Haruo Ohtani

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. pmc Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
    T Chiba
    Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Cancer 91:1711-7. 2004
  2. pmc Granuloma cells in chronic inflammation express CD205 (DEC205) antigen and harbor proliferating T lymphocytes: similarity to antigen-presenting cells
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 63:85-93. 2013
  3. doi request reprint In situ expression of the CCL20-CCR6 axis in lymphocyte-rich gastric cancer and its potential role in the formation of lymphoid stroma
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 61:645-51. 2011
  4. doi request reprint Autoimmune pancreatitis and biliary intraepithelial neoplasia of the common bile duct: a case with diagnostically challenging but pathogenetically significant association
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 61:481-5. 2011
  5. doi request reprint Morphometric analysis of the balance between CXCR3+ T cells and FOXP3+ regulatory T cells in lymphocyte-rich and conventional gastric cancers
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Ibaraki, 311 3193, Japan
    Virchows Arch 456:615-23. 2010
  6. doi request reprint Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma
    H Ohtani
    Department of Pathology, Mito Medical Centre, National Hospital Organization, Ibaraki, Japan
    J Pathol 217:21-31. 2009
  7. doi request reprint Submassive hepatocellular necrosis associated with infiltration by peripheral T-cell lymphoma of cytotoxic phenotype: report of two cases
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 58:133-7. 2008
  8. pmc Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, 280 Sakurano sato, Ibaraki 311 3193, Japan
    Cancer Immun 7:4. 2007
  9. ncbi request reprint Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: a proposal on tumor-host interactions
    Junichi Sugita
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 93:320-8. 2002
  10. ncbi request reprint CXC chemokine receptor 1 (CXCR1) is expressed mainly by neutrophils in inflamed gut and stomach tissues
    Noriko Ohtani
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 196:179-84. 2002

