Hiroaki Saito

Summary

Affiliation: National Institute of Agrobiological Sciences
Country: Japan

Publications

  1. doi Characteristics of lipid and fatty acid of marine gastropod Turbo cornutus: high levels of arachidonic and n-3 docosapentaenoic acid
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4, Fuku ura, Kanazawa Ku, Yokohama shi 236 8648, Japan Electronic address
    Food Chem 145:135-44. 2014
  2. ncbi Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Fuku ura, Kanazawa Ku, Yokohama shi, Japan
    J Oleo Sci 61:547-64. 2012
  3. ncbi Lipid characteristics of two subtropical Seriola fishes, Seriola dumerili and Seriola rivoliana, with differences between cultured and wild varieties
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4, Fuku ura, Kanazawa Ku, Yokohama shi 236 8648, Japan
    Food Chem 135:1718-29. 2012
  4. ncbi Identification of novel n-4 series polyunsaturated fatty acids in a deep-sea clam, Calyptogena phaseoliformis
    Hiroaki Saito
    National Research Institute of Fisheries Science, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Chromatogr A 1163:247-59. 2007
  5. ncbi Characteristics of the fatty acid composition of a deep-sea vent gastropod, Ifremeria nautilei
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, 236 8648, Japan
    Lipids 45:537-48. 2010
  6. doi Characteristics of fatty acid composition of the deep-sea vent crab, Shinkaia crosnieri Baba and Williams
    Hiroaki Saito
    National Research Institute of Fisheries Science, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama, 236 8648, Japan
    Lipids 46:723-40. 2011
  7. ncbi High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker)
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama shi, Japan
    Lipids 40:941-53. 2005
  8. doi Unusual novel n-4 polyunsaturated fatty acids in cold-seep mussels (Bathymodiolus japonicus and Bathymodiolus platifrons), originating from symbiotic methanotrophic bacteria
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Chromatogr A 1200:242-54. 2008
  9. ncbi High levels of icosapentaenoic acid in the lipids of oyster Crassostrea gigas ranging over both Japan and France
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Oleo Sci 59:281-92. 2010
  10. doi Sulfitobacter porphyrae sp. nov., isolated from the red alga Porphyra yezoensis
    Youhei Fukui
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama 236 8648, Japan
    Int J Syst Evol Microbiol 64:438-43. 2014

Collaborators

  • Masataka Satomi
  • Yutaka Yano
  • Hiroshi Oikawa
  • Kenji Ishihara
  • Hiroshi Takayanagi
  • Kazuo Umezawa
  • Kazufumi Osako
  • Takeshi Kubota
  • Kazuhiro Aoki
  • Tatsuya Miyata
  • Hiroshi Ogawa
  • Philip Boyd
  • Akira Yamaguchi
  • E Abraham
  • Youhei Fukui
  • Masahiro Kobayashi
  • Keiichi Ohya
  • Mahiko Abe
  • Kumiko Mitsui
  • Changhu Xue
  • Takefumi Kojima
  • Masashi Inoue
  • Anower Hussain Mian
  • Takao Katase
  • Michio Aoyama
  • Shunichi Tsujitani
  • Masahide Ikeguchi
  • Koichi Takeya
  • Haruhiko Fukaya
  • Yukio Hitotsuyanagi
  • Ryota Yamamura
  • Teruhisa Sakamoto
  • Shinichi Miyairi
  • Yoshifumi Suzuki
  • Roland Baron
  • Hiroshi Takatsuna
  • Eijiro Jimi
  • Wataru Komatsu
  • Yushi Shimada
  • Masaya Okabe
  • Hideshige Takada
  • Keiji Okuda
  • Yasuo Fujimoto
  • Taketo Uchiyama
  • Heesoo Eun
  • Hitoyata Shimokawa
  • Neil Alles
  • Yun Seok Kim
  • Sachiko Matsumoto
  • Mitsuko Makino
  • Hiroyuki Takano
  • Naoki Nagai
  • Akihiko Murata
  • Hiromi Kasai
  • Minhan Dai
  • Roger Kerouel
  • Atsushi Tsuda
  • Hidekazu Ota
  • Agnes Youenou
  • Doug Masten
  • Katsumi Yokouchi
  • Susan Becker
  • Kazuhiro Saito
  • Louis I Gordon
  • Nurit Kress
  • Takao Shimizu
  • Hideshi Daimon
  • Hisao Ito
  • Masaji Ishiguro
  • Hiroshi Nitta
  • Keizo Yamaguchi
  • Makoto Umeda
  • Theodore J Standiford
  • Kazuhiro Tateda
  • Manabu Horikawa
  • Etsu T Fuse
  • Chihiro Ueda
  • Shigeru Tatebe
  • Tohru Takabatake
  • Mitsuhiko Ozaki
  • Yoshikazu Ishii
  • Chie Sugiyama
  • Hidemi Yoshimasu
  • Toshihiro Osada
  • Masataka Asagiri
  • Teruo Amagasa
  • Kiichi Nonaka
  • Bobby J Varghese
  • Hideyuki Iwai
  • Kotaro Oka

