Research Topics
| Morio SaitoSummaryAffiliation: National Institute of Infectious Diseases Country: Japan Publications
| Collaborators
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Detail Information
Publications
An assessment of docosahexaenoic acid intake from the viewpoint of safety and physiological efficacy in matured ratsMorio Saito
National Institute of Health and Nutrition, Tokyo, Japan
Ann Nutr Metab 46:176-81. 2002....- Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in ratsMorio Saito
Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
Br J Nutr 89:19-28. 2003.... - Role of FOSHU (food for specified health uses) for healthier lifeMorio Saito
Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
Yakugaku Zasshi 127:407-16. 2007..as well as understanding mechanisms of the effectiveness of FOSHU, which ranges over pharmacology, medicine, and food and nutrition... - Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipidsM Saito
Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
Biofactors 13:15-24. 2000..Owing to these suppressive mechanisms, physiological efficacy of n-3 fatty acids may be exerted effectively... - High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testisM Saito
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Food Chem Toxicol 43:411-9. 2005..Accordingly, 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL)... - Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS ratsSeiji Sekine
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
Nutrition 22:385-94. 2006.... - Primary aminophospholipids in the external layer of liposomes protect their component polyunsaturated fatty acids from 2,2'-azobis(2-amidinopropane)- dihydrochloride-mediated lipid peroxidationKazuhiro Kubo
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
J Agric Food Chem 53:750-8. 2005.... - Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in ratsJunichi Nagata
Food Function and Labeling Program, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
J Nutr Sci Vitaminol (Tokyo) 53:133-7. 2007.... - Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppressed by higher intake of ascorbic acid in genetically scorbutic Osteogenic Disorder Shionogi/Shi-od/od ratsSeiji Sekine
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Toyama, Shinjuku-ku, Tokyo 162-8636, Japan
Br J Nutr 90:385-94. 2003..The present results suggest that higher than normal concentrations of tissue AsA are not necessarily associated with the suppressive mechanisms against dietary DHA-induced tissue lipid peroxide formation... - Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in ratsJun ichi Nagata
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Biofactors 22:157-60. 2004..Therefore, further study will be needed to ascertain the most desirable structural configuration... - Transbilayer distribution of aminophospholipids and the oxidative stability of their component polyunsaturated fatty acidsKazuhiro Kubo
Division of Food Science, Department of Food Science Research for Health, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Biofactors 21:235-9. 2004..Additionally, aminophospholipids in the external layer of smaller-sized liposomes were able to protect their component PUFAs from 2,2'-azobis(2-amidinopropane)dihydrochloride-mediated lipid peroxidation... - Effect of dietary DHA on DHA levels in retinal rod outer segments in young versus mature ratsChieko Nishizawa
Division of Food Science, Independent Administrative Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Int J Vitam Nutr Res 73:259-65. 2003..Our findings indicate that mature rats maintain a constant level of DHA in the ROS membranes even after being directly supplemented with high doses of DHA... - Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stressShun Sunada
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
Free Radic Res 40:837-46. 2006..These results suggest that dietary DHA does not necessarily promote lipid peroxidation in the retina even under high oxidative stress... - Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS ratsJin Ye Wang
Division of Food Science, Independently Administered Institution, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Free Radic Res 37:419-24. 2003..In conclusion, high DHA feeding induced a marked increase of phospholipid hydroperoxides in ROS membranes of ODS rats. Supplementation of ascorbic acid did not reverse this increase... - Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in ratsTomomi Sugiyama
Division of Applied Food Research, National Institute of Health and Nutrition, Shinjuku-ku, Japan
Life Sci 78:2188-93. 2006..Dietary intake of curcumin may protect against CCl(4)-induced hepatic CYP inactivation via its antioxidant properties, without inducing hepatic CYPs... - Effects of simultaneous intakes of indigestible dextrin and diacylglycerol on lipid profiles in rats fed cholesterol dietsJun ichi Nagata
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
Nutrition 22:395-400. 2006.... - Digestion of maize sphingolipids in rats and uptake of sphingadienine by Caco-2 cellsTatsuya Sugawara
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
J Nutr 133:2777-82. 2003..Isomers of 4,8-sphingadienine degraded from dietary plant cerebrosides appear to be poorly absorbed from the digestive tract... - Effects of water-soluble hemicellulose from soybean hull on serum antibody levels and activation of macrophages in ratsJ Nagata
Division of Food Science, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
J Agric Food Chem 49:4965-70. 2001..4 (mg/mL) compared with those of a saline group. These findings demonstrate that WSHC enhances humoral immunity and activation of macrophages, thereby leading to the augmentation of immune responses in rats... 
