N Nagaya

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
  2. ncbi request reprint Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka
    Intern Med 45:127-34. 2006
  3. ncbi request reprint Stem cell implantation for myocardial disorders
    Kenichi Yamahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Curr Drug Deliv 5:224-9. 2008
  4. ncbi request reprint Drug therapy of primary pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Am J Cardiovasc Drugs 4:75-85. 2004
  5. ncbi request reprint Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 104:2034-8. 2001
  6. ncbi request reprint Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 86:5854-9. 2001
  7. pmc Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension
    N Nagaya
    Division of Cardiology, Department of Medicine, National Cardiovascular Centre, Osaka, Japan
    Heart 87:340-5. 2002
  8. ncbi request reprint Plasma brain natriuretic peptide as a noninvasive marker for efficacy of pulmonary thromboendarterectomy
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Ann Thorac Surg 74:180-4; discussion 184. 2002
  9. ncbi request reprint Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Chest 123:338-43. 2003
  10. ncbi request reprint Pulmonary vasodilator response to adrenomedullin in patients with pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    Hypertens Res 26:S141-6. 2003

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
    ..We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF)...
  2. ncbi request reprint Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka
    Intern Med 45:127-34. 2006
    ..These results suggest that ghrelin has anti-cachectic effects through GH-dependent and independent mechanisms. Thus, administration of ghrelin may be a new therapeutic strategy for the treatment of cardiopulmonary-associated cachexia...
  3. ncbi request reprint Stem cell implantation for myocardial disorders
    Kenichi Yamahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Curr Drug Deliv 5:224-9. 2008
    ....
  4. ncbi request reprint Drug therapy of primary pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Am J Cardiovasc Drugs 4:75-85. 2004
    ..These noninvasive parameters may be helpful as part of the evaluation of treatment in patients with PPH and, in particular, as a guide to the selection and timing for alternative therapies...
  5. ncbi request reprint Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 104:2034-8. 2001
    ..We sought to investigate the pathophysiology of ghrelin in the cachexia associated with chronic heart failure (CHF)...
  6. ncbi request reprint Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 86:5854-9. 2001
    ..In summary, iv infusion of ghrelin, a potent GH-releasing peptide, had beneficial hemodynamic effects in patients with CHF in the absence of renal effects...
  7. pmc Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension
    N Nagaya
    Division of Cardiology, Department of Medicine, National Cardiovascular Centre, Osaka, Japan
    Heart 87:340-5. 2002
    ..To investigate the effect of beraprost sodium, an orally active prostacyclin analogue, on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension and chronic thromboembolic pulmonary hypertension...
  8. ncbi request reprint Plasma brain natriuretic peptide as a noninvasive marker for efficacy of pulmonary thromboendarterectomy
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Ann Thorac Surg 74:180-4; discussion 184. 2002
    ..However, whether plasma BNP may serve as a marker for the efficacy of pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension remains unknown...
  9. ncbi request reprint Prostacyclin therapy before pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Chest 123:338-43. 2003
    ....
  10. ncbi request reprint Pulmonary vasodilator response to adrenomedullin in patients with pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    Hypertens Res 26:S141-6. 2003
    ..These results suggest that, on a molar basis, AM may have much more potent pulmonary vasodilator activity than ACh and ATP, and thus may have beneficial hemodynamic effects in patients with pulmonary hypertension...
  11. ncbi request reprint Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Curr Opin Pharmacol 3:146-51. 2003
    ..These results suggest that ghrelin has therapeutic potential in the treatment of severe chronic heart failure...
  12. ncbi request reprint Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 114:71-7. 2003
    ..Thus, administration of ghrelin may be a new therapeutic strategy for the treatment of severe chronic heart failure (CHF)...
  13. ncbi request reprint Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 108:889-95. 2003
    ..We investigated whether transplantation of vasodilator gene-transduced EPCs ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats...
  14. ncbi request reprint Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease
    Takefumi Itoh
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 170:879-82. 2004
    ..In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function...
