Research Topics
Genomes and Genes | Haruo OhtaniSummaryAffiliation: National Hospital Organization Country: Japan Publications
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Publications
Granuloma cells in chronic inflammation express CD205 (DEC205) antigen and harbor proliferating T lymphocytes: similarity to antigen-presenting cellsHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Pathol Int 63:85-93. 2013..0001) or T cells in the T cell zone (paracortex) of chronic tonsillitis or reactive lymphadenitis (P = 0.002). These data indicate a close similarity between immune granulomas and antigen presenting cells...- In situ expression of the CCL20-CCR6 axis in lymphocyte-rich gastric cancer and its potential role in the formation of lymphoid stromaHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Pathol Int 61:645-51. 2011.... - Autoimmune pancreatitis and biliary intraepithelial neoplasia of the common bile duct: a case with diagnostically challenging but pathogenetically significant associationHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Pathol Int 61:481-5. 2011..This case, therefore, provides important new insight into the potential association of AIP and/or IgG4-SC with malignancy (or precursor lesions) of the pancreatobiliary system... - Morphometric analysis of the balance between CXCR3+ T cells and FOXP3+ regulatory T cells in lymphocyte-rich and conventional gastric cancersHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Ibaraki, 311 3193, Japan
Virchows Arch 456:615-23. 2010..To conclude, Tregs may play a more important role in conventional GCs than in Ly-rich GCs from the viewpoint of immunosuppression... - Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinomaH Ohtani
Department of Pathology, Mito Medical Centre, National Hospital Organization, Ibaraki, Japan
J Pathol 217:21-31. 2009..Given similar findings in the regional lymph nodes, the lymphoid stroma of lymphocyte-rich GCs may represent a tertiary lymphoid tissue with predominantly Th1-shifted immune responses... - Submassive hepatocellular necrosis associated with infiltration by peripheral T-cell lymphoma of cytotoxic phenotype: report of two casesHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Pathol Int 58:133-7. 2008.... 
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancerHaruo Ohtani
Department of Pathology, Mito Medical Center, National Hospital Organization, 280 Sakurano sato, Ibaraki 311 3193, Japan
Cancer Immun 7:4. 2007..Considered with precaution, these morphologic analyses on immune cell subtypes are important tools to understand the immune responses in human cancers...
Close association between Fas ligand (FasL; CD95L)-positive tumor-associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma: a proposal on tumor-host interactionsJunichi Sugita
Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
Jpn J Cancer Res 93:320-8. 2002..In conclusion, the present study shows the importance of FasL+ activated macrophages as one of the host defense mechanisms against cancer cell spread in human colorectal cancer...- CXC chemokine receptor 1 (CXCR1) is expressed mainly by neutrophils in inflamed gut and stomach tissuesNoriko Ohtani
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
Tohoku J Exp Med 196:179-84. 2002..Neutrophils protect the host from microbial pathogens. However, they also cause damages to host tissues in chronic inflammation. Therefore, our study underscores the importance of CXCR1 expression in inflammatory processes... - Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritisNoriko Ohtani
Department of Pathology, Tohoku University Graduate School of Medicine, Japan
Lab Invest 84:368-75. 2004..Our data also suggest a self-recruiting mechanism involving CCR5 and CCL5 for tissue accumulation of such T cells... - Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?Motoji Oki
Department of Internal Medicine Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
Lab Invest 85:137-45. 2005..Together with the notion that granuloma cells are possible antigen-presenting cells, our results suggest that the noncaseating granulomas could be one of the crucial sites of Th1-shifted immune responses in Crohn's disease... - Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skinFuminori Katou
Department of Oral and Maxillofacial Surgery I, Tohoku University School of Dentistry, Sendai, Japan
J Pathol 199:98-106. 2003..In normal skin, on the other hand, no cells immunoreactive for CCL19, CCL21, or CCR7 were found. The present study thus reveals a striking difference in the function of mature DCs between LNs and chronically inflamed skin... - Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitisKenichi Suzawa
Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan
Am J Gastroenterol 102:1499-509. 2007..The present study was undertaken to elucidate how these HEV-like vessels participate in the pathogenesis of UC and also to determine whether the presence of such vessels is correlated with clinical outcomes... - Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution modelHitoshi Ogawa
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Inflamm Bowel Dis 9:162-70. 2003..Epithelial expression of Reg III or HIP/PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon... - Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10/CXCL10 in their cytolytic granules: a potential self-recruiting mechanismWakana Iijima
Division of Oral Diagnosis and Radiology, Tohoku University Graduate School of Dentistry, Sendai, Japan
Am J Pathol 163:261-8. 2003..Furthermore, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+) T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells... - Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's diseaseSeiji Arihiro
