Atsushi Nambu

Summary

Affiliation: National Institute for Physiological Sciences
Country: Japan

Publications

  1. ncbi request reprint A new dynamic model of the cortico-basal ganglia loop
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
    Prog Brain Res 143:461-6. 2004
  2. doi request reprint Seven problems on the basal ganglia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Curr Opin Neurobiol 18:595-604. 2008
  3. ncbi request reprint [Functions of direct, indirect and hyperdirect pathways]
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Brain Nerve 61:360-72. 2009
  4. pmc Reduced pallidal output causes dystonia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Graduate University for Advanced Studies Okazaki, Japan
    Front Syst Neurosci 5:89. 2011
  5. pmc Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic "hyperdirect" pathway
    Ken ichi Inoue
    Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan
    PLoS ONE 7:e39149. 2012
  6. pmc Somatotopic organization of the primate Basal Ganglia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences Okazaki, Japan
    Front Neuroanat 5:26. 2011
  7. ncbi request reprint A new approach to understand the pathophysiology of Parkinson's disease
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
    J Neurol 252:IV1-IV4. 2005
  8. ncbi request reprint Globus pallidus internal segment
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Prog Brain Res 160:135-50. 2007
  9. ncbi request reprint [Physiology for the stereotactic neurosurgery: a guide to stereotactic brain operations]
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    No Shinkei Geka 32:179-91. 2004
  10. ncbi request reprint Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint A new dynamic model of the cortico-basal ganglia loop
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
    Prog Brain Res 143:461-6. 2004
    ..This sequential information processing ensures that only the selected motor program is initiated, executed and terminated at the appropriate times, whereas other competing programs are canceled...
  2. doi request reprint Seven problems on the basal ganglia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Curr Opin Neurobiol 18:595-604. 2008
    ....
  3. ncbi request reprint [Functions of direct, indirect and hyperdirect pathways]
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Brain Nerve 61:360-72. 2009
    ....
  4. pmc Reduced pallidal output causes dystonia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Graduate University for Advanced Studies Okazaki, Japan
    Front Syst Neurosci 5:89. 2011
    ..Thus, reduced GPi output may cause increased thalamic and cortical activity, resulting in the involuntary movements observed in dystonia...
  5. pmc Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic "hyperdirect" pathway
    Ken ichi Inoue
    Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan
    PLoS ONE 7:e39149. 2012
    ..The IT-mediated tract targeting technique will provide us with novel strategies for elucidating various neural network functions...
  6. pmc Somatotopic organization of the primate Basal Ganglia
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences Okazaki, Japan
    Front Neuroanat 5:26. 2011
    ..Disorganized somatotopy may explain, at least in part, the pathophysiology of movement disorders, such as Parkinson's disease and dystonia...
  7. ncbi request reprint A new approach to understand the pathophysiology of Parkinson's disease
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
    J Neurol 252:IV1-IV4. 2005
    ....
  8. ncbi request reprint Globus pallidus internal segment
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigo naka, Myodaiji, Okazaki 444 8585, Japan
    Prog Brain Res 160:135-50. 2007
    ..The GP(i) finally conveys processed information outside the basal ganglia. Changes in GABAergic neurotransmission have been reported in movement disorders and suggested to play an important role in the pathophysiology of the symptoms...
  9. ncbi request reprint [Physiology for the stereotactic neurosurgery: a guide to stereotactic brain operations]
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    No Shinkei Geka 32:179-91. 2004
  10. ncbi request reprint Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ....
  11. ncbi request reprint Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys
    Yoshihisa Tachibana
    Division of System Neurophysiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Myodaiji, Okazaki 444 8585, Japan
    Eur J Neurosci 27:238-53. 2008
    ..The inhibition is GABAergic and induced by the cortico-striato-GPi pathway. In addition, these inputs are the main factors governing the spontaneous activity of GPi neurons...
  12. ncbi request reprint Input-output organization of the rostral part of the dorsal premotor cortex, with special reference to its corticostriatal projection
    Yoshihisa Tachibana
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 48:45-57. 2004
    ..These data indicate that the input-output pattern of the PMdr resembles those of the presupplementary motor area and the rostral cingulate motor area, and that the PMdr may play critical roles in higher-order motor functions...
