Research Topics
Genomes and Genes | N MizushimaSummaryAffiliation: National Institute for Basic Biology Country: Japan Publications
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Detail Information
Publications
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cellsN Mizushima
Unit Process and Combined Circuit, PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
J Cell Biol 152:657-68. 2001..We also show that Apg12-Apg5 is required for targeting of a mammalian Aut7/Apg8 homologue, LC3, to the isolation membranes. These results suggest that the Apg12-Apg5 conjugate plays essential roles in isolation membrane development...
Methods for monitoring autophagyNoboru Mizushima
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
Int J Biochem Cell Biol 36:2491-502. 2004..Importantly, most of these proteins are conserved in mammals. Using these probes, we can now specifically monitor autophagic activity...- Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
J Cell Sci 116:1679-88. 2003..Because WD-repeat proteins provide a platform for protein-protein interactions, the approximately 800 kDa complex is expected to function in autophagosome formation, further interacting with other proteins in mammalian cells... - Autophagosome formation in mammalian cellsNoboru Mizushima
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
Cell Struct Funct 27:421-9. 2002..These findings are now being applied to studies on the physiological roles of autophagy in mammals... 
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationK Suzuki
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji cho, Okazaki 444 8585, Japan
EMBO J 20:5971-81. 2001..The Apg1p protein kinase complex functions in the late stage of autophagosome formation. Here, we present the classification of Apg proteins into three groups that reflect each step of autophagosome formation...- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingY Kabeya
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
EMBO J 19:5720-8. 2000..The amount of LC3-II is correlated with the extent of autophagosome formation. LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes... - The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathwayT Kirisako
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
J Cell Biol 151:263-76. 2000..A reaction similar to ubiquitination is probably involved in the second modification. The reversible modification of Apg8 appears to be coupled to the membrane dynamics of autophagy and the Cvt pathway... - Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathwayN Mizushima
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
EMBO J 18:3888-96. 1999..These results suggest that the Apg12p-Apg5p conjugate requires Apg16p to accomplish its role in the autophagy pathway, and Apg16p is a key molecule as a linker to form the Apg12p-Apg5p-Apg16p multimer... - A ubiquitin-like system mediates protein lipidationY Ichimura
Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
Nature 408:488-92. 2000..11) and Apg3, respectively. These reactions are necessary for the formation of Apg8-phosphatidylethanolamine. This lipidation has an essential role in membrane dynamics during autophagy... - The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cellsT Yoshimori
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Mol Biol Cell 11:747-63. 2000..The early endosome antigen EEA1 was also redistributed to these aberrant membranes. Taken together, our findings suggest that SKD1 regulates morphology of endosomes and membrane traffic through them... - A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagyN Mizushima
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
J Biol Chem 273:33889-92. 1998..These findings indicate that the Apg12 system is well conserved and may function in autophagy also in human cells... - Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeastT Shintani
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
EMBO J 18:5234-41. 1999..These findings indicate that Apg10p is a new type of protein-conjugating enzyme that functions in the Apg12p-Apg5p conjugation pathway... - A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotesK Furukawa
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
J Biol Chem 275:7462-5. 2000..This fact may provide an important clue regarding evolution of protein conjugation systems in eukaryotic cells... - Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid methodNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, 332 0012, Kawaguchi, Japan
FEBS Lett 532:450-4. 2002..This novel two-hybrid method, which we have named 'conjugation-mediated yeast two-hybrid', proves to be a simple and useful technique with which to analyze protein-protein conjugation... - Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeastAkiko Kuma
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
J Biol Chem 277:18619-25. 2002..These results suggest that the Apg12-Apg5 conjugate and Apg16 form a multimeric complex mediated by the Apg16 homo-oligomer, and formation of the approximately 350-kDa complex is required for autophagy in yeast... - A protein conjugation system essential for autophagyN Mizushima
