Satoshi Ono

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. doi request reprint Preoperative Toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery
    Satoshi Ono
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    World J Surg 35:365-71. 2011
  2. doi request reprint Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers
    Satoshi Ono
    Division of Traumatology, National Defense Medical College Research Institute, Saitama, Japan
    Surgery 153:262-71. 2013
  3. ncbi request reprint Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy
    Satoshi Ono
    Department of Surgery, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, Japan
    World J Surg 31:1996-2001. 2007
  4. ncbi request reprint Sex differences in cytokine production and surface antigen expression of peripheral blood mononuclear cells after surgery
    Satoshi Ono
    Department of Surgery I, National Defense Medical College Research Institute, Namiki 3 2, Tokorozawa, Saitama, 359 8513, Japan
    Am J Surg 190:439-44. 2005
  5. ncbi request reprint Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359 8513, Japan
    Shock 23:39-44. 2005
  6. doi request reprint Loss of hepatic B cells following lipopolysaccharide injection and polymicrobial sepsis
    Atsushi Matsumoto
    Department of Immunology, The National Defence Medical College, Tokorozawa, Japan
    J Gastroenterol Hepatol 24:262-9. 2009
  7. doi request reprint The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery
    Akifumi Kimura
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Res 175:e83-8. 2012
  8. doi request reprint Laparoscopic gastrectomy after incomplete endoscopic resection for early gastric cancer
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa 359 8513, Japan
    Oncol Rep 28:2205-10. 2012
  9. ncbi request reprint A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Hepatol 45:836-43. 2006
  10. doi request reprint Predictive value of pleural and serum interleukin-6 levels for pneumonia and hypo-oxygenations after esophagectomy
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    J Surg Res 182:e61-7. 2013

Collaborators

Detail Information

Publications66

  1. doi request reprint Preoperative Toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery
    Satoshi Ono
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    World J Surg 35:365-71. 2011
    ....
  2. doi request reprint Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers
    Satoshi Ono
    Division of Traumatology, National Defense Medical College Research Institute, Saitama, Japan
    Surgery 153:262-71. 2013
    ..We sought to investigate the role of CD4(+)CD25(+)Foxp3(+) Tregs in septic patients, and to evaluate the effect of hemoperfusion with PMX-F on the recovery from immunosuppression owing to septic shock...
  3. ncbi request reprint Effects of neutrophil elastase inhibitor on progression of acute lung injury following esophagectomy
    Satoshi Ono
    Department of Surgery, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, Japan
    World J Surg 31:1996-2001. 2007
    ..This clinical study showed that a neutrophil elastase inhibitor may thus be a potentially useful drug for treating acute lung injury following esophagectomy...
  4. ncbi request reprint Sex differences in cytokine production and surface antigen expression of peripheral blood mononuclear cells after surgery
    Satoshi Ono
    Department of Surgery I, National Defense Medical College Research Institute, Namiki 3 2, Tokorozawa, Saitama, 359 8513, Japan
    Am J Surg 190:439-44. 2005
    ..In addition, the clinical courses of male and female patients after gastrointestinal surgery were compared...
  5. ncbi request reprint Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, 359 8513, Japan
    Shock 23:39-44. 2005
    ..Neutrophil-derived NE may be associated with increased expression of monocyte/macrophage TLR-4, thereby serving as a positive feedback loop for the inflammatory response among the different cell populations...
  6. doi request reprint Loss of hepatic B cells following lipopolysaccharide injection and polymicrobial sepsis
    Atsushi Matsumoto
    Department of Immunology, The National Defence Medical College, Tokorozawa, Japan
    J Gastroenterol Hepatol 24:262-9. 2009
    ..B cells possess pleiotropic functions and are important for both humoral as well as cellular immune responses. However, there is little information about how hepatic B cells respond to lipopolysaccharide (LPS) and/or sepsis...
  7. doi request reprint The postoperative serum interleukin-15 concentration correlates with organ dysfunction and the prognosis of septic patients following emergency gastrointestinal surgery
    Akifumi Kimura
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Res 175:e83-8. 2012
    ....
  8. doi request reprint Laparoscopic gastrectomy after incomplete endoscopic resection for early gastric cancer
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa 359 8513, Japan
    Oncol Rep 28:2205-10. 2012
    ..LAG may be the first-choice radical treatment after incomplete ESD for early gastric cancer...
  9. ncbi request reprint A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Hepatol 45:836-43. 2006
    ..To date, there have not been any reports regarding the role of bacterial DNA in the systemic circulation on the development of sepsis...
