Masaaki Niino

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. ncbi request reprint Recurrent brainstem lesions mimicking infarctions in an elderly patient with neuromyelitis optica spectrum disorder
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Japan
    Intern Med 51:809-12. 2012
  2. doi request reprint CD5-positive B cell subsets in secondary progressive multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Yamanote 5 jo 7 chome, Sapporo 063 0005, Japan
    Neurosci Lett 523:56-61. 2012
  3. ncbi request reprint Suppression of IL-10 production by calcitriol in patients with multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan Electronic address
    J Neuroimmunol 270:86-94. 2014
  4. pmc Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Yamanote 5jo 7chome, Nishi ku, Sapporo 063 0005, Japan
    BMC Neurol 14:3. 2014
  5. doi request reprint Vitamin D and its immunoregulatory role in multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Nishi ku, Sapporo, Japan
    Drugs Today (Barc) 46:279-90. 2010
  6. pmc Structural equation modeling of factors contributing to quality of life in Japanese patients with multiple sclerosis
    Hiromi Kikuchi
    College of Nursing, Sapporo City University, Sapporo, Japan
    BMC Neurol 13:10. 2013
  7. ncbi request reprint Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations
    Yusei Miyazaki
    Department of Clinical Research, Hokkaido Medical Center, 1 1 Yamanote 5 jo 7 choume, Nishi ku, Sapporo 063 0005, Japan Department of Neurology, Hokkaido Medical Center, 1 1 Yamanote 5 jo 7 choume, Nishi ku, Sapporo 063 0005, Japan Electronic address
    Clin Immunol 151:127-35. 2014
  8. ncbi request reprint CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neuroimmunol 159:225-9. 2005
  9. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
  10. ncbi request reprint Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Recurrent brainstem lesions mimicking infarctions in an elderly patient with neuromyelitis optica spectrum disorder
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Japan
    Intern Med 51:809-12. 2012
    ..In patients with recurrent brainstem lesions, even in the elderly and those with symptoms mimicking infarction, NMO spectrum disorder should be considered as a differential diagnosis...
  2. doi request reprint CD5-positive B cell subsets in secondary progressive multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Yamanote 5 jo 7 chome, Sapporo 063 0005, Japan
    Neurosci Lett 523:56-61. 2012
    ..Patients with SPMS showed lower CCR5, CD25, and CD138 positivity on CD5(+) B cells than HC subjects. Our results indicate that CD5(+) B cell subsets might be associated with pathogenesis of SPMS...
  3. ncbi request reprint Suppression of IL-10 production by calcitriol in patients with multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan Electronic address
    J Neuroimmunol 270:86-94. 2014
    ..Moreover, the relative unit of IL-10 in PHA-stimulation was lower in MS patients, and negatively correlated with the Expanded Disability Status Scale. The anti-inflammatory response to vitamin D may be reduced in MS...
  4. pmc Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Yamanote 5jo 7chome, Nishi ku, Sapporo 063 0005, Japan
    BMC Neurol 14:3. 2014
    ..This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression...
  5. doi request reprint Vitamin D and its immunoregulatory role in multiple sclerosis
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Nishi ku, Sapporo, Japan
    Drugs Today (Barc) 46:279-90. 2010
    ..The current review discusses the immunological functions of vitamin D, the association between vitamin D and MS and expectations regarding the role of vitamin D in future treatments of MS...
  6. pmc Structural equation modeling of factors contributing to quality of life in Japanese patients with multiple sclerosis
    Hiromi Kikuchi
    College of Nursing, Sapporo City University, Sapporo, Japan
    BMC Neurol 13:10. 2013
    ..The aim of this study was to examine the causal and mutual relationships contributing to QOL in Japanese patients with MS, develop path diagrams, and explore interventions with the potential to improve patient QOL...
  7. ncbi request reprint Suppressed pro-inflammatory properties of circulating B cells in patients with multiple sclerosis treated with fingolimod, based on altered proportions of B-cell subpopulations
    Yusei Miyazaki
    Department of Clinical Research, Hokkaido Medical Center, 1 1 Yamanote 5 jo 7 choume, Nishi ku, Sapporo 063 0005, Japan Department of Neurology, Hokkaido Medical Center, 1 1 Yamanote 5 jo 7 choume, Nishi ku, Sapporo 063 0005, Japan Electronic address
    Clin Immunol 151:127-35. 2014
    ..The observed findings in B cells of MS-F might be related to the therapeutic effect of this drug in MS. ..
  8. ncbi request reprint CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neuroimmunol 159:225-9. 2005
    ....