Collaborators

Detail Information

Publications34

  1. pmc Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
    T Chiba
    Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Cancer 91:1711-7. 2004
    ..In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells...
  2. pmc Granuloma cells in chronic inflammation express CD205 (DEC205) antigen and harbor proliferating T lymphocytes: similarity to antigen-presenting cells
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 63:85-93. 2013
    ..0001) or T cells in the T cell zone (paracortex) of chronic tonsillitis or reactive lymphadenitis (P = 0.002). These data indicate a close similarity between immune granulomas and antigen presenting cells...
  3. doi request reprint In situ expression of the CCL20-CCR6 axis in lymphocyte-rich gastric cancer and its potential role in the formation of lymphoid stroma
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 61:645-51. 2011
    ....
  4. doi request reprint Autoimmune pancreatitis and biliary intraepithelial neoplasia of the common bile duct: a case with diagnostically challenging but pathogenetically significant association
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 61:481-5. 2011
    ..This case, therefore, provides important new insight into the potential association of AIP and/or IgG4-SC with malignancy (or precursor lesions) of the pancreatobiliary system...
  5. doi request reprint Morphometric analysis of the balance between CXCR3+ T cells and FOXP3+ regulatory T cells in lymphocyte-rich and conventional gastric cancers
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Ibaraki, 311 3193, Japan
    Virchows Arch 456:615-23. 2010
    ..To conclude, Tregs may play a more important role in conventional GCs than in Ly-rich GCs from the viewpoint of immunosuppression...
  6. doi request reprint Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma
    H Ohtani
    Department of Pathology, Mito Medical Centre, National Hospital Organization, Ibaraki, Japan
    J Pathol 217:21-31. 2009
    ..Given similar findings in the regional lymph nodes, the lymphoid stroma of lymphocyte-rich GCs may represent a tertiary lymphoid tissue with predominantly Th1-shifted immune responses...
  7. doi request reprint Submassive hepatocellular necrosis associated with infiltration by peripheral T-cell lymphoma of cytotoxic phenotype: report of two cases
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 58:133-7. 2008
    ....
  8. pmc Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer
    Haruo Ohtani
    Department of Pathology, Mito Medical Center, National Hospital Organization, 280 Sakurano sato, Ibaraki 311 3193, Japan
    Cancer Immun 7:4. 2007
    ..Considered with precaution, these morphologic analyses on immune cell subtypes are important tools to understand the immune responses in human cancers...
  9. ncbi request reprint Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: a proposal on tumor-host interactions
    Junichi Sugita
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Jpn J Cancer Res 93:320-8. 2002
    ..In conclusion, the present study shows the importance of FasL+ activated macrophages as one of the host defense mechanisms against cancer cell spread in human colorectal cancer...
  10. ncbi request reprint CXC chemokine receptor 1 (CXCR1) is expressed mainly by neutrophils in inflamed gut and stomach tissues
    Noriko Ohtani
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 196:179-84. 2002
    ..Neutrophils protect the host from microbial pathogens. However, they also cause damages to host tissues in chronic inflammation. Therefore, our study underscores the importance of CXCR1 expression in inflammatory processes...
  11. ncbi request reprint Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis
    Noriko Ohtani
    Department of Pathology, Tohoku University Graduate School of Medicine, Japan
    Lab Invest 84:368-75. 2004
    ..Our data also suggest a self-recruiting mechanism involving CCR5 and CCL5 for tissue accumulation of such T cells...
  12. ncbi request reprint Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
    Motoji Oki
    Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Lab Invest 85:137-45. 2005
    ..Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease...
  13. ncbi request reprint Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin
    Fuminori Katou
    Department of Oral and Maxillofacial Surgery I, Tohoku University School of Dentistry, Sendai, Japan
    J Pathol 199:98-106. 2003
    ..In normal skin, on the other hand, no cells immunoreactive for CCL19, CCL21, or CCR7 were found. The present study thus reveals a striking difference in the function of mature DCs between LNs and chronically inflamed skin...
  14. ncbi request reprint Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model
    Hitoshi Ogawa
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Inflamm Bowel Dis 9:162-70. 2003
    ..Epithelial expression of Reg III or HIP/PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon...
  15. ncbi request reprint Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis
    Kenichi Suzawa
    Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Gastroenterol 102:1499-509. 2007
    ..The present study was undertaken to elucidate how these HEV-like vessels participate in the pathogenesis of UC and also to determine whether the presence of such vessels is correlated with clinical outcomes...
  16. pmc Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism
    Wakana Iijima
    Division of Oral Diagnosis and Radiology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Pathol 163:261-8. 2003
    ..Furthermore, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+) T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells...
  17. ncbi request reprint Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease
    Seiji Arihiro
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 52:367-74. 2002
    ..Our data indicated more extensive expression of MAdCAM-1 in CrD, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD...