  10. doi request reprint Predictive value of pleural and serum interleukin-6 levels for pneumonia and hypo-oxygenations after esophagectomy
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    J Surg Res 182:e61-7. 2013
    ..The purpose of this study was to evaluate the predictive value of cytokine levels in sera and pleural drainage fluid for pneumonia and hypo-oxygenations following esophagectomy...
  11. doi request reprint Neutralization of interleukin-10 or transforming growth factor-β decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival
    Shuhichi Hiraki
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Surgery 151:313-22. 2012
    ..To investigate the role of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) in septic conditions, and to examine the potential of targeting them for the treatment of sepsis...
  12. ncbi request reprint Interleukin-18 restores immune suppression in patients with nonseptic surgery, but not with sepsis
    Shuhichi Hiraki
    Department of Surgery, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg 193:676-80. 2007
    ....
  13. doi request reprint Sentinel node navigation surgery attenuates the functional disorders in early gastric cancer
    Yoshihisa Yaguchi
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Oncol Rep 27:643-9. 2012
    ..In conclusion, SNRG has some advantages over GL in terms of postoperative disorders for at least one year after surgery, and is the recommended choice of a surgical procedure for early gastric cancer...
  14. ncbi request reprint Enhanced interferon-gamma production and bacterial clearance in the liver of splenectomized mice in the models of Escherichia coli injection or intestinal obstruction
    Shin ichi Ikuta
    Department of Surgery I, National Defense Medical College, Saitama 359 8513, Japan
    Shock 21:452-7. 2004
    ..In conclusion, splenectomy does not impair host defense against bacteria infection provided that recovery is sufficient to allow compensatory processes in the liver to occur...
  15. ncbi request reprint Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Clin Immunol 119:180-7. 2006
    ..We examined whether the same response occurred after surgical injury, and whether this reduced activity was associated with differential monocyte toll-like receptor (TLR) expression...
  16. doi request reprint Distance between the esophageal tumor and the aorta measured by using the contrast-enhanced attenuation on computed tomography for predicting this tumor invading aorta
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    J Gastroenterol Hepatol 28:297-302. 2013
    ..The aim of this study was to evaluate the predictive value of the computed tomography (CT) attenuation value between the tumor and the aorta for esophageal cancer...
  17. doi request reprint Video-assisted thoracoscopic surgery for esophageal cancer attenuates postoperative systemic responses and pulmonary complications
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Surgery 151:667-73. 2012
    ..However, the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS-e) with regard to postoperative morbidity and mortality remains controversial...
  18. doi request reprint Systemic inflammatory response syndrome as a predictor of anastomotic leakage after esophagectomy
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    Surg Today 42:141-6. 2012
    ..Esophageal anastomotic leakage is still a major cause of morbidity and mortality after esophagectomy. We conducted this study to elucidate how anastomotic leakage affects the systemic inflammatory response syndrome (SIRS) criteria...
  19. doi request reprint One-step nucleic acid amplification (OSNA) for the application of sentinel node concept in gastric cancer
    Yoshihisa Yaguchi
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg Oncol 18:2289-96. 2011
    ..We evaluated the efficacy of OSNA in terms of the intraoperative diagnosis of LN metastasis in patients with gastric cancer...
  20. doi request reprint Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells
    Kentaro Chochi
    Department of Surgery, National Defense Medical College, Namiki, Tokorozawa, Japan
    Clin Cancer Res 14:2909-17. 2008
    ..We investigated the mechanisms by which H. pylori affects gastric cancer growth and antitumor immunities in the host, focusing on H. pylori-derived lipopolysaccharide (LPS)...
  21. ncbi request reprint Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College Research Institute, Saitama, Japan
    J Endotoxin Res 10:229-37. 2004
    ....
  22. doi request reprint Outcome of overlap anastomosis using a linear stapler after laparoscopic total and proximal gastrectomy
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Langenbecks Arch Surg 397:833-40. 2012
    ..In this study, we evaluated the feasibility and safety of the overlap method for esophagojejunostomy or esophagogastrostomy after LTG or laparoscopic proximal gastrectomy (LPG), respectively...
  23. doi request reprint Neutralization of IL-10 restores the downregulation of IL-18 receptor on natural killer cells and interferon-γ production in septic mice, thus leading to an improved survival
    Shuichi Hiraki
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Shock 37:177-82. 2012
    ..Sepsis might impair IL-18R expression on liver and spleen NK cells and impair the IL-18-mediated IFN-γ response. Neutralization of IL-10 may restore this response in septic hosts, thereby improving survival...