  9. doi request reprint Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
    ..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS...
  10. ncbi request reprint Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003
    ..Our results suggest that the 8090th polymorphism might be associated with susceptibility to MS, while the 9583rd polymorphism might be associated with age of onset of MS...
  11. doi request reprint Decreased interferon-α production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012
    ..These results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-β induces anti-inflammatory cytokine secretion in the adaptive immune system in MS...
  12. ncbi request reprint Attack-related severity: a key factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders
    Toshiyuki Fukazawa
    Hokuyukai Neurology Hospital, Niju Yon Ken 2 2 4 30, Nishi ku, Sapporo 063 0802, Japan
    J Neurol Sci 225:71-8. 2004
    ..Attack-related severity may be an important factor if validated by prospective studies defining criteria and establishing relationships to disease course and treatment regimens...
  13. doi request reprint Five-year follow-up with low-dose tacrolimus in patients with myasthenia gravis
    Naoya Minami
    Department of Neurology, Hokkaido Medical Center, Sapporo, Japan
    J Neurol Sci 300:59-62. 2011
    ..Tacrolimus is an important option for treatment of MG; however, careful management is needed for long-term treatment with this drug...
  14. ncbi request reprint Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
    ..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER...
  15. ncbi request reprint Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku, Hokkaido, Sapporo, Japan
    Brain Res 964:228-36. 2003
    ..Our results suggest that proteasome inhibition causes the neurotoxicity in mesencephalic neurons, but that is not sufficient to reproduce the selective damage to dopaminergic neurons, such as that seen in PD...
  16. doi request reprint Impact and characteristics of quality of life in Japanese patients with multiple sclerosis
    Hiromi Kikuchi
    College of Nursing, Sapporo City University, Sapporo, Japan
    Qual Life Res 20:119-31. 2011
    ..To evaluate health-related quality of life (HRQOL) in Japanese patients with multiple sclerosis (MS) and investigate associations between the results of these QOL assessments and disease severity...
  17. ncbi request reprint [Interferons and autoimmune diseases]
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center
    Brain Nerve 65:1381-8. 2013
    ..This article reviews the basic clinical data on type I interferons in autoimmune diseases and type I interferons as potential targets for therapies in autoimmune diseases...
  18. pmc An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    BMC Neurol 2:8. 2002
    ..The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS...
  19. ncbi request reprint [Selection and optimization of therapy for progressive type multiple sclerosis]
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center
    Rinsho Shinkeigaku 52:1229-30. 2012
    ..In the near future, drugs for axonal regeneration and remyelination may become treatment options for patients with progressive type MS...
  20. ncbi request reprint Brefeldin A-induced neurotoxicity in cultured spinal cord neurons
    Seiji Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 71:591-9. 2003
    ..This in vitro model may be useful in attempts to study the mechanisms of this neurodegenerative disease and to examine therapeutic potentials...
  21. doi request reprint Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
    ..These results indicate that memory and naïve B-cell subsets, especially CD86(+) naïve B cells, CCR5(+) naïve B cells, and CD5(+) memory B cells, might be useful in the study of the pathogenesis of and therapy for MS...
  22. ncbi request reprint [Recent prognosis on etiology and pathophysiology of multiple sclerosis]
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center
    Nihon Rinsho 71:807-10. 2013
    ..Recent immunological studies have revealed the importance of IL-17 and Th17 cells in the pathogenesis of MS. This review discusses recent findings on etiology and pathophysiolosy of MS...
  23. ncbi request reprint [An update on the treatment options for multiple sclerosis]
    Masaaki Niino
    Department of Clinical Research, Hokkaido Medical Center, Sapporo, Japan
    Brain Nerve 64:1421-6. 2012
    ..This article reviews the recent progress in current therapeutic strategies for MS and the potential options for future MS treatments...
  24. doi request reprint Idiopathic hypoglossal nerve laceration detected by high-resolution three-dimensional constructive interference in steady state magnetic resonance imaging
    Ken Sakushima
    Department of Neurology, Hokkaido University Graduate School of Medicine, and Department of Radiology, Hokkaido University Hospital, Sapporo, Japan
    J Neuroimaging 21:e177-9. 2011
    ..In such patients, the cause of the defect is not always apparent and 3-dimensional CISS MRI may resolve this issue...
  25. ncbi request reprint Peroxisome proliferator-activated receptor agonists as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Mini Rev Med Chem 7:1129-35. 2007
    ..This article will outline current experimental evidence suggesting potential clinical benefits for patients with MS...