Hajime Miyaguchi

Summary

Affiliation: National Research Institute of Police Science
Country: Japan

Publications

  1. ncbi request reprint A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry
    Hajime Miyaguchi
    National Research Institute of Police Science, Kashiwa shi, Chiba, Japan
    Forensic Sci Int 157:57-70. 2006
  2. doi request reprint Determination of amphetamine-type stimulants, cocaine and ketamine in human hair by liquid chromatography/linear ion trap-Orbitrap hybrid mass spectrometry
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Analyst 136:3503-11. 2011
  3. doi request reprint Determination of zolpidem in human hair by micropulverized extraction based on the evaluation of relative extraction efficiency of seven psychoactive drugs from an incurred human hair specimen
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa shi, Chiba 277 0882, Japan
    J Chromatogr A 1293:28-35. 2013
  4. doi request reprint Rapid identification and quantification of methamphetamine and amphetamine in hair by gas chromatography/mass spectrometry coupled with micropulverized extraction, aqueous acetylation and microextraction by packed sorbent
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1216:4063-70. 2009
  5. doi request reprint Rapid analysis of methamphetamine in hair by micropulverized extraction and microchip-based competitive ELISA
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 184:1-5. 2009
  6. ncbi request reprint Development of a micropulverized extraction method for rapid toxicological analysis of methamphetamine in hair
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1163:43-8. 2007
  7. ncbi request reprint Microchip-based liquid-liquid extraction for gas-chromatography analysis of amphetamine-type stimulants in urine
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1129:105-10. 2006
  8. ncbi request reprint Determination of 4-hydroxy-3-methoxymethamphetamine as a metabolite of methamphetamine in rats and human liver microsomes using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Anal Toxicol 33:266-71. 2009
  9. doi request reprint Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Anal Chim Acta 608:95-103. 2008
  10. ncbi request reprint Determination of muscimol and ibotenic acid in Amanita mushrooms by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:430-5. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry
    Hajime Miyaguchi
    National Research Institute of Police Science, Kashiwa shi, Chiba, Japan
    Forensic Sci Int 157:57-70. 2006
    ..The detection limits (non-basic analytes, 1-50 ng/ml; basic analytes, 0.1-5 ng/ml) were sufficient to permit the screening of a single therapeutic administration of a target drug...
  2. doi request reprint Determination of amphetamine-type stimulants, cocaine and ketamine in human hair by liquid chromatography/linear ion trap-Orbitrap hybrid mass spectrometry
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Analyst 136:3503-11. 2011
    ..10 ng mg(-1) (AP, MA, DMA, NK and COC) and 0.50 ng mg(-1) (MDA). Two reference materials were analyzed for verification, and segmental analysis of single strands of hair specimens from actual cases was performed...
  3. doi request reprint Determination of zolpidem in human hair by micropulverized extraction based on the evaluation of relative extraction efficiency of seven psychoactive drugs from an incurred human hair specimen
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa shi, Chiba 277 0882, Japan
    J Chromatogr A 1293:28-35. 2013
    ..8-8.8% and 3.3-8.1%, respectively. The developed method was applied to three actual (incurred) samples, for which the concentrations of zolpidem were determined to be 78.9-18,300 (pg/mg)...
  4. doi request reprint Rapid identification and quantification of methamphetamine and amphetamine in hair by gas chromatography/mass spectrometry coupled with micropulverized extraction, aqueous acetylation and microextraction by packed sorbent
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1216:4063-70. 2009
    ..The carry over was estimated to be about 1-2%. This sample-preparation method coupled with GC/MS is fast and labor-saving in comparison with conventional methods...
  5. doi request reprint Rapid analysis of methamphetamine in hair by micropulverized extraction and microchip-based competitive ELISA
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 184:1-5. 2009
    ..Due to the small size of the system and the lack of an evaporation process, sample preparation and quantitation can be accomplished easily and quickly (less than 30 min) in small-scale contamination-free environments...
  6. ncbi request reprint Development of a micropulverized extraction method for rapid toxicological analysis of methamphetamine in hair
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1163:43-8. 2007
    ..Our method took less than 30 min for a set of chromatograms to be obtained from a washed hair sample...
  7. ncbi request reprint Microchip-based liquid-liquid extraction for gas-chromatography analysis of amphetamine-type stimulants in urine
    Hajime Miyaguchi
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr A 1129:105-10. 2006
    ..This study showed the potential of pressure-driven microfluidics to contribute to the rapid automation analysis in forensic toxicology...