  13. doi request reprint Multisynaptic projections from the ventrolateral prefrontal cortex to the dorsal premotor cortex in macaques - anatomical substrate for conditional visuomotor behavior
    Daisuke Takahara
    Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan
    Eur J Neurosci 36:3365-75. 2012
    ..These results indicate that the vlPFC outflow is directed toward the PMd in a multisynaptic fashion through the dPFC and/or dmMC...
  14. ncbi request reprint Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex
    Xiaofeng Lu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo, Japan
    Eur J Neurosci 25:2374-82. 2007
    ..These results indicate that the hindlimb, proximal forelimb and distal forelimb are arranged rostrocaudally in the DN and AIN, whereas there is dual somatotopy along the rostrocaudal and lateromedial axes in the cerebellar cortex...
  15. ncbi request reprint Organization of corticostriatal motor inputs in monkey putamen
    Atsushi Nambu
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1830-42. 2002
    ..In addition, the corticostriatal inputs from the forelimb region of the MI exhibited a distal to proximal somatotopic organization along the ventrodorsal axis of the Put...
  16. doi request reprint Subthalamo-pallidal interactions underlying parkinsonian neuronal oscillations in the primate basal ganglia
    Yoshihisa Tachibana
    Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    Eur J Neurosci 34:1470-84. 2011
    ....
  17. pmc Cortically evoked long-lasting inhibition of pallidal neurons in a transgenic mouse model of dystonia
    Satomi Chiken
    Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Graduate University for Advanced Studies, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 28:13967-77. 2008
    ..Long-lasting inhibition induced by cortical inputs in the internal pallidal segment may disinhibit thalamic and cortical activity, resulting in the motor hyperactivity observed in the transgenic mice...
  18. doi request reprint Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex
    Shigehiro Miyachi
    Cognitive Neuroscience Section, Primate Research Institute, Kyoto University, 41 2 Kanrin, Inuyama, Aichi, 484 8506, Japan
    Neurosci Res 76:141-9. 2013
    ..The present results suggest that the PF-MI multisynaptic projections may be organized such that the MI hand and mouth regions preferentially receive cognitive information for execution of elaborate motor actions...
  19. pmc Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin
    Masahiko Takada
    Masahiko Takada, Systems Neuroscience Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, 41 2 Kanrin, Inuyama, Aichi 484 8506, Japan takada masahiko 7x kyoto u ac jp
    Front Neural Circuits 7:140. 2013
    ..The IT-mediated pathway-selective ablation technique will provide a powerful tool for elucidating information processing in various neural networks...
  20. ncbi request reprint Thalamocortical and intracortical connections of monkey cingulate motor areas
    Nobuhiko Hatanaka
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Japan
    J Comp Neurol 462:121-38. 2003
    ....
  21. doi request reprint Differential activity patterns of putaminal neurons with inputs from the primary motor cortex and supplementary motor area in behaving monkeys
    Sayuki Takara
    Division of System Neurophysiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444 8585, Japan
    J Neurophysiol 106:1203-17. 2011
    ....
  22. ncbi request reprint Organization of multisynaptic inputs from prefrontal cortex to primary motor cortex as revealed by retrograde transneuronal transport of rabies virus
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurosci 25:2547-56. 2005
    ..The present results suggest the importance of ventral area 46 in the cognitive control of forelimb movements...
  23. ncbi request reprint Neural coding of "attention for action" and "response selection" in primate anterior cingulate cortex
    Yoshikazu Isomura
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Neurosci 23:8002-12. 2003
    ....
  24. ncbi request reprint Differential processing patterns of motor information via striatopallidal and striatonigral projections
    Katsuyuki Kaneda
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 88:1420-32. 2002
    ....
  25. doi request reprint Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques
    Yosuke Saga
    Tamagawa University Brain Science Institute, Machida, Tokyo, Japan Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Japan
    Eur J Neurosci 33:285-97. 2011
    ....
