Yasuhiro Matsumura

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint The drug discovery by nanomedicine and its clinical experience
    Yasuhiro Matsumura
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Jpn J Clin Oncol 44:515-25. 2014
  2. pmc Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats
    H Uchino
    Investigative Treatment Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Br J Cancer 93:678-87. 2005
  3. pmc NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
    T Hamaguchi
    Department of Medicine, President of National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 92:1240-6. 2005
  4. pmc NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel
    T Negishi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Br J Cancer 95:601-6. 2006
  5. pmc Improved recovery of exfoliated colonocytes from feces using newly developed immunomagnetic beads
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Gastroenterol Res Pract 2008:605273. 2008
  6. pmc Discovery of an uncovered region in fibrin clots and its clinical significance
    Yohei Hisada
    Division of Developmental Therapeutics, Research Centre for Innovative Oncology, National Cancer Centre Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Sci Rep 3:2604. 2013
  7. ncbi request reprint Gene expression analysis using a highly sensitive DNA microarray for colorectal cancer screening
    Yoshikatsu Koga
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Anticancer Res 34:169-76. 2014
  8. doi request reprint Cancer stromal targeting (CAST) therapy
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Japan
    Adv Drug Deliv Rev 64:710-9. 2012
  9. ncbi request reprint Preclinical and clinical studies of anticancer agent-incorporating polymer micelles
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Cancer Sci 100:572-9. 2009
  10. ncbi request reprint Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil)
    Yoshihisa Tsukioka
    Department of Medicine, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1145-53. 2002

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. ncbi request reprint The drug discovery by nanomedicine and its clinical experience
    Yasuhiro Matsumura
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Jpn J Clin Oncol 44:515-25. 2014
    ....
  2. pmc Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats
    H Uchino
    Investigative Treatment Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Br J Cancer 93:678-87. 2005
    ....
  3. pmc NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
    T Hamaguchi
    Department of Medicine, President of National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 92:1240-6. 2005
    ..001) and physiological (P<0.05) methods for the first time. The present study suggests that NK105 warrants a clinical trial for patients with metastatic solid tumours...
  4. pmc NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel
    T Negishi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Br J Cancer 95:601-6. 2006
    ..The present study results suggest that further clinical trials are warranted to determine the efficacy and feasibility of combined NK105 therapy with radiation...
  5. pmc Improved recovery of exfoliated colonocytes from feces using newly developed immunomagnetic beads
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Gastroenterol Res Pract 2008:605273. 2008
    ..The newly developed immunomagnetic beads may be useful for isolating colorectal cancer cells from feces, enabling the cytological or molecular biological diagnosis of CRC...
  6. pmc Discovery of an uncovered region in fibrin clots and its clinical significance
    Yohei Hisada
    Division of Developmental Therapeutics, Research Centre for Innovative Oncology, National Cancer Centre Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Sci Rep 3:2604. 2013
    ..Because erosive tumours are apt to cause micro-haemorrhages, even early asymptomatic tumours detected with a radiolabelled 102-10 mAb may be aggressively malignant...
  7. ncbi request reprint Gene expression analysis using a highly sensitive DNA microarray for colorectal cancer screening
    Yoshikatsu Koga
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Anticancer Res 34:169-76. 2014
    ..In the present study, the usefulness of CRC screening with a highly sensitive DNA microarray was evaluated in comparison with that by FOBT using fecal samples...
  8. doi request reprint Cancer stromal targeting (CAST) therapy
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Japan
    Adv Drug Deliv Rev 64:710-9. 2012
    ..Cancer-stroma targeting (CAST) therapy was thus validated as a new modality of oncological therapy, especially for refractory, stromal-rich cancers...
  9. ncbi request reprint Preclinical and clinical studies of anticancer agent-incorporating polymer micelles
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Cancer Sci 100:572-9. 2009
    ..Presently, several anticancer agent-incorporating micelle carrier systems are under preclinical and clinical evaluation. Furthermore, nucleic acid-incorporating micelle carrier systems are also being developed...