  8. ncbi request reprint Determination of 4-hydroxy-3-methoxymethamphetamine as a metabolite of methamphetamine in rats and human liver microsomes using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Anal Toxicol 33:266-71. 2009
    ..The results of the present study will be helpful in determining the type of drug used...
  9. doi request reprint Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Anal Chim Acta 608:95-103. 2008
    ..In conclusion, a portable ATR-FT-IR spectrometer with our library search system would be a useful tool for on-site identification of amphetamine-type stimulant tablets...
  10. ncbi request reprint Determination of muscimol and ibotenic acid in Amanita mushrooms by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:430-5. 2007
    ..This method was successfully applied to identify and quantify MUS and IBO in Amanita mushrooms naturally grown and circulated in the drug market...
  11. doi request reprint Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 180:105-9. 2008
    ..2-5.0/0.10-0.17 in the dried leaf products and 4.1-38.9/0.26-2.42 in the "concentrated extract" products. These findings would be useful for analysis of S. divinorum-related products circulated in the drug market...
  12. doi request reprint Analysis of amphetamine-type stimulants and their metabolites in plasma, urine and bile by liquid chromatography with a strong cation-exchange column-tandem mass spectrometry
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 867:78-83. 2008
    ..This analytical method should be useful for the pharmacokinetic analysis of ATSs...
  13. ncbi request reprint Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Biochim Biophys Acta 1778:42-50. 2008
    ..Various compounds with similar amine moieties inhibited the uptake, but substrates of organic cation transporters (OCT1-3) and an H+-coupled efflux antiporter, MATE, were not recognized...
  14. ncbi request reprint Interactions between 3,4-methylenedioxymethamphetamine, methamphetamine, ketamine, and caffeine in human intestinal Caco-2 cells and in oral administration to rats
    Kenji Kuwayama
    National Research Institute of Police Science, Kashiwanoha, Kashiwa, Chiba, Japan
    Forensic Sci Int 170:183-8. 2007
    ..In human, intakes of ATS tablets mixed with such components might result in similar interactions in intestinal absorption to those in Caco-2 cells and rats...
  15. doi request reprint Thermal desorption counter-flow introduction atmospheric pressure chemical ionization for direct mass spectrometry of ecstasy tablets
    Hiroyuki Inoue
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Mass Spectrom 44:1300-7. 2009
    ..The effectiveness of the combination of TD and CFI-APCI was demonstrated by application to the direct mass spectrometric analysis of ecstasy tablets and legal pharmaceutical products...
  16. doi request reprint Interaction of 3,4-methylenedioxymethamphetamine and methamphetamine during metabolism by in vitro human metabolic enzymes and in rats
    Kenji Kuwayama
    National Research Institute of Police Science, Kashiwa, Chiba, Japan
    J Forensic Sci 57:1008-13. 2012
    ..The results in this study imply that multiple components in ATS tablets can interact to mutually inhibit their metabolism and potentially enhance the toxicity of each component...
  17. doi request reprint Evaluation method for linking methamphetamine seizures using stable carbon and nitrogen isotopic compositions: a complementary study with impurity profiling
    Yuko T Iwata
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Rapid Commun Mass Spectrom 22:3816-22. 2008
    ..The results showed that complementary use of stable-isotopic compositions with impurity profiling provides useful information for evaluating the links between seizures...
  18. ncbi request reprint Analysis of hallucinogenic constituents in Amanita mushrooms circulated in Japan
    Kenji Tsujikawa
    National Research Institute of Police Science, First Chemistry Section, 6 3 1, Kashiwanoha, Kashiwa, Chiba, Japan
    Forensic Sci Int 164:172-8. 2006
    ..This is the first report of the chemical analysis of Amanita mushrooms that are circulated in the drug market...
  19. doi request reprint Synthesis and identification of urinary metabolites of 4-iodo-2,5-dimethoxyphenethylamine
    Tatsuyuki Kanamori
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Forensic Sci 56:1319-23. 2011
    ..The data presented in this study will be very useful for the analysis of 2C-I and its metabolites in forensic samples...
