Kanji Nagai

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi A randomized trial comparing induction chemotherapy followed by surgery with surgery alone for patients with stage IIIA N2 non-small cell lung cancer (JCOG 9209)
    Kanji Nagai
    Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 125:254-60. 2003
  2. ncbi Prognosis of resected non-small cell lung cancer patients with intrapulmonary metastases
    Kanji Nagai
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    J Thorac Oncol 2:282-6. 2007
  3. ncbi Histopathologic prognostic factors in resected colorectal lung metastases
    Satoshi Shiono
    Pathology Division, National Cancer Center Research Institute East, National Cancer Center Hospital East, Chiba, Japan
    Ann Thorac Surg 79:278-82; discussion 283. 2005
  4. doi Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma
    Shinya Neri
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg Oncol 19:3953-62. 2012
  5. doi Influence of cigarette smoking on survival and tumor invasiveness in clinical stage IA lung adenocarcinoma
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 93:1626-32. 2012
  6. ncbi Pleural lavage cytology before and after lung resection in non-small cell lung cancer patients
    Sotarou Enatsu
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Ann Thorac Surg 81:298-304. 2006
  7. doi Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms
    Masakazu Kojika
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Mod Pathol 22:1341-50. 2009
  8. ncbi Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan
    Kumi Saito-Nakaya
    Psycho Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Psychooncology 17:869-76. 2008
  9. ncbi Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phe
    Shotaro Ono
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 143:963-70. 2013
  10. doi Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis
    Yuki Matsumura
    Pathology Division, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 103:1342-7. 2012

Detail Information

Publications128 found, 100 shown here

  1. ncbi A randomized trial comparing induction chemotherapy followed by surgery with surgery alone for patients with stage IIIA N2 non-small cell lung cancer (JCOG 9209)
    Kanji Nagai
    Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 125:254-60. 2003
    ..We performed a prospective randomized trial in patients with potentially resectable stage IIIA N2 non-small cell lung cancer to confirm the efficacy of induction chemotherapy before surgical resection...
  2. ncbi Prognosis of resected non-small cell lung cancer patients with intrapulmonary metastases
    Kanji Nagai
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    J Thorac Oncol 2:282-6. 2007
    ..We analyzed the long-term survival of NSCLC patients to evaluate the prognostic impact of PM in relation to other prognostic factors...
  3. ncbi Histopathologic prognostic factors in resected colorectal lung metastases
    Satoshi Shiono
    Pathology Division, National Cancer Center Research Institute East, National Cancer Center Hospital East, Chiba, Japan
    Ann Thorac Surg 79:278-82; discussion 283. 2005
    ..The study was conducted to clarify the characteristics and identify the prognostic factors of the pulmonary metastases of colorectal cancer...
  4. doi Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma
    Shinya Neri
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg Oncol 19:3953-62. 2012
    ..However, whether podoplanin(+)-CAFs also can be recruited into metastatic lymph nodes and influence the prognosis remains unclear...
  5. doi Influence of cigarette smoking on survival and tumor invasiveness in clinical stage IA lung adenocarcinoma
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 93:1626-32. 2012
    ..The objective of this study was to investigate the association between cigarette smoking, cancer survival, and pathological features of clinical stage IA lung adenocarcinoma...
  6. ncbi Pleural lavage cytology before and after lung resection in non-small cell lung cancer patients
    Sotarou Enatsu
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Ann Thorac Surg 81:298-304. 2006
    ....
  7. doi Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms
    Masakazu Kojika
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Mod Pathol 22:1341-50. 2009
    ....
  8. ncbi Marital status and non-small cell lung cancer survival: the Lung Cancer Database Project in Japan
    Kumi Saito-Nakaya
    Psycho Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Psychooncology 17:869-76. 2008
    ..The association between marital status and survival in Japanese patients with non-small cell lung cancer (NSCLC) was prospectively investigated...
  9. ncbi Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phe
    Shotaro Ono
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 143:963-70. 2013
    ..The purpose of this study was to analyze the prognostic markers of stage I squamous cell carcinoma (SqCC), with special reference to the immunophenotypes of both cancer cells and CAFs...