  24. doi request reprint Optimal size of jejunal pouch as a reservoir after total gastrectomy: a single-center prospective randomized study
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    J Gastrointest Surg 15:1777-82. 2011
    ..In order to improve a patient's quality of life after total gastrectomy, jejunal pouch reconstruction has been employed. However, little information exists regarding the optimal size of the jejunal pouch after total gastrectomy...
  25. ncbi request reprint An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells
    Akira Motegi
    Department of Pediatrics, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    J Leukoc Biol 79:463-72. 2006
    ..The NK cells, NK-T cells, and macrophages, which change proportionally or functionally with aging, might be involved in the enhanced GSR response/septic shock observed in elderly patients...
  26. ncbi request reprint Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg 188:150-6. 2004
    ....
  27. doi request reprint Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination
    Hidekazu Sugasawa
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Int J Cancer 122:2535-41. 2008
    ..In conclusion, gastric cancer cells might thus induce CD4+ T cells to secrete CCL5 and exploit it for their progression, as well as to aid in the prevention of CD8+ T cell-involved tumor elimination...
  28. ncbi request reprint Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa
    Manabu Kinoshita
    Division of Basic Traumatology, Research Institute, National Defense Medical College, Namiki 3 2, Tokorozawa 359 8513, Japan
    J Immunol 177:4627-35. 2006
    ..IL-18 treatment for the burned mice and their resultant natural IgM production were thus found to strengthen the host defense against P. aeruginosa infection...
  29. pmc Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus
    Manabu Kinoshita
    Department of Microbiology, National Defense Medical College, Namiki 3 2, Tokorozawa 359 8513, Japan
    Infect Immun 79:2670-80. 2011
    ..Thus, although neutrophil functions were impaired in burn-injured mice, IL-18 therapy markedly activated neutrophil functions, thereby increasing survival from postburn MRSA infection...
  30. pmc How should tracers be injected to detect for sentinel nodes in gastric cancer--submucosally from inside or subserosally from outside of the stomach?
    Yoshihisa Yaguchi
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Exp Clin Cancer Res 27:79. 2008
    ....
  31. doi request reprint Peritoneal computed tomography attenuation values reflect the severity of peritonitis caused by gastrointestinal perforations
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Am J Surg 202:455-60. 2011
    ..The aim of this study was to evaluate the peritoneal computed tomography (CT) attenuation values and relate them to the severity of peritonitis in patients with gastrointestinal tract (GI) perforations...
  32. ncbi request reprint Cooperative IFN-gamma production of mouse liver B cells and natural killer cells stimulated with lipopolysaccharide
    Atsushi Matsumoto
    Department of Microbiology, National Defense Medical College, Tokorozawa, Japan
    J Hepatol 45:290-8. 2006
    ..Although mouse liver contains a large population of B cells, little is known about how hepatic B cells respond to bacterial lipopolysaccharide (LPS)...
  33. ncbi request reprint Opposite effects of enhanced tumor necrosis factor-alpha production from Kupffer cells by gadolinium chloride on liver injury/mortality in endotoxemia of normal and partially hepatectomized mice
    Manabu Kinoshita
    Division of Basic Traumatology, National Defense Medical College Research Institute, Namiki, Tokorozawa 359 8513, Japan
    Shock 23:65-72. 2005
    ..Meanwhile, the increased TNF-alpha production induced by GdCl3 supports liver regeneration and increases the survival after LPS challenge in PH mice...
  34. doi request reprint Isolated gastric metastasis from renal cell carcinoma 19 years after radical nephrectomy
    Hidekazu Sugasawa
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Int J Clin Oncol 15:196-200. 2010
    ..This case confirms the existence of a very slow growing type of RCC with the potential for late solitary metastases and describes the surgical resectability...
  35. doi request reprint Computed tomography lymphography for the detection of sentinel nodes in patients with gastric carcinoma
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Cancer Sci 101:2586-90. 2010
    ....
  36. doi request reprint Has the accuracy of preoperative diagnosis improved in cases of early-stage gastric cancer?
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    World J Surg 34:1840-6. 2010
    ..Adequate preoperative evaluation for gastric cancer staging is essential to develop an individualized treatment strategy involving surgery with reduced lymphadenectomy and laparoscopic gastrectomy...
  37. doi request reprint Postoperative serum concentrations of high mobility group box chromosomal protein-1 correlates to the duration of SIRS and pulmonary dysfunction following gastrointestinal surgery
    Risa Takahata
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Res 170:e135-40. 2011
    ....
