Yasuhiro Matsumura

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer
    Yasuhiro Matsumura
    Division of Gastrointestinal Oncology, Department of Medicine, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 32:9-13. 2002
  2. doi request reprint Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients
    Keiko Maekawa
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:646-58. 2011
  3. doi request reprint Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil
    Takako Eguchi Nakajima
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 122:2148-53. 2008
  4. ncbi request reprint Small cell carcinoma of the esophagus. Analysis of 14 cases and literature review
    Ayumu Hosokawa
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 52:1738-41. 2005
  5. ncbi request reprint Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
    Keiko Maekawa
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    J Hum Genet 52:804-19. 2007
  6. doi request reprint Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant
    Minoru Tada
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Immunogenetics 64:869-77. 2012
  7. ncbi request reprint Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population
    Yoshiro Saito
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:107-16. 2011
  8. doi request reprint Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
    Ken Kato
    Gastrointestinal Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Invest New Drugs 30:1621-7. 2012
  9. ncbi request reprint Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population
    Kimie Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 23:139-47. 2008
  10. ncbi request reprint Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors
    Kuniaki Shirao
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, 104 0045, Japan
    Jpn J Clin Oncol 36:295-300. 2006

Detail Information

Publications53

  1. ncbi request reprint Effect of a 3-hour interval between methotrexate and 5-fluorouracil in the treatment of metastatic colorectal cancer
    Yasuhiro Matsumura
    Division of Gastrointestinal Oncology, Department of Medicine, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 32:9-13. 2002
    ..This phase II study was designed to evaluate the efficacy and toxicity of 3-h interval sequential methotrexate (MTX) and 5-fluorouracil (5-FU) with leucovorin (LV) rescue in the treatment of patients with metastatic colorectal cancer...
  2. doi request reprint Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients
    Keiko Maekawa
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:646-58. 2011
    ..Finally, haplotype combinations of both genes were classified into 3 major types: GSTA1*A-GSTA2*C, GSTA1*A-GSTA2*B, and GSTA1*B-GSTA2*E. These findings will be useful in pharmacogenomic studies on xenobiotics including anticancer drugs...
  3. doi request reprint Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil
    Takako Eguchi Nakajima
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 122:2148-53. 2008
    ..Optimal therapeutic synergy was observed between NK012 and 5FU, therefore, this regimen is considered to hold promise of clinical benefit, especially for patients with colorectal cancer...
  4. ncbi request reprint Small cell carcinoma of the esophagus. Analysis of 14 cases and literature review
    Ayumu Hosokawa
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 52:1738-41. 2005
    ..The aims of this study are to retrospectively analyze data on the epidemiology, clinical characteristics, and treatment outcomes of 14 cases of small cell carcinoma of the esophagus...
  5. ncbi request reprint Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
    Keiko Maekawa
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    J Hum Genet 52:804-19. 2007
    ..This study provides fundamental information for pharmacogenetic studies for evaluating the efficacy and toxicity of 5-FU in Japanese and probably East Asians...
  6. doi request reprint Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant
    Minoru Tada
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Immunogenetics 64:869-77. 2012
    ..The current results suggest that L273P could have functional significance in the antibody-dependent clinical responses through FcγRIIa...
  7. ncbi request reprint Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population
    Yoshiro Saito
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:107-16. 2011
    ..03 frequencies accounted for more than 81% of the inferred haplotypes. This study provides fundamental and useful information for the pharmacogenetic studies of drugs metabolized by CYPs in the Japanese population...
  8. doi request reprint Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
    Ken Kato
    Gastrointestinal Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Invest New Drugs 30:1621-7. 2012
    ..This study aimed to evaluate the efficacy and safety of NK105 in patients with advanced gastric cancer after failure of first-line chemotherapy...
  9. ncbi request reprint Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population
    Kimie Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 23:139-47. 2008
    ..Moreover, the allele 1446C>T (Thr482Thr), which has increased activity, was not detected in our Japanese population. These findings imply possible differences in MRP2-mediated drug responses between Asians and Caucasians...
  10. ncbi request reprint Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors
    Kuniaki Shirao
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, 104 0045, Japan
    Jpn J Clin Oncol 36:295-300. 2006
    ..The generally recommended dose and schedule of oxaliplatin monotherapy is 130 mg/m(2) every 3 weeks. This trial was conducted to evaluate the safety and pharmacokinetics of oxaliplatin monotherapy in Japanese patients with solid tumors...
  11. ncbi request reprint Antitumor effect of MCC-465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts
    Tetsuya Hamaguchi
    Department of Medicine, Department of Pathology, President, National Cancer Center, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:608-13. 2004
    ..Immunohistochemistry with GAH revealed that 94% (100 of 106) of surgical specimens of colorectal cancer were GAH-positive. These results warrant a phase I clinical trial of MCC-465 for patients with metastatic colorectal cancer...
