Tian-Cheng Li


Affiliation: National Institute of Infectious Diseases
Country: Japan


  1. Yang F, Duan S, Guo Y, Li Y, Yoshizaki S, Takeda N, et al. Current status of hepatitis E virus infection at a rhesus monkey farm in China. Vet Microbiol. 2019;230:244-248 pubmed publisher
    ..However, no significant clinical signs were observed in these monkeys. Further studies are required to identify the source of infection and to evaluate the pathogenicity of HEV in rhesus monkeys. ..
  2. Li T, Yoshimatsu K, Yasuda S, Arikawa J, Koma T, Kataoka M, et al. Characterization of self-assembled virus-like particles of rat hepatitis E virus generated by recombinant baculoviruses. J Gen Virol. 2011;92:2830-7 pubmed publisher
    ..In addition, rat HEV RNA was detected in one rat serum sample that was positive for IgM. These results indicated that rat HEV is widespread and is transmitted among wild rats. ..
  3. Liu X, Saito M, Sayama Y, Suzuki E, Malbas F, Galang H, et al. Seroprevalence and molecular characteristics of hepatitis E virus in household-raised pig population in the Philippines. BMC Vet Res. 2015;11:11 pubmed publisher
    ..Only genotype 3 of HEV was observed, and genetically diverse strains of HEV were found to be circulating in pigs in this study. ..
  4. Li T, Kataoka M, Takahashi K, Yoshizaki S, Kato T, Ishii K, et al. Generation of hepatitis E virus-like particles of two new genotypes G5 and G6 and comparison of antigenic properties with those of known genotypes. Vet Microbiol. 2015;178:150-7 pubmed publisher
    ..Moreover, both anti-G5 and anti-G6 VLPs antibodies could neutralize G3 HEV's ability to infect PLC/PRF/5 cells, suggesting that G5 and G6 HEV have the same serotype as human HEV. ..
  5. Zhou X, Kataoka M, Liu Z, Takeda N, Wakita T, Li T. Characterization of self-assembled virus-like particles of dromedary camel hepatitis e virus generated by recombinant baculoviruses. Virus Res. 2015;210:8-17 pubmed publisher
    ..We also found that the amino acid residue Met-358 affects the small DcHEV-LPs assembly. ..
  6. Li T, Yoshizaki S, Yang T, Kataoka M, Nakamura T, Ami Y, et al. Production of infectious ferret hepatitis E virus in a human hepatocarcinoma cell line PLC/PRF/5. Virus Res. 2016;213:283-288 pubmed publisher
    ..The establishment of ferret HEV cell culture system might be useful to understand the life cycle, mechanism of infection and replication of ferret HEV. ..
  7. Li T, Yoshizaki S, Zhou X, Sentsui H, Shirato K, Matsuyama S, et al. Serological evidence of hepatitis E virus infection in dromedary camels in Ethiopia. J Virol Methods. 2017;246:34-37 pubmed publisher
    ..In addition, not only DcHEV-LPs, but also virus-like particles (VLPs) delivered from G1, G3 and G5 HEV are likely applicable for the detection of the anti-DcHEV IgG antibody. ..
  8. Takemura K, Adegoke O, Takahashi N, Kato T, Li T, Kitamoto N, et al. Versatility of a localized surface plasmon resonance-based gold nanoparticle-alloyed quantum dot nanobiosensor for immunofluorescence detection of viruses. Biosens Bioelectron. 2017;89:998-1005 pubmed publisher
    ..The detection of influenza virus H1N1 was accomplished with high sensitivity. The versatility of the biosensor was demonstrated for the detection of clinically isolated influenza virus H3N2 and norovirus-like particles (NoV-LPs). ..
  9. Li T, Yang T, Yoshizaki S, Ami Y, Suzaki Y, Ishii K, et al. Ferret hepatitis E virus infection induces acute hepatitis and persistent infection in ferrets. Vet Microbiol. 2016;183:30-6 pubmed publisher

More Information


  1. Li T, Zhou X, Yoshizaki S, Ami Y, Suzaki Y, Nakamura T, et al. Production of infectious dromedary camel hepatitis E virus by a reverse genetic system: Potential for zoonotic infection. J Hepatol. 2016;65:1104-1111 pubmed publisher
    ..Cynomolgus monkeys experimentally infected with DcHEV indicated serological signs of infection, suggesting that DcHEV has the potential to cause zoonotic HEV infection. ..
  2. Ahmed S, Takemeura K, Li T, Kitamoto N, Tanaka T, Suzuki T, et al. Size-controlled preparation of peroxidase-like graphene-gold nanoparticle hybrids for the visible detection of norovirus-like particles. Biosens Bioelectron. 2017;87:558-565 pubmed publisher
    ..We believe that the engineered catalytic Grp-Au NP hybrids could find potential applications in the future development of biocatalysts and bioassays. ..
  3. Li T, Yoshizaki S, Kataoka M, Ami Y, Suzaki Y, Doan Y, et al. Genetic and physicochemical analyses of a novel ferret hepatitis E virus, and clinical signs of infection after birth. Infect Genet Evol. 2017;51:153-159 pubmed publisher
    ..There was no evidence that the particles were associated with the cell membrane. The ferret HEV RNA was not constantly detected in urine, suggesting that the excretion of ferret HEV into urine is not a common feature of HEV infection. ..
  4. Li T, Scotti P, Miyamura T, Takeda N. Latent infection of a new alphanodavirus in an insect cell line. J Virol. 2007;81:10890-6 pubmed
    ..Phylogenetic analysis suggested that this new nodavirus belongs to the genus Alphanodavirus in the family Nodaviridae. ..
  5. request reprint
    Li T, Saito M, Ogura G, Ishibashi O, Miyamura T, Takeda N. Serologic evidence for hepatitis E virus infection in mongoose. Am J Trop Med Hyg. 2006;74:932-6 pubmed
    ..These results are consistent with the possibility that mongooses in Okinawa are occasionally infected with HEV; however, they are not considered the major zoonotic reservoir of HEV...
  6. Zhang W, Sano N, Kataoka M, Ami Y, Suzaki Y, Wakita T, et al. Virus-like particles of porcine bocavirus generated by recombinant baculoviruses can be applied to sero-epidemic studies. Virus Res. 2016;217:85-91 pubmed publisher
    ..The seven PBoV strains detected in wild boars separated into four subgroups, demonstrating the genetic diversity of PBoV. ..
  7. Li T, Ami Y, Suzaki Y, Yasuda S, Yoshimatsu K, Arikawa J, et al. Characterization of full genome of rat hepatitis E virus strain from Vietnam. Emerg Infect Dis. 2013;19:115-8 pubmed publisher
    ..The entire genome of V-105 shared only 76.8%-76.9% nucleotide sequence identities with rat HEV strains from Germany, which suggests that V-105 is a new genotype of rat HEV...
  8. Li T, Ochiai S, Ishiko H, Wakita T, Miyamura T, Takeda N. A retrospective study on imported hepatitis E in Japan. Travel Med Infect Dis. 2012;10:80-5 pubmed publisher
    ..These results indicated that some sporadic cases of hepatitis E in Japan are caused by imported HEV, and that phylogenetic analyses enable us to identify the country or area where a patient has been infected...