  10. doi Morphophenotypic characteristics of intralymphatic cancer and stromal cells susceptible to lymphogenic metastasis
    Yuki Matsumura
    Pathology Division, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 103:1342-7. 2012
    ..The present study reveals that intralymphatic cancer cell and stromal cell phenotypes are susceptible to lymphogenic metastasis, suggesting that lymphogenic metastasis may be affected by the intralymphatic microenvironment they create...
  11. ncbi Visceral pleural invasion classification in non-small cell lung cancer: a proposal on the basis of outcome assessment
    Kimihiro Shimizu
    Division of Thoracic Oncology, National Cancer Center Research Institute East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 127:1574-8. 2004
    ..The purpose of this study was to evaluate the significance of the extent of pleural involvement as a prognostic factor and to propose a refined TNM classification on the basis of visceral pleural invasion...
  12. doi A novel histopathological evaluation method predicting the outcome of non-small cell lung cancer treated by neoadjuvant therapy: the prognostic importance of the area of residual tumor
    Yuki Yamane
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:49-55. 2010
    ..The purpose of this study was to assess a novel histopathological evaluation method for predicting the outcome of NSCLC treated by neoadjuvant therapy...
  13. doi Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma
    Akikazu Kawase
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 123:1053-9. 2008
    ..092). The results of this study highlight the importance of podoplanin expression by CAFs and provide new insights into the biology of the cancer microenvironment in adenocarcinoma of the lung...
  14. doi Identification of a low risk subgroup of stage IB lung adenocarcinoma patients
    Tetsuya Mizuno
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 62:302-8. 2008
    ..The aim of this study was to investigate prognostic factors of resected stage IB adenocarcinoma and identify a subgroup with a better prognosis, in which adjuvant chemotherapy could be omitted...
  15. doi The impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer
    Keiju Aokage
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 139:1246-52, 1252.e1. 2010
    ..The aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence...
  16. doi Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients
    Junji Yoshida
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    J Thorac Oncol 5:546-50. 2010
    ..However, recently three of the 24 patients, with mixed GGO lesions intraoperatively diagnosed as type B, developed a solid lesion at the cut-end scar...
  17. doi Prognostic impact of node involvement pattern in pN1 non-small cell lung cancer patients
    Masayuki Nakao
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1576-82. 2010
    ..The purpose of this study was to evaluate the prognostic effect of node involvement patterns in pN1 non-small cell lung cancer (NSCLC) patients, with special attention given to any differences between SCC and adenocarcinoma (AD)...
  18. doi Dynamic molecular changes associated with epithelial-mesenchymal transition and subsequent mesenchymal-epithelial transition in the early phase of metastatic tumor formation
    Keiju Aokage
    Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 128:1585-95. 2011
    ..001) expression in comparison with cancer cells in BVBs. Our results suggested that in the early phase of metastatic tumor formation cancer cells undergo dynamic phenotypic change associated with EMT and subsequent MET...
  19. doi Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness
    Yoko Yamaguchi
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1361-8. 2010
    ..This morphologic feature is increasingly being recognized as an adverse prognostic factor. The purpose of this study was to evaluate the clinicopathologic significance of tumor budding in adenocarcinomas of the lung...
  20. doi Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, and daggerDepartment of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1246-50. 2010
    ..The purpose of this study was to quantify the risk of late recurrence in patients with stage IA non-small cell lung cancer (NSCLC) who remained recurrence-free for more than 5 years after resection...
  21. doi Mutational status of EGFR and KIT in thymoma and thymic carcinoma
    Kiyotaka Yoh
    Division of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 62:316-20. 2008
    ..The results of this study indicate that EGFR and KIT mutations in thymomas and thymic carcinomas are rare, but that many of the tumors express EGFR or KIT protein...
  22. doi Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma
    Kaoru Kaseda
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    Cancer Sci 104:1262-9. 2013
    ....
  23. doi Roles of osteoclasts and bone-derived IGFs in the survival and growth of human breast cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice
    Takafumi Sangai
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan
    Clin Exp Metastasis 25:401-10. 2008
    ....
