Affiliation: National Cancer Center
Mutoh M, Komiya M, Teraoka N, Ueno T, Takahashi M, Kitahashi T, et al
. Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice. Int J Cancer. 2009;125:2505-10 pubmed publisher
..It is speculated that lipid accumulation in the intestinal polyps may play an important role in intestinal polyp formation in Apc-deficient mice...
Mutoh M, Teraoka N, Takasu S, Takahashi M, Onuma K, Yamamoto M, et al
. Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. Gastroenterology. 2011;140:2000-8, 2008.e1-2 pubmed publisher
..APN and its receptor might be developed as targets for cancer chemopreventive agents. ..
Fujimoto K, Fujii G, Taguchi K, Yasuda K, Matsuo Y, Hashiyama A, et al
. Involvement of trefoil factor family 2 in the enlargement of intestinal tumors in Apc(Min/+) mice. Biochem Biophys Res Commun. 2015;463:859-63 pubmed publisher
..Overexpressing Tff2 in cultured cells reduced doubling time inÂ vitro and rapidly increased xenograft tumor size inÂ vivo. We found Tff2 as a novel important factor that to be able to enlarge an intestinal tumor size. ..
Miyamoto S, Komiya M, Fujii G, Hamoya T, Nakanishi R, Fujimoto K, et al
. Preventive Effects of Heat-Killed Enterococcus faecalis Strain EC-12 on Mouse Intestinal Tumor Development. Int J Mol Sci. 2017;18: pubmed publisher
..Our results suggest that heat-killed EC-12 very weakly suppresses intestinal polyp development in Min mice, in part by attenuating ?-catenin signaling, and this implies that heat-killed EC-12 could be used as a "functional food". ..
Noma N, Fujii G, Miyamoto S, Komiya M, Nakanishi R, Shimura M, et al
. Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice. Int J Mol Sci. 2017;18: pubmed publisher
..Our results suggested that CA is involved in intestinal carcinogenesis. Acetazolamide could inhibit polyp formation through suppressing local/general cytokine levels, i.e., IL-6, via NRF2 activation. ..
Ishigamori R, Komiya M, Takasu S, Mutoh M, Imai T, Takahashi M. Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice. Int J Mol Sci. 2017;18: pubmed publisher
..Suppression of OPN expression could contribute to tumor prevention, but complete deficiency of OPN may cause some adverse effects. ..