  10. ncbi request reprint Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil)
    Yoshihisa Tsukioka
    Department of Medicine, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1145-53. 2002
    ..It has been suggested that drug carrier systems such as liposomes and micelles should be selected appropriately bearing in mind the characteristics of the tumor vasculature and the tumor interstitium...
  11. pmc Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
    Y Matsumura
    Investigative Treatment Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    Br J Cancer 91:1775-81. 2004
    ..NK911 was well tolerated and produced only moderate nausea and vomiting at myelosuppressive dosages. The recommended phase II dose was determined to be 50 mg m(-2) every 3 weeks...
  12. ncbi request reprint Phase I and pharmacokinetic study of MCC-465, a doxorubicin (DXR) encapsulated in PEG immunoliposome, in patients with metastatic stomach cancer
    Y Matsumura
    Investigative Treatment Division, National Cancer Center Research Institute East, National Cancer Center Hospital, Tokyo, Japan
    Ann Oncol 15:517-25. 2004
    ..The main purpose of this trial was to define the maximum tolerated dose (MTD), dose limiting toxicity (DLT), recommended phase II dose and pharmacokinetics (PK) of MCC-465...
  13. doi request reprint Polymeric micellar delivery systems in oncology
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 38:793-802. 2008
    ..Phase 1 studies of a cisplatin-incorporated micelle, NC-6004 and an SN-38-incorporated micelle, NK012, are now underway. A Phase 2 study of a paclitaxel-incorporated micelle, NK105, against stomach cancer is also underway...
  14. ncbi request reprint An interim analysis of phase I clinical trial of MCC-465, a doxorubicin (DXR) encapsulated in PEG-immunoliposome, in patients with metastatic stomach cancer
    Y Matsumura
    Investigative Treatment Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Adv Exp Med Biol 519:179-93. 2003
  15. doi request reprint Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center of Innovative Oncology, Kashiwanoha, Kashiwa, Japan
    Adv Drug Deliv Rev 63:184-92. 2011
    ..Phase II studies are ongoing in patients with colorectal cancer in Japan and in patients with triple negative breast cancer and small cell lung cancer in the USA...
  16. doi request reprint Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer
    Tatsuya Nagano
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 127:2699-706. 2010
    ..NK012/S-1 combination is a promising candidate regimen against NSCLC without inducing toxicities such as severe diarrhea and therefore warrants clinical evaluation...
  17. doi request reprint Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil
    Takako Eguchi Nakajima
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 122:2148-53. 2008
    ..Optimal therapeutic synergy was observed between NK012 and 5FU, therefore, this regimen is considered to hold promise of clinical benefit, especially for patients with colorectal cancer...
  18. doi request reprint The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts
    Hirotsugu Kenmotsu
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan
    Cancer 116:4597-604. 2010
    ..In the current study, the authors examined the antitumor effect of NK012 in combination with Bv against human lung cancer...
  19. ncbi request reprint Weekly hepatic arterial infusion of 5-fluorouracil and subsequent systemic chemotherapy for liver metastases from colorectal cancer
    Ayumu Hosokawa
    Gastrointestinal Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 33:132-5. 2003
    ..In addition, the present study also evaluated the efficacy of second-line chemotherapy after termination of HAI...
  20. doi request reprint Antitumor effect of NK012, a 7-ethyl-10-hydroxycamptothecin-incorporating polymeric micelle, on U87MG orthotopic glioblastoma in mice compared with irinotecan hydrochloride in combination with bevacizumab
    Jun Ichiro Kuroda
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Japan
    Clin Cancer Res 16:521-9. 2010
    ..To clarify the effect of bevacizumab on NK012 therapy in mice bearing U87MG glioblastoma orthotopic xenografts in comparison with the combination therapy of irinotecan hydrochloride (CPT-11) with bevacizumab...