  38. doi request reprint Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer
    Hidekazu Sugasawa
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Oncol 97:445-50. 2008
    ..The clinical significance of CCL5 has been reported in several malignancies. In this study, we examined the prognostic impact of serum CCL5 levels and the expression of CCL5 receptors on tumor cells in patients with gastric cancer...
  39. ncbi request reprint Detection of microbial DNA in the blood of surgical patients for diagnosing bacterial translocation
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, 359 8513, Japan
    World J Surg 29:535-9. 2005
    ..It is also valuable in septic patients who do not have a defined focus of infection...
  40. doi request reprint Laparoscopic treatment for median arcuate ligament syndrome: the usefulness of intraoperative Doppler ultrasound to confirm the decompression of the celiac artery
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Namiki, Tokorozawa, Japan
    Surg Laparosc Endosc Percutan Tech 22:e71-5. 2012
    ..The intraoperative Doppler ultrasound is useful for confirming the decompression of the celiac artery, although long-term follow-up is mandatory...
  41. doi request reprint Successful gastric submucosal tumor resection using laparoscopic and endoscopic cooperative surgery
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    World J Surg 36:327-30. 2012
    ..However, laparoscopic wedge resection is not applicable for tumors located near the gastric inlet or outlet and requires resection of relatively large sections of healthy stomach, particularly if laparoscopic linear staplers are used...
  42. doi request reprint Gastric tube reconstruction by laparoscopy-assisted surgery attenuates postoperative systemic inflammatory response after esophagectomy for esophageal cancer
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    World J Surg 34:2830-6. 2010
    ..However, it is unclear whether laparoscopy-assisted gastric tube reconstruction (LAGT) can attenuate the postoperative systemic inflammatory response after esophagectomy for esophageal cancer...
  43. doi request reprint Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation
    Tomoharu Shimizu
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan
    Langenbecks Arch Surg 394:303-11. 2009
    ....
  44. doi request reprint Impact of postoperative infection on long-term survival after potentially curative resection for gastric cancer
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Ann Surg Oncol 16:311-8. 2009
    ..However, further immunological study and prospective trials are necessary to confirm the biological significance of these findings...
  45. ncbi request reprint Serum granulysin level as a novel prognostic marker in patients with gastric carcinoma
    Susumu Saigusa
    First Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    J Gastroenterol Hepatol 22:1322-7. 2007
    ..However, few studies have estimated serum granulysin concentrations in patients with solid or hematological malignancies...
  46. doi request reprint Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes?
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Gastric Cancer 13:212-21. 2010
    ....
  47. doi request reprint Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress
    Manabu Kinoshita
    Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan
    J Leukoc Biol 93:689-98. 2013
    ..Therefore, IL-18 treatment may be an attractive and useful therapeutic tool against bacterial complications in immunocompromised hosts after severe surgical stress...
  48. pmc Outcomes for patients following hepatic resection of metastatic tumors from gastric cancer
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513 Japan
    Hepatol Int 4:406-13. 2010
    ..Although several studies have reported the efficacy of hepatic resection for the long-term survival of patients with gastric cancer metastases, the optimal treatment remains to be determined...
  49. doi request reprint Assessment of a tissue-engineered gastric wall patch in a rat model
    Tomoyuki Maemura
    Research Institute Division of Basic Traumatology, National Defense Medical College, Saitama, Japan
    Artif Organs 36:409-17. 2012
    ....
  50. ncbi request reprint Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Surgery 134:92-100. 2003
    ..The purpose of this study was to assess the correlation between liver and spleen innate cytokine responses and organ dysfunction in sepsis syndrome...
  51. pmc Paradoxical effect of IL-18 therapy on the severe and mild Escherichia coli infections in burn-injured mice
    Manabu Kinoshita
    Division of Basic Traumatology, National Defense Medical College Research Institute, National Defense Medical College, Namiki, Tokorozawa, Japan
    Ann Surg 240:313-20. 2004
    ..To investigate the effects of IL-18 therapy on severe and mild bacterial infection after burn injury...
  52. ncbi request reprint Preoperative chemoradiotherapy for esophageal cancer enhances the postoperative systemic inflammatory response
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Jpn J Clin Oncol 36:632-7. 2006
    ..Chemoradiotherapy (CRT) has been established to improve the long-term survival in patients with esophageal carcinoma. However, little is known about whether preoperative CRT may affect the postoperative systemic response...
  53. doi request reprint Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-γ produced from NK cells in burn-injured mice
    Hiromi Miyazaki
    Division of Traumatology, National Defense Medical College Research Institute, Tokorozawa, Japan
    Burns 37:1208-15. 2011
    ..In conclusion, IL-18 therapy in burn-injured mice enhanced function of CD68(+) Kupffer cells via the activation of liver NK cells and augmentation of their IFN-γ production, thereby improving survival after E. coli infection...