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
Pathol Int 52:367-74. 2002..Our data indicated more extensive expression of MAdCAM-1 in CrD, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD... - Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissectionMasatoshi Akiyama
Department of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
Virchows Arch 448:811-21. 2006.... - Primary breast mucosa-associated lymphoid tissue (MALT) lymphoma with high-grade transformation evidenced by prominent lymphoepithelial lesionsYoshinori Taeda
Department of Surgery, Mito Medical Center, National Hospital Organization, 280 Sakurano-sato, Ibaraki-machi, Higashi-ibaraki-gun, Ibaraki 311-3193, Japan
Breast Cancer 13:322-7. 2006..After 18 months, no tumor recurrence was observed. We emphasize the importance of lymphoepithelial lesions for the diagnosis of MALT lymphoma of the breast... - Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumoursOsamu Dohi
Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Histopathology 55:432-40. 2009..The aim was to identify cell types that express FAP and DPP-IV in human bone and soft tissue tumours, and to determine whether there are any correlations between the expression of FAP and DPP-IV and the malignant potential of tumours... - Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colonTomoya Kato
Department of Pathology, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Pathol Int 55:524-9. 2005.... - World Health Organization Classification (2004)-based re-evaluation of 95 nonfunctioning "malignant" pancreatic endocrine tumors reported in JapanAsuka Tsuchiya
Department of Surgery, Mito Medical Center, National Hospital Organization, Ibaraki, Japan
Surg Today 39:500-9. 2009..The significance of this classification remains to be assessed in Japan... - Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host diseaseMasatoshi Deguchi
Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Arch Dermatol Res 294:297-302. 2002..The differences in the numbers of APCs in lesional skin appeared to reflect differences in the pathophysiology of these inflammatory skin diseases... - Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastasesSatomi Suzuki-Uematsu
Department of Surgery, Mito Medical Center, National Hospital Organization, Ibaraki, Ibaraki, Japan
Breast Cancer 17:218-24. 2010..We reviewed 15 malignant phyllodes tumors with metastases reported in Japan. The estimated 2.2-year survival rate following detection of metastasis was 11%, thus confirming the aggressiveness of the disease... - Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: a case reportTakahiro Mori
Department of Surgery, National Hospital Organization Mito Medical Center, 280 Sakuranosato, Ibaraki, Japan
Cases J 2:6646. 2009..Primary mantle cell lymphoma of the esophagus is quite rare, and we report here a case of a submucosal polypoid tumor of the esophagus that was pathologically similar, but not identical, to mantle cell lymphoma... - Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptorTohru Hoshida
Division of Advanced Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
Pancreas 25:111-21. 2002..Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. The soluble form of flt-1 VEGF receptor inhibits VEGF activity in a dominant-negative manner... - Papillary carcinoma of the thyroid gland forming a myofibroblastic nodular tumor: report of two cases and review of the literatureHiroshi Naganuma
Department of Pathology, Sendai City Hospital, Sendai, Miyagi, Japan
Pathol Int 52:54-8. 2002..The present names of this disease may not represent the proper features of this tumor because all the reported cases formed fibroma-like nodules. We propose the name 'papillary carcinoma forming myofibroblastic nodular tumors'... - Internalization of antibodies by endothelial cells via fibronectin implicating a novel mechanism in lupus nephritisHiroshi Fujii
Department of Pathology, Ehime University School of Medicine, Ehime, Japan
Kidney Int 64:1662-70. 2003..This may be one of the mechanisms of glomerular injury in lupus nephritis... - Diffuse large B-cell lymphoma carrying both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32)Yukitaka Katsura
Department of Hematology, Mito Medical Center, National Hospital Organization, Japan
Intern Med 50:905-8. 2011..The patient has remained in complete remission for over 24 months. This case is noteworthy because both genetic abnormalities are implicated in lymphomagenesis... - Differing phenotypes between intraepithelial and stromal lymphocytes in early-stage tongue cancerFuminori Katou
Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
Cancer Res 67:11195-201. 2007..These results suggest the first-step occurrence of an immune evasion mechanism in the tumor nest of oral squamous cell carcinoma... - Infiltration of CD19+ plasma cells with frequent labeling of Ki-67 in corticosteroid-resistant active ulcerative colitisYoshio Jinno
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
Virchows Arch 448:412-21. 2006..High labeling of Ki-67 in CD19(+) plasma cells is specific for active ulcerative colitis that was resistant to medical treatment by corticosteroids... - Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancerEiichi Sato
Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:18538-43. 2005..We conclude that intraepithelial CD8+ TILs and a high CD8+/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer... - Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinomaHiroaki Musha
Department of Surgery, Tohoku University School of Medicine, Japan
Int J Cancer 116:949-56. 2005....