Affiliation: National Cardiovascular Center
Mochizuki N. Vascular integrity mediated by vascular endothelial cadherin and regulated by sphingosine 1-phosphate and angiopoietin-1. Circ J. 2009;73:2183-91 pubmed
..This review spotlights the recent studies of vascular endothelial cadherin and of sphingosine 1-phosphate signaling and angiopoietin-Tie signaling. ..
Fukuhara S, Zhang J, Yuge S, Ando K, Wakayama Y, Sakaue Sawano A, et al
. Visualizing the cell-cycle progression of endothelial cells in zebrafish. Dev Biol. 2014;393:10-23 pubmed publisher
..Thus, we anticipate that the EC-zFucci Tg line can serve as a tool for detailed studies of the proliferation of ECs in various forms of vascular development in vivo. ..
Fukui H, Terai K, Nakajima H, Chiba A, Fukuhara S, Mochizuki N. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev Cell. 2014;31:128-36 pubmed publisher
..Consistently, ctgfa morphants showed defects of the endodermal sheet and cardia bifida. Collectively, we show that S1pr2/Yap1-regulated ctgfa expression is essential for the proper endoderm formation required for CPC migration. ..
Chiba A, Watanabe Takano H, Terai K, Fukui H, Miyazaki T, Uemura M, et al
. Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish. Development. 2017;144:334-344 pubmed publisher
..These data demonstrate that Ostn secreted from the heart contributes to bone formation as an endocrine hormone. ..
Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, et al
. Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev Cell. 2017;40:523-536.e6 pubmed publisher
..Yap1 mutant zebrafish showed a defect in vascular stability, indicating an essential role for Yap1 in blood vessels. Our data imply that endothelial Yap1 functions in response to flow to maintain blood vessels. ..
Chiba A, Watanabe Takano H, Miyazaki T, Mochizuki N. Cardiomyokines from the heart. Cell Mol Life Sci. 2018;75:1349-1362 pubmed publisher
..Therefore, through its endocrine function, the heart can maintain physiological conditions and prevent organ damage under pathological conditions. ..