 1994
    ..Consequently, dietary n-3 fatty acids further elevated the PB-induced MFO activities effectively. These results suggest a differential response of dietary n-6 and n-3 fatty acids to the PB-induced MFO activities...
  31. ncbi request reprint Mixed function oxidases in response to different types of dietary lipids in rats
    M Saito
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    Br J Nutr 63:249-57. 1990
    ..From these results, it appears that high intakes of polyunsaturated fatty acids (18:2n-6, 18:3n-3, 20:5n-3 and 22:6n-3) stimulate the liver microsomal mixed function oxidase system...
  32. doi request reprint Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland
    K Ueda
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan
    Int J Oral Maxillofac Surg 38:79-84. 2009
    ..These findings suggest that tenascin-C and fibronectin affect only the duct-acinar structures, and type IV but not type III collagen is involved in the regeneration of acinar cells...
  33. ncbi request reprint Induction of multidrug resistance-associated protein MRP3 in the liver of rats fed with docosahexaenoic acid
    Kazuhiro Kubo
    Nursing Course, Narabunka Women s College, Incorporated Educational Institution, Nara Gakuen, Yamatotakada shi, Nara 635 8530, Japan
    Biosci Biotechnol Biochem 70:1672-80. 2006
    ..This study is the first to report the gene expression of MRP3 by DHA ingestion. There might exist, therefore, some relationship between the DHA intake and MRP3 induction in regulating lipid peroxide accumulation in the liver...