  24. doi Risk factors for tumor recurrence in patients with early-stage (stage I and II) non-small cell lung cancer: patient selection criteria for adjuvant chemotherapy according to the seventh edition TNM classification
    Ryo Maeda
    Department of Thoracic Oncology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Chest 140:1494-502. 2011
    ..The purpose of this study was to evaluate risk factors for tumor recurrence in patients with completely resected early-stage non-small cell lung cancer (NSCLC)...
  25. doi Late recurrence of non-small cell lung cancer more than 5 years after complete resection: incidence and clinical implications in patient follow-up
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    Chest 138:145-50. 2010
    ..The purpose of this study was to evaluate the risk of late recurrence in patients who had undergone complete resection for non-small cell lung cancer (NSCLC) and remained recurrence-free for > or = 5 years...
  26. doi Prognostic impact of node involvement pattern in pulmonary pN1 squamous cell carcinoma patients
    Masayuki Nakao
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 5:504-9. 2010
    ..The purpose of this study was to evaluate the prognostic impact of lymph node involvement patterns in pulmonary pN1 SCC patients...
  27. doi Pleomorphic carcinoma of the lung expressing podoplanin and calretinin
    Hirotsugu Kenmotsu
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Pathol Int 58:771-4. 2008
    ..When making the differential diagnosis between PC and the sarcomatoid component of mesothelioma, care is required in diagnosing biopsy specimens of peripheral lung spindle-cell tumors that are positive for both podoplanin and calretinin...
  28. ncbi Evaluation of extratumoral lymphatic permeation in non-small cell lung cancer as a means of predicting outcome
    Takamoto Saijo
    Division of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Lung Cancer 55:61-6. 2007
    ..Lymphatic permeation (ly) has been described as a potential prognostic factor for non-small cell lung cancer (NSCLC)...
  29. doi Low podoplanin expression of tumor cells predicts poor prognosis in pathological stage IB squamous cell carcinoma of the lung, tissue microarray analysis of 136 patients using 24 antibodies
    Takeo Ito
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba, Japan
    Lung Cancer 63:418-24. 2009
    ..008 and p=0.024, respectively). The results showed that patient age and a novel biological prognostic marker, podoplanin, are useful for predicting a poor outcome of patients after complete resection of stage IB SqCC of the lung...
  30. ncbi Predictive factors for local recurrence of resected colorectal lung metastases
    Satoshi Shiono
    Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
    Ann Thorac Surg 80:1040-5. 2005
    ..However, local recurrence at the surgical margin is a problem with limited resections. This study attempted to identify predictive factors associated with local recurrences at the surgical margin after resection of pulmonary metastases...
  31. doi Identification of prognostic immunophenotypic features in cancer stromal cells of high-grade neuroendocrine carcinomas of the lung
    Akiko Takahashi
    Pathology Division, Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa City, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 139:1869-78. 2013
    ....
  32. doi Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of Cd204-positive macrophages to the tumor-promoting microenvironment
    Shunki Hirayama
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 7:1790-7. 2012
    ..The aim of this study was to clarify the correlation between CD204 (+) TAMs and the clinicopathological features of lung squamous cell carcinoma...
  33. doi Low-fat diet management strategy for chylothorax after pulmonary resection and lymph node dissection for primary lung cancer
    Teruhisa Takuwa
    Division of Thoracic Surgery, Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 146:571-4. 2013
    ..We reviewed our experience of iatrogenic chylothorax after pulmonary resection for primary lung cancer to evaluate a low-fat diet management strategy...
  34. ncbi Prostate-specific antigen induces apoptosis of osteoclast precursors: potential role in osteoblastic bone metastases of prostate cancer
    Masato Goya
    Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
    Prostate 66:1573-84. 2006
    ..We previously reported that prostate-specific antigen (PSA) stimulated the proliferation and the activation of osteoblasts. In this study, we investigated the effect of PSA on osteoclastogenesis...