  54. doi request reprint Limited gastrectomy with dissection of sentinel node stations for early gastric cancer with negative sentinel node biopsy
    Takashi Ichikura
    From the Department of Surgery, National Defense Medical College Hospital, Tokorozawa, Japan
    Ann Surg 249:942-7. 2009
    ..To evaluate the early results of sentinel node (SN)-navigated limited surgery for early gastric cancer...
  55. doi request reprint Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice
    Toshimichi Takigawa
    Dept of Immunology and Microbiology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513 Japan
    Am J Physiol Gastrointest Liver Physiol 305:G427-38. 2013
    ..coli, LPS, or Con-A challenge. Taken together, these results suggest that IFN-γ-reducing immunomodulatory property of UDCA is mediated by elevated GR in the liver lymphocytes in an IL-12/18-independent manner. ..
  56. pmc Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice and thereby improves surgical site Staphylococcus aureus infection
    Hidekazu Yano
    Department of General Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    Infect Immun 80:4409-16. 2012
    ..Glycemic control by insulin also normalized the neutrophil superoxide-producing capability in HFD mice. Thus, insulin may restore neutrophil phagocytosis and bactericidal activity, thereby ameliorating SSI...
  57. doi request reprint An ultrathin poly(L-lactic acid) nanosheet as a burn wound dressing for protection against bacterial infection
    Hiromi Miyazaki
    Division of Traumatology, Research Institute, National Defense Medical College, Tokorozawa, Japan
    Wound Repair Regen 20:573-9. 2012
    ..The ultrathin PLLA nanosheet may be applied as a protective dressing to reduce environmental contamination of bacteria in a partial-thickness burn wound...
  58. doi request reprint Role of Toll-like receptors in the development of sepsis
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Japan
    Shock 29:315-21. 2008
    ..This mechanism(s) may contribute to the organ dysfunction and mortality that occurs in sepsis. A better understanding of TLR biology may unveil novel therapeutic approaches for sepsis...
  59. ncbi request reprint Interleukin-18 concentration in the peritoneal fluid correlates with the severity of peritonitis
    Shin ichi Ikuta
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, 359 8513, Saitama, Japan
    Am J Surg 185:550-5. 2003
    ..The aim of this study was to investigate the clinical significance of peritoneal IL-18 concentrations in patients with peritonitis...
  60. doi request reprint Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Namiki, Tokorozawa, Japan
    Surg Endosc 24:471-5. 2010
    ..In this article, we introduce a minimally invasive endoscopic full-thickness resection technique after laparoscopic repair for the local resection of duodenal carcinoid tumors...
  61. doi request reprint Role of translocation of pathogen-associated molecular patterns in sepsis
    Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Dig Surg 26:100-9. 2009
    ..The literature on the consequences of novel insights of bacterial translocation was reviewed...
  62. ncbi request reprint [The pathogenesis of the systemic inflammatory response syndrome and compensatory antiinflammatory response syndrome following surgical stress]
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Tokorozawa, Japan
    Nihon Geka Gakkai Zasshi 104:499-505. 2003
    ..In this manuscript, we explain the pathogenesis of SIRS and CARS following surgical stress by analyzing cytokine production and surface membrane molecules in the inflammation charge cells...
  63. ncbi request reprint [Mechanism of immune suppression after surgical stress and host defense against infection]
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Tokorozawa, Japan
    Nihon Geka Gakkai Zasshi 104:822-7. 2003
    ..In this manuscript, we explain the mechanism of immune suppression after surgical stress and the host defense against infection by analyzing cytokine production and surface membrane molecules in mononuclear cells...
  64. ncbi request reprint [Rapid measurement system of humoral mediator]
    Satoshi Ono
    Department of Surgery I, National Defense Medical College
    Nihon Rinsho 62:2269-75. 2004
    ..In this manuscript, we discussed that the role of humoral mediators in the SIRS and septic conditions and the clinical significance of established method for rapid measurement of humoral mediators...
  65. ncbi request reprint Role of macrophage inflammatory protein 2 in acute lung injury in murine peritonitis
    Hironori Tsujimoto
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    J Surg Res 103:61-7. 2002
    ....
  66. doi request reprint Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older
    Nobutsugu Abe
    Department of Surgery, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo, Japan
    Gastric Cancer 15:70-5. 2012
    ..Little information is available on the long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in patients of advanced age (≥80 years)...