  21. doi request reprint Genetic variation and haplotype structures of the glutathione S-transferase genes GSTA1 and GSTA2 in Japanese colorectal cancer patients
    Keiko Maekawa
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:646-58. 2011
    ..Finally, haplotype combinations of both genes were classified into 3 major types: GSTA1*A-GSTA2*C, GSTA1*A-GSTA2*B, and GSTA1*B-GSTA2*E. These findings will be useful in pharmacogenomic studies on xenobiotics including anticancer drugs...
  22. doi request reprint MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Cancer Prev Res (Phila) 3:1435-42. 2010
    ..miRNA expression analysis of the isolated colonocytes may be a useful method for CRC screening. Furthermore, oncogenic miRNA highly expressed in CRC should be investigated for CRC screening tests in the future...
  23. ncbi request reprint Small cell carcinoma of the esophagus. Analysis of 14 cases and literature review
    Ayumu Hosokawa
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 52:1738-41. 2005
    ..The aims of this study are to retrospectively analyze data on the epidemiology, clinical characteristics, and treatment outcomes of 14 cases of small cell carcinoma of the esophagus...
  24. doi request reprint Antitumour activity of NK012, SN-38-incorporating polymeric micelles, in hypovascular orthotopic pancreatic tumour
    Yohei Saito
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Eur J Cancer 46:650-8. 2010
    ..NK012 appeared to exert potent antitumour activity against intractable stroma-rich orthotopic pancreatic tumour xenografts due to its sufficient accumulation followed by the effective sustained release of SN-38 from NK012...
  25. doi request reprint Detection of the DNA point mutation of colorectal cancer cells isolated from feces stored under different conditions
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Jpn J Clin Oncol 39:62-9. 2009
    ..The aim of the present study was to investigate with real-time PCR and direct sequencing analysis whether the cancer cells could be detected in feces stored under different conditions after evacuation...
  26. ncbi request reprint Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model
    Yoshiyuki Yamamoto
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan Department of Gastroenterology and Hepatology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Cancer 135:214-23. 2014
    ..The combined use of the micelles was associated with remarkable efficacy and favorable toxicities in the human gastric cancer model, and warrants the conduct of clinical trials. ..
  27. ncbi request reprint Antitumor activity of NK012 combined with cisplatin against small cell lung cancer and intestinal mucosal changes in tumor-bearing mouse after treatment
    Tatsuya Nagano
    Investigative Treatment Division, Research Center for Innovative Oncology and Thoracic Oncology Division, National Cancer Center Hospital East, Chiba, Japan
    Clin Cancer Res 15:4348-55. 2009
    ....
  28. ncbi request reprint Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
    Keiko Maekawa
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    J Hum Genet 52:804-19. 2007
    ..This study provides fundamental information for pharmacogenetic studies for evaluating the efficacy and toxicity of 5-FU in Japanese and probably East Asians...
  29. doi request reprint Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan
    Takako Eguchi Nakajima
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Res 68:9318-22. 2008
    ..NK012 also showed antitumor activity against peritoneal nodules. Thus, NK012 showing enhanced distribution with prolonged SN-38 release may be ideal for cancer treatment because the antitumor activity of SN-38 is time dependent...
  30. doi request reprint NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin
    Amane Takahashi
    Division of Developmental Therapeutics, Research Center for Innovative Oncology, Kashiwa, Japan
    Cancer Sci 104:920-5. 2013
    ..In contrast, cardiac functions of NC-6300 treated mice were no less well maintained than in control mice. This study warrants a clinical evaluation of NC-6300 in patients with hepatocellular carcinoma or other cancers...
  31. ncbi request reprint Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test
    Yoshikatsu Koga
    Authors Affiliations Division of Developmental Therapeutics, Research Center for Innovative Oncology Colorectal and Pelvic Surgery Division, National Cancer Center Hospital East, Kashiwa Colorectal Surgery Division, National Cancer Center Hospital and Screening Technology and Development Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 22:1844-52. 2013
    ..In this study, we investigated a new colorectal cancer screening method combining iFOBT and FmiRT to improve the sensitivity compared with iFOBT alone...
