Genomes and Genes
Affiliation: National Institute of Advanced Industrial Science and Technology
- The sarcolemmal proteins dysferlin and caveolin-3 interact in skeletal muscleC Matsuda
Molecular Neurobiology Group, Neuroscience Research Institute, AIST, Central 6, Tsukuba 305 8566, Japan
Hum Mol Genet 10:1761-6. 2001..This is the first description of a possible dysferlin interacting protein; it suggests the hypothesis that one function of dysferlin may be to interact with caveolin-3 to subserve signaling functions of caveolae...
- Dysferlin interacts with affixin (beta-parvin) at the sarcolemmaChie Matsuda
Research Institute of Neurobiology, Neuroscience Research Institute, AIST, Central 6, Tsukuba, Ibaraki, Japan
J Neuropathol Exp Neurol 64:334-40. 2005..We also found N-terminal calponin homology domain of affixin as a binding site for dysferlin. Our results suggest that affixin may participate in membrane repair with dysferlin...
- Affixin activates Rac1 via betaPIX in C2C12 myoblastChie Matsuda
Neuroscience Research Institute, AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
FEBS Lett 582:1189-96. 2008..These results suggest that affixin is involved in reorganization of subsarcolemmal cytoskeletal actin by activation of Rac1 through alpha and betaPIXs in skeletal muscle...
- The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interactionRyusuke Yoshimi
Department of Internal Medicine and Clinical Immunology, Yokohama City Graduate School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
J Immunol 176:3611-24. 2006....
- Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II)Eriko Fujita
Divisions of Development and Differentiation, Department of Human Inherited Metabolic Disease, Yokohama, Kanagawa, Japan
Hum Mol Genet 16:618-29. 2007..Mutant dysferlin aggregates on the ER are degraded by the autophagy/lysosome ERAD(II), as an alternative to ERAD(I), when retrotranslocon/ERAD(I) system is impaired by these mutant aggregates...
- Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weaknessLawrence J Hayward
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Clin Invest 118:1437-49. 2008....