Detail Information

Publications37

  1. doi Characteristics of lipid and fatty acid of marine gastropod Turbo cornutus: high levels of arachidonic and n-3 docosapentaenoic acid
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4, Fuku ura, Kanazawa Ku, Yokohama shi 236 8648, Japan Electronic address
    Food Chem 145:135-44. 2014
    ..The viscera may effectively serve as a source of ARA for infant formulas. High levels of ARA, EPA, and n-3 DPA in the phospholipids of T. cornutus were observed. T. cornutus is a healthful marine food containing high levels of n-3 DPA. ..
  2. ncbi Characteristic of lipids and fatty acid compositions of the neon flying squid, Ommastrephes bartramii
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Fuku ura, Kanazawa Ku, Yokohama shi, Japan
    J Oleo Sci 61:547-64. 2012
    ..bartramii, similar to that in highly migratory fishes. The high DHA levels in all its organs suggest that O. bartramii lipids is a healthy marine source for DHA supplements...
  3. ncbi Lipid characteristics of two subtropical Seriola fishes, Seriola dumerili and Seriola rivoliana, with differences between cultured and wild varieties
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4, Fuku ura, Kanazawa Ku, Yokohama shi 236 8648, Japan
    Food Chem 135:1718-29. 2012
    ..The ratio (R(LA/ARA)) of LA to ARA in the cultured samples was markedly higher than were those of the wild samples...
  4. ncbi Identification of novel n-4 series polyunsaturated fatty acids in a deep-sea clam, Calyptogena phaseoliformis
    Hiroaki Saito
    National Research Institute of Fisheries Science, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Chromatogr A 1163:247-59. 2007
    ..Thus, the present findings confirm a perfect and closed novel food chain in the cold-seep bivalve and in its symbionts, which is independent from the photosynthetic food chain...
  5. ncbi Characteristics of the fatty acid composition of a deep-sea vent gastropod, Ifremeria nautilei
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, 236 8648, Japan
    Lipids 45:537-48. 2010
    ....
  6. doi Characteristics of fatty acid composition of the deep-sea vent crab, Shinkaia crosnieri Baba and Williams
    Hiroaki Saito
    National Research Institute of Fisheries Science, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama, 236 8648, Japan
    Lipids 46:723-40. 2011
    ..Such unique fatty acid composition differs from that reported for other common marine animals, which depend on organic matter derived from phytoplankton lipids...
  7. ncbi High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker)
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama shi, Japan
    Lipids 40:941-53. 2005
    ..In contrast, the FA composition of other species is generally variable and their DHA contents of TAG are usually less than 20% of TFA...
  8. doi Unusual novel n-4 polyunsaturated fatty acids in cold-seep mussels (Bathymodiolus japonicus and Bathymodiolus platifrons), originating from symbiotic methanotrophic bacteria
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Chromatogr A 1200:242-54. 2008
    ..Such a highly diversified variety of n-4 family PUFAs in the mussels and the clam under different environments presumably increase the great potential of the chemosynthetic bacteria...
  9. ncbi High levels of icosapentaenoic acid in the lipids of oyster Crassostrea gigas ranging over both Japan and France
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama 236 8648, Japan
    J Oleo Sci 59:281-92. 2010
    ..The fluctuation of total PUFA levels in the polar lipids between samples of both countries suggests the influence of diet. In addition, the consistently high EPA levels in the phospholipids may compensate for the variation in DHA levels...
  10. doi Sulfitobacter porphyrae sp. nov., isolated from the red alga Porphyra yezoensis
    Youhei Fukui
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama 236 8648, Japan
    Int J Syst Evol Microbiol 64:438-43. 2014
    ..On the basis of the phylogenetic, genetic and phenotypic properties of the new isolates, the name Sulfitobacter porphyrae sp. nov. is proposed, with strain SCM-1(T) ( = LMG 27110(T) = NBRC 109054(T)) as the type strain...
  11. doi Polaribacter porphyrae sp. nov., isolated from the red alga Porphyra yezoensis, and emended descriptions of the genus Polaribacter and two Polaribacter species
    Youhei Fukui
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, 236 8648, Japan
    Int J Syst Evol Microbiol 63:1665-72. 2013
    ..nov. is proposed. The type strain is LNM-20(T) ( = LMG 26671(T)  = NBRC 108759(T)). Emended descriptions of the genus Polaribacter and P. dokdonensis and P. gangjinensis are also proposed...
  12. doi Algimonas ampicilliniresistens sp. nov., isolated from the red alga Porphyra yezoensis, and emended description of the genus Algimonas
    Youhei Fukui
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama 236 8648, Japan
