Yasuo Mori

Summary

Affiliation: National Institute for Physiological Sciences
Country: Japan

Publications

  1. ncbi Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system
    Yasuo Mori
    Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Intitutes and School of Life Sciences, The Graduate University of Advanced Studies, Okazaki, Aichi, Japan
    Trends Cardiovasc Med 12:270-5. 2002
  2. ncbi Ca2+ store-independent augmentation of [Ca2+]i responses to G-protein coupled receptor activation in recombinantly TRPC5-expressed rat pheochromocytoma (PC12) cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 358:161-4. 2004
  3. ncbi A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses
    Takashi Kodama
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Eur J Neurosci 24:2993-3007. 2006
  4. ncbi Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
    Y Mori
    Department of Information Physiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, Japan
    J Neurosci 20:5654-62. 2000
  5. ncbi Dissecting receptor-mediated Ca2+ influx pathways: TRP channels and their native counterparts
    Y Mori
    Center for Integrative Bioscience, Okazaki National Research Institutes, Japan
    Jpn J Pharmacol 87:245-52. 2001
  6. pmc Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes
    Yasuo Mori
    Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    J Exp Med 195:673-81. 2002
  7. ncbi LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death
    Yuji Hara
    Center for Integrative Bioscience, The Graduate University for Advanced Studies, 444 8585, Okazaki, Japan
    Mol Cell 9:163-73. 2002
  8. pmc Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes
    Motohiro Nishida
    Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444 8585, Japan
    EMBO J 22:4677-88. 2003
  9. ncbi Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
    Kaori Matsushita
    Department of Information Physiology, Center for Brain Experiment, National Institute for Physiological Sciences, Okazaki National Research Institutes, Okazaki 444 8585, Japan
    J Neurosci 22:4388-98. 2002
  10. pmc Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice
    Kunitoshi Uchida
    National Institutes of Natural Sciences, Okazaki, Japan
    Diabetes 60:119-26. 2011

Detail Information

Publications65

  1. ncbi Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system
    Yasuo Mori
    Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Intitutes and School of Life Sciences, The Graduate University of Advanced Studies, Okazaki, Aichi, Japan
    Trends Cardiovasc Med 12:270-5. 2002
    ....
  2. ncbi Ca2+ store-independent augmentation of [Ca2+]i responses to G-protein coupled receptor activation in recombinantly TRPC5-expressed rat pheochromocytoma (PC12) cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 358:161-4. 2004
    ..These results suggest that TRPC5 channels expressed in PC12 cells function as ROCs activated by G-protein/phospholipase C coupled receptors, but not as SOCs...
  3. ncbi A CaV2.1 calcium channel mutation rocker reduces the number of postsynaptic AMPA receptors in parallel fiber-Purkinje cell synapses
    Takashi Kodama
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Eur J Neurosci 24:2993-3007. 2006
    ..These lines of evidence suggest that even a moderate dysfunction of CaV2.1 Ca2+ channel can cause substantial changes in postsynaptic molecular composition of the PF-PC synapses and dendritic structure of PCs...
  4. ncbi Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))
    Y Mori
    Department of Information Physiology, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, Japan
    J Neurosci 20:5654-62. 2000
    ....
  5. ncbi Dissecting receptor-mediated Ca2+ influx pathways: TRP channels and their native counterparts
    Y Mori
    Center for Integrative Bioscience, Okazaki National Research Institutes, Japan
    Jpn J Pharmacol 87:245-52. 2001
    ..In this review, we focus on the dramatic progress in the molecular investigation of RMCC in mammalian systems. The recent findings should provide powerful tools for the development of novel pharmaceutical targets...
  6. pmc Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes
    Yasuo Mori
    Center for Integrative Bioscience, Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji cho, Okazaki 444 8585, Japan
    J Exp Med 195:673-81. 2002
    ....
  7. ncbi LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death
    Yuji Hara
    Center for Integrative Bioscience, The Graduate University for Advanced Studies, 444 8585, Okazaki, Japan
    Mol Cell 9:163-73. 2002
    ..Thus, LTRPC2 represents an important intrinsic mechanism that mediates Ca2+ and Na+ overload in response to disturbance of redox state in cell death...
