Tomoko Ohta

Summary

Affiliation: National Institute of Genetics
Country: Japan

Publications

  1. ncbi request reprint Evolution by gene duplication revisited: differentiation of regulatory elements versus proteins
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    Genetica 118:209-16. 2003
  2. pmc Near-neutrality, robustness, and epigenetics
    Tomoko Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Japan
    Genome Biol Evol 3:1034-8. 2011
  3. ncbi request reprint Origin of the neutral and nearly neutral theories of evolution
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    J Biosci 28:371-7. 2003
  4. pmc Near-neutrality in evolution of genes and gene regulation
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    Proc Natl Acad Sci U S A 99:16134-7. 2002
  5. ncbi request reprint Evolution of gene families
    T Ohta
    National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Gene 259:45-52. 2000
  6. pmc Mechanisms of molecular evolution
    T Ohta
    National Institute of Genetics, Mishima, Japan
    Philos Trans R Soc Lond B Biol Sci 355:1623-6. 2000
  7. ncbi request reprint Effect of gene conversion on polymorphic patterns at major histocompatibility complex loci
    T Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Japan
    Immunol Rev 167:319-25. 1999
  8. ncbi request reprint On the pattern of polymorphisms at major histocompatibility complex loci
    T Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    J Mol Evol 46:633-8. 1998
  9. ncbi request reprint The meaning of near-neutrality at coding and non-coding regions
    T Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Gene 205:261-7. 1997
  10. ncbi request reprint Complex formation and functional versatility of Mre11 of budding yeast in recombination
    T Usui
    National Institute of Genetics, Mishima, Shizuoka, Japan
    Cell 95:705-16. 1998

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Evolution by gene duplication revisited: differentiation of regulatory elements versus proteins
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    Genetica 118:209-16. 2003
    ..It is pointed out that constraints coming from regulatory networks are most important for survival of duplicate genes, and that both drift and selection are at work in the process of acquisition of new gene expression and function...
  2. pmc Near-neutrality, robustness, and epigenetics
    Tomoko Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Japan
    Genome Biol Evol 3:1034-8. 2011
    ..Both are bridges to link genotypes with phenotypes and important for understanding how weak selection and drift interact in the evolution of complex systems...
  3. ncbi request reprint Origin of the neutral and nearly neutral theories of evolution
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    J Biosci 28:371-7. 2003
  4. pmc Near-neutrality in evolution of genes and gene regulation
    Tomoko Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    Proc Natl Acad Sci U S A 99:16134-7. 2002
    ..In addition to the effective population size, molecular chaperones such as heat shock protein 90 have significant effects on the range of near neutrality...
  5. ncbi request reprint Evolution of gene families
    T Ohta
    National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Gene 259:45-52. 2000
    ..Positive selection is necessary for the evolution of novel functions. However, many examples of current gene families suggest that both drift and selection are at work on their evolution...
  6. pmc Mechanisms of molecular evolution
    T Ohta
    National Institute of Genetics, Mishima, Japan
    Philos Trans R Soc Lond B Biol Sci 355:1623-6. 2000
    ..Positive selection is necessary for the evolution of novel functions. However, many examples of current gene families suggest that both drift and selection are at work on their evolution...
  7. ncbi request reprint Effect of gene conversion on polymorphic patterns at major histocompatibility complex loci
    T Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Japan
    Immunol Rev 167:319-25. 1999
    ..A quantitative analysis on the patchwork pattern was attempted by using identity excess among nucleotide sites of a gene. Comparison of simulation results with DNA data analysis shows that the rate of allelic conversion is high...
  8. ncbi request reprint On the pattern of polymorphisms at major histocompatibility complex loci
    T Ohta
    National Institute of Genetics, Mishima 411 8540, Japan
    J Mol Evol 46:633-8. 1998
    ..However, the average divergence among alleles tends to be lower in the latter than in the former under similar conditions...
  9. ncbi request reprint The meaning of near-neutrality at coding and non-coding regions
    T Ohta
    Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Gene 205:261-7. 1997
    ..Weak selection at non-coding regions may come from chromosome organization, and may be regional in character, which differs from that at coding regions. The problem of genetic load is thought to disappear in these circumstances...
  10. ncbi request reprint Complex formation and functional versatility of Mre11 of budding yeast in recombination
    T Usui
    National Institute of Genetics, Mishima, Shizuoka, Japan
    Cell 95:705-16. 1998
    ..It has two regions to bind to Rad50. Mre11 repairs methyl methanesulfonate-induced DSBs by reactions that require the nuclease activities and those that do not...
  11. pmc DNA supercoiling factor localizes to puffs on polytene chromosomes in Drosophila melanogaster
    M Kobayashi
    The Graduate University for Advanced Studies, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Mol Cell Biol 18:6737-44. 1998
    ..Upon heat treatment of larvae, the staining on the endogenous puffs disappeared, and strong staining appeared on heat shock puffs. These results implicate SCF in gene expression...
  12. pmc Amino acid substitution at the Adh locus of Drosophila is facilitated by small population size
    T Ohta
    National Institute of Genetics, Mishima, Japan
    Proc Natl Acad Sci U S A 90:4548-51. 1993
    ..These observations suggest that amino acid substitutions are facilitated by small population size. The result is in accord with the nearly neutral theory of molecular evolution...