  26. ncbi request reprint Input-output organization of jaw movement-related areas in monkey frontal cortex
    Nobuhiko Hatanaka
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Japan
    J Comp Neurol 492:401-25. 2005
    ..Our results suggest that the four jaw movement-related cortical areas may play important roles in the formation of distinctive masticatory patterns...
  27. ncbi request reprint Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
    ..Through this sequential information processing, only the selected motor program is initiated, executed and terminated at the selected timing, whereas other competing programs are canceled...
  28. doi request reprint Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra
    Hiromi Sano
    Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Neurosci 33:7583-94. 2013
    ..These observations suggest that phasic late excitation in the SNr through the striatopallidal indirect pathway plays a key role in stopping movements...
  29. doi request reprint High-frequency pallidal stimulation disrupts information flow through the pallidum by GABAergic inhibition
    Satomi Chiken
    Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Graduate University for Advanced Studies, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 33:2268-80. 2013
    ..These findings suggest that GPi-DBS dissociates inputs and outputs in the GPi by intense GABAergic inhibition and disrupts information flow through the GPi...
  30. ncbi request reprint Differential expression patterns of mGluR1 alpha in monkey nigral dopamine neurons
    Katsuyuki Kaneda
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neuroreport 14:947-50. 2003
    ..These results suggest that mGluR1alpha expression may be involved at least partly in the vulnerability of dopaminergic neurons to parkinsonian insults...
  31. pmc A neural correlate of the processing of multi-second time intervals in primate prefrontal cortex
    Naosugi Yumoto
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo, Japan
    PLoS ONE 6:e19168. 2011
    ..These results suggest that area 9 may process multi-second intervals not only in perceptual recognition, but also in internal generation of time intervals...
  32. ncbi request reprint Transdural doppler ultrasonography monitors cerebral blood flow changes in relation to motor tasks
    Nobuhiko Hatanaka
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Japan
    Cereb Cortex 19:820-31. 2009
    ..Moreover, BFV changes in the SMA depended on task difficulty. The present results indicate that TDD is useful for evaluating regional brain functions...
  33. ncbi request reprint Activity and distribution patterns of monkey pallidal neurons in response to peripheral nerve stimulation
    Toshikazu Akazawa
    Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Lett 339:161-5. 2003
    ..The present results indicate that the somatotopical arrangement in the globus pallidus can be outlined based on the neuronal responses to peripheral nerve stimulation...
  34. doi request reprint Reconstruction of movement-related intracortical activity from micro-electrocorticogram array signals in monkey primary motor cortex
    Hidenori Watanabe
    Division of Behavioral Development, Department of Developmental Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Neural Eng 9:036006. 2012
    ..55 ± 0.04. A time-frequency analysis of the reconstructed LFP showed clear transition between resting and movements by the monkey. These methods would be a powerful tool with wide-ranging applicability in neuroscience studies...
  35. ncbi request reprint [Pathophysiology of movement disorders]
    Atsushi Nambu
    Division of System Neurophysiology, National Institute for Physiological Sciences
    Rinsho Shinkeigaku 52:1198-200. 2012
    ..Each model will be critically discussed in this review...
  36. ncbi request reprint Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 26:6554-62. 2006
    ....
  37. ncbi request reprint Balance of monosynaptic excitatory and disynaptic inhibitory responses of the globus pallidus induced after stimulation of the subthalamic nucleus in the monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 25:8611-9. 2005
    ....
  38. ncbi request reprint Serotonin modulates pallidal neuronal activity in the awake monkey
    Hitoshi Kita
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Memphis, Memphis, Tennessee 38163, USA
    J Neurosci 27:75-83. 2007
    ..Thus, present results imply that 5-HT modulates synaptic inputs of both pallidal segments and exerts a significant role in movement control...
  39. ncbi request reprint Two-state membrane potential transitions of striatal spiny neurons as evidenced by numerical simulations and electrophysiological recordings in awake monkeys
    Katsunori Kitano
    Department of Information Communication Engineering, Tamagawa University, Machida, Tokyo 194 8610, Japan
    J Neurosci 22:RC230. 2002
    ..Thus, the membrane potential shifts between the up and down states appear to occur in striatal spiny neurons of the behaving animal...