Department of Cell Biology, National Institute for Basic Biology, Okazaki, Japan
Nature 395:395-8. 1998..Furthermore, Apg5 and Apg12 have mammalian homologues, suggesting that this new modification system is conserved from yeast to mammalian cells... - Two ubiquitin-like conjugation systems essential for autophagyYoshinori Ohsumi
Department of Cell Biology, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan
Semin Cell Dev Biol 15:231-6. 2004 - LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formationYukiko Kabeya
Department of Cell Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444 8585, Japan
J Cell Sci 117:2805-12. 2004..Generation of the form II correlates with autophagosome association of GABARAP and GATE16. These results suggest that all mammalian Atg8 homologues receive a common modification to associate with autophagosomal membrane as the form II... - In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerNoboru Mizushima
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Mol Biol Cell 15:1101-11. 2004..Our results suggest that the regulation of autophagy is organ dependent and the role of autophagy is not restricted to the starvation response. This transgenic mouse model is a useful tool to study mammalian autophagy... - [Molecular mechanism of autophagy: the role of the Apg12 conjugation system]Noboru Mizushima
PRESTO, Japan Science and Technology Corporation (JST, Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaijicho, Okazaki, Aichi 444-8585
Seikagaku 74:523-37. 2002 - Role of the Apg12 conjugation system in mammalian autophagyNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan
Int J Biochem Cell Biol 35:553-61. 2003..Discovery of the Apg12 system has facilitated our understanding of the molecular mechanism of autophagosome formation... - The role of autophagy during the early neonatal starvation periodAkiko Kuma
Time s Arrow and Biosignaling, PRESTO, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
Nature 432:1032-6. 2004..These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation... - Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid dropletsMasato Ohashi
Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
J Biol Chem 278:36819-29. 2003..These results add to the growing notion that the lipid droplet is an organelle endowed with more complex roles in various biological phenomena... - SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formationAtsuki Nara
Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, Japan
Cell Struct Funct 27:29-37. 2002..These results indicate that SKD1-dependent endosomal membrane trafficking is required for formation of autolysosomes... - LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localizationAkiko Kuma
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
Autophagy 3:323-8. 2007..Therefore, LC3 localization should be carefully interpreted, particularly if LC3 is overexpressed by transient transfection or if aggregates are formed within cells... - [Methods for monitoring macroautophagy]Noboru Mizushima
Tanpakushitsu Kakusan Koso 51:1542-8. 2006 - The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomesEdward T W Bampton
Department of Biochemistry, University of Cambridge, Cambridge, UK
Autophagy 1:23-36. 2005..Use of fluorescent LC3 and a counter-fluorescent endosomal/lysosomal protein clearly allows the entire autophagic process to be followed by live cell imaging with high fidelity... - [Regulators of mammalian cellular autophagy]Taichi Hara
Tanpakushitsu Kakusan Koso 51:1484-9. 2006 - ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagyJason Szeto
Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Autophagy 2:189-99. 2006..Together, these findings demonstrate that ALIS act as generalized stress-induced protein storage compartments for substrates of the proteasome and autophagy... - Cellular autophagy machinery is not required for vaccinia virus replication and maturationHaiyan Zhang
Department of Pharmacology, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Autophagy 2:91-5. 2006..This study indicates that the cellular autophagy machinery is not required for the life-cycle of vaccinia virus, suggesting that the primary vaccinia viral membrane does not originate from the autophagic membrane... - Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 miceAkiko Kuma
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan SORST, Japan Science and Technology Agency, Kawaguchi, Japan
Autophagy 4:61-2. 2008..Homozygous GFP-LC3 mice (GFP-LC3(tg/tg)) were healthy, fertile and did not show an abnormal phenotype. Thus, GFP-LC3 integration in this model appears not to affect functions of other genes, justifying use of this mouse model... - Autophagy: process and functionNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Genes Dev 21:2861-73. 2007..In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner... - Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response... 