  35. doi Long-term outcomes of 50 cases of limited-resection trial for pulmonary ground-glass opacity nodules
    Masayuki Nakao
    Department of Thoracic Oncology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Oncol 7:1563-6. 2012
    ..From 1998 to 2002, we performed a trial of prospective limited resection for pulmonary ground-glass opacity lesions 2 cm or smaller. This is the second report on the long-term outcome...
  36. doi Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma
    Masayuki Nakao
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer 115:2732-43. 2009
    ....
  37. ncbi Eg5 expression is closely correlated with the response of advanced non-small cell lung cancer to antimitotic agents combined with platinum chemotherapy
    Takamoto Saijo
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 54:217-25. 2006
    ..Eg5 is a microtubule motor protein that functions in bipolar spindle assembly. We investigated the relationship between Eg5 expression and the response to chemotherapy of patients with advanced non-small cell lung cancer (NSCLC)...
  38. doi Structural and biological properties of a papillary component generating a micropapillary component in lung adenocarcinoma
    Tatsuya Nagano
    Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Lung Cancer 67:282-9. 2010
    ....
  39. doi Extratumoral vascular invasion is a significant prognostic indicator and a predicting factor of distant metastasis in non-small cell lung cancer
    Yoshihisa Shimada
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:970-5. 2010
    ....
  40. doi Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma
    Yoichi Ohtaki
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1507-15. 2010
    ..Alternatively, activated macrophages (M2 phenotype) are known to be related to tumor progression and outcome, and CD204 has been reported to be expressed in M2 macrophages in some tumors...
  41. ncbi Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung
    Kazuhito Funai
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwanoha, Chiba, Japan
    Am J Surg Pathol 27:978-84. 2003
    ..The central and peripheral types of lung squamous cell carcinoma have different clinicopathologic characteristics and should be classified under respectively different categories...
  42. doi Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung
    Toshihiro Shiozawa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Pathol Int 63:77-84. 2013
    ..Our study demonstrated that EGFR mutated Ad-Sq had similar clinicopathological features as EGFR mutated adenocarcinoma...
  43. doi Distinctive histopathological features of lepidic growth predominant node-negative adenocarcinomas 3-5 cm in size
    Yusuke Takahashi
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Lung Cancer 79:118-24. 2013
    ..However, in large adenocarcinomas (3-5 cm in size), the clinicopathological significance of LG components remains unclear...
  44. doi Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma
    Tomonari Kinoshita
    Division of Pathology, Research Center for Innovative Oncology, Chiba, Japan
    Cancer Sci 104:409-15. 2013
    ..Our studies suggest the possibility that CAF expressing immunoregulatory cytokines may induce Treg in the stroma, creating a tumor-promoting microenvironment in lung adenocarcinoma that leads to a poor outcome...
  45. doi Characteristic immunophenotype of solid subtype component in lung adenocarcinoma
    Teruhisa Takuwa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Surg Oncol 19:3943-52. 2012
    ..The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components...
  46. doi Prognostic impact of cancer-associated stromal cells in patients with stage I lung adenocarcinoma
    Masami Ito
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 142:151-8. 2012
    ..This study evaluated the significance of podoplanin-positive CAFs and CD204-positive TAMs, which may reflect tumor-promoting CAFs and TAMs, as risk factors for recurrence in patients with stage I lung adenocarcinoma...
  47. doi Predictive factors of pathologically proven noninvasive tumor characteristics in T1aN0M0 peripheral non-small cell lung cancer
    Yoshihisa Shimada
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 141:1003-9. 2012
    ....
  48. doi Number of circulating endothelial progenitor cells and intratumoral microvessel density in non-small cell lung cancer patients: differences in angiogenic status between adenocarcinoma histologic subtypes
    Ryo Maeda
    Department of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 7:503-11. 2012
    ....
  49. doi Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens
    Yoshihisa Shimada
    Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Lung Cancer 75:368-73. 2012
    ..The aim of this study was to elucidate the clinical features of high-grade neuroendocrine carcinoma (HGNEC)-probable LCNEC diagnosed by biopsy, and compare therapeutic efficacy with patients with SCLC...