  18. ncbi request reprint Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection
    Masatoshi Akiyama
    Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    Virchows Arch 448:811-21. 2006
    ....
  19. doi request reprint World Health Organization Classification (2004)-based re-evaluation of 95 nonfunctioning "malignant" pancreatic endocrine tumors reported in Japan
    Asuka Tsuchiya
    Department of Surgery, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Surg Today 39:500-9. 2009
    ..The significance of this classification remains to be assessed in Japan...
  20. ncbi request reprint Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colon
    Tomoya Kato
    Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
    Pathol Int 55:524-9. 2005
    ....
  21. pmc Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Histopathology 55:432-40. 2009
    ..The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours...
  22. ncbi request reprint Primary breast mucosa-associated lymphoid tissue (MALT) lymphoma with high-grade transformation evidenced by prominent lymphoepithelial lesions
    Yoshinori Taeda
    Department of Surgery, Mito Medical Center, National Hospital Organization, 280 Sakurano sato, Ibaraki machi, Higashi ibaraki gun, Ibaraki 311 3193, Japan
    Breast Cancer 13:322-7. 2006
    ..After 18 months, no tumor recurrence was observed. We emphasize the importance of lymphoepithelial lesions for the diagnosis of MALT lymphoma of the breast...
  23. ncbi request reprint Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host disease
    Masatoshi Deguchi
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Arch Dermatol Res 294:297-302. 2002
    ..The differences in the numbers of APCs in lesional skin appeared to reflect differences in the pathophysiology of these inflammatory skin diseases...
  24. ncbi request reprint Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor
    Tohru Hoshida
    Division of Advanced Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 25:111-21. 2002
    ..Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. The soluble form of flt-1 VEGF receptor inhibits VEGF activity in a dominant-negative manner...
  25. doi request reprint Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases
    Satomi Suzuki-Uematsu
    Department of Surgery, Mito Medical Center, National Hospital Organization, Ibaraki, Ibaraki, Japan
    Breast Cancer 17:218-24. 2010
    ..We reviewed 15 malignant phyllodes tumors with metastases reported in Japan. The estimated 2.2-year survival rate following detection of metastasis was 11%, thus confirming the aggressiveness of the disease...
  26. ncbi request reprint Germ cell-specific expression of microphthalmia-associated transcription factor mRNA in mouse testis
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575
    J Biochem 134:143-50. 2003
    ..Notably, Mitf mRNA is undetectable in somatic Leydig cells and peritubular cells. Therefore, multiple promoters may direct differential expression of the Mitf gene in the testis and contribute to functional diversity of Mitf isoforms...
  27. pmc Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: a case report
    Takahiro Mori
    Department of Surgery, National Hospital Organization Mito Medical Center, 280 Sakuranosato, Ibaraki, Japan
    Cases J 2:6646. 2009
    ..Primary mantle cell lymphoma of the esophagus is quite rare, and we report here a case of a submucosal polypoid tumor of the esophagus that was pathologically similar, but not identical, to mantle cell lymphoma...
  28. ncbi request reprint Diffuse large B-cell lymphoma carrying both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32)
    Yukitaka Katsura
    Department of Hematology, Mito Medical Center, National Hospital Organization, Japan
    Intern Med 50:905-8. 2011
    ..The patient has remained in complete remission for over 24 months. This case is noteworthy because both genetic abnormalities are implicated in lymphomagenesis...
  29. ncbi request reprint Internalization of antibodies by endothelial cells via fibronectin implicating a novel mechanism in lupus nephritis
    Hiroshi Fujii
    Department of Pathology, Ehime University School of Medicine, Ehime, Japan
    Kidney Int 64:1662-70. 2003
    ..These clones are useful for analyzing the mechanisms of glomerular deposition of antibodies in lupus nephritis at the monoclonal level...
  30. ncbi request reprint Papillary carcinoma of the thyroid gland forming a myofibroblastic nodular tumor: report of two cases and review of the literature
    Hiroshi Naganuma
    Department of Pathology, Sendai City Hospital, Sendai, Miyagi, Japan
    Pathol Int 52:54-8. 2002
    ..The present names of this disease may not represent the proper features of this tumor because all the reported cases formed fibroma-like nodules. We propose the name 'papillary carcinoma forming myofibroblastic nodular tumors'...
  31. ncbi request reprint Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancer
    Fuminori Katou
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cancer Res 67:11195-201. 2007
    ..These results suggest the first-step occurrence of an immune evasion mechanism in the tumor nest of oral squamous cell carcinoma...
  32. pmc Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    Eiichi Sato
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:18538-43. 2005
    ..We conclude that intraepithelial CD8+ TILs and a high CD8+/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer...
  33. ncbi request reprint Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma
    Hiroaki Musha
    Department of Surgery, Tohoku University School of Medicine, Japan
    Int J Cancer 116:949-56. 2005
    ....
  34. ncbi request reprint Infiltration of CD19+ plasma cells with frequent labeling of Ki-67 in corticosteroid-resistant active ulcerative colitis
    Yoshio Jinno
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Virchows Arch 448:412-21. 2006
    ..High labeling of Ki-67 in CD19(+) plasma cells is specific for active ulcerative colitis that was resistant to medical treatment by corticosteroids...