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesisMatthew A King
Southampton Neuroscience Group, School of Biological Sciences, University of Southampton Bassett Crescent East, Southampton SO16 7PX, UK
Mol Pharmacol 73:1052-63. 2008..This finding may have important therapeutic implications...- GFP-like proteins stably accumulate in lysosomesHiroyuki Katayama
Laboratory for Cell Function Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN
Cell Struct Funct 33:1-12. 2008.... - Autophagosomes in GFP-LC3 Transgenic MiceNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
Methods Mol Biol 445:119-24. 2008..To analyze autophagy in whole animals, we generated GFP-LC3 transgenic mice and describe here how we determine the occurrence of autophagy in vivo using this mouse model... - FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cellsTaichi Hara
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
J Cell Biol 181:497-510. 2008..These results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs... - Autophagy is essential for preimplantation development of mouse embryosSatoshi Tsukamoto
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Science 321:117-20. 2008..Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals... - Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1Mamoru Shibata
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 281:14474-85. 2006..100, 15077-15082), we propose that the age-dependent decrease of beclin 1 expression may lead to a reduction of autophagic activity during aging, which in turn promotes the accumulation of mutant Htt and the progression of the disease... - Escape of intracellular Shigella from autophagyMichinaga Ogawa
Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Science 307:727-31. 2005..Rather, Shigella VirG, a protein required for intracellular actin-based motility, induced autophagy by binding to the autophagy protein, Atg5. In nonmutant Shigella, this binding is competitively inhibited by IcsB binding to VirG... - Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genesShigeomi Shimizu
Department of Post-Genomics and Diseases, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Nat Cell Biol 6:1221-8. 2004..These results indicate that the Bcl-2 family of proteins not only regulates apoptosis, but also controls non-apoptotic programmed cell death that depends on the autophagy genes... - Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell deathJong Ok Pyo
Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
J Biol Chem 280:20722-9. 2005..These results suggest that Atg5 plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD... - Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranesAnne Simonsen
Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
J Cell Sci 117:4239-51. 2004..By electron microscopy, similar structures can be found within autophagosomes. We propose that Alfy might target cytosolic protein aggregates for autophagic degradation... - Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceMasaaki Komatsu
Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
J Cell Biol 169:425-34. 2005..Our results indicate the important role of autophagy in starvation response and the quality control of proteins and organelles in quiescent cells... - The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8Kenji Sugawara
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
Genes Cells 9:611-8. 2004..We also propose the functional implications of the ubiquitin fold as a recognition module of target proteins... - Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeastTohru Ichimura
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
Biochemistry 43:6149-58. 2004..This study presents the first comprehensive overview of the genes and proteins that are affected by the depletion of Bmh1/2p and extends the scope of knowledge of the regulatory roles of Bmh1/2p in S. cerevisiae... - Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagySophie Pattingre
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cell 122:927-39. 2005..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death... - Coronavirus replication complex formation utilizes components of cellular autophagyErik Prentice
Department of Microbiology and Immunology, Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee 37221, USA
J Biol Chem 279:10136-41. 2004..Furthermore, the rough endoplasmic reticulum is implicated as the possible source of membranes for replication complexes... - Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagySusmita Kaushik
Departments of Anatomy and Structural Biology and Developmental and Molecular Biology, Marion Bessin Liver Research Center and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Mol Biol Cell 19:2179-92. 2008..This work supports a direct cross-talk between these two forms of autophagy, and it identifies changes in the lysosomal compartment that underlie the basis for the communication between both autophagic pathways... - Crystallization and preliminary X-ray analysis of LC3-IKenji Sugawara
Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan
Acta Crystallogr D Biol Crystallogr 59:1464-5. 2003..39, c = 36.89 A. The other form belongs to space group P4(1) or P4(3), with unit-cell parameters a = 60.48, c = 35.28 A. From the latter form, a complete diffraction data set was collected to 2.1 A resolution... - Analysis of the role of autophagy in replication of herpes simplex virus in cell cultureDiane E Alexander
Department of Ophthalmology, Washington University School of Medicine, St Louis, MO 63110, USA
