Yuko Miyagoe-Suzuki

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. doi Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro
    Yuko Miyagoe-Suzuki
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Mech Dev 126:107-16. 2009
  2. ncbi Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgene
    Miki Sakamoto
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 293:1265-72. 2002
  3. ncbi Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice
    Madoka Ikemoto
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Mol Ther 15:2178-85. 2007
  4. ncbi Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
  5. pmc Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts
    Norio Motohashi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 173:781-91. 2008
  6. doi Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle
    Jun Tanihata
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawa Higashi, Kodaira, Tokyo, Japan
    J Gene Med 10:702-13. 2008
  7. ncbi Functional heterogeneity of side population cells in skeletal muscle
    Akiyoshi Uezumi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 341:864-73. 2006
  8. pmc Alpha1-syntrophin-deficient skeletal muscle exhibits hypertrophy and aberrant formation of neuromuscular junctions during regeneration
    Yukio Hosaka
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira 187 8502, Tokyo, Japan
    J Cell Biol 158:1097-107. 2002
  9. ncbi The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine
    Joji Takahashi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    J Gene Med 7:237-48. 2005
  10. ncbi AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype
    Madoka Yoshimura
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Mol Ther 10:821-8. 2004

Collaborators

Detail Information

Publications20

  1. doi Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro
    Yuko Miyagoe-Suzuki
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Mech Dev 126:107-16. 2009
    ..Our results suggest that proper glycosylation of alpha-DG is important for maintenance of the proliferative activity of satellite cells in vivo...
  2. ncbi Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgene
    Miki Sakamoto
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 293:1265-72. 2002
    ..These data suggest that the rod structure, and its length in particular, is crucial for the function of micro-dystrophin...
  3. ncbi Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice
    Madoka Ikemoto
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Mol Ther 15:2178-85. 2007
    ..These results suggest that there is potential for lentiviral vector-mediated ex vivo gene therapy for DMD...
  4. ncbi Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
    ..Our data provide roles of CTR in quiescent satellite cells and a solid scaffold to further dissect molecular regulation of satellite cells. Disclosure of potential conflicts of interest is found at the end of this article...
  5. pmc Muscle CD31(-) CD45(-) side population cells promote muscle regeneration by stimulating proliferation and migration of myoblasts
    Norio Motohashi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 173:781-91. 2008
    ..Future studies to further define the molecular and cellular mechanisms of muscle regeneration will aid in the development of cell therapies for muscular dystrophy...
  6. doi Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle
    Jun Tanihata
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawa Higashi, Kodaira, Tokyo, Japan
    J Gene Med 10:702-13. 2008
    ..4-kb 5'-flanking region of the utrophin promoter...
  7. ncbi Functional heterogeneity of side population cells in skeletal muscle
    Akiyoshi Uezumi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 341:864-73. 2006
    ..Our results revealed the heterogeneity of muscle SP cells and suggest that CD31(-)CD45(-) SP cells participate in muscle regeneration...
  8. pmc Alpha1-syntrophin-deficient skeletal muscle exhibits hypertrophy and aberrant formation of neuromuscular junctions during regeneration
    Yukio Hosaka
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira 187 8502, Tokyo, Japan
    J Cell Biol 158:1097-107. 2002
    ....
  9. ncbi The utrophin promoter A drives high expression of the transgenic LacZ gene in liver, testis, colon, submandibular gland, and small intestine
    Joji Takahashi
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    J Gene Med 7:237-48. 2005
    ..To investigate the utrophin promoter A activity in vivo, we generated nuclear localization signal-tagged LacZ transgenic mice, where the LacZ gene was driven by the 5-kb flanking region of the A-utrophin gene...
  10. ncbi AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype
    Madoka Yoshimura
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Mol Ther 10:821-8. 2004
    ..Thus, we concluded that AAV2-MCKDeltaCS1 could be a powerful tool for gene therapy of DMD...
  11. pmc NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS
    Naoki Suzuki
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    J Clin Invest 117:2468-76. 2007
    ..We conclude that nNOS/NO mediates muscle atrophy via regulation of Foxo transcription factors and is a new therapeutic target for disuse-induced muscle atrophy...
  12. doi Recombinant adeno-associated virus type 8-mediated extensive therapeutic gene delivery into skeletal muscle of alpha-sarcoglycan-deficient mice
    Akiyo Nishiyama
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    Hum Gene Ther 19:719-30. 2008
    ..This extensive rAAV8-mediated alpha-SG transduction in LGMD 2D model animals paves the way for future clinical application...
  13. ncbi Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration
    Koichi Ojima
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 321:1050-61. 2004
    ..Taken together, our data suggest that neither HSCs nor mature inflammatory cells, but Mac-1(low) early myeloid cells in the BM-derived SP fraction, play an important role in regenerating skeletal muscles...
  14. doi Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle
    Yusuke Ono
    Department of Molecular Therapy, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    J Cell Sci 125:1309-17. 2012
    ..Taken together, our results indicate that undifferentiated slow-dividing satellite cells retain stemness for generating progeny capable of long-term self-renewal, and so might be essential for muscle homeostasis throughout life...
  15. doi Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy
    Naoki Ito
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Nat Med 19:101-6. 2013
    ....
  16. pmc Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin
    Akira Hirata
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Am J Pathol 163:203-15. 2003
    ..Our studies suggest OPN may serve as an adhesion molecule that promotes macrophage binding to necrotic fibers and may be an important mediator in the early phase of muscle regeneration...
  17. pmc Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy
    Naoki Ito
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Channels (Austin) 7:221-4. 2013
    ..Furthermore, the TRPV1-induced phosphorylation patterns resembled those induced by mechanical load. Our results continue to highlight the importance of TRPV1-mediated calcium signaling in load-induced intracellular signaling pathways...
  18. doi Gene therapy for muscle disease
    Yuko Miyagoe-Suzuki
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo, Japan
    Exp Cell Res 316:3087-92. 2010
    ..Ongoing clinical trials show restoration of dystrophin in DMD patients without serious side effects. Here, we summarize the recent progress in gene therapy, with an emphasis on exon skipping for DMD...
  19. doi Establishment of bipotent progenitor cell clone from rat skeletal muscle
    Yousuke Murakami
    Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, Japan
    Anim Sci J 82:764-72. 2011
    ..These results indicate the presence of bipotent progenitor cells in rat skeletal muscle, and suggest that such cells may contribute to ectopic fat formation in skeletal muscle...
  20. ncbi Interleukin 6 induces overexpression of the sarcolemmal utrophin in neonatal mdx skeletal muscle
    Keita Fujimori
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Hum Gene Ther 13:509-18. 2002
    ..Taken together, these results suggest that IL-6 can induce overexpression of utrophin on the extrasynaptic sarcolemma but requires preexisting factors in neonatal mdx muscle to fully regulate utrophin expression...