Ravshan Z Sabirov

Summary

Affiliation: National Institute for Physiological Sciences
Country: Japan

Publications

  1. doi request reprint Plasmalemmal VDAC controversies and maxi-anion channel puzzle
    Ravshan Z Sabirov
    Laboratory of Molecular Physiology, Institute of Pysiology and Biphysics, Academy of Science, RUz, Tashkent, Uzbekistan
    Biochim Biophys Acta 1818:1570-80. 2012
  2. ncbi request reprint Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki 444 8585, Japan
    J Biol Chem 281:1897-904. 2006
  3. pmc Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathway
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biophys J 87:1672-85. 2004
  4. pmc Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique
    Amal K Dutta
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biophys J 94:1646-55. 2008
  5. doi request reprint Activation of maxi-anion channel by protein tyrosine dephosphorylation
    Abduqodir H Toychiev
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Am J Physiol Cell Physiol 297:C990-1000. 2009
  6. ncbi request reprint Roles of two types of anion channels in glutamate release from mouse astrocytes under ischemic or osmotic stress
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Glia 54:343-57. 2006
  7. doi request reprint Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells
    Md Rafiqul Islam
    Dept of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Am J Physiol Cell Physiol 303:C924-35. 2012
  8. doi request reprint ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore
    Oleg V Krasilnikov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    J Physiol Sci 61:267-78. 2011
  9. ncbi request reprint ATP-conducting maxi-anion channel: a new player in stress-sensory transduction
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444 8585 Japan
    Jpn J Physiol 54:7-14. 2004
  10. pmc Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji cho, Okazaki, Aichi 444 8585, Japan
    J Physiol 587:2197-209. 2009