J Virol 81:12128-34. 2007..These data show that while ICP34.5 regulates autophagy, it is the prevention of translational arrest by ICP34.5 rather than its control of autophagy that is the pivotal determinant of efficient HSV-1 replication in primary cell culture... - Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal deathJun Nishiyama
Department of Physiology, School of Medicine, Keio University, Tokyo, Japan
Autophagy 3:591-6. 2007..These results suggest that Atg5 plays important roles in the maintenance of axon morphology and membrane structures, and its loss of function leads to the swelling of axons, followed by progressive neurodegeneration in mammalian neurons... - Autophagy defends cells against invading group A StreptococcusIchiro Nakagawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Science 306:1037-40. 2004..In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens... - Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient miceMasaaki Komatsu
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
Cell 131:1149-63. 2007.... - Involvement of autophagy in trypsinogen activation within the pancreatic acinar cellsDaisuke Hashimoto
Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
J Cell Biol 181:1065-72. 2008..These results suggest that autophagy exerts devastating effects in pancreatic acinar cells by activation of trypsinogen to trypsin in the early stage of acute pancreatitis through delivering trypsinogen to the lysosome... - Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneXueping Qu
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 112:1809-20. 2003..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers... - How to interpret LC3 immunoblottingNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan
Autophagy 3:542-5. 2007..Accordingly, simple comparison of LC3-I and LC3-II, or summation of LC3-I and LC3-II for ratio determinations, may not be appropriate, and rather, the amount of LC3-II can be compared between samples... - The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stressAtsuko Nakai
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
Nat Med 13:619-24. 2007.... - Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activityTakahiro Kamimoto
Department of Cell Genetics, National Institute of Genetics, Mishima, Japan
J Biol Chem 281:4467-76. 2006.... - Organelle degradation during the lens and erythroid differentiation is independent of autophagyMakoto Matsui
Department of Bioregulation and Metabolism, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
Biochem Biophys Res Commun 339:485-9. 2006..Our data suggest that degradation system(s) other than autophagy play major roles in organelle degradation during these processes... - Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceTaichi Hara
Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
Nature 441:885-9. 2006.... - Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagyKenji Sugawara
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo 060 0812, Japan
J Biol Chem 280:40058-65. 2005..The structure and in vitro mutational analyses provide the basis for the specificity and catalysis of HsAtg4B. This will enable the design of Atg4-specific inhibitors that block autophagy... - [Autophagy: a strategy for neogenesis]Noboru Mizushima
Tanpakushitsu Kakusan Koso 50:393-402. 2005 - Cerebral ischemia-hypoxia induces intravascular coagulation and autophagyFaisal Adhami
Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Pathol 169:566-83. 2006..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain... - Induction of autophagy in axonal dystrophy and degenerationQing Jun Wang
Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, New York 10021, USA
J Neurosci 26:8057-68. 2006..We propose that induction of autophagy serves as an early stress response in axonal dystrophy and may participate in the remodeling of axon structures... - [Physiological role in constitutive autophagy]Masaaki Komatsu
Tanpakushitsu Kakusan Koso 51:1515-8. 2006 - A critical role for the autophagy gene Atg5 in T cell survival and proliferationHeather H Pua
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Exp Med 204:25-31. 2007..These results demonstrate a critical role for Atg5 in multiple aspects of lymphocyte development and function and suggest that autophagy may be essential for both T lymphocyte survival and proliferation... - Autophagy-dependent viral recognition by plasmacytoid dendritic cellsHeung Kyu Lee
Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Science 315:1398-401. 2007..These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7... - Protein turnover via autophagy: implications for metabolismNoboru Mizushima
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Annu Rev Nutr 27:19-40. 2007..We review the current information on the mechanism of autophagy, with a focus on its role in protein metabolism and intracellular homeostasis... - Collaboration of proteolytic systemsNoboru Mizushima
Autophagy 3:179-80. 2007 - Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)Masato Koike
Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, Suita, Japan
Am J Pathol 167:1713-28. 2005..These data strongly argue for a major involvement of autophagy in the pathogenesis of Batten disease/lysosomal storage disorders... - Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for toleranceJelena Nedjic
Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
Nature 455:396-400. 2008..In doing so, it contributes to T-cell selection and is essential for the generation of a self-tolerant T-cell repertoire...