Shigeru Obayashi

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Functional brain mapping of monkey tool use
    S Obayashi
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neuroimage 14:853-61. 2001
  2. doi request reprint Monkey brain activity modulated by reward preferences: a positron emission tomography study
    Shigeru Obayashi
    Department of Molecular Neuroimaging, Molecular Imaging Center MIC, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neurosci Res 64:421-8. 2009
  3. ncbi request reprint Macaque prefrontal activity associated with extensive tool use
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, CREST JST, Chiba, Japan
    Neuroreport 13:2349-54. 2002
  4. ncbi request reprint Fronto-parieto-cerebellar interaction associated with intermanual transfer of monkey tool-use learning
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neurosci Lett 339:123-6. 2003
  5. ncbi request reprint Monkey brain areas underlying remote-controlled operation
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Eur J Neurosci 19:1397-407. 2004
  6. ncbi request reprint Functional organization of monkey brain for abstract operation
    Shigeru Obayashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Cortex 43:389-96. 2007
  7. ncbi request reprint Possible mechanism for transfer of motor skill learning: implication of the cerebellum
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Cerebellum 3:204-11. 2004
  8. ncbi request reprint In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, Inage Ku, Chiba, Japan
    Cell Transplant 14:655-63. 2005
  9. ncbi request reprint Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography
    Yuji Nagai
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 61:809-19. 2007
  10. ncbi request reprint Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 52:283-91. 2004

Detail Information

Publications21

  1. ncbi request reprint Functional brain mapping of monkey tool use
    S Obayashi
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neuroimage 14:853-61. 2001
    ..These tool use-specific areas may participate in maintaining and updating the body-image for the precise guidance of a hand-held rake onto a distant reward...
  2. doi request reprint Monkey brain activity modulated by reward preferences: a positron emission tomography study
    Shigeru Obayashi
    Department of Molecular Neuroimaging, Molecular Imaging Center MIC, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neurosci Res 64:421-8. 2009
    ..The present results may include the brain regions subserving motivational changes by subjective reward significances...
  3. ncbi request reprint Macaque prefrontal activity associated with extensive tool use
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, CREST JST, Chiba, Japan
    Neuroreport 13:2349-54. 2002
    ..These results suggest that interactions between the fronto-cerebellar and the fronto-parietal circuit are responsible for appropriate and effective modifications of tools in their functions...
  4. ncbi request reprint Fronto-parieto-cerebellar interaction associated with intermanual transfer of monkey tool-use learning
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, CREST JST, Chiba 263 8555, Japan
    Neurosci Lett 339:123-6. 2003
    ..The results suggest that those regions may be related to intermanual transfer of tool-use learning, presumably in terms of modifying a motor engram specific for OH...
  5. ncbi request reprint Monkey brain areas underlying remote-controlled operation
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Eur J Neurosci 19:1397-407. 2004
    ..These shared areas may not simply be associated with organization of individual motor imagery, but also with context-dependent processing of reorganization based on current functions by means of internal representation...
  6. ncbi request reprint Functional organization of monkey brain for abstract operation
    Shigeru Obayashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Cortex 43:389-96. 2007
    ....
  7. ncbi request reprint Possible mechanism for transfer of motor skill learning: implication of the cerebellum
    Shigeru Obayashi
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Cerebellum 3:204-11. 2004
    ..Finally, this article proposes the relationship between the cerebellum and the possible mechanism underlying non-specific transfer that allows thinking in a flexible and productive manner...
  8. ncbi request reprint In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, Inage Ku, Chiba, Japan
    Cell Transplant 14:655-63. 2005
    ..Repeated PET measurements of DA transporters are a useful tool in assessing the effectiveness of neural transplantations...
  9. ncbi request reprint Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography
    Yuji Nagai
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 61:809-19. 2007
    ....
  10. ncbi request reprint Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 52:283-91. 2004
    ..11)C]DAA1106 binding was four times higher compared to the binding of [(11)C]PK11195 in the monkey occipital cortex. These results indicated that [(11)C]DAA1106 might be a good ligand for in vivo imaging of PBR...
  11. ncbi request reprint 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain
    Ming Rong Zhang
    Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 48:1853-61. 2007
    ..The aim of this study was to synthesize and evaluate N-benzyl-N-ethyl-2-(7-(11)C-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ((11)C-AC-5216) as a PET ligand for imaging PBR in the primate brain...
  12. ncbi request reprint In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems
    Eisuke Haneda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:205-15. 2007
    ....
  13. pmc Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system
    Masaki Tokunaga
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 29:1887-96. 2009
    ....
  14. ncbi request reprint Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, 4 9 1 Aragawa, Inage, Chiba 305 8555, Japan
    Brain Res 1064:136-45. 2005
    ....
  15. doi request reprint Preparation of acute living hippocampal slice from common marmoset (Callithrix jacchus) for synaptic function analysis
    Arata Oh-Nishi
    Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Neurosci Res 72:275-8. 2012
    ..This study thus presents an efficient preparation method for acute living hippocampal slice from which synaptic function of the hippocampus in non-human primate can be analyzed...
  16. ncbi request reprint Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Clin Neurosci 58:330-2. 2004
    ..It is suggested that the threshold level of cortical dopamine D(2) receptor occupancy for the suppression of CAR is demonstrated in the present study...
  17. ncbi request reprint Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain
    Ming Rong Zhang
    Department of Medical Imaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Med Chem 47:2228-35. 2004
    ..No radioactive metabolite of [(18)F]5 was detected in the mouse brain. The biological data indicate that [(18)F]5 is a useful PET ligand for PBR and is currently used for imaging PBR in human brain...
  18. doi request reprint Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: a positron emission tomography study
    Yuji Nagai
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Neurosci Res 73:61-7. 2012
    ....
  19. ncbi request reprint Visualization of alpha5 subunit of GABAA/benzodiazepine receptor by 11C Ro15-4513 using positron emission tomography
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 47:200-8. 2003
    ....
  20. doi request reprint Maternal immune activation by polyriboinosinic-polyribocytidilic acid injection produces synaptic dysfunction but not neuronal loss in the hippocampus of juvenile rat offspring
    Arata Oh-Nishi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Brain Res 1363:170-9. 2010
    ..These results indicate that maternal immune activation leads to synaptic dysfunction without neuronal loss in the hippocampus of juvenile offspring, and this may be one of the early stages of schizophrenia pathologies...
  21. ncbi request reprint Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[11C]methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: a PET tracer for imaging sigma(1) receptors
    Ming Rong Zhang
    CREST, Japan Sciences and Technology Corporation, Kawaguchi, Japan
    Nucl Med Biol 29:469-76. 2002
    ..These results indicate that [11C]1 may have some specific binding to the sigma(1) receptors, which is consistent with the result of in vitro autoradiography...