  8. pmc Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes
    Motohiro Nishida
    Division of Molecular and Cellular Physiology, Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444 8585, Japan
    EMBO J 22:4677-88. 2003
    ..We suggest that coupling of Ca2+ entry with PLCgamma2 translocation and activation controls the amplification and co-ordination of receptor signalling...
  9. ncbi Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice
    Kaori Matsushita
    Department of Information Physiology, Center for Brain Experiment, National Institute for Physiological Sciences, Okazaki National Research Institutes, Okazaki 444 8585, Japan
    J Neurosci 22:4388-98. 2002
    ....
  10. pmc Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice
    Kunitoshi Uchida
    National Institutes of Natural Sciences, Okazaki, Japan
    Diabetes 60:119-26. 2011
    ..To clarify the involvement of TRPM2 in insulin secretion, we analyzed TRPM2 knockout (TRPM2-KO) mice...
  11. ncbi TRP channels: formation of signal complex and regulation of cellular functions
    Motohiro Nishida
    Center for Integrative Bioscience, Okazaki National Research Institutes, Japan
    Nihon Yakurigaku Zasshi 121:223-32. 2003
    ..These findings encourage usage of TRP channels and their signalplexes as powerful tools for the development of novel pharmaceutical targets...
  12. ncbi Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
    Yasushi Okamura
    Section of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Physiol Genomics 22:269-82. 2005
    ..Such genome-wide information of ion channel genes in basal chordates enables us to begin correlating the innovation and remodeling of genes with the adaptation of more recent chordates to their physical environment...
  13. pmc TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
    Kazuya Togashi
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Aichi, Japan
    EMBO J 25:1804-15. 2006
    ....
  14. pmc The ΔC splice-variant of TRPM2 is the hypertonicity-induced cation channel in HeLa cells, and the ecto-enzyme CD38 mediates its activation
    Tomohiro Numata
    Department of Cell Physiology, National Institute of Physiological Sciences, Okazaki 444 8585, Japan
    J Physiol 590:1121-38. 2012
    ..With the biotransformation of nucleotides running in parallel, continuous zero trans-conditions are achieved which will render the system infinitely sensitive...
  15. ncbi Effects of calmodulin and Ca2+ channel blockers on omega-conotoxin GVIA binding to crude membranes from alpha1B subunit (Cav2.2) expressed BHK cells and mice brain lacking the alpha1B subunits
    Tetsuyuki Wada
    Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, 577 8502, Higashiosaka, Japan
    Neurochem Res 30:1045-54. 2005
    ..2 channels which are also inhibited by CaM and have not specific binding sites for omega-CTX MVIIC, although omega-CTX MVIIC is a blocker for both Cav2.1 (alpha1A; P/Q-type) and Cav2.2 channels...
  16. ncbi The role of canonical transient receptor potential 7 in B-cell receptor-activated channels
    Jean Philippe Lievremont
    Department of Health and Human Services, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 280:35346-51. 2005
    ..This represents the first demonstration of a physiological function for endogenous TRPC7 channels...
  17. pmc TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy
    Naoya Onohara
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka
    EMBO J 25:5305-16. 2006
    ..These data suggest that DAG-induced Ca(2+) signaling pathway through TRPC3 and TRPC6 is essential for Ang II-induced NFAT activation and cardiac hypertrophy...
  18. pmc Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
    Christian Erxleben
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 103:3932-7. 2006
    ..We propose that aberrant phosphorylation, or "phosphorylopathy," of the CaV1.2 channel protein contributes to the excitotoxicity associated with Timothy syndrome and with chronic cyclosporin treatment of transplant patients...
  19. pmc Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism
    Guillermo Vazquez
    NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 281:25250-8. 2006
    ..However, with conditions expected to produce greater expression levels, TRPC7 functioned independently of the presence of IP3R. This finding may serve to resolve previously conflicting reports from expression studies of TRPC channels...
  20. ncbi TRP channels: molecular diversity and physiological function
    Motohiro Nishida
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Microcirculation 13:535-50. 2006
    ..These findings encourage the usage of TRP channels and their signalplexes as powerful tools for developing novel pharmaceutical targets...
  21. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  22. pmc Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
    Yoshihiro Baba
    Laboratory for Lymphocyte Differentiation and Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 103:16704-9. 2006
    ....