  50. ncbi Intrapulmonary metastasis in resected pathologic stage IIIB non-small cell lung cancer: possible contribution of aerogenous metastasis to the favorable outcome
    Keiju Aokage
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 134:386-91. 2007
    ..The objective of this study was to extract a subgroup of patients with stage IIIB PM+ non-small cell lung cancer with a better prognosis and assess their biological characteristics and metastatic mechanisms...
  51. doi Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Chest 138:357-62. 2010
    ....
  52. ncbi Multiple resections for hepatic and pulmonary metastases of colorectal carcinoma
    Shinichiro Takahashi
    Department of Hepato biliary National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 37:186-92. 2007
    ....
  53. ncbi Dominant papillary subtype is a significant predictor of the response to gefitinib in adenocarcinoma of the lung
    Young Hak Kim
    Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
    Clin Cancer Res 10:7311-7. 2004
    ..The aim of this study was to identify the clinicopathological and immunohistochemical features that are favorable to the use of gefitinib in adenocarcinoma patients...
  54. doi Tumor invasion of extralobar soft tissue beyond the hilar region does not affect the prognosis of surgically resected lung cancer patients
    Hajime Otsuka
    Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1571-5. 2010
    ..The purpose of this study is to evaluate the significance of tumor invasion of that region as a prognostic factor...
  55. doi Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases
    Takahiro Mochizuki
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Am J Surg Pathol 32:1727-35. 2008
    ..We concluded that PC should be considered as an aggressive disease and massive necrosis should be routinely reported and used as a factor in clinical assessments...
  56. ncbi Negative psychological aspects and survival in lung cancer patients
    Naoki Nakaya
    Psycho Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Psychooncology 17:466-73. 2008
    ....
  57. doi Visceral pleura invasion impact on non-small cell lung cancer patient survival: its implications for the forthcoming TNM staging based on a large-scale nation-wide database
    Junji Yoshida
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 4:959-63. 2009
    ..The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification...
  58. doi Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation
    Hideomi Ichinokawa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277 8577 Chiba, Japan
    Hum Pathol 44:2636-42. 2013
    ..The current study clearly demonstrated that mucinous adenocarcinomas with KRAS mutations have clinicopathologic characteristics different from those of mucinous adenocarcinoma without such mutations. ..
  59. doi Prognostic impact of intratumoural microvascular invasion and microlymphatic permeation on node-negative non-small-cell lung cancer: which indicator is the stronger prognostic factor?
    Tomoyuki Hishida
    Division of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 43:772-7. 2013
    ..The aim of the current study was to clarify the prognostic impact of microvascular invasion and microlymphatic permeation on resected node-negative NSCLC by comparative analyses...
  60. doi Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung adenocarcinoma
    Tatsuya Yoshida
    Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, 277 8577, Japan
    J Cancer Res Clin Oncol 139:1691-700. 2013
    ....
  61. ncbi Is surgical resection indicated for a solitary non-small cell lung cancer recurrence?
    Tomoyuki Hishida
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Cardiovasc Surg 131:838-42. 2006
    ..Some investigators have reported long-term survival after surgical resection of a solitary non-small cell lung cancer recurrence in various sites. However, the role and indications of the second operation remain unclear...
  62. doi The clinical outcome of non-small cell lung cancer patients with adjacent lobe invasion: the optimal classification according to the status of the interlobar pleura at the invasion point
    Yoichi Ohtaki
    Division of Thoracic Surgery, National Cancer Centre Hospital East, Chiba, Japan
    Eur J Cardiothorac Surg 43:302-9. 2013
    ..The aim of this study was to analyse the survival of non-small cell lung cancer (NSCLC) patients with adjacent lobe invasion (ALI) with emphasis on the interlobar fissure status at the tumour invasion point...
  63. doi Reasonable extent of lymph node dissection in intentional segmentectomy for small-sized peripheral non-small-cell lung cancer: from the clinicopathological findings of patients who underwent lobectomy with systematic lymph node dissection
    Yuki Matsumura
    Division of Thoracic Surgery, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    J Thorac Oncol 7:1691-7. 2012
    ..The purpose of this study was to clarify the reasonable extent of dissection during intentional segmentectomy for peripheral cT1aN0M0 NSCLC...