  12. doi request reprint Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors
    Tetsuya Hamaguchi
    Division of Gastrointestinal Oncology, National Cancer Center Hospital, Pharmaceutical Research Laboratories and Pharmaceutical Development, Nippon Kayaku Co Ltd, Tokyo, Japan
    Clin Cancer Res 16:5058-66. 2010
    ..We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic profile, and document any antitumor activity of NK012, a novel SN-38-incorporating micellar nanoparticle...
  13. ncbi request reprint Long-term survivor of gastric small cell carcinoma
    Ayumu Hosokawa
    Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 51:1567-70. 2004
    ..In March 2001, the tumor recurred in the stomach and the patient underwent a total gastrectomy. He has survived free of disease for more than 2 years after the first diagnosis...
  14. pmc Characteristics and outcomes of patients with advanced gastric cancer who declined to participate in a randomized clinical chemotherapy trial
    Chiharu Tanai
    Medical Oncology Division, National Cancer Center Hospital, Tokyo Faculty of Pharmaceutical Science, Josai University, Saitama Medical Oncology Division, Aichi Cancer Central, Aichi Medical Oncology Division, Oita University, Oita Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan
    J Oncol Pract 7:148-53. 2011
    ..We have analyzed the characteristics and outcomes of patients who declined to participate in a randomized trial in comparison with those who participated in the trial...
  15. ncbi request reprint Weekly hepatic arterial infusion of 5-fluorouracil and subsequent systemic chemotherapy for liver metastases from colorectal cancer
    Ayumu Hosokawa
    Gastrointestinal Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 33:132-5. 2003
    ..In addition, the present study also evaluated the efficacy of second-line chemotherapy after termination of HAI...
  16. ncbi request reprint Phase I and pharmacokinetic study of KRN5500, a spicamycin derivative, for patients with advanced solid tumors
    Noboru Yamamoto
    Division of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 33:302-8. 2003
    ..KRN5500, a novel spicamycin derivative, shows an inhibitory effect on protein synthesis. This phase I study was aimed at investigating the toxicity, maximum tolerated dose (MTD) and pharmacokinetics of this compound...
  17. ncbi request reprint Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:509-16. 2006
    ..In Blocks 1 and 3, 7 and 19 haplotypes were determined/inferred, respectively. Our findings provide fundamental and useful information for genotyping TYMS in the Japanese and probably other Asian populations...
  18. ncbi request reprint New approaches for pancreatic cancer in Japan
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Cancer Chemother Pharmacol 54:S78-82. 2004
    ..The expanding understanding of molecular and genetic biology should facilitate research to develop novel molecular-targeted agents and to establish individualized therapy regimens for this disease...
  19. ncbi request reprint Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis
    Akiko Ishii-Watabe
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 25:578-87. 2010
    ..These results suggested that at least no common functional polymorphic site with amino acid change was present in the FCGRT of our Japanese population...
  20. ncbi request reprint Prevalence of diseases and statistical power of the Japan Nurses' Health Study
    Toshiharu Fujita
    Department of Data Science, The Institute of Statistical Mathematics, Tokyo, Japan
    Ind Health 45:687-94. 2007
    ..0. For these diseases, the statistical power to detect risk factors with a relative risk of 1.5 or more within ten years, was 70% or higher...
  21. ncbi request reprint Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil)
    Yoshihisa Tsukioka
    Department of Medicine, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1145-53. 2002
    ..It has been suggested that drug carrier systems such as liposomes and micelles should be selected appropriately bearing in mind the characteristics of the tumor vasculature and the tumor interstitium...
  22. doi request reprint Polymeric micellar delivery systems in oncology
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 38:793-802. 2008
    ..Phase 1 studies of a cisplatin-incorporated micelle, NC-6004 and an SN-38-incorporated micelle, NK012, are now underway. A Phase 2 study of a paclitaxel-incorporated micelle, NK105, against stomach cancer is also underway...
  23. ncbi request reprint Preclinical and clinical studies of anticancer agent-incorporating polymer micelles
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Cancer Sci 100:572-9. 2009
    ..Presently, several anticancer agent-incorporating micelle carrier systems are under preclinical and clinical evaluation. Furthermore, nucleic acid-incorporating micelle carrier systems are also being developed...
  24. doi request reprint Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center of Innovative Oncology, Kashiwanoha, Kashiwa, Japan
    Adv Drug Deliv Rev 63:184-92. 2011
    ..Phase II studies are ongoing in patients with colorectal cancer in Japan and in patients with triple negative breast cancer and small cell lung cancer in the USA...
