Shunsuke Ohnishi

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    Stem Cells 25:1166-77. 2007
  2. ncbi request reprint Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    FEBS Lett 581:3961-6. 2007
  3. ncbi request reprint Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema
    Bobby Yanagawa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Cardiovasc Res 76:110-8. 2007
  4. ncbi request reprint Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block
    Milki Yokokawa
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Cell Transplant 17:1145-55. 2008
  5. doi request reprint Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia
    Shin Ishikane
    Department of Perinatology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Stem Cells 26:2625-33. 2008
  6. ncbi request reprint CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 356:60-6. 2007
  7. doi request reprint Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles
    Kentaro Otani
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Control Release 133:146-53. 2009
  8. doi request reprint Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers
    Kazuhiko Harada
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Regul Pept 168:21-6. 2011
  9. ncbi request reprint Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 177:195-201. 2008
  10. doi request reprint Contrast sonography enables noninvasive and quantitative assessment of neovascularization after stem cell transplantation
    Kentaro Otani
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
    Ultrasound Med Biol 34:1893-900. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    Stem Cells 25:1166-77. 2007
    ..Our results may provide information on the differential molecular mechanisms regulating the properties of MSC and MNC under ischemic conditions. Disclosure of potential conflicts of interest is found at the end of this article...
  2. ncbi request reprint Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    FEBS Lett 581:3961-6. 2007
    ..MSC may exert paracrine anti-fibrotic effects at least in part through regulation of CFB proliferation and collagen synthesis...
  3. ncbi request reprint Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema
    Bobby Yanagawa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Cardiovasc Res 76:110-8. 2007
    ..Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model...
  4. ncbi request reprint Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block
    Milki Yokokawa
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Cell Transplant 17:1145-55. 2008
    ..In addition, local injection of MSC conditioned medium recovered AV conduction in 2 of 15 rats (13%). MSC transplantation improved AV conduction in a rat model of complete AVB, at least in part through antifibrotic paracrine effects...
  5. doi request reprint Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia
    Shin Ishikane
    Department of Perinatology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Stem Cells 26:2625-33. 2008
    ..Thus, allogeneic injection of FM-MSC may be a new therapeutic strategy for the treatment of severe peripheral vascular disease. Disclosure of potential conflicts of interest is found at the end of this article...
  6. ncbi request reprint CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 356:60-6. 2007
    ..In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects...
  7. doi request reprint Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles
    Kentaro Otani
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Control Release 133:146-53. 2009
    ..Our results indicate that US-MB could serve as a nonviral delivery method of siRNA into MSC. The transplantation of genetically modified MSC by US-MB could be a useful strategy for regenerative medicine in the future...
  8. doi request reprint Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers
    Kazuhiko Harada
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Regul Pept 168:21-6. 2011
    ..Therefore, sustained-release AM ointment may be a novel therapeutic agent for pressure ulcers...
  9. ncbi request reprint Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 177:195-201. 2008
    ..Therefore, we developed a new drug delivery system for prostacyclin. We prepared ONO-1301MS, a novel sustained-release prostacyclin analog polymerized with poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres...
  10. doi request reprint Contrast sonography enables noninvasive and quantitative assessment of neovascularization after stem cell transplantation
    Kentaro Otani
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Japan
    Ultrasound Med Biol 34:1893-900. 2008
    ..01; vs. capillary density: r = 0.52, p < 0.05). The results of our study imply that the contrast sonography-derived beta-ratio is a useful parameter that reflects the perfusion after cell transplantation in ischemic hindlimb...
  11. ncbi request reprint Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Osaka 565 8565, Japan
    J Mol Cell Cardiol 42:88-97. 2007
    ..MSC transplantation attenuated myocardial injury and dysfunction in a rat model of acute myocarditis, at least in part through paracrine effects of MSC...
  12. doi request reprint Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
    Donghao Jin
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 80:339-45. 2008
    ..Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedema...
  13. ncbi request reprint Mesenchymal stem cells for the treatment of heart failure
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Int J Hematol 86:17-21. 2007
    ..On the basis of information obtained from basic and translational research, several clinical trials have recently been started to evaluate the safety and efficacy of autologous MSC for heart failure...
  14. pmc Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells
    Kenichi Yamahara
    Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan
    PLoS ONE 9:e88319. 2014
    ..Our results highlight that human amnion- and chorion-derived MSCs, which showed differences in their soluble factor secretion and angiogenic/immuno-suppressive function, could be ideal cell sources for regenerative medicine. ..
  15. ncbi request reprint Prepare cells to repair the heart: mesenchymal stem cells for the treatment of heart failure
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Am J Nephrol 27:301-7. 2007
    ..Based on these findings, several clinical trials have just been started to evaluate the safety and efficacy of MSC for the treatment of heart failure...
  16. ncbi request reprint [Ghrelin]
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 65:186-90. 2007
  17. pmc Tissue regeneration as next-generation therapy for COPD--potential applications
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Int J Chron Obstruct Pulmon Dis 3:509-14. 2008
    ....
  18. ncbi request reprint Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats
    Yoshinori Miyahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 349:1242-9. 2006
    ..These results suggest that beraprost has beneficial effects on ischemic myocardium partly by its ability to enhance neovascularization in ischemic myocardium by mobilizing bone marrow cells...
  19. ncbi request reprint Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis
    Souichi Furuhata
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Cell Biochem 298:125-38. 2007
    ..In situ hybridization showed that the genes were expressed in isolated cells in the fetal liver at E11.5 and E14.5 of mouse development...
  20. ncbi request reprint Downregulation and growth inhibitory effect of epithelial-type Kr├╝ppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    Shunsuke Ohnishi
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:251-6. 2003
    ..The transduction of KLF4, but not KLF5, suppressed cell growth and induced apoptosis. Our study suggests that inactivation of KLF4 is one of the frequent steps towards bladder carcinogenesis...