  15. ncbi request reprint Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats
    Noritoshi Nagaya
    Dept of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 285:H2125-31. 2003
    ..10% 6-wk survival, log-rank test, P < 0.01). In conclusion, repeated inhalation of AM inhibited MCT-induced pulmonary hypertension without systemic hypotension and thereby improved survival in MCT rats...
  16. ncbi request reprint Adrenomedullin in the treatment of pulmonary hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujisjirodai, Suita, Osaka 565 8565, Japan
    Peptides 25:2013-8. 2004
    ..These results suggest that additional administration of AM may be effective in patients with pulmonary hypertension. AM may be a promising endogenous peptide for the treatment of pulmonary hypertension...
  17. ncbi request reprint Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 109:351-6. 2004
    ..Accordingly, we investigated the effects of AM inhalation on pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension...
  18. ncbi request reprint Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    Circulation 104:1430-5. 2001
    ..We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF)...
  19. pmc Pulmonary artery sarcoma
    N Kotooka
    Heart 89:1388. 2003
  20. ncbi request reprint Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka 565 - 8565, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1483-7. 2001
    ..In summary, human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate...
  21. ncbi request reprint Role of increased circulating and renal adrenomedullin in rats with malignant hypertension
    T Nishikimi
    Research Institute, Fujishirodai, Suita, Osaka 565, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R2079-87. 2001
    ....
  22. ncbi request reprint Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension
    N Nagaya
    Department of Internal Medicine and Department of Pharmacy, National Cardiovascular Center, and Osaka Seamen's Insurance Hospital, Osaka, Japan
    Am J Respir Crit Care Med 163:887-91. 2001
    ..These results suggest that oral supplementation of L-arginine may have beneficial effects on hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension...
  23. pmc Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension
    N Nagaya
    Division of Cardiology, Department of Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565, Japan
    Heart 84:653-8. 2000
    ..To investigate whether infusion of adrenomedullin, a potent vasorelaxant peptide, has beneficial haemodynamic and hormonal effects in patients with pulmonary hypertension...
  24. ncbi request reprint Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome
    Y Tanabe
    Department of Internal Medicine, Okayama University Medical School, Suita, Japan
    J Am Coll Cardiol 37:911-9. 2001
    ....
  25. ncbi request reprint Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes
    T Nishikimi
    Division of Hypertension, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Eur J Pharmacol 353:337-44. 1998
    ..These results suggest that myocytes and nonmyocytes secrete adrenomedullin and that adrenomedullin increases cAMP levels possibly via different receptors in myocytes and nonmyocytes...
  26. pmc Acute and chronic effects of surgical thromboendarterectomy on exercise capacity and ventilatory efficiency in patients with chronic thromboembolic pulmonary hypertension
    T Iwase
    Department of Internal Medicine, National Cardiovascular Centre, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
    Heart 86:188-92. 2001
    ..In contrast, exercise capacity may continue to improve towards the late phase, reflecting peripheral adaptation to exercise...
  27. ncbi request reprint Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy
    F Sakamaki
    Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 102:2720-5. 2000
    ....
  28. ncbi request reprint The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension
    T Nishikimi
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 100:61-6. 2001
    ....
  29. ncbi request reprint Abnormality of left ventricular sympathetic nervous function assessed by (123)I-metaiodobenzylguanidine imaging in patients with COPD
    F Sakamaki
    Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Chest 116:1575-81. 1999
    ..Cardiac and systemic autonomic nervous function may be impaired in patients with COPD. Few reports, however, have described sympathetic nervous function of the left ventricle (LV) in COPD patients...
  30. ncbi request reprint Comparison of intravenous adrenomedullin with atrial natriuretic peptide in patients with congestive heart failure
    H Oya
    Department of Internal Medicine, Research Institute, Osaka, Japan
    Am J Cardiol 86:94-8. 2000
  31. ncbi request reprint [Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension]
    N Nagaya
    Division of Cardiology, Department of Medicine, National Cardiovascular Center, Fujishirodai 5-7-1, Suita, Osaka 565-8565
    J Cardiol 37:110-1. 2001
    ..0001). CONCLUSIONS: A high level of plasma BNP, and in particular, a further increase in plasma BNP during follow-up, may have a strong, independent association with increased mortality in patients with primary pulmonary hypertension...
