Kazuyasu Mori

Summary

Affiliation: National Institute of Biomedical Innovation
Country: Japan

Publications

  1. pmc Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model
    Kazuyasu Mori
    AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 79:10386-96. 2005
  2. doi request reprint Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 89:554-66. 2008
  3. pmc Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Virol 86:9323-36. 2012
  4. ncbi request reprint Loss of virus-specific CD4(+) T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques
    Wen hui Lun
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 85:1955-63. 2004
  5. pmc Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS ONE 5:e11678. 2010
  6. pmc nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes
    Chie Sugimoto
    Tsukuba Primate Center for Medical Sciences, National Institute of Infectious Diseases, Tsukuba, Japan
    J Virol 77:4169-80. 2003
  7. ncbi request reprint Reference strand-mediated conformation analysis-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci
    Yumiko Tanaka-Takahashi
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Electrophoresis 28:918-24. 2007
  8. ncbi request reprint Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:590-9. 2002
  9. pmc Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection
    Nattawat Onlamoon
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunology 124:277-93. 2008
  10. pmc Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:10-24. 2003

Collaborators

Detail Information

Publications15

  1. pmc Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model
    Kazuyasu Mori
    AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 79:10386-96. 2005
    ..This study demonstrated that the prime-boost Env vaccine was effective against homologous SIVmac239 challenge. Changes in glycosylation affected both cell-mediated and humoral immune responses and vaccine efficacy...
  2. doi request reprint Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 89:554-66. 2008
    ....
  3. pmc Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    J Virol 86:9323-36. 2012
    ....
  4. ncbi request reprint Loss of virus-specific CD4(+) T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques
    Wen hui Lun
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 85:1955-63. 2004
    ....
  5. pmc Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV
    Chie Sugimoto
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS ONE 5:e11678. 2010
    ..In summary, results of this study indicate that deglycosylated live-attenuated vaccines may provide a platform for the elucidation of correlates of protection needed for a successful HIV vaccine against diverse isolates...
  6. pmc nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes
    Chie Sugimoto
    Tsukuba Primate Center for Medical Sciences, National Institute of Infectious Diseases, Tsukuba, Japan
    J Virol 77:4169-80. 2003
    ..Thus, our in vivo study indicated that the nef gene enhances SIV replication by robust productive infection in memory CD4(+) T cells in the T-cell-rich region in lymphoid tissues...
  7. ncbi request reprint Reference strand-mediated conformation analysis-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci
    Yumiko Tanaka-Takahashi
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Electrophoresis 28:918-24. 2007
    ..By comparing the data from the parents with those from the descendants in the breeding colony, several MHC class I haplotypes consisting of variable numbers of functional Mamu-A and Mamu-B alleles could be assigned...
  8. ncbi request reprint Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:590-9. 2002
    ....
  9. pmc Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection
    Nattawat Onlamoon
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunology 124:277-93. 2008
    ..The results of these studies serve as a foundation for future in vivo trials of the use of rMamu-PD-1 to potentially enhance and/or restore antiviral immune responses in vivo...
  10. pmc Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:10-24. 2003
    ....
  11. pmc The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Autoimmun 28:152-9. 2007
    ....
  12. pmc Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial
    Tetsuro Matano
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 199:1709-18. 2004
    ..Our results indicate that vaccine induction of highly effective CTLs can result in the containment of replication of a highly pathogenic immunodeficiency virus...
  13. ncbi request reprint Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Immunol Res 29:1-18. 2004
    ..This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses...
  14. doi request reprint Impaired astrocytes and diffuse activation of microglia in the cerebral cortex in simian immunodeficiency virus-infected Macaques without simian immunodeficiency virus encephalitis
    Hui Qin Xing
    Division of Molecular Pathology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Neuropathol Exp Neurol 67:600-11. 2008
    ..These results indicate that an astrocytic abnormality and a compensatory activation of microglia might provide a protective effect against neuronal degeneration in the frontal cortex of SIV-infected macaques without SIV encephalitis...
  15. ncbi request reprint Simian immunodeficiency virus encephalitis in the white matter and degeneration of the cerebral cortex occur independently in simian immunodeficiency virus-infected monkey
    Hui Qin Xing
    Division of Molecular Pathology and Genetic Epidemiology, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, Japan
    J Neurovirol 9:508-18. 2003
    ....