  32. doi request reprint Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Cancer Sci 99:1977-83. 2008
    ..Therefore, improvement of the colonocyte retrieval system from feces may be necessary for the technique to be developed for clinical use...
  33. doi request reprint Application of the fecal microRNA test to the residuum from the fecal occult blood test
    Nobuyoshi Yamazaki
    Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Kashiwa, Japan
    Jpn J Clin Oncol 43:726-33. 2013
    ..Here we investigated the applicability of the fecal microRNA test to fecal samples that had been used for a previous fecal occult blood test and stored under various conditions...
  34. doi request reprint Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer
    Kazuyoshi Yanagihara
    Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan
    Ther Deliv 5:129-38. 2014
    ..Gastric cancer with liver metastasis (LM) is associated with poor prognosis due to rapid progression. It is, therefore, important to develop a quantitative and highly reproducible animal model of LM using human gastric cancer cells...
  35. ncbi request reprint Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data
    Hiro Takahashi
    Graduate School of Horticulture, Chiba University, 648 Matsudo, Matsudo, Chiba 271 8510, Japan Plant Biology Research Center, Chubu University, Matsumoto cho 1200, Kasugai, Aichi 487 8501, Japan Division of Genetics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan Electronic address
    J Biosci Bioeng 116:768-73. 2013
    ..These results suggest that rs2293347 is a potential predictive factor for selecting chemotherapies, such as fluoropyrimidine alone or combination chemotherapies...
  36. ncbi request reprint Antitumor effect of MCC-465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts
    Tetsuya Hamaguchi
    Department of Medicine, Department of Pathology, President, National Cancer Center, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:608-13. 2004
    ..Immunohistochemistry with GAH revealed that 94% (100 of 106) of surgical specimens of colorectal cancer were GAH-positive. These results warrant a phase I clinical trial of MCC-465 for patients with metastatic colorectal cancer...
  37. doi request reprint Enhanced distribution of NK012, a polymeric micelle-encapsulated SN-38, and sustained release of SN-38 within tumors can beat a hypovascular tumor
    Yohei Saito
    Investigative Treatment Division, Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Cancer Sci 99:1258-64. 2008
    ..Because the antitumor activity of SN-38 is time dependent, NK012, which combines enhanced distribution with sustained release of SN-38 within tumors, may be ideal for the treatment of hypovascular tumors, such as pancreatic cancer...
  38. doi request reprint Detailed distribution of NK012, an SN-38-incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases
    Amane Takahashi
    Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Clin Cancer Res 16:4822-31. 2010
    ....
  39. doi request reprint Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant
    Minoru Tada
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Immunogenetics 64:869-77. 2012
    ..The current results suggest that L273P could have functional significance in the antibody-dependent clinical responses through FcγRIIa...
  40. ncbi request reprint New method for colorectal cancer diagnosis based on SSCP analysis of DNA from exfoliated colonocytes in naturally evacuated feces
    Shigeki Onouchi
    Investigative Treatment Division, Research Center for Innovate Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Japan
    Anticancer Res 28:145-50. 2008
    ....
  41. ncbi request reprint Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population
    Yoshiro Saito
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 26:107-16. 2011
    ..03 frequencies accounted for more than 81% of the inferred haplotypes. This study provides fundamental and useful information for the pharmacogenetic studies of drugs metabolized by CYPs in the Japanese population...
  42. ncbi request reprint Phase I and pharmacokinetic study of KRN5500, a spicamycin derivative, for patients with advanced solid tumors
    Noboru Yamamoto
    Division of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 33:302-8. 2003
    ..KRN5500, a novel spicamycin derivative, shows an inhibitory effect on protein synthesis. This phase I study was aimed at investigating the toxicity, maximum tolerated dose (MTD) and pharmacokinetics of this compound...