  64. ncbi Limited resection trial for pulmonary ground-glass opacity nodules: fifty-case experience
    Junji Yoshida
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    J Thorac Cardiovasc Surg 129:991-6. 2005
    ..This study was undertaken to determine the recurrence rate after limited resection of small lung carcinoma and to evaluate intraoperative frozen-section examination accuracy for Noguchi classification...
  65. doi Characterization of the immunophenotype of the tumor budding and its prognostic implications in squamous cell carcinoma of the lung
    Tetsuhiko Taira
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 76:423-30. 2012
    ....
  66. ncbi Two lung adenocarcinomas in the same lobe: multiple primaries or intrapulmonary metastasis?
    Kentaro Yoshimoto
    Department of Thoracic Oncolog, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Ann Thorac Cardiovasc Surg 17:584-7. 2011
    ..Although we expected EGFR gene mutation analysis would help us distinguish the 2 lesions from each other, it was of little help. Disease history can be more important in evaluating multiple pulmonary cancers...
  67. doi Differences between squamous cell carcinoma and adenocarcinoma of the lung: are adenocarcinoma and squamous cell carcinoma prognostically equal?
    Akikazu Kawase
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 42:189-95. 2012
    ..We analyzed pulmonary squamous cell carcinoma and adenocarcinoma patient survival in our single institution database, to evaluate the relationship of histologic analysis to survival and tumor aggressiveness...
  68. ncbi The proportion of consolidation to ground-glass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarcinoma
    Yasuhisa Ohde
    Department of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 42:303-10. 2003
    ..The purpose of this study is to define high resolution CT (HRCT) findings that indicate pathologic T1N0M0 tumor without vessel invasion...
  69. ncbi Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma
    Hidehiro Kon-no
    Pathology Division, Center for Innovative Oncology, National Cancer Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 54:409-18. 2006
    ..0269 and 0.0011, respectively). Our results suggest that CA IX expression is strongly associated with tumor progression and indicates a poor prognosis for patients with stages I+II lung adenocarcinoma...
  70. doi Clinicopathological characteristics of primary lung adenocarcinoma predominantly composed of goblet cells in surgically resected cases
    Hideomi Ichinokawa
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba
    Pathol Int 61:423-9. 2011
    ..In conclusion, APGC formed a distinct subset and should be considered separately from lung adenocarcinoma based on frequent involvement of the left and lower lung and lack of central fibrosis...
  71. doi Prognostic significance of a solid component in pulmonary adenocarcinoma
    Yoichi Ohtaki
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Ann Thorac Surg 91:1051-7. 2011
    ....
  72. ncbi Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients
    Kazuya Takamochi
    Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    Lung Cancer 47:235-42. 2005
    ..However, few studies have assessed its limitations. The aim of the present study is to clarify clinico-pathologic factors responsible for false PET results...
  73. doi Poor prognostic factors in patients with stage IB non-small cell lung cancer according to the seventh edition TNM classification
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Chest 139:855-61. 2011
    ..This study investigated poor prognostic factors in patients with stage IB non-small cell lung cancer (NSCLC) according to the seventh edition of the TNM classification...
  74. doi Influence of cigarette smoking on histological subtypes of stage I lung adenocarcinoma
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 6:743-50. 2011
    ..The purpose of this study was to examine the association between cigarette smoking and histological subtypes of lung adenocarcinoma...
  75. ncbi D2-40-positive solitary fibrous tumors of the pleura: diagnostic pitfall of biopsy specimen
    Yoichi Naito
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Pathol Int 57:618-21. 2007
    ..Care is required in diagnosing biopsy specimens of D2-40-positive pleural spindle-cell tumors, especially in making the differential diagnosis between SFTP and malignant mesothelioma...
  76. doi Histological progression of small intrapulmonary metastatic tumor from primary lung adenocarcinoma
    Keiju Aokage
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Pathol Int 60:765-73. 2010
    ..These findings suggest that implanted cancer cells display lepidic growth in the early metastatic phase and recapitulate the morphological heterogeneity of the original tumor as the metastasis enlarges...