    Int J Syst Evol Microbiol 63:4407-12. 2013
    ..nov. is proposed. The type strain is 14A-2-7(T) ( = LMG 26421(T) = NBRC 108219(T)). An emended description of the genus Algimonas is also proposed. ..
  13. ncbi Lipid and FA composition of the pearl oyster Pinctada fucata martensii: influence of season and maturation
    Hiroaki Saito
    National Research Institute of Fisheries Science Fisheries Research Agency, Yokohama shi 236 8648, Japan
    Lipids 39:997-1005. 2004
    ..In particular, NMID derivatives are considered to be biosynthesized in the PE; thus, they might play a particular role in the membrane, because NMID were characteristically localized only in the PE...
  14. doi Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis
    Changhu Xue
    National Research Institute of Fisheries Science, Fisheries Research Agency, 2 12 4 Fuku ura, Kanazawa Ku, Yokohama shi 236 8648, Japan
    Lipids 47:75-92. 2012
    ..From these results, we concluded that the Setogawa River population actively concentrates long-chain PUFA in its polar lipids and has high adaptability to low temperature...
  15. ncbi Lipid Classes and Fatty Acid Profile of Cultured and Wild Black Rockfish, Sebastes schlegeli
    Hiroaki Saito
    National Research Institute of Fisheries Science, Fisheries Research Agency
    J Oleo Sci 63:555-66. 2014
    ..3-40.2% for cultured and 40.1-43.5% for wild). Therefore, the nutritional values of cultured and wild adult S. schlegeli are expected to be similar. ..
  16. doi Algimonas porphyrae gen. nov., sp. nov., a member of the family Hyphomonadaceae, isolated from the red alga Porphyra yezoensis
    Youhei Fukui
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama 236 8648, Japan
    Int J Syst Evol Microbiol 63:314-20. 2013
    ..nov., sp. nov. is proposed. The type strain of Algimonas porphyrae is 0C-2-2(T) (= LMG 26424(T) = NBRC 108216(T))...
  17. ncbi Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice
    Kenji Ishihara
    Marine Biochemistry Division, National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, Japan
    Lipids 37:481-6. 2002
    ..GC analysis of plasma and splenocyte FA profiles showed an increase in the levels of 20:4n-3, 20:5n-3, and 22:6n-3 in mice fed the diet containing 18:4n-3...
  18. ncbi Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1
    Hiroshi Takatsuna
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    J Bone Miner Res 20:653-62. 2005
    ..DHMEQ, a newly designed NF-kappaB inhibitor, inhibited RANKL-induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor of osteoclastogenesis...
  19. ncbi Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus
    Kazufumi Osako
    Food Science and Technology Section, Nagasaki Prefectural Institute of Fisheries, Nagasaki shi 851 2213, Japan
    Lipids 41:713-20. 2006
    ....
  20. ncbi Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress
    Wataru Komatsu
    Department of Human Nutrition and Food Management, Toita Women s College, Tokyo, Japan
    Free Radic Biol Med 34:1006-16. 2003
    ..Our results demonstrate that DHA inhibits NO production in macrophages and this inhibition is, in part, mediated by upregulation of GSH...
  21. ncbi Year-round high arachidonic acid levels in herbivorous rabbit fish Siganus fuscescens tissues
    Kazufumi Osako
    Food Science and Technology Section, Nagasaki Prefectural Institute of Fisheries, 1551 4 Taira machi, Nagasaki 851 2213, Japan
    Lipids 41:473-89. 2006
    ..Moreover, it was suggested that S. fuscescens has potential utility as a natural marine source of nutritional lipids, because the fish contain comparatively high levels of DHA and AA...
  22. ncbi A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis
    Hiroaki Saito
    Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1164-74. 2007
    ..We undertook this study to compare the effects of the WP9QY peptide on collagen-induced arthritis (CIA) in mice with those of anti-TNFalpha monoclonal antibody...
  23. ncbi Interleukin-10 expression significantly correlates with minor CD8+ T-cell infiltration and high microvessel density in patients with gastric cancer
    Teruhisa Sakamoto
    Department of Surgery, Division of Surgical Oncology, Tottori University School of Medicine, Yonago 683 8504, Japan
    Int J Cancer 118:1909-14. 2006
    ..Multivariate analysis indicated IL-10 expression was an independent prognostic factor. IL-10 might be associated with tumor progression by stimulating angiogenesis and suppressing immune responses in gastric cancer...
  24. ncbi Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis
    Takefumi Kojima
    Maxillofacial Surgery, Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:91-9. 2005
    ..The WP9QY treatment prevented the inflammation as well as bone destruction of the joints in the CIA mice, suggesting that the administration of WP9QY peptide might be useful for developing a drug to prevent inflammatory bone destruction...