  32. ncbi request reprint Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
    Yoshinori Miyahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nat Med 12:459-65. 2006
    ..Thus, transplantation of monolayered mesenchymal stem cells may be a new therapeutic strategy for cardiac tissue regeneration...
  33. ncbi request reprint Pulmonary artery reflection for differentially diagnosing primary pulmonary hypertension and chronic pulmonary thromboembolism
    Y Nakayama
    Department of Cardiology, Ishikiriseiki Hospital, Osaka, Japan
    J Am Coll Cardiol 38:214-8. 2001
    ..Inflection time separated the two groups reasonably well (97 +/- 20 ms and 210 +/- 49 ms, respectively, p < 0.001). CONCLUSIONS: The analysis of pulmonary arterial reflection is useful in the differential diagnosis of CPTE and PPH...
  34. ncbi request reprint Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block
    Milki Yokokawa
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Cell Transplant 17:1145-55. 2008
    ..In addition, local injection of MSC conditioned medium recovered AV conduction in 2 of 15 rats (13%). MSC transplantation improved AV conduction in a rat model of complete AVB, at least in part through antifibrotic paracrine effects...
  35. ncbi request reprint Adrenomedullin enhances therapeutic potency of bone marrow transplantation for myocardial infarction in rats
    Takafumi Fujii
    Department of Cardiac Physiology, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Physiol Heart Circ Physiol 288:H1444-50. 2005
    ..This beneficial effect may be mediated partly by the angiogenic property of AM itself and by its antiapoptotic effect on MNC...
  36. ncbi request reprint K(ATP) channels predominantly regulate conduit vessel tone in normoxic cat pulmonary arteries in vivo
    M Shirai
    Department of Cardiac Physiology National Cardiovascular Center Research Institute 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Eur J Pharmacol 422:181-4. 2001
    ..The data suggest that K(ATP) channels are active and capable of regulating basal vascular tone primarily within conduit pulmonary arteries even though these channels are present in all pulmonary arteries...
  37. ncbi request reprint A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats
    Takefumi Itoh
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Respir Crit Care Med 169:34-8. 2004
    ..These results suggest that combination therapy with oral sildenafil and beraprost attenuates the development of MCT-induced pulmonary hypertension compared with treatment with each drug alone...
  38. ncbi request reprint C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats
    Takefumi Itoh
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 170:1204-11. 2004
    ..These beneficial effects may be mediated by regeneration of pulmonary endothelium, inhibition of endothelial cell apoptosis, and prevention of monocyte/macrophage infiltration and fibrinolysis impairment...
  39. ncbi request reprint [Adrenomedullin in pulmonary hypertension]
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:264-8. 2004
  40. ncbi request reprint Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Circulation 111:356-62. 2005
    ..Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. We investigated whether AM enhances bone marrow cell-induced angiogenesis...
  41. doi request reprint Pathological role of angiostatin in heart failure: an endogenous inhibitor of mesenchymal stem-cell activation
    K Yamahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka, Japan
    Heart 95:283-9. 2009
    ....
  42. ncbi request reprint Orally active prostacyclin analogue for cardiovascular disease
    N Nagaya
    Nagaya Cardiovascular and Respiratory Clinic, Osaka, Japan
    Int Angiol 29:14-8. 2010
    ..These results suggest that oral administration of beraprost has beneficial effects on cardiovascular disease. Orally active prostacyclin analogues, are promising drugs for the treatment of cardiovascular disease...
  43. ncbi request reprint Two molecular forms of adrenomedullin in congenital heart disease
    K Watanabe
    Department of Pediatrics, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Pediatr Cardiol 24:559-65. 2003
    ..These results suggest that plasma AM-m and AM-Gly are similarly regulated and the main clearance site of AM-m is the lung in patients with congenital heart disease...