  25. doi request reprint A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women
    Takeshi Aso
    Department of Obstetrics and Gynecology, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    J Womens Health (Larchmt) 21:92-100. 2012
    ..The objective of this clinical trial was to examine the efficacy of a supplement containing natural S-(-)equol, a daidzein metabolite, in reducing menopausal symptoms...
  26. ncbi request reprint New Quantitative Index for Dietary Diversity (QUANTIDD) and its annual changes in the Japanese
    Kota Katanoda
    Division of Health Informatics and Education, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 22:283-7. 2006
    ..This report proposes a new dietary diversity index based on quantitative distribution of consumed foods to allow objective measurement of dietary diversity...
  27. doi request reprint The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
    Takuro Furusawa
    Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
    Hum Genet 127:287-94. 2010
    ..The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations...
  28. ncbi request reprint Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice
    Nobuhiro Nishiyama
    Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
    Cancer Res 63:8977-83. 2003
    ..These data suggest that CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors...
  29. ncbi request reprint Is the national nutrition survey in Japan representative of the entire Japanese population?
    Kota Katanoda
    Division of Health Informatics and Education, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 21:964-6. 2005
    ..We examined the representativeness of the sample used in the National Nutrition Survey in Japan (J-NNS)...
  30. ncbi request reprint Incorporation of the anticancer agent KRN5500 into polymeric micelles diminishes the pulmonary toxicity
    Yasuo Mizumura
    Department of Medicine, National Cancer Center, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1237-43. 2002
    ..These results indicate that KRN/m may be useful for reducing the pulmonary toxicity associated with the current formulation of KRN5500, while fully maintaining its antitumor activity...
  31. doi request reprint Poly (amino acid) micelle nanocarriers in preclinical and clinical studies
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa City, 277 8577 Japan
    Adv Drug Deliv Rev 60:899-914. 2008
    ..Phase 1 studies of a CDDP incorporated micelle, Nc-6004, and an sN-38 incorporated micelle, NK012, are now underway. A phase 2 study of a PTX incorporated micelle, NK105, against stomach cancer is also underway...
  32. ncbi request reprint Randomized study of dexamethasone treatment for delayed emesis, anorexia and fatigue induced by irinotecan
    Akira Inoue
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryomachi Aobaku, 980 8575, Sendai, Japan
    Support Care Cancer 11:528-32. 2003
    ..These results suggest that treatment with Dex may be beneficial to reduce post-chemotherapy symptoms induced by irinotecan, specifically anorexia and fatigue, with acceptable toxicities...
  33. ncbi request reprint Prognostic factors for patients with metastatic colorectal cancer receiving protracted venous infusion of 5-FU
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research Jikei University School of Medicine, Chiba, Japan
    Am J Clin Oncol 25:182-6. 2002
    ..In multivariate analysis, the favorable prognostic factors were normal albumin level (<or=3.7 g/dl), histologic grades I, II, and low carcinoembryonic antigen level (<100 ng/ml)...
  34. ncbi request reprint [Micelle carrier system in clinical trial]
    Yasuhiro Matsumura
    Investigative Treatment Division, National Cancer Center Research Institute East
    Nihon Rinsho 64:316-21. 2006
    ....
  35. ncbi request reprint Preclinical and clinical studies of anticancer drug-incorporated polymeric micelles
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Drug Target 15:507-17. 2007
    ..Here I overview some of the more important approaches, assessing usefulness and seeking to identify the most promising ways to apply the phenomenon of passive targeting for improved clinical outcome...
  36. doi request reprint Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I
    Masashi Imanishi
    Chemistry Research Laboratories, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba shi, Ibaraki, Japan
    J Med Chem 51:1925-44. 2008
    ..This represents the first demonstrated result dealing with beta 3-AR agonists...
  37. ncbi request reprint Dietary diversity in the Japanese national dietary guidelines
    Kota Katanoda
    Nutr Rev 63:37. 2005
  38. ncbi request reprint [Establishment of Healthy Japan 21 Regional plans according to local community type]
    Kota Katanoda
    Division of Health Informatics and Education, National Institute of Health and Nutrition, Japan
    Nihon Koshu Eisei Zasshi 52:817-23. 2005
    ..To examine the establishment of Health Japan 21 regional plans according to the local community type...
  39. ncbi request reprint Multigenerational family structure in Japanese society: impacts on stress and health behaviors among women and men
    Yasuhisa Takeda
    Harvard School of Public Health, Center for Society and Health, 677 Huntington Avenue, Boston, MA 02115 6096, USA
    Soc Sci Med 59:69-81. 2004
    ..These findings suggest gender-specific patterns of worries and health behaviors that reflect both the health-protecting and health-damaging effects of living in multigenerational households...