  43. ncbi request reprint Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors
    Fumiaki Koizumi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Res 66:10048-56. 2006
    ..NK012 markedly enhanced the antitumor activity of SN-38, especially in highly VEGF-secreting tumors, and could be a promising SN-38-based formulation...
  44. doi request reprint Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
    Ken Kato
    Gastrointestinal Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Invest New Drugs 30:1621-7. 2012
    ..This study aimed to evaluate the efficacy and safety of NK105 in patients with advanced gastric cancer after failure of first-line chemotherapy...
  45. ncbi request reprint Long-term survivor of gastric small cell carcinoma
    Ayumu Hosokawa
    Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 51:1567-70. 2004
    ..In March 2001, the tumor recurred in the stomach and the patient underwent a total gastrectomy. He has survived free of disease for more than 2 years after the first diagnosis...
  46. doi request reprint Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma
    Jun Ichiro Kuroda
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Int J Cancer 124:2505-11. 2009
    ..Currently, a phase I study of NK012 is almost complete in Japan and the US. The present translational study warrants the clinical phase II study of NK012 in patients with malignant glioma...
  47. doi request reprint Poly (amino acid) micelle nanocarriers in preclinical and clinical studies
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa City, 277 8577 Japan
    Adv Drug Deliv Rev 60:899-914. 2008
    ..Phase 1 studies of a CDDP incorporated micelle, Nc-6004, and an sN-38 incorporated micelle, NK012, are now underway. A phase 2 study of a PTX incorporated micelle, NK105, against stomach cancer is also underway...
  48. ncbi request reprint Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  49. ncbi request reprint Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors
    Kuniaki Shirao
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, 104 0045, Japan
    Jpn J Clin Oncol 36:295-300. 2006
    ..The generally recommended dose and schedule of oxaliplatin monotherapy is 130 mg/m(2) every 3 weeks. This trial was conducted to evaluate the safety and pharmacokinetics of oxaliplatin monotherapy in Japanese patients with solid tumors...
  50. doi request reprint Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors
    Tetsuya Hamaguchi
    Division of Gastrointestinal Oncology, National Cancer Center Hospital, Pharmaceutical Research Laboratories and Pharmaceutical Development, Nippon Kayaku Co Ltd, Tokyo, Japan
    Clin Cancer Res 16:5058-66. 2010
    ..We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic profile, and document any antitumor activity of NK012, a novel SN-38-incorporating micellar nanoparticle...
  51. doi request reprint Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue
    Masahiro Yasunaga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba, Japan
    Bioconjug Chem 22:1776-83. 2011
    ..Cancer-stroma-targeting immunoconjugate therapy was thus validated as a new modality of oncological therapy, especially for refractory, stromal-rich cancers...
  52. ncbi request reprint Prognostic factors for patients with metastatic colorectal cancer receiving protracted venous infusion of 5-FU
    Yoshihisa Namiki
    Institute of Clinical Medicine and Research Jikei University School of Medicine, Chiba, Japan
    Am J Clin Oncol 25:182-6. 2002
    ..In multivariate analysis, the favorable prognostic factors were normal albumin level (<or=3.7 g/dl), histologic grades I, II, and low carcinoembryonic antigen level (<100 ng/ml)...
  53. ncbi request reprint Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity
    Y Mizumura
    Department of Medicine, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:328-36. 2001
    ..CDDP / m treatment caused much less renal damage than CDDP. These results indicate that CDDP / m treatment can reduce CDDP-induced nephrotoxicity without compromising the anticancer cytotoxicity of CDDP...
  54. ncbi request reprint Incorporation of the anticancer agent KRN5500 into polymeric micelles diminishes the pulmonary toxicity
    Yasuo Mizumura
    Department of Medicine, National Cancer Center, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1237-43. 2002
    ..These results indicate that KRN/m may be useful for reducing the pulmonary toxicity associated with the current formulation of KRN5500, while fully maintaining its antitumor activity...
