Michihiro Mutoh


Affiliation: National Cancer Center
Country: Japan


  1. Mutoh M, Komiya M, Teraoka N, Ueno T, Takahashi M, Kitahashi T, et al. Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice. Int J Cancer. 2009;125:2505-10 pubmed publisher
    ..It is speculated that lipid accumulation in the intestinal polyps may play an important role in intestinal polyp formation in Apc-deficient mice...
  2. Mutoh M, Teraoka N, Takasu S, Takahashi M, Onuma K, Yamamoto M, et al. Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. Gastroenterology. 2011;140:2000-8, 2008.e1-2 pubmed publisher
    ..APN and its receptor might be developed as targets for cancer chemopreventive agents. ..
  3. Fujimoto K, Fujii G, Taguchi K, Yasuda K, Matsuo Y, Hashiyama A, et al. Involvement of trefoil factor family 2 in the enlargement of intestinal tumors in Apc(Min/+) mice. Biochem Biophys Res Commun. 2015;463:859-63 pubmed publisher
    ..Overexpressing Tff2 in cultured cells reduced doubling time in vitro and rapidly increased xenograft tumor size in vivo. We found Tff2 as a novel important factor that to be able to enlarge an intestinal tumor size. ..
  4. Miyamoto S, Komiya M, Fujii G, Hamoya T, Nakanishi R, Fujimoto K, et al. Preventive Effects of Heat-Killed Enterococcus faecalis Strain EC-12 on Mouse Intestinal Tumor Development. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our results suggest that heat-killed EC-12 very weakly suppresses intestinal polyp development in Min mice, in part by attenuating ?-catenin signaling, and this implies that heat-killed EC-12 could be used as a "functional food". ..
  5. Noma N, Fujii G, Miyamoto S, Komiya M, Nakanishi R, Shimura M, et al. Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our results suggested that CA is involved in intestinal carcinogenesis. Acetazolamide could inhibit polyp formation through suppressing local/general cytokine levels, i.e., IL-6, via NRF2 activation. ..
  6. Ishigamori R, Komiya M, Takasu S, Mutoh M, Imai T, Takahashi M. Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Suppression of OPN expression could contribute to tumor prevention, but complete deficiency of OPN may cause some adverse effects. ..