  23. ncbi Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells
    Hironao Saegusa
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Mol Cell Neurosci 34:261-70. 2007
    ..Therefore, our results do not support the notion that the alteration of the channel properties may underlie the pathogenic mechanism of SCA6...
  24. ncbi Characterization of a tobacco TPK-type K+ channel as a novel tonoplast K+ channel using yeast tonoplasts
    Shin Hamamoto
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aobayama 6 6 07, Sendai 980 8579, Japan
    J Biol Chem 283:1911-20. 2008
    ..5 also markedly increased NtTPK1-mediated K(+) currents. These results show that NtTPK1 is a novel tonoplast K(+) channel belonging to a different group from the previously characterized vacuolar channels SV, FV, and VK...
  25. ncbi Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels
    Takafumi Miki
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
    Channels (Austin) 1:144-7. 2007
    ..1 and L-type Ca(v)1.4 channels. Thus, our data can raise an interesting possibility that CORD7 phenotypes including retinal deficits and enhanced cognition are at least partly due to altered regulation of presynaptic VDCC currents...
  26. pmc Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells
    Juan Shi
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 561:415-32. 2004
    ..These results collectively suggest that TRPC6 and 7 channels are multiply regulated by Ca2+ from both sides of the membrane through differential Ca2+-CaM-dependent and -independent mechanisms...
  27. pmc Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop
    Christian Erxleben
    Laboratory of Signal Transduction and Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 100:2929-34. 2003
    ....
  28. ncbi Molecular candidates for capacitative and non-capacitative Ca2+ entry in smooth muscle
    Ryuji Inoue
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Novartis Found Symp 246:81-90; discussion 221-7. 2002
    ..Thus, at present, TRP proteins may be the most important clues for elucidating the molecular entities of receptor- and store-operated Ca2+ entry mechanisms in smooth muscle and their roles in smooth muscle functions...
  29. ncbi A unified nomenclature for the superfamily of TRP cation channels
    Craig Montell
    Mol Cell 9:229-31. 2002
  30. ncbi Molecular characterization of a two-domain form of the neuronal voltage-gated P/Q-type calcium channel alpha(1)2.1 subunit
    Jyothi Arikkath
    Howard Hughes Medical Institute, Department of Physiology, University of Iowa College of Medicine, 400 Eckstein Medical Research Building, Iowa City, IA 52242 1101, USA
    FEBS Lett 532:300-8. 2002
    ..These studies suggest an in vivo role for the 95kD-alpha(1)2.1 in altering synaptic activity via protein-protein interactions and/or regulation of P/Q-type currents...
  31. ncbi Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites
    Raquel Gouvea Dos Santos
    INSERM U464 and CNRS UMR6560, Institut Jean Roche, Universite de la Mediterranee, Faculte de Medecine Secteur Nord, Marseille, France
    J Biol Chem 277:13856-62. 2002
    ..3 microm). (125)I-omegaPtxIIA thus defines a unique high affinity binding site that is predominantly associated with Ca(v)2.1 or Ca(v)2.2 channels...
  32. pmc FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current
    Stefan I McDonough
    Department of Neuroscience, Amgen Inc, Thousand Oaks, California, USA
    Biophys J 88:211-23. 2005
    ..Instead, FPL somehow affects the coupling of charge movement to opening and closing of the pore. An intriguing possibility is that the drug causes an inactivated state to become conducting without otherwise affecting gating transitions...
  33. ncbi [Physiological role of presynaptic Ca2+ channel complexes on neurotransmitter release]
    Shigeki Kiyonaka
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan
    Seikagaku 80:658-61. 2008
  34. ncbi Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum
    Veronique Cornet
    INSERM U464, Laboratoire de Neurobiologie des Canaux Ioniques, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Eur J Neurosci 16:883-95. 2002
    ..a correct folding of Cavalpha in order to mask several internal ER-retention determinants and (ii). the association of other proteins, including the Cavbeta subunit, to suppress the remaining ER-retention determinants...
  35. ncbi Regulatory role of neuron-restrictive silencing factor in expression of TRPC1
    Takayoshi Ohba
    Second Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 351:764-70. 2006
    ..Our findings strongly suggest that NRSF regulates TRP1 gene expression and causes changes in the levels of calcium entry through SOCCs...