  77. ncbi Marital status, social support and survival after curative resection in non-small-cell lung cancer
    Kumi Saito-Nakaya
    Psycho Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa 277 8577, and Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 97:206-13. 2006
    ..7 (0.4-1.3) (P-value=0.28). The present data do not support the hypothesis that marital status and social support are associated with survival in NSCLC...
  78. doi CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors
    Haruki Chiba
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center, Kashiwa, Kashiwa City, Chiba, Japan
    Stem Cells 26:2523-30. 2008
    ..These findings are the first clear proof that the CD105(+) MNC fraction in the pulmonary arterial blood of adult lung cancer patients includes MPCs. Disclosure of potential conflicts of interest is found at the end of this article...
  79. doi Subcarinal lymph node in upper lobe non-small cell lung cancer patients: is selective lymph node dissection valid?
    Keiju Aokage
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 70:163-7. 2010
    ..It appears valid to omit subcarinal node dissection in upper lobe NSCLC patients, especially in clinical N0 squamous cell carcinoma patients...
  80. doi Visceral pleural invasion classification in non-small cell lung cancer
    Akikazu Kawase
    Division of Thoracic Surgery, National Cancer Center Hospital East, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 5:1784-8. 2010
    ....
  81. ncbi Primary lung adenocarcinoma with massive lymphocyte infiltration
    Koji Tsuta
    Pathology Division, National Cancer Center Research, Institute East and the Clinical Laboratory, National Cancer Center Hospital East, Chiba, Japan
    Am J Clin Pathol 123:547-52. 2005
    ..This type of adenocarcinoma occurs in old age, and good outcome and distinctive histologic features were observed. We refer to it as primary lung adenocarcinoma with massive lymphocyte infiltration...
  82. ncbi Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases
    Koji Tsuta
    Clinical Laboratory Division, National Cancer Center Hospital East, Chiba, Japan
    Am J Surg Pathol 28:868-74. 2004
    ....
  83. ncbi Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer
    Kimihiro Shimizu
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Thorac Cardiovasc Surg 130:160-5. 2005
    ..We assessed the relationship between visceral pleural invasion and other clinicopathologic characteristics and evaluated its significance as a prognostic factor...
  84. ncbi The lung cancer database project at the National Cancer Center, Japan: study design, corresponding rate and profiles of cohort
    Naoki Nakaya
    Psycho Oncology Division, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Japan
    Jpn J Clin Oncol 36:280-4. 2006
    ..The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future...
  85. ncbi Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung
    Kazuhiro Araki
    Pathology Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 40:173-80. 2003
    ..The finding that c-kit expression in LCNEC is similar to its expression in SCLC suggests that inhibition of c-kit may be effective as a therapy targeting LCNEC as well as SCLC...
  86. ncbi Late pulmonary metastasis of a rectal cancer resected 20 years after low anterior resection
    Kenji Takahashi
    Department of Thoracic Oncology, National Cancer Center Hospital East, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 14:386-9. 2008
    ..This shows that pulmonary metastasis from colorectal cancer is possible even 20 years after the initial operation...
  87. doi Fibrous stroma is associated with poorer prognosis in lung squamous cell carcinoma patients
    Yusuke Takahashi
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 6:1460-7. 2011
    ..The aim of this study was to examine whether the histological properties of peritumoral stroma are correlated with squamous cell carcinoma (SqCC) aggressiveness and clinical outcome...
  88. doi Prognostic impact of histology on early-stage non-small cell lung cancer
    Ryo Maeda
    Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Chest 140:135-45. 2011
    ..The purpose of this study is to evaluate the significance of histology as a predictor of recurrence after resection in patients with early-stage non-small cell lung cancer...
  89. ncbi Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients
    Genichiro Ishii
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center, Kashiwa, 6 5 1 Kashiwanoha, Kashiwa City, Chiba 277 8577, Japan
    Stem Cells 25:1469-77. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  90. ncbi Postoperative morbidity, mortality, and survival in lung cancer associated with idiopathic pulmonary fibrosis
    Hidenori Kawasaki
    Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Surg Oncol 81:33-7. 2002
    ..The frequency of postoperative morbidity and mortality rates in patients with lung cancer who have IPF have seldom been reported, however...