  44. ncbi request reprint Bone marrow mononuclear cell transplantation had beneficial effects on doxorubicin-induced cardiomyopathy
    Michiko Ishida
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center, Osaka, Japan
    J Heart Lung Transplant 23:436-45. 2004
    ..However, the effect of BMMNC transplantation in non-ischemic dilated cardiomyopathy is unknown. In this study, we evaluated the efficacy of BMMNC transplantation in doxorubicin-induced cardiomyopathy in a rat model...
  45. doi request reprint Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in a rat model of hind limb ischemia
    Shin Ishikane
    Department of Perinatology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Stem Cells 26:2625-33. 2008
    ..Thus, allogeneic injection of FM-MSC may be a new therapeutic strategy for the treatment of severe peripheral vascular disease. Disclosure of potential conflicts of interest is found at the end of this article...
  46. ncbi request reprint Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction
    Satoshi Yasuda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 112:43-9. 2007
    ..A pleiotropic effect of statins appears to be associated with the modulation of cardiac MMP activation, which may be potentially beneficial in the attenuation of post-infarction LV remodelling...
  47. ncbi request reprint Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Cardiovasc Res 66:543-51. 2005
    ..Accordingly, we injected equal numbers of MSC or MNC in a rat model of hindlimb ischemia and compared their therapeutic potential...
  48. ncbi request reprint Adrenomedullin enhances therapeutic potency of mesenchymal stem cells after experimental stroke in rats
    Kenichiro Hanabusa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Stroke 36:853-8. 2005
    ..Transplantation of mesenchymal stem cells (MSCs) has been shown to improve neurological deficits after stroke in rats. We investigated whether AM enhances the therapeutic potency of MSC transplantation...
  49. ncbi request reprint Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure
    T Nishikimi
    Research Institute, National Cardiovascular Centre, Osaka, Japan
    J Hypertens 19:765-73. 2001
    ....
  50. ncbi request reprint Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
    Am J Physiol Heart Circ Physiol 279:H3031-9. 2000
    ....
  51. ncbi request reprint Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 177:195-201. 2008
    ..Therefore, we developed a new drug delivery system for prostacyclin. We prepared ONO-1301MS, a novel sustained-release prostacyclin analog polymerized with poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres...
  52. ncbi request reprint [Regenerative medicine for heart failure]
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 66:978-83. 2008
    ..On the basis of information obtained from basic and translational research, several clinical trials have recently been started to evaluate the safety and efficacy of autologous MSC for heart failure...
  53. doi request reprint Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells
    Chiaki Nakanishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 374:11-6. 2008
    ..In conclusion, MSC-derived conditioned medium had protective effects on CPC and enhanced their migration and differentiation...
  54. ncbi request reprint [Ghrelin and cardiovascular disease]
    Yoshito Shimizu
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:396-8. 2004
  55. ncbi request reprint Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene
    Hui Ying Qiu
    Division of Hematology and Oncology, Department of Medicine, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Int J Oncol 28:815-21. 2006
    ..The immortalized HYCEC-1 cells are suggested to be a class of EPCs that can efficiently participate in postnatal neovasculogenesis in the ischemic hind limb, and may also be a useful tool for studying tumor vessel formation...
  56. ncbi request reprint Effect of orally active prostacyclin analogue on survival in patients with chronic thromboembolic pulmonary hypertension without major vessel obstruction
    Fumiaki Ono
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Chest 123:1583-8. 2003
    ....
  57. ncbi request reprint Intravenous adrenomedullin in myocardial function and energy metabolism in patients after myocardial infarction
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Pharmacol 39:754-60. 2002
    ..Unlike ANP, IV administration of adrenomedullin enhanced left ventricular myocardial contraction and improved left ventricular relaxation without increasing myocardial oxygen consumption in patients who had had a myocardial infarction...