  25. ncbi Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
    Eijiro Jimi
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Med 10:617-24. 2004
    ..Therefore, selective inhibition of NF-kappa B activation offers an effective therapeutic approach for inhibiting chronic inflammatory diseases involving bone resorption...
  26. ncbi The decline and fate of an iron-induced subarctic phytoplankton bloom
    Philip W Boyd
    NIWA Centre for Chemical and Physical Oceanography, Department of Chemistry, University of Otago, PO Box 56, Dunedin, 9003, New Zealand
    Nature 428:549-53. 2004
    ....
  27. ncbi Effect of starvation on lipid metabolism and stability of DHA content of lipids in horse mackerel (Trachurus japonicus) tissues
    Kazufumi Osako
    Nagasaki Prefectural Institute of Fisheries, Taira, Nagasaki 851 2213, Japan
    Lipids 38:1263-7. 2003
    ..The findings suggest that preservation of DHA in cell membrane lipid PE and PC is necessary for self-protection functions in starving fish...
  28. ncbi A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice
    Yoshifumi Suzuki
    Section of Periodontology, Graduate School, Tokyo Medical and Dental University, Japan
    J Periodontal Res 41:81-91. 2006
    ..It efficiently antagonizes the effect of TNF-alpha binding to the TNF receptor (I)...
  29. pmc A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss
    Kazuhiro Aoki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 116:1525-34. 2006
    ..These results suggest that a peptide that mimics a TNFR ligand contact site blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF...
  30. ncbi Hydroxylated gedunin derivatives from Cedrela sinensis
    Kumiko Mitsui
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 69:1310-4. 2006
    ..The structures of 1-4 were determined by a combination of 2D NMR experiments and chemical methods and by X-ray crystallography of 1 and 2...
  31. doi Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer
    Masashi Inoue
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Yonago, Japan
    Int J Cancer 123:2696-701. 2008
    ..Therefore, intraperitoneal administration of NF-kappaB p65 siRNA and paclitaxel may provide a breakthrough in the treatment of peritoneal metastasis of gastric cancer...
  32. doi Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo
    Anower Hussain Mian
    Section of Pharmacology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    J Bone Miner Metab 26:469-77. 2008
    ..The present data indicate that TNFR1 is critical for bone resorption at the site of LPS injection and that TNFR2 might have a protective role on the LPS-induced inflammatory bone resorption process...
  33. doi Enhanced hydrophobicity of fluorinated lipid bilayer: a molecular dynamics study
    Hiroaki Saito
    Research Institute for Computational Sciences RICS, Research Institute of Advanced Industrial Science and Technology AIST, Central 2, 1 1 1 Umezono, Tsukuba 305 8568, Japan
    J Phys Chem B 112:11305-9. 2008
    ..A cavity distribution analysis elucidated the reduced free volume in the fluorinated membrane due to the neatly packed chains, which should account for the higher free energy barrier...
  34. ncbi Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection
    Shinichi Miyairi
    Laboratory of Bio organic Chemistry, College of Pharmacy, Nihon University, Chiba 274 8555, Japan
    J Med Microbiol 55:1381-7. 2006
    ..The present data identify a promising potential vaccine strategy targeting bacterial quorum-sensing molecules, including autoinducers...
  35. ncbi Estrogen equivalent concentration of 13 branched para-nonylphenols in three technical mixtures by isomer-specific determination using their synthetic standards in SIM mode with GC-MS and two new diasteromeric isomers
    Takao Katase
    College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Chemosphere 70:1961-72. 2008
    ..208 for TCI, 0.206 for Aldrich and 0.205 for Fluka. The predicted estrogenic activity of measured concentration of para-NP in technical mixtures was approximately 5-fold greater than the measured estrogen agonist activity...
  36. ncbi Apotirucallane and tirucallane triterpenoids from Cedrela sinensis
    Kumiko Mitsui
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    Chem Pharm Bull (Tokyo) 55:1442-7. 2007
    ..The structures of 1-9 were determined by the 2D NMR experiments, chemical methods, and X-ray crystallography...
  37. ncbi Recent comparability of oceanographic nutrients data: results of a 2003 intercomparison exercise using reference materials
    Michio Aoyama
    Meteorological Research Institute, Japan Meteorological Agency, Japan
    Anal Sci 23:1151-4. 2007
    ..Therefore, the use of common reference materials, i.e. certified RM, is essential to establish and improve the comparability of nutrient data of the world's oceans...