Tsutomu Ohta

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
  2. pmc Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Proc Natl Acad Sci U S A 105:13568-73. 2008
  3. doi PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt
    Tatsuya Kawase
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cell 136:535-50. 2009
  4. ncbi Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    Tatsuhiro Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:1358-1368, 1368.e1-4. 2008
  5. pmc CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells
    Mari Masuda
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Biol Chem 285:15511-22. 2010
  6. doi Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
    Robert Nakayama
    Genetics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:333-9. 2008
  7. pmc Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
    Hideki Ogino
    ADP ribosylation in Oncology Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    BMC Genomics 8:41. 2007
  8. ncbi Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk
    Takashi Kohno
    Center for Medical Genomics, Tokyo, Japan
    Carcinogenesis 27:2448-54. 2006
  9. ncbi Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma
    Makoto Chuma
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Hepatol 41:629-36. 2004
  10. ncbi Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 98:985-91. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
    ..Thus, inhibition of NRF2 may provide new therapeutic approaches in lung cancers with activation of Nrf2...
  2. pmc Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Proc Natl Acad Sci U S A 105:13568-73. 2008
    ..Congruously, the present study also provides in vivo validation of the two-site substrate recognition model for Nrf2 activation by the Keap1-Cul3-based E3 ligase...
  3. doi PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt
    Tatsuya Kawase
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cell 136:535-50. 2009
    ..Loss of the PHLDA3 genomic locus was frequently observed in primary lung cancers, suggesting a role of PHLDA3 in tumor suppression. Our results reveal a new mode of coordination between the p53 and Akt pathways...
  4. ncbi Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    Tatsuhiro Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:1358-1368, 1368.e1-4. 2008
    ..We attempted to examine whether deregulation of Nrf2, a master transcriptional factor of various cytoprotective genes against oxidative stress, plays a role in the carcinogenesis of BTC...
  5. pmc CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells
    Mari Masuda
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Biol Chem 285:15511-22. 2010
    ..Our results indicate that Tiam1 integrates signals from CADM1 to regulate the actin cytoskeleton through Rac activation, which may lead to tissue infiltration of leukemic cells in ATL patients...
  6. doi Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
    Robert Nakayama
    Genetics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 99:333-9. 2008
    ....
  7. pmc Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
    Hideki Ogino
    ADP ribosylation in Oncology Project, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    BMC Genomics 8:41. 2007
    ..However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet...
  8. ncbi Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk
    Takashi Kohno
    Center for Medical Genomics, Tokyo, Japan
    Carcinogenesis 27:2448-54. 2006
    ..0 (95% CI: 1.2-3.2, P=0.002). The present results indicate that inter-individual differences in MTH1 activities due to SNPs are involved in susceptibility to SCLC...
  9. ncbi Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma
    Makoto Chuma
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Hepatol 41:629-36. 2004
    ..The molecular basis of the metastasis of hepatocellular carcinoma (HCC) is not fully understood. The aim of this study was to elucidate the crucial genes involved in metastasis of HCC...
  10. ncbi Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 98:985-91. 2007
    ....
  11. pmc Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses
    Hiro Takahashi
    Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi, Japan Plant Biology Research Center, Chubu University, Kasugai, Aichi, Japan Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 8:e78250. 2013
    ..Furthermore, in vitro cell growth inhibition experiments by MIF and SCD1 inhibitors support the hypothesis. These results suggest that the gene set is useful as a prognostic marker associated with tumor progression. ..
  12. ncbi Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma
    Robert Nakayama
    Cancer Transcriptome Project, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 20:749-59. 2007
    ..Taken together, gene expression profiling could be a useful tool to unveil the difference in the underlying molecular backgrounds, which leads to a rational taxonomy and diagnosis of a diverse group of soft tissue sarcomas...
  13. pmc The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma
    Michiko Ishida
    Genter for Medical Genomics, Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji Chuo ku, Tokyo 104 0045, Japan
    Mol Cell Biol 27:1348-55. 2007
    ..Increased COM1 expression resulted in induced apoptosis and in reduced cell growth and colony formation activity. Our results suggested that restoration of COM1 expression may be of therapeutic benefit in synovial sarcoma...
  14. ncbi Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis
    Rieko Ohki
    Radiobiology Division, National Cancer Center Research Institute, Tsujiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 98:189-200. 2007
    ..These results demonstrate the significance of the regulation and differential roles of the N-terminal TADs in p53 transcriptional activity...
  15. ncbi The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
    Yoshiko Masuda
    Cancer Medicine and Biophysics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Hum Genet 51:652-64. 2006
    ..These results suggest that DFNA5 plays a role in the p53-regulated cellular response to genotoxic stress probably by cooperating with p53...
  16. doi Up-regulation of PSF1 promotes the growth of breast cancer cells
    Izumi Nakahara
    Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Genes Cells 15:1015-24. 2010
    ..These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth. Therefore, PSF1 inhibition might provide new therapeutic approaches for breast cancer...
  17. ncbi Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis
    Makoto Chuma
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Keio J Med 53:90-7. 2004
    ..HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis...
  18. ncbi Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk
    Tokuki Sakiyama
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 114:730-7. 2005
    ..The present results suggest that these 4 SNPs function as genetic factors underlying lung cancer susceptibility by modulating activities to maintain the genome integrity of each individual...
  19. pmc Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule
    Daisuke Yamada
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 26:3610-24. 2006
    ..These findings suggest that TSLC1/IGSF4 expression is indispensable for the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa...
  20. ncbi Improvement of hyperlipidemia by indomethacin in Min mice
    Naoko Niho
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 121:1665-9. 2007
    ..Furthermore, TNFalpha was downregulated. These results indicate that indomethacin might suppress intestinal tumor formation together with a hyperlipidemic state by regulating LPL and other lipid metabolic factors...
  21. ncbi Transcriptional co-activator activity of SYT is negatively regulated by BRM and Brg1
    Michiko Ishida
    Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1 Tsukiji Chuo ku, Tokyo 104 0045, Japan
    Genes Cells 9:419-28. 2004
    ..This indicates that the SWI/SNF protein complexes regulate SYT activity using the chromatin remodelling activity...
  22. ncbi Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    Kyoko Fujiwara
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1495-505. 2004
    ..Our results suggest that Paneth cell differentiation in colon epithelial cells could be an early morphological change in cryptic cells during colon carcinogenesis...