  58. ncbi request reprint Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway
    Hiroyuki Okumura
    Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    Circulation 109:242-8. 2004
    ..Infusion of adrenomedullin (AM) has beneficial hemodynamic effects in patients with heart failure. However, the effect of AM on myocardial ischemia/reperfusion remains unknown...
  59. ncbi request reprint Increase in thrombomodulin concentrations after pulmonary thromboendarterectomy in chronic thromboembolic pulmonary hypertension
    Fumio Sakamaki
    Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Chest 124:1305-11. 2003
    ....
  60. ncbi request reprint Myocardial imaging with 123I-BMIPP in patients with congestive heart failure
    Y Ishida
    Department of Radiology, National Cardiovascular Center, Osaka, Japan
    Int J Card Imaging 15:71-7. 1999
    ..These results suggest that myocardial utilization of free fatty acid may be preserved in the presence of higher ventricular wall stress...
  61. ncbi request reprint CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis
    Hiroaki Obata
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 356:60-6. 2007
    ..In conclusion, CNP infusion attenuated cardiac function in acute myocarditis through anti-inflammatory and angiogenic effects...
  62. ncbi request reprint Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    Stem Cells 25:1166-77. 2007
    ..Our results may provide information on the differential molecular mechanisms regulating the properties of MSC and MNC under ischemic conditions. Disclosure of potential conflicts of interest is found at the end of this article...
  63. ncbi request reprint Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Osaka 565 8565, Japan
    J Mol Cell Cardiol 42:88-97. 2007
    ..MSC transplantation attenuated myocardial injury and dysfunction in a rat model of acute myocarditis, at least in part through paracrine effects of MSC...
  64. ncbi request reprint Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats
    Yoshinori Miyahara
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 349:1242-9. 2006
    ..These results suggest that beraprost has beneficial effects on ischemic myocardium partly by its ability to enhance neovascularization in ischemic myocardium by mobilizing bone marrow cells...
  65. ncbi request reprint Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Osaka 565 8565, Japan
    FEBS Lett 581:3961-6. 2007
    ..MSC may exert paracrine anti-fibrotic effects at least in part through regulation of CFB proliferation and collagen synthesis...
  66. ncbi request reprint Therapeutic potential of ghrelin in the treatment of heart failure
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Drugs 66:439-48. 2006
    ..Thus, administration of ghrelin may be a new therapeutic strategy for the treatment of severe CHF...
  67. ncbi request reprint Sex hormone and gender difference--role of testosterone on male predominance in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 18:415-21. 2007
    ..Brugada syndrome has been reported to be thinner than asymptomatic normal controls. We tested the hypothesis that higher testosterone level associated with lower visceral fat may relate to Brugada phenotype and male predominance...
  68. ncbi request reprint Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema
    Bobby Yanagawa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Cardiovasc Res 76:110-8. 2007
    ..Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model...
  69. ncbi request reprint Higher prevalence of obstructive airway disease in patients with thoracic or abdominal aortic aneurysm
    Fumio Sakamaki
    Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, Suita Shi, Osaka, Japan
    J Vasc Surg 36:35-40. 2002
    ..This study was performed to determine whether patients with AA have a higher than average prevalence of obstructive airway disease...
  70. ncbi request reprint Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 39:1984-91. 2002
    ..This study compared the effects of beta-blockade on transmural and spatial dispersion of repolarization (TDR and SDR, respectively) between the LQT1 and LQT2 forms of congenital long QT syndrome (LQTS)...
  71. ncbi request reprint Quantitative analysis of lung perfusion in patients with primary pulmonary hypertension
    Kazuki Fukuchi
    Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan
    J Nucl Med 43:757-61. 2002
    ..The aim of this study was to evaluate quantitatively the heterogeneity of lung perfusion scans in patients with primary pulmonary hypertension (PPH) and to compare it with the severity of disease...
  72. doi request reprint Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
    Donghao Jin
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 80:339-45. 2008
    ..Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedema...
