Akira Nakanishi

Summary

Affiliation: National Institute for Longevity Sciences
Country: Japan

Publications

  1. ncbi request reprint SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids
    Akira Nakanishi
    National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Virology 379:110-7. 2008
  2. doi request reprint An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect
    Shoichiro Tange
    National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Virus Res 157:116-20. 2011
  3. pmc Initiation of human astrovirus type 1 infection was blocked by inhibitors of phosphoinositide 3-kinase
    Shoichiro Tange
    Section of Gene Therapy, Department of Aging Intervention, National Center for Geriatrics and Gerontology, 35, Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Virol J 10:153. 2013
  4. ncbi request reprint Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1
    Naoki Yokoyama
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Biochem 141:279-86. 2007
  5. pmc Minor capsid proteins of simian virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome
    Akira Nakanishi
    Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, 456 Boyer Hall, University of California, Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 81:3778-85. 2007
  6. pmc Molecular dissection of nuclear entry-competent SV40 during infection
    Akira Nakanishi
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Virus Res 124:226-30. 2007
  7. pmc Identification of amino acid residues within simian virus 40 capsid proteins Vp1, Vp2, and Vp3 that are required for their interaction and for viral infection
    Akira Nakanishi
    Molecular Biology Institute, University of California Los Angeles, 611 East Charles E Young Drive, Los Angeles, CA 90095 1570, USA
    J Virol 80:8891-8. 2006
  8. ncbi request reprint The VP2/VP3 minor capsid protein of simian virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particles
    Masa aki Kawano
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan
    J Biol Chem 281:10164-73. 2006
  9. pmc Pairs of Vp1 cysteine residues essential for simian virus 40 infection
    Peggy P Li
    Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 79:3859-64. 2005
  10. pmc Interaction of the Vp3 nuclear localization signal with the importin alpha 2/beta heterodimer directs nuclear entry of infecting simian virus 40
    Akira Nakanishi
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:9368-77. 2002

Collaborators

  • Shoichiro Tange
  • Peggy P Li
  • Naoki Yokoyama
  • Masa aki Kawano
  • Hiroko Tsukamoto
  • Teruya Enomoto
  • Ryou u Takahashi
  • Takamasa Inoue
  • Takeshi Imai
  • Tadashi Wada
  • Hiroshi Handa
  • Harumi Kasamatsu
  • Tatsuya Takaya
  • Noriaki Yamamoto
  • Kohsuke Kataoka
  • Vanessa Fontanes
  • Sean W Clark

Detail Information

Publications11

  1. ncbi request reprint SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids
    Akira Nakanishi
    National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Virology 379:110-7. 2008
    ..This method can be used to develop a surrogate system to study the functions of capsid proteins of polyomaviruses and to generate a set of polyomaviral vectors targeted at specific cell types...
  2. doi request reprint An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect
    Shoichiro Tange
    National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    Virus Res 157:116-20. 2011
    ..The results indicate that tsD mutation in minor capsid proteins has a more profound impact on viral propagation, and that lack of VP4 ORF seems to have little influence on viral growth...
  3. pmc Initiation of human astrovirus type 1 infection was blocked by inhibitors of phosphoinositide 3-kinase
    Shoichiro Tange
    Section of Gene Therapy, Department of Aging Intervention, National Center for Geriatrics and Gerontology, 35, Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Virol J 10:153. 2013
    ..Recent studies showed that activation of extracellular signal-regulated kinase 1/2 (ERK1/2) is important for HAstV infection, though the involvement of other signaling cascades remains unclear...
  4. ncbi request reprint Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1
    Naoki Yokoyama
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Biochem 141:279-86. 2007
    ..By understanding how to alter VLP sizes and shapes contributes to the development of drug delivery systems using VLPs...
  5. pmc Minor capsid proteins of simian virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome
    Akira Nakanishi
    Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, 456 Boyer Hall, University of California, Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 81:3778-85. 2007
    ..Further, the nucleocapsids' ability to enter cells implies that Vp1 contains the major determinants for cell attachment and entry. We propose that the major role of Vp2/3 in infectivity is to mediate the nuclear entry of viral DNA...
  6. pmc Molecular dissection of nuclear entry-competent SV40 during infection
    Akira Nakanishi
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Virus Res 124:226-30. 2007
    ..All these results suggest that once SV40 enters the cytoplasm, it undergoes an architectural modification that exposes the virion's NLSs for nuclear entry...
  7. pmc Identification of amino acid residues within simian virus 40 capsid proteins Vp1, Vp2, and Vp3 that are required for their interaction and for viral infection
    Akira Nakanishi
    Molecular Biology Institute, University of California Los Angeles, 611 East Charles E Young Drive, Los Angeles, CA 90095 1570, USA
    J Virol 80:8891-8. 2006
    ..Our results defined the residues of Vp1 and the minor capsid proteins that are essential for both the interaction of the capsid proteins and viral viability in permissive cells...
  8. ncbi request reprint The VP2/VP3 minor capsid protein of simian virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particles
    Masa aki Kawano
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan
    J Biol Chem 281:10164-73. 2006
    ..These results are relevant for controlling recombinant capsid formation in vitro, which is potentially useful for the in vitro development of SV40 virus vectors...
  9. pmc Pairs of Vp1 cysteine residues essential for simian virus 40 infection
    Peggy P Li
    Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 79:3859-64. 2005
    ....
  10. pmc Interaction of the Vp3 nuclear localization signal with the importin alpha 2/beta heterodimer directs nuclear entry of infecting simian virus 40
    Akira Nakanishi
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:9368-77. 2002
    ....
  11. pmc Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm
    Peggy P Li
    Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1353-8. 2002
    ..Such disulfide dynamics may be a general phenomenon for other cysteine-bearing mammalian proteins that fold in the cytoplasm...