Collaborators

Detail Information

Publications24

  1. doi request reprint Plasmalemmal VDAC controversies and maxi-anion channel puzzle
    Ravshan Z Sabirov
    Laboratory of Molecular Physiology, Institute of Pysiology and Biphysics, Academy of Science, RUz, Tashkent, Uzbekistan
    Biochim Biophys Acta 1818:1570-80. 2012
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  2. ncbi request reprint Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki 444 8585, Japan
    J Biol Chem 281:1897-904. 2006
    ..The lack of correlation between VDAC protein expression and maxianion channel activity strongly argues against the long held hypothesis of plasmalemmal VDAC being the maxianion channel...
  3. pmc Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathway
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biophys J 87:1672-85. 2004
    ..60 nm). We therefore conclude that the nanoscopic maxi-anion channel pore provides sufficient room to accommodate ATP and is well suited to its function as a conductive pathway for ATP release in cell-to-cell communication...
  4. pmc Spatial distribution of maxi-anion channel on cardiomyocytes detected by smart-patch technique
    Amal K Dutta
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biophys J 94:1646-55. 2008
    ..This study showed that the smart-patch technique provides a powerful method to detect a unitary event of channels that are localized at some specific site in the narrow region...
  5. doi request reprint Activation of maxi-anion channel by protein tyrosine dephosphorylation
    Abduqodir H Toychiev
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Am J Physiol Cell Physiol 297:C990-1000. 2009
    ..Thus it is concluded that activation of the maxi-anion channel involves protein dephosphorylation mediated by protein tyrosine phosphatases that include RPTPzeta in mouse fibroblasts, but not in C127 cells...
  6. ncbi request reprint Roles of two types of anion channels in glutamate release from mouse astrocytes under ischemic or osmotic stress
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Glia 54:343-57. 2006
    ..We conclude that these two channels jointly represent a major conductive pathway for the release of glutamate from swollen and ischemia-challenged astrocytes, with the contribution of maxi-anion channels being predominant...
  7. doi request reprint Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells
    Md Rafiqul Islam
    Dept of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Am J Physiol Cell Physiol 303:C924-35. 2012
    ....
  8. doi request reprint ATP hydrolysis-dependent asymmetry of the conformation of CFTR channel pore
    Oleg V Krasilnikov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    J Physiol Sci 61:267-78. 2011
    ....
  9. ncbi request reprint ATP-conducting maxi-anion channel: a new player in stress-sensory transduction
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444 8585 Japan
    Jpn J Physiol 54:7-14. 2004
    ..A newly discovered property, its ATP conductivity and its activation in response to stress signals, indicates that this channel has a central role in stress-sensory transduction for cell volume regulation and tubuloglomerular feedback...
  10. pmc Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji cho, Okazaki, Aichi 444 8585, Japan
    J Physiol 587:2197-209. 2009
    ..Since bradykinin is an initial mediator of inflammation, VSOR might play a role in glia-neuron communication in the brain during inflammation...
  11. pmc Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells
    Iskandar F Abdullaev
    Department of Cell Physiology, National Institute for Physiological Sciences, CREST of Japan Science and Technology Corporation, Okazaki 444 8585, Japan
    J Physiol 549:749-58. 2003
    ..We thus conclude that the EGF receptor tyrosine kinase upregulates the activity of the VSOR Cl- channel, mainly by enhancing the volume sensitivity...
  12. doi request reprint Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Cell Res 18:558-65. 2008
    ..Thus, we propose that the maxi-anion channel constitutes a major pathway for swelling-induced ATP release from cultured mouse astrocytes as well...
  13. doi request reprint The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444 8585, Japan
    J Physiol Sci 59:3-21. 2009
    ..Molecular identification of the maxi-anion channel is an urgent task that would greatly promote investigation in the fields not only of anion channel but also of physiological/pathophysiological signaling in the brain, heart and kidney...
  14. ncbi request reprint Sizing the pore of the volume-sensitive anion channel by differential polymer partitioning
    Vadim I Ternovsky
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    FEBS Lett 576:433-6. 2004
    ..The cut-off radius of the VSOR channel pore was assessed to be 0.63 nm...
  15. pmc Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions
    Amal K Dutta
    Department of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    J Physiol 559:799-812. 2004
    ..These results indicate that neonatal rat cardiomyocytes respond to ischaemia, hypoxia or hypotonic stimulation with ATP release via maxi-anion channels...
  16. pmc Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes
    Ravshan Z Sabirov
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    PLoS ONE 8:e55646. 2013
    ..We suggest that the VSOR anion channel constitutes a major part of the γ-glutamyl cycle in thymocytes and, in cooperation with OATP-like and OAT-like transporters, provides a pathway for the GSH efflux from osmotically swollen cells...
  17. ncbi request reprint Down-regulation of volume-sensitive Cl- channels by CFTR is mediated by the second nucleotide-binding domain
    Yuhko Ando-Akatsuka
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Pflugers Arch 445:177-86. 2002
    ..Thus, we conclude that an ATP-hydrolysable conformation of NBD2 is essential for the regulation of the VSOR by the CFTR protein, and that VSOR is a first channel regulated by CFTR through its NBD2...
  18. ncbi request reprint Ca(2+)-dependent glycolysis activation mediates apoptotic ATP elevation in HeLa cells
    Maria V Zamaraeva
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Biochem Biophys Res Commun 363:687-93. 2007
    ..We conclude that Ca(2+)-dependent activation of anaerobic glycolysis, but not aerobic mitochondrial oxidative phosphorylation, is responsible for the STS-induced elevation of ATP in apoptotic HeLa cells...
  19. ncbi request reprint Detecting ATP release by a biosensor method
    Seiji Hayashi
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Sci STKE 2004:pl14. 2004
    ..The ATP release is quantified by a calibration procedure utilizing local puff applications of ATP at preset concentrations...
  20. ncbi request reprint Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes
    Hiromi Uramoto
    Department of Cell Physiology, National Institute for Physiological Sciences and Japan Science and Technology Agency, Okazaki, 444 8585 Japan
    Jpn J Physiol 53:357-65. 2003
    ..These findings indicate that a plasmalemmal expression of CFTR is transiently enhanced under glucose-free hypoxic conditions presumably because of a posttranslational control...
  21. ncbi request reprint Calcium-activated nonselective cationic channel in macula densa cells
    Jean Yves Lapointe
    National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    Am J Physiol Renal Physiol 285:F275-80. 2003
    ....
  22. pmc Oxygen-glucose deprivation induces ATP release via maxi-anion channels in astrocytes
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki, 444 8585, Japan
    Purinergic Signal 4:147-54. 2008
    ..11. Thus, it is concluded that ischemic stress induces ATP release from astrocytes and that the maxi-anion channel may serve as a major ATP-releasing pathway under ischemic conditions...
  23. pmc Swelling-activated anion channels are essential for volume regulation of mouse thymocytes
    Ranokhon S Kurbannazarova
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan E Mails R S K S V B R Z S
    Int J Mol Sci 12:9125-37. 2011
    ..The inhibitory effect of DIOA was also strong, and, most likely, it occurred via blocking the VSOR Cl(-) channels...
  24. pmc Regulation of an ATP-conductive large-conductance anion channel and swelling-induced ATP release by arachidonic acid
    Amal K Dutta
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Physiol 542:803-16. 2002
    ..Thus, we conclude that swelling-induced ATP release and its putative pathway, the VDACL anion channel, are under a negative control by intracellular arachidonic acid signalling in mammary C127 cells...