  73. pmc Tissue regeneration as next-generation therapy for COPD--potential applications
    Shunsuke Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Int J Chron Obstruct Pulmon Dis 3:509-14. 2008
    ....
  74. ncbi request reprint Effects of continuous IV prostacyclin in a patient with pulmonary veno-occlusive disease
    Hiroyuki Okumura
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Chest 122:1096-8. 2002
    ..These results suggest that continuous IV PGI(2) therapy may serve as a bridge to transplantation in some cases of PVOD...
  75. ncbi request reprint Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis
    Noritoshi Nagaya
    Dept of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Heart Circ Physiol 287:H2670-6. 2004
    ..05 vs. control). These results suggest that intravenous administration of MSCs improves cardiac function after acute myocardial infarction through enhancement of angiogenesis and myogenesis in the ischemic myocardium...
  76. pmc Changes in functional and histological distributions of nitric oxide synthase caused by chronic hypoxia in rat small pulmonary arteries
    Mikiyasu Shirai
    Department of Cardiac Physiology, National Cardiovascular Centre Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Br J Pharmacol 139:899-910. 2003
    ..Such NOS upregulation may serve to attenuate hypoxic vasoconstriction, which occurs primarily in MPA and inhibit the progress of pulmonary hypertension...
  77. ncbi request reprint Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Japan
    Heart Rhythm 1:276-83. 2004
    ..The aim of this study was to test the hypothesis that epinephrine test may have diagnostic value for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome (LQTS)...
  78. ncbi request reprint [Ghrelin in the treatment of cardiovascular disease]
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:430-4. 2004
  79. doi request reprint Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles
    Kentaro Otani
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    J Control Release 133:146-53. 2009
    ..Our results indicate that US-MB could serve as a nonviral delivery method of siRNA into MSC. The transplantation of genetically modified MSC by US-MB could be a useful strategy for regenerative medicine in the future...
  80. ncbi request reprint Adrenomedullin: angiogenesis and gene therapy
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Physiol Regul Integr Comp Physiol 288:R1432-7. 2005
    ..These results suggest that in vivo and in vitro transfer of AM gene using gelatin may be applicable for intractable cardiovascular disease...
  81. ncbi request reprint Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Am Coll Cardiol 41:633-42. 2003
    ..This study was designed to test the hypothesis that epinephrine infusion may be a provocative test able to unmask nonpenetrant KCNQ1 mutation carriers...
  82. ncbi request reprint Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans
    Mitsunobu Enomoto
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Clin Sci (Lond) 105:431-5. 2003
    ..In conclusion, subcutaneous administration of ghrelin dose-dependently induced relatively specific GH release and enhanced cardiac performance in humans...
  83. ncbi request reprint Treatment of cachexia with ghrelin in patients with COPD
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Chest 128:1187-93. 2005
    ..We investigated whether ghrelin improves cachexia and functional capacity in patients with COPD...
  84. ncbi request reprint Postexercise VO2 "Hump" phenomenon as an indicator for inducible myocardial ischemia in patients with acute anterior myocardial infarction
    Hiroshi Takaki
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Osaka, 565 8565, Japan
    Int J Cardiol 111:67-74. 2006
    ..We examined this hypothesis in patients with anterior q-wave myocardial infarction in whom the accuracy to identify ischemia by exercise ECG is limited...
  85. ncbi request reprint [Combined therapy with adrenomedullin and cell transplantation]
    Takashi Iwase
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:296-301. 2004
  86. ncbi request reprint Sustained upregulation of inflammatory chemokine and its receptor in aneurysmal and occlusive atherosclerotic disease: results form tissue analysis with cDNA macroarray and real-time reverse transcriptional polymerase chain reaction methods
    Masakazu Yamagishi
    Division of Cardiovascular Medicine and Bioscience, National Cardiovascular Center and Research Institute, Suita, Japan
    Circ J 69:1490-5. 2005
    ....