  55. ncbi request reprint Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice
    Nobuhiro Nishiyama
    Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
    Cancer Res 63:8977-83. 2003
    ..These data suggest that CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors...
  56. doi request reprint Tailored immunoconjugate therapy depending on a quantity of tumor stroma
    Masahiro Yasunaga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Sci 104:231-7. 2013
    ..The conjugate-design, in parallel with the choice of targeting antibodies, should be selected to maximize the therapeutic effect in each individual tumor having a distinct stromal structure...
  57. doi request reprint The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody
    Yohei Saito
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, and Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Eur J Cancer 47:2230-9. 2011
    ..The newly established anti-human TF neutralisation antibody may be useful for the treatment of pancreatic and other invasive cancers...
  58. ncbi request reprint Preclinical and clinical studies of anticancer drug-incorporated polymeric micelles
    Yasuhiro Matsumura
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    J Drug Target 15:507-17. 2007
    ..Here I overview some of the more important approaches, assessing usefulness and seeking to identify the most promising ways to apply the phenomenon of passive targeting for improved clinical outcome...
  59. ncbi request reprint Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population
    Kimie Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 23:139-47. 2008
    ..Moreover, the allele 1446C>T (Thr482Thr), which has increased activity, was not detected in our Japanese population. These findings imply possible differences in MRP2-mediated drug responses between Asians and Caucasians...
  60. ncbi request reprint [Micelle carrier system in clinical trial]
    Yasuhiro Matsumura
    Investigative Treatment Division, National Cancer Center Research Institute East
    Nihon Rinsho 64:316-21. 2006
    ....
  61. ncbi request reprint A new method for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis
    Hisayuki Matsushita
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Gastroenterology 129:1918-27. 2005
    ....
  62. ncbi request reprint Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FU-resistant gastric cancer: a case report
    Y Tsukioka
    Division of Gastrointestinal Oncology, Department of Medicine, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 31:450-3. 2001
    ..We consider that the efficacy of S-1 for treatment of 5-FU-resistant gastric cancer should be verified...
  63. doi request reprint New concept of cytotoxic immunoconjugate therapy targeting cancer-induced fibrin clots
    Masahiro Yasunaga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Cancer Sci 102:1396-402. 2011
    ..This new cancer stroma-targeting therapy may result in an increased duration of drug exposure and be a highly effective new therapy, particularly for refractory, stroma-rich cancers...
  64. ncbi request reprint Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancer
    Satoshi Yajima
    Genetics Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 31:1029-37. 2007
    ..Our extensive gene list provides other markers for fecal RNA-based colorectal cancer screening...
  65. ncbi request reprint Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:509-16. 2006
    ..In Blocks 1 and 3, 7 and 19 haplotypes were determined/inferred, respectively. Our findings provide fundamental and useful information for genotyping TYMS in the Japanese and probably other Asian populations...
  66. ncbi request reprint PCR-based assessment of the recovery rate of exfoliated colonocytes or cancer cells from fecal samples depends on the storage conditions after defecation
    Shigeki Onouchi
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
    J Gastrointestin Liver Dis 16:369-72. 2007
    ..The purpose of the present study was to determine how long after defecation and at what temperature the fecal samples should be stored to isolate the colonocytes successfully...
  67. pmc Exosome can prevent RNase from degrading microRNA in feces
    Yoshikatsu Koga
    Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa
    J Gastrointest Oncol 2:215-22. 2011
    ..Because the stability of miRNA in feces has not been clarified, we examined the stability of miRNA in feces...
  68. pmc Characteristics and outcomes of patients with advanced gastric cancer who declined to participate in a randomized clinical chemotherapy trial
    Chiharu Tanai
    Medical Oncology Division, National Cancer Center Hospital, Tokyo Faculty of Pharmaceutical Science, Josai University, Saitama Medical Oncology Division, Aichi Cancer Central, Aichi Medical Oncology Division, Oita University, Oita Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan
    J Oncol Pract 7:148-53. 2011
    ..We have analyzed the characteristics and outcomes of patients who declined to participate in a randomized trial in comparison with those who participated in the trial...
