Motohiro Nishida


Affiliation: National Institute for Physiological Sciences
Country: Japan


  1. Numaga Tomita T, Nishida M, Putney J, Mori Y. TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation. Biochem J. 2016;473:201-10 pubmed publisher
    ..These results suggest that TRPC3 reorganizes the BCR signalling complex by switching the subtype of small G-proteins to sustain ERK activation in B-lymphocytes. ..
  2. Tanaka T, Nishimura A, Nishiyama K, Goto T, Numaga Tomita T, Nishida M. Mitochondrial dynamics in exercise physiology. Pflugers Arch. 2019;: pubmed publisher
    ..These recent advancements in the field of mitochondrial biology may lead to a greater understanding of exercise signaling. ..
  3. Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, et al. Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. Sci Signal. 2018;11: pubmed publisher
  4. Numaga Tomita T, Oda S, Nishiyama K, Tanaka T, Nishimura A, Nishida M. TRPC channels in exercise-mimetic therapy. Pflugers Arch. 2019;471:507-517 pubmed publisher
    ..In this review, we describe current understanding of the roles of TRPC channels in striated muscle (patho)physiology and propose that targeting TRPC-based protein complexes could be a new strategy to imitate exercise therapy. ..
  5. Nishimura A, Sunggip C, Tozaki Saitoh H, Shimauchi T, Numaga Tomita T, Hirano K, et al. Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension. Sci Signal. 2016;9:ra7 pubmed publisher
    ..These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II. ..
  6. Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T. Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells. Free Radic Biol Med. 2017;109:132-140 pubmed publisher
  7. Sunggip C, Nishimura A, Shimoda K, Numaga Tomita T, Tsuda M, Nishida M. Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension. Pharmacol Res. 2017;120:51-59 pubmed publisher
    ..These findings suggest that P2Y6R is a therapeutic target to prevent age-related hypertension. ..
  8. Yamaguchi Y, Iribe G, Nishida M, Naruse K. Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology. Prog Biophys Mol Biol. 2017;130:264-272 pubmed publisher
    ..We here overview experimental evidence of the involvement of TRPC3 and TRPC6 in cardiac physiology and pathophysiology in response to stretch. ..
  9. Nishimura A, Sunggip C, Oda S, Numaga Tomita T, Tsuda M, Nishida M. Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases. Pharmacol Ther. 2017;180:113-128 pubmed publisher
    ..These results strongly suggest that targeting P2Y6R oligomerization could be an effective new strategy to reduce the risk of cardiovascular diseases. ..

More Information


  1. Oda S, Numaga Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, et al. TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice. Sci Rep. 2017;7:7511 pubmed publisher
    ..These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced heart failure by TRPC6. ..