N Ohkura

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa 258 0000, Japan
    Gene 211:79-85. 1998
  2. ncbi An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochim Biophys Acta 1444:69-79. 1999
  3. ncbi The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing
    Naganari Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 277:535-43. 2002
  4. ncbi The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Dev Neurosci 23:17-24. 2001
  5. ncbi Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 282:1206-10. 2001
  6. ncbi Structure and distribution of rat menin mRNA
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Cell Endocrinol 156:25-33. 1999
  7. ncbi Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa, Japan
    Biochim Biophys Acta 1308:205-14. 1996
  8. ncbi Complementary DNA structure and genomic organization of Drosophila menin
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Mol Cell Endocrinol 168:135-40. 2000
  9. ncbi Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 231:417-20. 1997
  10. ncbi Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells
    N Ohkura
    TERUMO R and D Center, Kanagawa, Japan
    Biochem Biophys Res Commun 205:1959-65. 1994

Collaborators

Detail Information

Publications25

  1. ncbi Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa 258 0000, Japan
    Gene 211:79-85. 1998
    ....
  2. ncbi An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochim Biophys Acta 1444:69-79. 1999
    ..These results indicate that the C-terminal truncated isoform, Nurr2, may act as a negative regulator of the NGFI-B family signaling...
  3. ncbi The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing
    Naganari Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 277:535-43. 2002
    ..Altogether, our findings reveal that EWS/NOR1 gains a novel activity affecting pre-mRNA splicing...
  4. ncbi The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Dev Neurosci 23:17-24. 2001
    ..This study provides, after the association of Ftz and Ftz-F1 in Drosophila, another example of a dimer formation of a homeobox protein and an orphan nuclear receptor...
  5. ncbi Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23
    N Ohkura
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 282:1206-10. 2001
    ..This result suggests that this interaction may play important roles in the biological functions of the menin protein, including tumor suppressor activity...
  6. ncbi Structure and distribution of rat menin mRNA
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Cell Endocrinol 156:25-33. 1999
    ..These findings are consistent with those reported on human menin...
  7. ncbi Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa, Japan
    Biochim Biophys Acta 1308:205-14. 1996
    ..This suggests that the Nur77/NGFI-B family has evolved from a common ancestral gene. Fluorescence in situ hybridization (FISH) revealed that the gene is located on chromosome 9q...
  8. ncbi Complementary DNA structure and genomic organization of Drosophila menin
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Mol Cell Endocrinol 168:135-40. 2000
    ..The presence of menin ortholog in insect indicates that menin is an evolutionally conserved protein with a fundamental role in biological processes...
  9. ncbi Retinoic acids differentially regulate NOR-1 and its closely related orphan nuclear receptor genes in breast cancer cell line MCF-7
    K Maruyama
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 231:417-20. 1997
    ..These findings suggest that NOR-1, NGFI-B, and Nurr1 play distinct roles in the retinoic acid signaling in MCF-7 cells...
  10. ncbi Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells
    N Ohkura
    TERUMO R and D Center, Kanagawa, Japan
    Biochem Biophys Res Commun 205:1959-65. 1994
    ....
  11. ncbi Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23
    Hiroko Yaguchi
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 277:38197-204. 2002
    ..These results suggest that menin is an atypical GTPase stimulated by nm23...
  12. ncbi Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamily
    Shinji Kagaya
    Genox Research Inc, Tokyo, Japan
    Biol Pharm Bull 28:1603-7. 2005
    ..These observations suggest that PGA2 can serve as a transactivator of NOR1, and thus suggest a possibility of pharmacological modulation of the NOR1 pathways by PGA2-related compounds...
  13. doi Differential transactivation by orphan nuclear receptor NOR1 and its fusion gene product EWS/NOR1: possible involvement of poly(ADP-ribose) polymerase I, PARP-1
    Naganari Ohkura
    Tumor Endocrinology Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Cell Biochem 105:785-800. 2008