  69. ncbi request reprint Alcohol consumption and other risk factors for self-reported diabetes among middle-aged Japanese: a population-based prospective study in the JPHC study cohort I
    K Waki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabet Med 22:323-31. 2005
    ..This study was undertaken to evaluate the risk factors for Type 2 diabetes in a population-based prospective study of middle-aged Japanese...
  70. doi request reprint Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo ku 104 0045, Tokyo, Japan
    Carcinogenesis 29:1042-8. 2008
    ..Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer...
  71. doi request reprint 10-Year risk of colorectal cancer: development and validation of a prediction model in middle-aged Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Epidemiol 34:534-41. 2010
    ..As fewer studies on cancer risk prediction were seen so far, we initially developed an assessment tool with synthesizing key information from a variety of CRC risk factors through a large population-based cohort study...
  72. ncbi request reprint Development of the polymer micelle carrier system for doxorubicin
    T Nakanishi
    Drug Research Department, Nippon Kayaku Co, Ltd, 3 31 12 Shimo, Kita ku, 115 8588, Tokyo, Japan
    J Control Release 74:295-302. 2001
    ..We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001...
  73. ncbi request reprint Phase I-II study of irinotecan combined with mitomycin-C in patients with advanced gastric cancer
    T Yamao
    Department of Internal Medicine, Cancer Institute Hospital, Tokyo, National Cancer Center Hospital, Tokyo, Japan
    Ann Oncol 12:1729-35. 2001
    ..The goals of this study were to determine the maximum tolerated dose (MTD), the dose limiting toxicity, the recommended dose (RD), and preliminary anti-tumor activity in a combined CPT-11 and MMC treatment of advanced gastric cancer...
  74. doi request reprint The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution
    Masahiro Yasunaga
    Division of Therapeutics Development, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Sci Rep 3:3050. 2013
    ..NK105 treatment yielded a greater antitumour effect and less neural toxicity in mice than did PTX treatment. The use of high-resolution MALDI-IMS may be an innovative approach for pharmacological evaluation and drug design support. ..
  75. ncbi request reprint Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis
    Akiko Ishii-Watabe
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 25:578-87. 2010
    ..These results suggested that at least no common functional polymorphic site with amino acid change was present in the FCGRT of our Japanese population...
  76. ncbi request reprint Prevalence of diseases and statistical power of the Japan Nurses' Health Study
    Toshiharu Fujita
    Department of Data Science, The Institute of Statistical Mathematics, Tokyo, Japan
    Ind Health 45:687-94. 2007
    ..0. For these diseases, the statistical power to detect risk factors with a relative risk of 1.5 or more within ten years, was 70% or higher...
  77. ncbi request reprint New approaches for pancreatic cancer in Japan
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Cancer Chemother Pharmacol 54:S78-82. 2004
    ..The expanding understanding of molecular and genetic biology should facilitate research to develop novel molecular-targeted agents and to establish individualized therapy regimens for this disease...
  78. doi request reprint Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men: a nested case-control study
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Sci 101:2652-7. 2010
    ..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...
  79. doi request reprint Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan
    Taichi Shimazu
    Research Center for Cancer Prevention and Screening, National Cancer Center Tokyo Japan
    Am J Clin Nutr 91:722-8. 2010
    ..Moreover, no prospective study has addressed this association in men...
  80. doi request reprint Plasma levels of C-reactive protein and serum amyloid A and gastric cancer in a nested case-control study: Japan Public Health Center-based prospective study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Carcinogenesis 31:712-8. 2010
    ..005). In conclusion, our results suggest that those who react strongly to inflammation or who have a high host immune response, as reflected by extremely elevated plasma levels of CRP and SAA, are at a high risk to develop gastric cancer...