  87. ncbi request reprint Lesion severity and hypercholesterolemia determine long-term prognosis of vasospastic angina treated with calcium channel antagonists
    Masakazu Yamagishi
    Division of Cardiovascular Medicine, National Cardiovascular Center, Suita, Japan
    Circ J 67:1029-35. 2003
    ..High LDL-C, which might alter the underlying coronary endothelial function and/or accelerate atherosclerotic lesions, could also contribute to the occurrence of cardiac events, particularly in patients without significant CAS...
  88. ncbi request reprint Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy
    Noritoshi Nagaya
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    Circulation 112:1128-35. 2005
    ..However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure...
  89. ncbi request reprint Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome
    T Noda
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Eur Heart J 23:975-83. 2002
    ..This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome...
  90. ncbi request reprint Late reperfusion (6-24 hours after onset) improves left ventricular function in patients with acute myocardial infarction
    S Miyamoto
    Division of Cardiology, Takeda Hospital, Kyoto, Japan
    Jpn Circ J 65:389-94. 2001
    ..Late reperfusion with a high patency rate of the IRA significantly improves LV global and regional function in patients with AMI...
  91. ncbi request reprint Adrenomedullin: molecular mechanisms and its role in cardiac disease
    B Yanagawa
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Amino Acids 32:157-64. 2007
    ..In agreement, early experimental and preliminary clinical studies suggest that AM is a new and promising therapy for cardiovascular diseases...
  92. doi request reprint Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells
    S Ohnishi
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan
    Cell Prolif 42:309-16. 2009
    ..Therefore, we aimed to compare the proliferation and gene expression profile of cultured human visceral ASC (VASC) and subcutaneous ASC (SASC), and to identify a novel gene involved in proliferation and differentiation of ASC...
  93. ncbi request reprint Hemodynamic and hormonal effects of beraprost sodium, an orally active prostacyclin analogue, in patients with secondary precapillary pulmonary hypertension
    Fumiaki Ono
    Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Circ J 67:375-8. 2003
    ..Thus, oral administration of BPS may be a new therapeutic strategy for the treatment of secondary precapillary PH...
  94. ncbi request reprint Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction
    Yutaka Sakakibara
    Department of Cardiovascular Surgery, Kyoto University, Graduate School of Medicine, Japan
    Ann Thorac Surg 74:25-30. 2002
    ..This study was designed to investigate whether cardiomyocyte transplantation is effective in rats with chronic myocardial infarction...
  95. ncbi request reprint Mesenchymal stem cells for the treatment of heart disease
    Kenichi Yamahara
    Regen Med 2:107-9. 2007
  96. ncbi request reprint Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats
    Yoshito Shimizu
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Biochem Biophys Res Commun 310:830-5. 2003
    ..These results suggest that administration of ghrelin improves endothelial dysfunction and increases eNOS expression in rats through GH-independent mechanisms...
  97. ncbi request reprint Transplantation of genetically engineered mesenchymal stem cells improves cardiac function in rats with myocardial infarction: benefit of a novel nonviral vector, cationized dextran
    Jun ichiro Jo
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Tissue Eng 13:313-22. 2007
    ..Thus, this genetic engineering technology using the non-viral spermine-dextran is a promising strategy to improve MSC therapy for ischemic heart disease...
  98. ncbi request reprint Myocardial velocity gradient reflects the severity of myocardial damage regardless of the presence or absence of mitral regurgitation
    Yoshito Shimizu
    Second Department of Internal Medicine, Hiroshima University School of Medicine, Hirsohima, Japan
    J Am Soc Echocardiogr 16:246-53. 2003
    ..MVG may reflect the severity of myocardial damage regardless of the presence or absence of complicating MR...
  99. ncbi request reprint Combined procedure of surgical repair and cell transplantation for left ventricular aneurysm: an experimental study
    Yutaka Sakakibara
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circulation 106:I193-7. 2002
    ..This study was designed to investigate the efficacy of the combined procedure of left ventricular (LV) repair and fetal cardiomyocyte transplantation (CM-TX) in a rat myocardial infarction model...