Akihide Ryo

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
  2. pmc SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 105:294-9. 2008
  3. doi request reprint Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis
    Kanji Endoh
    Drug Discovery Research Center, Taiho Pharmaceutical Co, Ltd, Tsukuba, Japan
    Prostate 72:626-37. 2012
  4. doi request reprint Pinning down HER2-ER crosstalk in SMRT regulation
    Akihide Ryo
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Trends Biochem Sci 34:162-5. 2009
  5. doi request reprint Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag
    Mayuko Nishi
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    FEBS Lett 583:1243-50. 2009
  6. ncbi request reprint A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Biol Chem 282:36671-81. 2007
  7. doi request reprint DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity
    Masaru Shimada
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:4920-7. 2010
  8. doi request reprint Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Sci Signal 5:ra73. 2012
  9. pmc A distinct role for Pin1 in the induction and maintenance of pluripotency
    Mayuko Nishi
    Department of Microbiology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Biol Chem 286:11593-603. 2011
  10. pmc BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction
    Kei Miyakawa
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS Pathog 5:e1000700. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
    Yih Cherng Liou
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 424:556-61. 2003
    ..Thus, Pin1 is pivotal in protecting against age-dependent neurodegeneration, providing insight into the pathogenesis and treatment of Alzheimer's disease and other tauopathies...
  2. pmc SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Proc Natl Acad Sci U S A 105:294-9. 2008
    ..These results together indicate that SOCS1 is a crucial host factor that regulates the intracellular dynamism of HIV-1 Gag and could therefore be a potential new therapeutic target for AIDS and its related disorders...
  3. doi request reprint Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis
    Kanji Endoh
    Drug Discovery Research Center, Taiho Pharmaceutical Co, Ltd, Tsukuba, Japan
    Prostate 72:626-37. 2012
    ..Although Pin1 has been shown to be involved in cell transformation and the maintenance of the malignant phenotype in prostate cancer, its specific substrates during these processes have not yet been determined...
  4. doi request reprint Pinning down HER2-ER crosstalk in SMRT regulation
    Akihide Ryo
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Trends Biochem Sci 34:162-5. 2009
    ..Pin1 functions downstream of HER2, positioning it as an important modulator of the crosstalk between ER and growth factor signaling...
  5. doi request reprint Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag
    Mayuko Nishi
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    FEBS Lett 583:1243-50. 2009
    ..We thus propose that the microtubule network plays a role in SOCS1-mediated HIV-1 Gag transport and virus particle formation...
  6. ncbi request reprint A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    J Biol Chem 282:36671-81. 2007
    ....
  7. doi request reprint DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity
    Masaru Shimada
    Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:4920-7. 2010
    ..These results demonstrate that covalent antigen modification with an Ig sequence can modulate antigen-specific cellular immune responses. The approach may be useful for vaccine development...
  8. doi request reprint Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu
    Kei Miyakawa
    Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236 0004, Japan
    Sci Signal 5:ra73. 2012
    ..Together, these results suggest that SCYL2 serves as a regulatory factor for Vpu, reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction...
  9. pmc A distinct role for Pin1 in the induction and maintenance of pluripotency
    Mayuko Nishi
    Department of Microbiology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    J Biol Chem 286:11593-603. 2011
    ..These data suggest that the manipulation of Pin1 function could be a potential strategy for the stable induction and proliferation of human iPS cells...
  10. pmc BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction
    Kei Miyakawa
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS Pathog 5:e1000700. 2009
    ....
  11. doi request reprint Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1
    Kenji Ohba
    AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjyuku ku, Tokyo, Japan
    J Immunol 183:524-32. 2009
    ..We have thus elucidated a novel regulatory mechanism in which FDCs are a potent positive bystander that facilitates HIV-1 replication in adjacent infected monocytic cells via a juxtacrine signaling mechanism...
  12. ncbi request reprint Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Japan
    J Biol Chem 281:4117-25. 2006
    ..These results indicate that Pin1-mediated prolyl-isomerization plays a pivotal role in a post-translational modification pathway for alpha-synuclein aggregation and in the resultant Lewy body formations in PD...
  13. doi request reprint Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels
    Tomoaki Ishigami
    1Yokohama City University Graduate School of Medicine, Department of Medical Science and Cardio renal Medicine, 3 9, Fukuura, Kanazawa Ku, Yokohama City, Kanagawa Ken, 236 0004, Japan
    FASEB J 27:3437-45. 2013
    ..Minegishi, S., Ryo, A., Matsunaga, S., Matsuoka, K., Takeda, H., Sawasaki, T., Umemura, S., and Endo, Y. Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels. ..
  14. doi request reprint The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation
    Soo Jin Jeong
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 381:294-9. 2009
    ..Our current study demonstrates an important role for Pin1 in the post-translational regulation of Tax and suggests that the targeting of Pin1 may offer a new insight into the pathogenesis of HTLV-1 related diseases...
  15. ncbi request reprint Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer
    Akihide Ryo
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Clin Cancer Res 11:7523-31. 2005
    ..In the present study, we sought to determine the potential of Pin1-targeted gene silencing in inhibiting cellular growth and tumorigenicity in prostate cancer...
  16. doi request reprint Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis
    Satoko Matsunaga
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Proteomics 75:4863-73. 2012
    ..This system may provide an attractive means for analyzing the function of retrovirus proteases and provide a technology platform for drug screening...
  17. pmc Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study
    Ryohei Takeuchi
    Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Yokohama City, Kanagawa, Japan
    Arthritis Res Ther 10:R77. 2008
    ....
  18. doi request reprint Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells
    Sayaka Yashima
    Department of Molecular Biodefence Research, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Vaccine 28:3257-64. 2010
    ..This viral interference may involve soluble factor(s), secreted by virus-infected cells. Our study may help in designing a vaccination regimen and in investigating viral interference...
  19. ncbi request reprint Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements
    Nobuo Kondoh
    Department of Biochemistry II, National Defense Medical College, Saitama 359 8513, Japan
    Int J Oncol 23:1575-83. 2003
    ..Thus, the specific interaction of methylation-sensitive factors to the upstream and downstream elements may be essential for the activation of the Gal-1 gene in HCC cells...