  81. ncbi request reprint Reduction of the side effects of an antitumor agent, KRN5500, by incorporation of the drug into polymeric micelles
    Y Matsumura
    Department of Medicine, National Cancer Center Hospital, Tokyo
    Jpn J Cancer Res 90:122-8. 1999
    ..v. Therefore, we expect that KRN/m will be superior to KRN5500 for clinical use and that the methodology of polymeric micelle drug carrier systems can be applied to other water-insoluble drugs...
  82. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009
    ..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...
  83. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
    ..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...
  84. doi request reprint Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, 104 0045 Japan
    Cancer Epidemiol Biomarkers Prev 20:419-27. 2011
    ....
  85. pmc Impact of lifestyle on overall cancer risk among Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Epidemiol 20:90-6. 2010
    ..Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population...
  86. doi request reprint Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 124:1644-9. 2009
    ..Women with hepatitis virus infection may be advised to abstain from isoflavone consumption. Further studies are warranted to confirm these findings...
  87. doi request reprint Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Causes Control 19:1095-102. 2008
    ..Here, we investigated the association between alcohol consumption and lung cancer incidence...
  88. ncbi request reprint Daily total physical activity level and premature death in men and women: results from a large-scale population-based cohort study in Japan (JPHC study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 18:522-30. 2008
    ..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...
  89. doi request reprint Plasma organochlorine levels and subsequent risk of breast cancer among Japanese women: a nested case-control study
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Sci Total Environ 402:176-83. 2008
    ..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...
  90. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  91. ncbi request reprint Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I
    Mitsumasa Umesawa
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Stroke 39:2449-56. 2008
    ....
  92. ncbi request reprint Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study
    Taiki Yamaji
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:1935-40. 2008
    ..Finally, cruciferous vegetables deserve further investigation as foods possibly effective in the prevention of esophageal SCC...
  93. pmc A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation
    T Hamaguchi
    Department of Medicine National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 97:170-6. 2007
    ..NK105 was well tolerated, and the RD for the phase II study was determined to be 150 mg m(-2) every 3 weeks. The results of this phase I study warrant further clinical evaluation...
  94. doi request reprint Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 17:930-7. 2008
    ..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...
  95. doi request reprint Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study)
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Lett 275:240-6. 2009
    ..10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response...
  96. doi request reprint Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:294-91. 2009
    ..15–3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men...
  97. pmc Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil
    Y Yamada
    Medical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 89:816-20. 2003
    ..The AUC(0-10 h) of FBAL was markedly lower and plasma uracil concentrations were significantly higher for S-1 than for PVI of 5-FU, clearly demonstrating the effect of DPD inhibition...
  98. doi request reprint Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 18:26-32. 2009
    ..This finding indicates that ALT level is a good independent determinant of the need for intervention. Clinical application of these findings may help decrease HCC-associated mortality in hepatitis virus-endemic regions...
  99. doi request reprint Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Causes Control 20:741-50. 2009
    ..We prospectively examined whether metabolic factors predicts the subsequent risk of HCC in the Japan Public Health Center-based Prospective Study Cohort II, in consideration of hepatitis virus infection status...
  100. doi request reprint A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women
    Takeshi Aso
    Department of Obstetrics and Gynecology, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    J Womens Health (Larchmt) 21:92-100. 2012
    ..The objective of this clinical trial was to examine the efficacy of a supplement containing natural S-(-)equol, a daidzein metabolite, in reducing menopausal symptoms...
  101. ncbi request reprint New Quantitative Index for Dietary Diversity (QUANTIDD) and its annual changes in the Japanese
    Kota Katanoda
    Division of Health Informatics and Education, National Institute of Health and Nutrition, Tokyo, Japan
    Nutrition 22:283-7. 2006
    ..This report proposes a new dietary diversity index based on quantitative distribution of consumed foods to allow objective measurement of dietary diversity...