  40. ncbi request reprint Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles
    Nobuhiro Nishiyama
    Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
    Bioconjug Chem 14:449-57. 2003
    ..The results suggest that use of the macromolecular carriers may yield additional therapeutic effects over free drug...
  41. ncbi request reprint National Nutrition Survey in Japan--its methodological transition and current findings
    Kota Katanoda
    Division of Health Informatics and Education, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:423-32. 2002
    ..Then the findings of the J-NNS are summarized, which highlights annual changes in the intake of energy, macronutrients, micronutrients and food groups. The current findings of the dietary habit questionnaire are also given in brief...
  42. ncbi request reprint PCR-based assessment of the recovery rate of exfoliated colonocytes or cancer cells from fecal samples depends on the storage conditions after defecation
    Shigeki Onouchi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    J Gastrointestin Liver Dis 16:369-72. 2007
    ..The purpose of the present study was to determine how long after defecation and at what temperature the fecal samples should be stored to isolate the colonocytes successfully...
  43. ncbi request reprint Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors
    Fumiaki Koizumi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Res 66:10048-56. 2006
    ..NK012 markedly enhanced the antitumor activity of SN-38, especially in highly VEGF-secreting tumors, and could be a promising SN-38-based formulation...
  44. ncbi request reprint Time-lag estimate between dietary intake and breast cancer mortality in Japan
    Emiko Harashima
    Faculty of Human Life Sciences, Jissen Women s University, 4 1 1 Osakaue, Hino shi, Tokyo 191 8510, Japan
    Asia Pac J Clin Nutr 16:193-8. 2007
    ..It is deduced from the results that the increased MBC in Japanese women is related to the long-term effect from the intake of a high-fat, high-animal protein and low-fiber diet typical in the western world...
  45. ncbi request reprint Respiratory symptoms correlating to smoking prevalence: the National Nutrition Survey and the National Life-style Survey in Japan
    Shinichi Asahi
    Department of Public Health, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Epidemiol 13:226-31. 2003
    ..Although the fact that smoking habits have adverse effects on health, whether the high proportion of smokers elevates the prevalence of symptoms relating to the smoking in a community is still unknown...
  46. ncbi request reprint Design of the Japan Nurses' Health Study: a prospective occupational cohort study of women's health in Japan
    Kunihiko Hayashi
    Department of Basic Allied Medicine, School of Health Sciences, Gunma University, Gunma, Japan
    Ind Health 45:679-86. 2007
    ..Changes in lifestyle, healthcare, incidence of disease, and health outcomes over time will now be studied. The cohort receives annual JNHS newsletters and biennial follow-up questionnaires by mail...
  47. ncbi request reprint Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancer
    Satoshi Yajima
    Genetics Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 31:1029-37. 2007
    ..Our extensive gene list provides other markers for fecal RNA-based colorectal cancer screening...
  48. ncbi request reprint Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I to assess dietary fiber intake: comparison with dietary records
    Satoshi Sasaki
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa, Chiba, Japan
    J Epidemiol 13:S106-14. 2003
    ..The FFQ can be used for ranking individuals for dietary fiber intakes in epidemiologic studies, despite the difficulty in estimating mean intake...
  49. doi request reprint Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor
    Yohei Saito
    Investigative Treatment Division, Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Cancer Sci 99:1258-64. 2008
    ..Because the antitumor activity of SN-38 is time dependent, NK012, which combines enhanced distribution with sustained release of SN-38 within tumors, may be ideal for the treatment of hypovascular tumors, such as pancreatic cancer...
  50. ncbi request reprint Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles
    Ryo Suzuki
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, Teikyo University, 1091 1 Suwarashi, Sagamiko, Sagamihara, Kanagawa 229 0195, Japan
    J Control Release 125:137-44. 2008
    ..We conclude that the combination of Bubble liposomes and ultrasound is a minimally-invasive and tumor specific gene transfer method in vivo...
  51. ncbi request reprint New method for colorectal cancer diagnosis based on SSCP analysis of DNA from exfoliated colonocytes in naturally evacuated feces
    Shigeki Onouchi
    Investigative Treatment Division, Research Center for Innovate Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Japan
    Anticancer Res 28:145-50. 2008
    ....
  52. doi request reprint Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression
    Makoto Sumitomo
    Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Cancer Res 68:1631-5. 2008
    ..Our study shows the outstanding advantage of polymeric micelle-based drug carriers and suggests that NK012 would be effective in treating disseminated RCCs with irregular vascular architectures...
  53. ncbi request reprint A new method for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis
    Hisayuki Matsushita
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Gastroenterology 129:1918-27. 2005
    ....