  36. ncbi Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells
    Kenichi Kato
    Department of Cell Physiology and Molecular Biology, Fukuoka Dental College, Fukuoka 814 0193, Japan
    Neuropharmacology 42:1099-108. 2002
    ..The data also suggest that cilnidipine binds to sites independent of those controlling voltage-sensing and channel kinetics in these alpha(1B) subunits...
  37. ncbi Upregulation of TRPC1 in the development of cardiac hypertrophy
    Takayoshi Ohba
    Second Department of Internal Medicine, Akita University School of Medicine, Hondoh, Akita, Japan
    J Mol Cell Cardiol 42:498-507. 2007
    ..These findings establish TRPC1 as a functionally important regulator of cardiac hypertrophy...
  38. ncbi [The TRP proteins, a rapidly expanding Ca2+ entry channel family and a new molecular target for drug development]
    Ryuji Inoue
    Department of Pharmacology, Graduate School of Medical Science, Kyushu University
    Nihon Rinsho 60:18-24. 2002
    ..This short paper briefly overviews the current knowledge about these proteins as a new target for drug discovery and development...
  39. ncbi Transient receptor potential channels in Alzheimer's disease
    Shinichiro Yamamoto
    Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Biochim Biophys Acta 1772:958-67. 2007
    ..An understanding of the involvement of TRP channels in AD may lead to the development of new target therapies...
  40. pmc RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
    Shigeki Kiyonaka
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615 8510, Japan
    Nat Neurosci 10:691-701. 2007
    ....
  41. ncbi Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
    Nobuaki Takahashi
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
    Channels (Austin) 2:287-98. 2008
    ..Interestingly, the Cys421 mutation critically impaired the TRPA1 response to H(+) as well. Our findings suggest that TRPA1 channels are targeted by an array of inflammatory mediators to elicit inflammatory pain in the nervous system...
  42. ncbi Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome
    Nicole Martin-Moutot
    INSERM U641, Marseille F 13916, France
    Neurobiol Dis 22:57-63. 2006
    ..1 and/or Cav2.2 antibodies detected using two different omega-conotoxins. Thus, the 125I-omegaPtxIIA assay detects a broader spectrum of autoantibody specificities than current omega-conotoxin-based assays...
  43. ncbi A new fluorescent biosensor for inositol trisphosphate
    Takashi Morii
    Institute of Advanced Energy, Kyoto University, PRESTO, Japan Science and Technology Corporation, Uji, Kyoto 611 0011, Japan
    J Am Chem Soc 124:1138-9. 2002
    ....
  44. ncbi Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels
    Masakazu Ishii
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo 142 8555, Japan
    Anticancer Res 27:3987-92. 2007
    ..TRPM2 seems to be a candidate for gene therapy in glioblastoma cells, since the insertion of TRPM2 into A172 cells can facilitate cell death through Ca2+ increase after H2O2 treatment without increasing malignancy...
  45. pmc TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
    Shinichiro Yamamoto
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto 615 8510, Japan
    Nat Med 14:738-47. 2008
    ..We propose functional inhibition of TRPM2 channels as a new therapeutic strategy for treating inflammatory diseases...
  46. ncbi Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel
    Yuusuke Maruyama
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Umezono 1 1 4, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 282:36961-70. 2007
    ..This indicates that the agonist-binding ADPRase domain and the ion gate in the transmembrane region are separately located in the molecule...
  47. pmc Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation
    Yuichi Aiba
    Laboratories of Lymphocyte Differentiation and Immunogenomics, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 101:16612-7. 2004
    ..Hence, our data suggest that PKC, after being activated by diacylglycerol, phosphorylates RasGRP3, thereby contributing to its full activation...
  48. ncbi Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells
    Hideaki Oike
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochim Biophys Acta 1761:1078-84. 2006
    ..These results strongly suggest the possibility that arachidonic acid acts as a modulator of TRPM5 in taste signaling pathways...
  49. ncbi Polyglutamine repeats of spinocerebellar ataxia 6 impair the cell-death-preventing effect of CaV2.1 Ca2+ channel--loss-of-function cellular model of SCA6
    Zenjiro Matsuyama
    Department of Neurology and Geriatrics Gifu University, Graduate School of Medicine, Gifu 501 1194, Japan
    Neurobiol Dis 17:198-204. 2004
    ....
