Hiroshi Nakao

Summary

Affiliation: National Research Institute for Child Health and Development
Country: Japan

Publications

  1. ncbi Escherichia coli Shiga toxin
    H Nakao
    Department of Infectious Diseases Research, National Children s Medical Research Center, National Children s Hospital, Tokyo, Japan
    J Nat Toxins 9:299-313. 2000
  2. ncbi Monoclonal antibody to shiga toxin 1, which blocks receptor binding and neutralizes cytotoxicity
    Hiroshi Nakao
    Department of Infectious Diseases, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo 154 8567, Japan
    Microbiol Immunol 46:777-80. 2002
  3. ncbi Subtyping of Shiga toxin 2 variants in human-derived Shiga toxin-producing Escherichia coli strains isolated in Japan
    Hiroshi Nakao
    Department of Infectious Diseases, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567Japan
    FEMS Immunol Med Microbiol 34:289-97. 2002
  4. ncbi Characterization of a shiga-toxin 1-resistant stock of vero cells
    Takaomi Sekino
    Department of Developmental Biology, National Research Institute for Child Health and Development, Tokyo, Japan
    Microbiol Immunol 48:377-87. 2004
  5. ncbi Inhibition of shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine
    Takaomi Sekino
    Department of Pathology, National Children's Medical Research Center, Setagaya-ku, Tokyo, Japan
    J Infect Dis 185:785-96. 2002
  6. ncbi Mixture of sugar and povidone-iodine stimulates healing of MRSA-infected skin ulcers on db/db mice
    Chong Ming Shi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Arch Dermatol Res 299:449-56. 2007
  7. ncbi Development of humanized monoclonal antibody TMA-15 which neutralizes Shiga toxin 2
    Tsuyoshi Kimura
    Teijin Institute for Biomedical Research, Teijin Limited, 4 3 2 Asahigaoka, Hino, Tokyo 191 8512, Japan
    Hybrid Hybridomics 21:161-8. 2002
  8. ncbi Characterization of a Shiga toxin 1-neutralizing recombinant Fab fragment isolated by phage display system
    Kazuyuki Inoue
    Department of Pharmaceutical Science, Akita University Hospital, Hondo, Japan
    Tohoku J Exp Med 203:295-303. 2004
  9. ncbi [Shiga toxin producing Escherichia coli infection]
    Hiroshi Nakao
    Department of Infectious Diseases Research, National Children's Medical Research Center, National Children's Hospital
    Nippon Rinsho 60:545-50. 2002
  10. ncbi Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus
    Yong Hwa Moon
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Microbiol Immunol 48:389-98. 2004

Collaborators

  • Kouichi Kimura
  • Yohko U Katagiri
  • N Kiyokawa
  • Tsuyoshi Kimura
  • Kunihiko Itoh
  • Tomotaka Tanabe
  • Shigeo Yamamoto
  • Takaomi Sekino
  • Shizuo Narimatsu
  • Yong Hwa Moon
  • Tae Takeda
  • Tatsuya Funahashi
  • Jiyou Wang
  • Chong Ming Shi
  • Tomofusa Tsuchiya
  • Yuji Inoue
  • Ayaka Naka
  • Yong-Hwa Moon
  • Kazuyuki Inoue
  • Hiroaki Aso
  • Kazuhiro Ohmi
  • Hideki Nakajima
  • Tomoko Taguchi
  • Junichiro Fujimoto
  • Toyo Suzuki
  • Shin Ichi Miyoshi
  • Yoko Maehara
  • Shin-ichi Miyoshi
  • Tomoko Sasaki
  • Ryoji Tsuboi
  • Chong-Ming Shi
  • Hideoki Ogawa
  • Masashi Yamazaki
  • Teruo Kuroda
  • Noriko Takata
  • Tomomichi Ono
  • Kei ichi Shiuchi
  • Wei-Ran Tang
  • Hajime Okita
  • Masahiro Saito
  • Toshio Suzuki
  • Hisami Takenouchi
  • Jun Matsui
  • Kei-ichi Shiuchi
  • Yoshio Fujii
  • Keinosuke Okamoto
  • Susumu Furukawa