  20. ncbi request reprint Distribution measurement of amphetamine-type stimulants in organs using micropulverized extraction and liquid chromatography/tandem mass spectrometry to complement drug distribution using mass spectrometry imaging
    Kenji Kuwayama
    National Research Institute of Police Science, Kashiwa, Chiba, Japan
    Rapid Commun Mass Spectrom 25:2397-406. 2011
    ..This method could be applicable to the measurement of the distribution of compounds in various solid samples and could be used as a complementary method for the measurement of the distribution of compounds by MSI...
  21. doi request reprint A fatal case of suspected anaphylaxis with cefoperazone and sulbactam: LC-MS analysis
    Kenji Tsujikawa
    First Chemistry Section, National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Forensic Sci 53:226-31. 2008
    ..In conclusion, this procedure is useful for detecting and quantitating cefoperazone and sulbactam in postmortem blood and may be useful in the evaluation of anaphylaxis...
  22. doi request reprint Distribution measurements of 3,4-methylenedioxymethamphetamine and its metabolites in organs by matrix-assisted laser desorption/ionization imaging mass spectrometry using an automatic matrix spraying system with an air brush and a turntable
    Kenji Kuwayama
    National Research Institute of Police Science, Kashiwa, Chiba, Japan
    Anal Bioanal Chem 404:1823-30. 2012
    ..The AMSS would be suitable for preparing samples for measuring the distributions of drugs in organs at toxic dose levels in forensic toxicological applications...
  23. doi request reprint Identification and differentiation of methcathinone analogs by gas chromatography-mass spectrometry
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba, 277 0882, Japan
    Drug Test Anal 5:670-7. 2013
    ..These results will be useful for the forensic analysis of MC analogues in confiscated materials. Copyright © 2012 John Wiley & Sons, Ltd. ..
  24. doi request reprint Applicability of chemically modified capillaries in chiral capillary electrophoresis for methamphetamine profiling
    Yuko T Iwata
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 226:235-9. 2013
    ..Repeatability, speed, and good chiral resolution sufficient for routine MA profiling were achieved with the Type S capillary...
  25. ncbi request reprint Degradation pathways of 4-methylmethcathinone in alkaline solution and stability of methcathinone analogs in various pH solutions
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 220:103-10. 2012
    ..Their degradation rates increased with increasing pH, and varied with their chemical structures. These findings will be very useful for not only forensic analysis but also future pharmacokinetic analysis...
  26. doi request reprint Rapid, simple, and highly sensitive analysis of drugs in biological samples using thin-layer chromatography coupled with matrix-assisted laser desorption/ionization mass spectrometry
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Anal Bioanal Chem 402:1257-67. 2012
    ..Accordingly, this method could be applied to rapid drug screening and precise identification of toxic substances in poisoning cases and postmortem examinations...
  27. ncbi request reprint Urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam and 4-hydroxytriazolam
    Kenji Tsujikawa
    National Research Institute of Police Science 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Anal Toxicol 29:240-3. 2005
    ..Meanwhile, 4-OHTRZ was excreted more slowly than alpha-OHTRZ. The alpha-OHTRZ/4-OHTRZ ratios were initially greater than 19.7, then decreased rapidly, reaching a nearly constant value for times in excess of 12 h...
  28. doi request reprint Chemical profiling of seized methamphetamine putatively synthesized from phenylacetic acid derivatives
    Kenji Tsujikawa
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    Forensic Sci Int 227:42-4. 2013
    ..This proposed preparation route was in accordance with recent reports of seizures worldwide of the raw materials of MA such as phenylacetic acid derivatives, methylamine, and tartaric acid (optical resolving reagent)...
  29. doi request reprint Time-course measurements of caffeine and its metabolites extracted from fingertips after coffee intake: a preliminary study for the detection of drugs from fingerprints
    Kenji Kuwayama
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba, 277 0882, Japan
    Anal Bioanal Chem 405:3945-52. 2013
    ..The method could be used to prove drug intake in criminal investigations...
  30. doi request reprint Urinary excretion profiles of N-hydroxy-3,4-methylenedioxymethamphetamine in rats
    Kenji Tsujikawa
    Third Department of Forensic Science, National Research Institute of Police Science, Kashiwa, Chiba, Japan
    Xenobiotica 41:578-84. 2011
    ..1% of dose. Urinary excretion profiles of MDMA were similar to that of N-OH-MDMA. It may be difficult to differentiate between abuse of MDMA and N-OH-MDMA by urine analysis...