  91. ncbi [A case of well-differentiated nonmucinous adenocarcinoma of the lung with an 18-year clinical course before surgery]
    Kazuhiro Araki
    Division of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Nihon Kokyuki Gakkai Zasshi 41:708-11. 2003
    ..Although this tumor was untreated for 18 years from the first detection using chest radiography, the critical invasive features were not in evidence pathologically...
  92. ncbi Localized pure ground-glass opacity on high-resolution CT: histologic characteristics
    Ryu Nakajima
    Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
    J Comput Assist Tomogr 26:323-9. 2002
    ..The diameter of the nonaerogenous components varied between 0.2 and 2.0 mm. CONCLUSION: Because 10% of LPGGO lesions include invasive disease, patients with LPGGO should undergo pathologic examination for confirmation...
  93. ncbi Successful management of solitary malar metastasis from lung cancer
    Kimihiro Shimizu
    Division of Thoracic Surgery, National Cancer Center Hospital East, 6 5 1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Lung Cancer 36:337-9. 2002
    ..The patient is well without signs of recurrence 5 years after resection of the malar mass. This is the first report of a malar metastasis from lung cancer and of successful resection for malar metastasis...
  94. ncbi Progression of focal pure ground-glass opacity detected by low-dose helical computed tomography screening for lung cancer
    Ryutaro Kakinuma
    Division of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwa no ha, Kashiwa, Chiba 277 8577, Japan
    J Comput Assist Tomogr 28:17-23. 2004
    ..To clarify the progression of focal pure ground-glass opacity (pGGO) detected by low-dose helical computed tomography (CT) screening for lung cancer...
  95. ncbi Depression and psychological distress in patients during the year after curative resection of non-small-cell lung cancer
    Yosuke Uchitomi
    Psycho Oncology Division, National Cancer Center Research Institute East, and Psychiatry Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Clin Oncol 21:69-77. 2003
    ..The purpose of this study was to clarify the clinical course of depression and psychological distress of such patients during the year after surgery and to identify predictors of their long-term outcome...
  96. ncbi Weekly chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide is an effective treatment for advanced thymic carcinoma
    Kiyotaka Yoh
    Division of Thoracic Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Cancer 98:926-31. 2003
    ..The purpose of the current study was to determine the efficacy and tolerability of a weekly chemotherapy regimen consisting of cisplatin, vincristine, doxorubicin, and etoposide (CODE) for the treatment of advanced thymic carcinoma...
  97. ncbi Neuroendocrine neoplasms of the lung: a prognostic spectrum
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Clin Oncol 24:70-6. 2006
    ..Their clinicopathologic profiles and relative grade of malignancy have not been defined...
  98. pmc A randomised phase II trial of preoperative chemotherapy of cisplatin-docetaxel or docetaxel alone for clinical stage IB/II non-small-cell lung cancer results of a Japan Clinical Oncology Group trial (JCOG 0204)
    H Kunitoh
    Department of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 99:852-7. 2008
    ..Preoperative DP was associated with encouraging resection rate and DFS data, and phase III trials for c-stage IB/II NSCLC are warranted...
  99. ncbi Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival
    Naoki Nakaya
    Psycho Oncology Division, National Cancer Center Research Institute East, Kashiwa, Japan
    Acta Oncol 44:399-405. 2005
    ..54-2.21) and 1.17 (0.55-2.46), respectively (p for trend = 0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer...
  100. doi The role of pulmonary resection in tumors metastatic from head and neck carcinomas
    Hiroyuki Daiko
    Department of Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 40:639-44. 2010
    ..The purpose of this study was to determine the role of surgical treatment and to identify factors affecting the survival of patients undergoing pulmonary resection for tumors metastatic from head and neck carcinomas...
  101. ncbi Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project
    Tomotaka Sobue
    Cancer Information and Epidemiology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    J Clin Oncol 20:911-20. 2002
    ..To provide data on screening performance of low-dose helical computed tomography (CT) scanning and its efficacy in terms of survival, a one-arm longitudinal screening project was conducted...