    ....
  14. pmc Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway
    Hiroko Yaguchi
    Tumor Endocrinology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 24:6569-80. 2004
    ..These findings reveal that MEN1-causing missense mutations lead to a loss of function of menin due to enhanced proteolytic degradation, which may be a common mechanism for inactivating tumor suppressor gene products in familial cancer...
  15. ncbi Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific manner
    Naganari Ohkura
    Tumor Endocrinology Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Biol Chem 280:28927-35. 2005
    ..In addition, CARM1-v3 shows tissue-specific expression patterns distinct from those of the other isoforms. These results suggest that the transcriptional coactivator can affect the splice site decision in an isoform-specific manner...
  16. ncbi The NR4A nuclear receptor family in eosinophils
    Ryoichi Hashida
    Genox Research Inc, Bunkyo, Tokyo, 112 8088, Japan
    J Hum Genet 52:13-20. 2007
    ..NR4A nuclear receptor genes were selected following comprehensive analysis of differentially expressed genes in eosinophils of atopic dermatitis patients compared with healthy volunteers...
  17. ncbi A whole MEN1 gene deletion flanked by Alu repeats in a family with multiple endocrine neoplasia type 1
    Atsushi Fukuuchi
    Department of Breast and Endocrine Surgery, Mitsui Memorial Hospital, Tokyo, Japan
    Jpn J Clin Oncol 36:739-44. 2006
    ....
  18. ncbi Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1
    Mariko Kikuchi
    Tumor Endocrinology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 208:81-8. 2004
    ..This is the first case of a large germline deletion responsible for multiple endocrine neoplasia type 1, in which the size and end points were determined precisely...
  19. ncbi Detection of APC gene deletion by double competitive polymerase chain reaction in patients with familial adenomatous polyposis
    Maho Takahashi
    Tumor Endocrinology Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 29:413-21. 2006
    ..These findings indicate that this gene dose assay is a useful technique to detect large gene deletions of the APC gene and to determine their genomic breakpoints...
  20. ncbi The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle
    Michael A Pearen
    Institute for Molecular Bioscience, Division of Molecular Genetics and Development, University of Queensland, St Lucia, Queensland 4072, Australia
    Endocrinology 147:5217-27. 2006
    ..Concordantly the myostatin promoter was repressed by NOR-1 expression. In conclusion, NOR-1 is highly responsive to beta-adrenergic signaling and regulates the expression of genes controlling fatty acid use and muscle mass...
  21. pmc The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation
    Takashi Nomiyama
    Division of Endocrinology and Molecular Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 281:33467-76. 2006
    ....
  22. ncbi NR4A orphan nuclear receptor family in peripheral blood eosinophils from patients with atopic dermatitis and apoptotic eosinophils in vitro
    Shinji Kagaya
    Genox Research Inc, Bunkyo, Japan
    Int Arch Allergy Immunol 137:35-44. 2005
    ..These results suggest that the expression of the NR4A receptor family genes through CD30 signaling may regulate eosinophil apoptosis in allergic conditions such as AD...
  23. ncbi Early induction of nerve growth factor-induced genes after liver resection-reperfusion injury
    Takao Ohkubo
    Hepatobiliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Hepatol 36:210-7. 2002
    ..Nur-related factor 1 (Nurr1) has been implicated in liver generation after hepatectomy. We hypothesized that the genes in the nerve growth factor-induced gene B (NGFI-B) family was induced in liver ischemia-reperfusion injury...
  24. ncbi Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca(2+)/calmodulin-dependent protein kinase cascade
    Hiroyuki Inuzuka
    Department of Chemistry, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
    FEBS Lett 522:88-92. 2002
    ..7 kb NOR-1 promoter containing triple cAMP response elements. Disruption of each element significantly reduced the promoter activity, indicating the direct transcriptional regulation of NOR-1 by CaM-KIV cascade...
  25. ncbi Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    Masahiro Ono
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Nature 446:685-9. 2007
    ..This transcriptional control of T(R)-cell function by an interaction between Foxp3 and AML1 can be exploited to control physiological and pathological T-cell-mediated immune responses...