Effect of Docosahexaenoic Acid Ingestion on Temporal Change in Urinary Excretion of Mercapturic Acid in ODS RatsSeiji Sekine
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
J Clin Biochem Nutr 41:184-90. 2007..Accordingly, we presume from these results that after dietary DHA-induced lipid peroxidation, a proportion of the lipid peroxidation-derived aldehydic degradation products is excreted into urine as mercapturic acids...- Effects of highly purified structured lipids containing medium-chain fatty acids and linoleic acid on lipid profiles in ratsJun ichi Nagata
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Tokyo, Japan
Biosci Biotechnol Biochem 67:1937-43. 2003..These results indicate that the feeding of highly purified L-M-L types could effectively improve serum and liver lipid profiles and that M-L-M types may be a preferable substrate for the pancreas and contribute to energy supply in rats... - Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidationKazuhiro Kubo
Division of Food Science, Department of Food Science Research for Health, Independent Administrative Institution, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan
Arch Biochem Biophys 410:141-8. 2003..Additionally, PE-DHA in the external layer of liposomes prepared using a filter with smaller pore sizes could protect DHA itself from 2,2(')-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation... - Dietary supplementation of N-3 fatty acids and hydroperoxide levels in rat retinasJ Y Wang
Division of Food Science, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
Free Radic Res 35:367-75. 2001..But UV irradiation on separated ROS membranes accelerated the formation of phospholipid hydroperoxides in high DHA feeding rats, and PEOOH was produced more efficiently than PCOOH in vitro... - Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cellsTatsuya Sugawara
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 102 8471, Japan
Biosci Biotechnol Biochem 68:2541-6. 2004..Thus P-glycoprotein probably contributes to the selective absorption of sphingosine from dietary sphingolipids in the digestive tract... - [Current situation and future perspective in FOSHU (foods for specified health uses)]Morio Saito
Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition, Shinjiku-ku, Tokyo, Japan
Shokuhin Eiseigaku Zasshi 46:J289-91. 2005 - CDNA cloning of feline leptin and its mRNA expression in adipose tissueN Sasaki
Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
J Vet Med Sci 63:1115-20. 2001..brain and skeletal muscle. These data show that feline leptin is highly homologous to leptins of other species, and expressed in adipose tissues in cats... - Influence of different types and levels of dietary lipids on liver microsomal mixed function oxidase system in ratsM Saito
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
Ann Nutr Metab 34:288-96. 1990..5% linolenic acid seemed unlikely to stimulate enough the mixed function oxidase system. On the other hand, no definite effects of large doses of dietary lipids, 25% in the diets, on the mixed function oxidase system were observed... - Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob ratsM Saito
Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo, 105 8461, Japan
Osteoporos Int 17:1514-23. 2006..Seventy male WBN/Kob rats were obtained at the ages of 1 to 18 months... - A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosisA Shiraishi
Product Research Laboratory, Chugai Pharmaceutical Co, Ltd, Tokyo, Japan
Calcif Tissue Int 71:69-79. 2002..These results have important implications in understanding the characteristic actions of vitamin K and active vitamin D on bone metabolism... - Toluene inhalation induced epididymal sperm dysfunction in ratsA Ono
Division of Toxicology, National Institute of Health Sciences, Tokyo, Japan
Toxicology 139:193-205. 1999..These results indicate that high concentrations of toluene may directly target sperm in the epididymis and disrupt sperm maturation... - Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in ratsM Saito
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
Ann Nutr Metab 38:212-20. 1994..Consequently, dietary n-3 fatty acids further elevated the PB-induced MFO activities effectively. These results suggest a differential response of dietary n-6 and n-3 fatty acids to the PB-induced MFO activities... - Mixed function oxidases in response to different types of dietary lipids in ratsM Saito
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
Br J Nutr 63:249-57. 1990..From these results, it appears that high intakes of polyunsaturated fatty acids (18:2n-6, 18:3n-3, 20:5n-3 and 22:6n-3) stimulate the liver microsomal mixed function oxidase system... 
Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular glandK Ueda
Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan
Int J Oral Maxillofac Surg 38:79-84. 2009..These findings suggest that tenascin-C and fibronectin affect only the duct-acinar structures, and type IV but not type III collagen is involved in the regeneration of acinar cells...- Induction of multidrug resistance-associated protein MRP3 in the liver of rats fed with docosahexaenoic acidKazuhiro Kubo
Nursing Course, Narabunka Women s College, Incorporated Educational Institution, Nara Gakuen, Yamatotakada shi, Nara 635 8530, Japan
Biosci Biotechnol Biochem 70:1672-80. 2006..This study is the first to report the gene expression of MRP3 by DHA ingestion. There might exist, therefore, some relationship between the DHA intake and MRP3 induction in regulating lipid peroxide accumulation in the liver...