Detail Information

Publications15

  1. ncbi Escherichia coli Shiga toxin
    H Nakao
    Department of Infectious Diseases Research, National Children s Medical Research Center, National Children s Hospital, Tokyo, Japan
    J Nat Toxins 9:299-313. 2000
    ..Apoptosis is considered to contribute to the pathogenesis of HUS caused by STEC. In this review, recent progress in Stx-related research is summarized...
  2. ncbi Monoclonal antibody to shiga toxin 1, which blocks receptor binding and neutralizes cytotoxicity
    Hiroshi Nakao
    Department of Infectious Diseases, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo 154 8567, Japan
    Microbiol Immunol 46:777-80. 2002
    ....
  3. ncbi Subtyping of Shiga toxin 2 variants in human-derived Shiga toxin-producing Escherichia coli strains isolated in Japan
    Hiroshi Nakao
    Department of Infectious Diseases, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567Japan
    FEMS Immunol Med Microbiol 34:289-97. 2002
    ..A multiplex PCR that can detect the stx1, stx2, and G1 genes was developed as a means of rapid and easy typing to better understand the roles of the different types of Stx...
  4. ncbi Characterization of a shiga-toxin 1-resistant stock of vero cells
    Takaomi Sekino
    Department of Developmental Biology, National Research Institute for Child Health and Development, Tokyo, Japan
    Microbiol Immunol 48:377-87. 2004
    ..Further study of R-Vero cells may provide a model of Stx1 resistance via distinct intracellular transport of Stx1...
  5. ncbi Inhibition of shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine
    Takaomi Sekino
    Department of Pathology, National Children's Medical Research Center, Setagaya-ku, Tokyo, Japan
    J Infect Dis 185:785-96. 2002
    ..Investigation of the NBTI-mediated protection mechanism against Stx cytotoxicity may provide insights into the analysis of Stx-mediated cell damage and lead to improvements in therapeutic approaches for diseases caused by Stx...
  6. ncbi Mixture of sugar and povidone-iodine stimulates healing of MRSA-infected skin ulcers on db/db mice
    Chong Ming Shi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Arch Dermatol Res 299:449-56. 2007
    ..These results indicate that wounding on db/db mice provides a useful animal model of bacterial skin infections, and that SP is an effective topical agent for the treatment of diabetic skin ulcers...
  7. ncbi Development of humanized monoclonal antibody TMA-15 which neutralizes Shiga toxin 2
    Tsuyoshi Kimura
    Teijin Institute for Biomedical Research, Teijin Limited, 4 3 2 Asahigaoka, Hino, Tokyo 191 8512, Japan
    Hybrid Hybridomics 21:161-8. 2002
    ..These results suggest that TMA-15 will have clinical potency in Stx-producing Escherichia coli infections, including E. coli O157 infections...
  8. ncbi Characterization of a Shiga toxin 1-neutralizing recombinant Fab fragment isolated by phage display system
    Kazuyuki Inoue
    Department of Pharmaceutical Science, Akita University Hospital, Hondo, Japan
    Tohoku J Exp Med 203:295-303. 2004
    ..Among the regions, CDR2 showed the most frequent nucleotide and amino acid substitutions. These results suggest that heavy chain CDR2 may mainly be associated with the 5-5B function, that is neutralizing cytotoxicity of Stx1...
  9. ncbi [Shiga toxin producing Escherichia coli infection]
    Hiroshi Nakao
    Department of Infectious Diseases Research, National Children's Medical Research Center, National Children's Hospital
    Nippon Rinsho 60:545-50. 2002
    ..In conclusion, the prevention of primary infection is thought to be the best way to prevent the life-threatening complications caused by STEC, and second way is identification as early as possible...
  10. ncbi Identification and characterization of two contiguous operons required for aerobactin transport and biosynthesis in Vibrio mimicus
    Yong Hwa Moon
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Microbiol Immunol 48:389-98. 2004
    ..This is the first report demonstrating that aerobactin transport and biosynthesis genes are present in a species outside the family Enterobacteriaceae...
  11. ncbi Identification of an AraC-like regulator gene required for induction of the 78-kDa ferrioxamine B receptor in Vibrio vulnificus
    Tomotaka Tanabe
    Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    FEMS Microbiol Lett 249:309-14. 2005
    ..These results suggest that the desR gene is required for desferrioxamine B-inducible production of DesA in iron-starved cells...
  12. ncbi A novel aerobactin utilization cluster in Vibrio vulnificus with a gene involved in the transcription regulation of the iutA homologue
    Tomotaka Tanabe
    Department of Molecular Biopharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-naka, Okayama, Japan
    Microbiol Immunol 49:823-34. 2005
    ..This is the first example of a regulator gene involved in aerobactin-enhanced production of IutA...
  13. ncbi Involvement of the Vibrio parahaemolyticus pvsC gene in export of the siderophore vibrioferrin
    Tomotaka Tanabe
    Department of Molecular Biopharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Microbiol Immunol 50:871-6. 2006
    ..Vibrioferrin release could be regained by introducing the intact pvsC gene on a complementing plasmid. These results indicate that the pvsC gene product functions as an inner membrane exporter of vibrioferrin...
  14. ncbi An iron-regulated gene required for utilization of aerobactin as an exogenous siderophore in Vibrio parahaemolyticus
    Tatsuya Funahashi
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Microbiology 149:1217-25. 2003
    ..parahaemolyticus. However, additional genes required for ferric aerobactin transport across the inner membrane remain to be clarified...
  15. ncbi Variation of extracellular proteases produced by Vibrio vulnificus clinical isolates: genetic diversity of the metalloprotease gene (vvp), and serine protease secretion by vvp-negative strains
    Jiyou Wang
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima Naka, Okayama 700 8530, Japan
    Microb Pathog 44:494-500. 2008
    ..These findings suggest that, in addition to metalloprotease, the extracellular serine protease may contribute to pathogenicity of V. vulnificus...