  50. ncbi The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end
    Kazuhiro Mio
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Umezono 1 1 4, Tsukuba, Ibaraki 305 8568, Japan
    Biochem Biophys Res Commun 333:768-77. 2005
    ..The total image of the protein is a blunt-edged trapezoid of 200 x 200 x 235 A. This large dimension of TRPC3 is also supported by the Stokes radius (92 A) obtained from gel filtration chromatography...
  51. ncbi Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells
    Toyohisa Hanano
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Pharmacol Sci 95:403-19. 2004
    ..These results suggest a significant regulatory role of TRPM7 for RB cell proliferation as a spontaneously activated Ca(2+) influx pathway...
  52. pmc Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
    Shunichi Shimizu
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    J Physiol 570:219-35. 2006
    ....
  53. ncbi [Ionic mechanisms underlying the regulation of cell proliferation, differentiation and death]
    Yasuo Mori
    Ctr Integ Biosci, Okazaki Natl Res Inst, Japan
    Nihon Yakurigaku Zasshi 122:201-14. 2003
    ..Finally, topics about activation of specific types of Cl(-) channels and K(+) channels, which are responsible for the induction of apoptosis or proliferation in several types of cells, were introduced...
  54. ncbi [TRP channels as targets for novel calcium antagonists]
    Shigeki Kiyonaka
    Nihon Yakurigaku Zasshi 126:317-20, 328. 2005
  55. ncbi [New high-throughput electrophysiology platform using voltage clamp noise analysis]
    Takashi Yoshida
    Nihon Yakurigaku Zasshi 126:335-40. 2005
  56. ncbi New target molecules in the drug control of blood pressure and circulation
    Ryuji Inoue
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Curr Drug Targets Cardiovasc Haematol Disord 3:59-72. 2003
    ..This review overviews what is known about the role of ionic channels in blood pressure control with main focus on the above-mentioned new molecules as promising targets for drug discovery and development...
  57. ncbi Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat beta-cell line RIN-5F
    Masakazu Ishii
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Cell Calcium 39:487-94. 2006
    ....
  58. ncbi Transient receptor potential protein as a novel non-voltage-gated Ca2+ entry channel involved in diverse pathophysiological functions
    Ryuji Inoue
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Pharmacol Sci 91:271-6. 2003
    ..This short paper briefly overviews the current knowledge about these channels with a main focus on their possible linkage with in vivo function...
  59. ncbi A critical role of TRPM2 in neuronal cell death by hydrogen peroxide
    Shuji Kaneko
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Pharmacol Sci 101:66-76. 2006
    ..These results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons...
  60. ncbi Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F
    Masakazu Ishii
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    J Pharmacol Sci 101:174-8. 2006
    ..H2O2-induced Ca2+ entry through TRPM2 was not affected by extracellular ADP-ribose. These findings suggest that extracellular-added ADP-ribose induces Ca2+ release through the PLC-IP3 pathway and does not act as a TRPM2 activator...
  61. ncbi Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii
    Koji Yamazaki
    Laboratory of Neurophysiology, Department of Neuroscience, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato, Tokyo 105 8461, Japan
    Brain Res 1104:103-13. 2006
    ....
  62. ncbi Functional reassembly of a split PH domain
    Kenji Sugimoto
    Institute of Advanced Energy, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Am Chem Soc 125:5000-4. 2003
    ....
  63. ncbi Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis
    Shinji Satoh
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, 874 0838, Japan
    Mol Cell Biochem 294:205-15. 2007
    ..TRPC7 might be a key initiator linking AT1-activation to myocardial apoptosis, and thereby contributing to the process of heart failure...
  64. ncbi Oligo-Asp tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins
    Akio Ojida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto, 615 8510, Japan
    J Am Chem Soc 128:10452-9. 2006
    ....
  65. ncbi Subunit dissociation of TRPC3 ion channel under high-salt condition
    Kazuhiro Mio
    Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Umezono 1 1 4, Tsukuba, Ibaraki 305 8568, Japan
    J Electron Microsc (Tokyo) 56:111-7. 2007
    ..These results also suggested that electron microscopy is highly effective when used in the "quality check" of the specimen in each purification step...